BRPI0608138A2 - cloridrato de lercanidipina amorfa - Google Patents

cloridrato de lercanidipina amorfa

Info

Publication number
BRPI0608138A2
BRPI0608138A2 BRPI0608138-0A BRPI0608138A BRPI0608138A2 BR PI0608138 A2 BRPI0608138 A2 BR PI0608138A2 BR PI0608138 A BRPI0608138 A BR PI0608138A BR PI0608138 A2 BRPI0608138 A2 BR PI0608138A2
Authority
BR
Brazil
Prior art keywords
pure
amorphous lercanidipine
lercanidipine hydrochloride
amorphous
hydrochloride
Prior art date
Application number
BRPI0608138-0A
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Fabio Berlati
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36585434&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0608138(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Publication of BRPI0608138A2 publication Critical patent/BRPI0608138A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/04—Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)

Abstract

CLORIDRATO DE LERCANIDIPINA AMORFA. A invenção apresenta um cloridrato de lercanidipina amorfa substancialmente puro, com uma pureza de pelo menos 95% puro, de preferência pelo menos cerca de 97% puro, mais preferivelmente pelo menos cerca de 99% puro e, ainda mais preferivelmente, pelo menos cerca de 99,5% puro. A invenção também apresenta métodos de preparação de lercanidipina amorfa substancialmente pura e composições farmacêuticas contendo a lercanidipina amorfa substancialmente pura.
BRPI0608138-0A 2005-02-25 2006-02-24 cloridrato de lercanidipina amorfa BRPI0608138A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65683605P 2005-02-25 2005-02-25
PCT/EP2006/001782 WO2006089787A1 (en) 2005-02-25 2006-02-24 Amorphous lercanidipine hydrochloride

Publications (1)

Publication Number Publication Date
BRPI0608138A2 true BRPI0608138A2 (pt) 2009-11-17

Family

ID=36585434

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608138-0A BRPI0608138A2 (pt) 2005-02-25 2006-02-24 cloridrato de lercanidipina amorfa

Country Status (32)

Country Link
US (1) US7820701B2 (pt)
EP (1) EP1856051B1 (pt)
JP (1) JP2008531515A (pt)
KR (1) KR20070105979A (pt)
CN (1) CN101124204A (pt)
AR (1) AR052918A1 (pt)
AU (1) AU2006218026B9 (pt)
BR (1) BRPI0608138A2 (pt)
CA (1) CA2598016A1 (pt)
CY (1) CY1122429T1 (pt)
DK (1) DK1856051T3 (pt)
EA (1) EA014383B1 (pt)
ES (1) ES2339213T3 (pt)
HR (1) HRP20192302T1 (pt)
HU (1) HUE046910T2 (pt)
IL (1) IL184349A0 (pt)
LT (1) LT1856051T (pt)
ME (1) ME03659B (pt)
MX (1) MX2007010093A (pt)
MY (1) MY142129A (pt)
NO (1) NO344559B1 (pt)
NZ (1) NZ556667A (pt)
PE (1) PE20061014A1 (pt)
PL (1) PL1856051T3 (pt)
PT (1) PT1856051T (pt)
RS (1) RS59654B1 (pt)
SI (1) SI1856051T1 (pt)
TW (1) TW200640861A (pt)
UA (1) UA90130C2 (pt)
UY (1) UY29401A1 (pt)
WO (1) WO2006089787A1 (pt)
ZA (1) ZA200708127B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532248B1 (en) * 2002-07-26 2009-04-01 Novartis Vaccines and Diagnostics, Inc. Modified small interfering rna molecules and methods of use
AR052918A1 (es) 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
WO2007031865A2 (en) 2005-09-16 2007-03-22 Glenmark Pharmaceuticals Limited Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof
PT2046745E (pt) * 2006-08-04 2014-01-15 Recordati Ireland Ltd Processo para preparação de cloridrato de lercanidipina amorfo
WO2008068777A2 (en) * 2006-12-06 2008-06-12 Torrent Pharmaceuticals Limited Stable lercanidipine formulation
CN101868442A (zh) * 2007-03-05 2010-10-20 阿克塔维什集团Ptc公司 盐酸乐卡地平多晶型物和1,1,n-三甲基-n-(3,3-二苯基丙基)-2-氨基乙酰醋酸乙酯的改进制法
JP5637568B2 (ja) * 2009-05-12 2014-12-10 コーセプト セラピューティクス， インコーポレイテッド 固体形態および調製のためのプロセス
DE102010005124A1 (de) * 2010-01-19 2012-03-01 Stada Arzneimittel Ag Feste pharmazeutische Zusammensetzung umfassend Lercanidipin
EP2444394A1 (en) 2010-10-21 2012-04-25 Alembic Pharmaceuticals Limited Process for the preparation of amorphous form of lercanidipine HCI
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法
CN102531999B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 无定形盐酸乐卡地平及其制备方法
CN102600146B (zh) * 2012-04-11 2014-10-08 兆科药业（合肥）有限公司 一种盐酸乐卡地平和氯沙坦钾复方制剂及其制备方法
US9951009B2 (en) * 2013-08-29 2018-04-24 Cadila Healthcare Limited Polymorphic form of pyrrole derivative and intermediate thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
US5696139A (en) 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
US5912351A (en) 1995-05-12 1999-06-15 Recordati, S.A. Chemical And Pharmaceutical Company Anhydrous 1,4-Dihydropyridines and salts thereof
IT1274480B (it) 1995-05-12 1997-07-17 Recordati Chem Pharm Procedimento migliorato per la preparazione della lercanidipina cloridrato
US20030069285A1 (en) 2001-08-06 2003-04-10 Recordati Ireland Limited Novel solvate and crystalline forms of lercanidipine hydrochloride
ITMI20011727A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi
US6852737B2 (en) 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US20030180355A1 (en) 2001-10-16 2003-09-25 Amedeo Leonardi Combination therapy for hypertension
US20040147566A1 (en) 2002-10-16 2004-07-29 Amedeo Leonardi Lisinopril/lercanidipine combination therapy
JP4749660B2 (ja) * 2002-10-16 2011-08-17 武田薬品工業株式会社 安定な固形製剤
US20040198789A1 (en) 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations
TW200613275A (en) 2004-08-24 2006-05-01 Recordati Ireland Ltd Lercanidipine salts
TW200616681A (en) 2004-10-05 2006-06-01 Recordati Ireland Ltd Lercanidipine capsules
KR100651212B1 (ko) 2004-10-27 2006-12-01 제일약품주식회사 무정형 레르카니디핀의 제조방법
AR052918A1 (es) 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
WO2007031865A2 (en) 2005-09-16 2007-03-22 Glenmark Pharmaceuticals Limited Polymorphic form of lercanidipine hydrochloride and process for the preparation thereof
WO2007054969A2 (en) 2005-09-21 2007-05-18 Torrent Pharmaceuticals Limited Process for the preparation of lercanidipine and amorphous form of lercanidipine hydrochloride
PT2046745E (pt) 2006-08-04 2014-01-15 Recordati Ireland Ltd Processo para preparação de cloridrato de lercanidipina amorfo

Also Published As

Publication number Publication date
JP2008531515A (ja) 2008-08-14
LT1856051T (lt) 2020-01-10
WO2006089787A1 (en) 2006-08-31
CN101124204A (zh) 2008-02-13
ES2339213T1 (es) 2010-05-18
NZ556667A (en) 2009-10-30
US7820701B2 (en) 2010-10-26
EA014383B1 (ru) 2010-10-29
US20060211742A1 (en) 2006-09-21
UA90130C2 (ru) 2010-04-12
TW200640861A (en) 2006-12-01
AU2006218026B2 (en) 2009-04-02
UY29401A1 (es) 2006-06-30
ZA200708127B (en) 2008-11-26
PL1856051T3 (pl) 2020-05-18
NO344559B1 (no) 2020-02-03
MY142129A (en) 2010-09-30
AU2006218026A1 (en) 2006-08-31
RS59654B1 (sr) 2020-01-31
CA2598016A1 (en) 2006-08-31
MX2007010093A (es) 2007-10-12
EP1856051B1 (en) 2019-11-13
SI1856051T1 (sl) 2020-02-28
AR052918A1 (es) 2007-04-11
PT1856051T (pt) 2020-01-07
NO20074874L (no) 2007-11-26
IL184349A0 (en) 2007-10-31
ES2339213T3 (es) 2020-05-28
DK1856051T3 (da) 2020-01-02
HRP20192302T1 (hr) 2020-03-06
HUE046910T2 (hu) 2020-04-28
ME03659B (me) 2021-01-20
EP1856051A1 (en) 2007-11-21
EA200701687A1 (ru) 2008-02-28
KR20070105979A (ko) 2007-10-31
PE20061014A1 (es) 2006-10-03
CY1122429T1 (el) 2021-01-27
AU2006218026B9 (en) 2011-10-27

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]
B07C Technical examination (opinion): republication [chapter 7.3 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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