BRPI0608273A2 - peptìdeos para diminuição da pressão sanguìnea a partir de glicomacropeptìdeo - Google Patents
peptìdeos para diminuição da pressão sanguìnea a partir de glicomacropeptìdeoInfo
- Publication number
- BRPI0608273A2 BRPI0608273A2 BRPI0608273-4A BRPI0608273A BRPI0608273A2 BR PI0608273 A2 BRPI0608273 A2 BR PI0608273A2 BR PI0608273 A BRPI0608273 A BR PI0608273A BR PI0608273 A2 BRPI0608273 A2 BR PI0608273A2
- Authority
- BR
- Brazil
- Prior art keywords
- proline
- glycomacropeptide
- blood pressure
- protein
- protein source
- Prior art date
Links
- 230000036772 blood pressure Effects 0.000 title abstract 2
- 108010067454 caseinomacropeptide Proteins 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 3
- 101710118538 Protease Proteins 0.000 abstract 2
- 102000004400 Aminopeptidases Human genes 0.000 abstract 1
- 108090000915 Aminopeptidases Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 108010031424 isoleucyl-prolyl-proline Proteins 0.000 abstract 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108010032563 oligopeptidase Proteins 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PEPTìDEOS PARA DIMINUIçãO DA PRESSãO SANGUìNEA A PARTIR DE GLICOMACROPEPTìDEO. Um processo para produzir IPP a partir de uma fonte de proteína, pelo que a fonte de proteína compreende uma proteína tendo a seqúência -I-P-P- e tendo, na seqúência de aminoácido da proteína, pelo menos 6 vezes mais -I-P--P-presente do que -V-P-P- (base molar), o qual compreende hidrólise da fonte de proteína para liberar pelo menos 40% da seqúência -I-P--P- no peptídeo IPP e pelo que uma enzima proteolítica é usada a qual cliva, no carbóxi-término, os resíduos de prolina presentes na fonte de proteína, a enzima é, de preferência, uma endoprotease prolina-específica ou oligopeptidase prolina-específica, mais preferivelmente uma endoprotease prolina-específica e opcionalmente uma amino peptidase.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05101417 | 2005-02-24 | ||
| EP05110236 | 2005-11-01 | ||
| PCT/EP2006/060198 WO2006089921A1 (en) | 2005-02-24 | 2006-02-23 | Blood pressure lowering peptides from glycomacropeptide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0608273A2 true BRPI0608273A2 (pt) | 2009-12-15 |
| BRPI0608273B1 BRPI0608273B1 (pt) | 2017-04-04 |
| BRPI0608273B8 BRPI0608273B8 (pt) | 2021-07-27 |
Family
ID=36061583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0608273A BRPI0608273B8 (pt) | 2005-02-24 | 2006-02-23 | processo para produzir ipp a partir de gmp (glicomacropeptídeo de kappa caseína), composição de peptídeo e uso da mesma, bem como processo para preparar um produto alimentício, produto de bebida ou suplemento dietético |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8088597B2 (pt) |
| EP (1) | EP1851323B1 (pt) |
| JP (1) | JP5770411B2 (pt) |
| KR (1) | KR101244995B1 (pt) |
| CN (2) | CN103463615B (pt) |
| AU (1) | AU2006217901B2 (pt) |
| BR (1) | BRPI0608273B8 (pt) |
| EA (1) | EA016396B1 (pt) |
| ES (1) | ES2599859T3 (pt) |
| NZ (1) | NZ560601A (pt) |
| PL (1) | PL1851323T3 (pt) |
| WO (1) | WO2006089921A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004237455B2 (en) | 2003-05-05 | 2007-08-02 | Dsm Ip Assets B.V. | Hydrolysed casein product comprising tripeptides IPP and/ or VPP |
| CN101084004A (zh) | 2004-12-22 | 2007-12-05 | 帝斯曼知识产权资产管理有限公司 | 单个酶促步骤中的血压降低寡肽 |
| AU2006239560B2 (en) * | 2005-04-28 | 2010-03-25 | Unilever Plc | Peptides having an ace inhibiting effect |
| WO2009057725A1 (ja) * | 2007-10-31 | 2009-05-07 | Ito En, Ltd. | 蛋白質分解酵素処理モロヘイヤ抽出物組成物とその製造方法及び該組成物を含む血圧降下剤又は飲食物 |
| NZ571856A (en) * | 2008-10-09 | 2011-02-25 | Fonterra Corporate Res And Dev Ltd | Use of a phospholipid and ganglioside composition for the treatment or prevention of gout |
| AU2010334383B2 (en) * | 2009-12-21 | 2014-10-02 | Centre Hospitalier Universitaire Vaudois (Chuv) | Synergic action of a prolyl protease and tripeptidyl proteases |
| WO2016062855A1 (en) * | 2014-10-24 | 2016-04-28 | Dupont Nutrition Biosciences Aps | Proline tolerant tripeptidyl peptidases and uses thereof |
| US11129404B2 (en) | 2015-12-28 | 2021-09-28 | Abbott Laboratories | Nutritional compositions comprising hydrolyzed protein and a modified fat system and uses thereof |
| JP6967404B2 (ja) * | 2017-08-31 | 2021-11-17 | 雪印メグミルク株式会社 | アッカーマンシア・ムシニフィラ増加促進用組成物 |
| JP6993142B2 (ja) * | 2017-08-31 | 2022-01-13 | 雪印メグミルク株式会社 | アッカーマンシア・ムシニフィラ増加促進用組成物 |
| CN109380728B (zh) * | 2018-10-17 | 2022-03-22 | 汤臣倍健股份有限公司 | 一种具有辅助降血压功效的组合物及保健食品 |
| US11825860B1 (en) | 2023-01-13 | 2023-11-28 | Leprino Foods Company | Denatured milk proteins and methods of making them |
| US12349701B2 (en) | 2023-01-13 | 2025-07-08 | Leprino Foods Company | Denatured milk proteins, methods of making, and protein fortified foods |
| CN121344131A (zh) * | 2025-12-22 | 2026-01-16 | 内蒙古蒙牛乳业（集团）股份有限公司 | 一种具备卡扣立体结构特征的抑制Aβ42聚集的酪蛋白酶解物及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3311051A1 (de) * | 1983-03-25 | 1984-09-27 | Siemens AG, 1000 Berlin und 8000 München | Flexibles heizelement in bandform, das aus elektrisch leitfaehigen koernchen aus ptc-material und einem organischen isolierenden kunststoff als bindemittel besteht, und verfahren zur herstellung des flexiblen heizelementes |
| JP2622686B2 (ja) * | 1987-05-15 | 1997-06-18 | 雪印乳業株式会社 | ｋ−カゼイングリコマクロペプチドの製造法 |
| JPH01291795A (ja) * | 1988-05-18 | 1989-11-24 | Takara Shuzo Co Ltd | プロリン残基特異的ペプチダーゼの製造方法 |
| JP2673828B2 (ja) * | 1989-04-19 | 1997-11-05 | 雪印乳業株式会社 | κ―カゼイングリコマクロペプチドの製造法 |
| JP2920427B2 (ja) * | 1991-01-21 | 1999-07-19 | 雪印乳業株式会社 | κ−カゼイングリコマクロペプチドの製造法 |
| DK8892D0 (da) * | 1992-01-23 | 1992-01-23 | Symbicom Ab | Humant proteingen |
| US5391497A (en) * | 1992-10-13 | 1995-02-21 | University Of Colorado Foundation, Inc. | Human k-casein |
| JPH06345664A (ja) * | 1993-06-11 | 1994-12-20 | Takako Tomita | 新規な血圧上昇抑制用組成物 |
| JP3567012B2 (ja) * | 1995-03-28 | 2004-09-15 | 雪印乳業株式会社 | 新規ペプチド及びその利用 |
| JPH09164A (ja) * | 1995-06-22 | 1997-01-07 | Asahi Chem Ind Co Ltd | 加水分解蛋白質の製造方法 |
| JPH1033115A (ja) * | 1996-07-24 | 1998-02-10 | Nouchikusangiyou Shinko Jigyodan | ホエー飲料とその製造法 |
| WO1998014071A1 (en) * | 1996-10-01 | 1998-04-09 | John Stephen Ayers | Process for isolating glycomacropeptide from dairy products with a phenylalanine impurity of 0.5 %w/w |
| US6323008B1 (en) * | 1997-08-14 | 2001-11-27 | Neose Technologies, Inc. | Methods for producing sialyloligosaccharides in a dairy source |
| JP4727770B2 (ja) * | 1997-09-26 | 2011-07-20 | カルピス株式会社 | 尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びＦｉｓｃｈｅｒ比低下の少なくとも１つの軽減剤 |
| US5968586A (en) * | 1997-10-09 | 1999-10-19 | Wisconsin Alumni Research Foundation | Production of κ-casein macropeptide for nutraceutical uses |
| US6168823B1 (en) * | 1997-10-09 | 2001-01-02 | Wisconsin Alumni Research Foundation | Production of substantially pure kappa casein macropeptide |
| FI113741B (fi) * | 1999-11-01 | 2004-06-15 | Valio Oy | Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi |
| JP4633876B2 (ja) * | 1999-11-11 | 2011-02-16 | カルピス株式会社 | トリペプチドの製造方法 |
| ATE475324T1 (de) | 2000-12-07 | 2010-08-15 | Dsm Ip Assets Bv | Mit carboxy-terminal prolin peptide angereicherte proteinhydrolysate |
| JP4815568B2 (ja) * | 2001-01-05 | 2011-11-16 | 独立行政法人産業技術総合研究所 | 好熱性プロリルエンドペプチダーゼ |
| DE10149668A1 (de) * | 2001-10-09 | 2003-04-10 | Numico Res B V | Insulinmimetische Aminosäuresequenzen |
| ES2540926T3 (es) * | 2002-06-04 | 2015-07-14 | Dsm Ip Assets B.V. | Hidrolizado de proteínas rico en tripéptidos |
| AU2004237455B2 (en) | 2003-05-05 | 2007-08-02 | Dsm Ip Assets B.V. | Hydrolysed casein product comprising tripeptides IPP and/ or VPP |
| JP5341300B2 (ja) * | 2003-08-01 | 2013-11-13 | カルピス株式会社 | アンジオテンシン変換酵素阻害活性又は血圧降下作用を有する剤 |
| EA200601575A1 (ru) | 2004-03-01 | 2007-06-29 | Пептера Фармасьютикалс Лтд. | Казеиновые пептиды и их терапевтическое применение |
| CA2569926A1 (en) * | 2004-07-12 | 2006-01-19 | Dsm Ip Assets B.V. | Blood pressure lowering protein hydrolysates |
-
2006
- 2006-02-23 WO PCT/EP2006/060198 patent/WO2006089921A1/en not_active Ceased
- 2006-02-23 BR BRPI0608273A patent/BRPI0608273B8/pt not_active IP Right Cessation
- 2006-02-23 ES ES06708461.6T patent/ES2599859T3/es not_active Expired - Lifetime
- 2006-02-23 AU AU2006217901A patent/AU2006217901B2/en not_active Ceased
- 2006-02-23 NZ NZ560601A patent/NZ560601A/en not_active IP Right Cessation
- 2006-02-23 PL PL06708461T patent/PL1851323T3/pl unknown
- 2006-02-23 EP EP06708461.6A patent/EP1851323B1/en not_active Expired - Lifetime
- 2006-02-23 CN CN201310272306.8A patent/CN103463615B/zh not_active Expired - Fee Related
- 2006-02-23 US US11/884,448 patent/US8088597B2/en not_active Expired - Fee Related
- 2006-02-23 KR KR1020077019369A patent/KR101244995B1/ko not_active Expired - Fee Related
- 2006-02-23 EA EA200701778A patent/EA016396B1/ru not_active IP Right Cessation
- 2006-02-23 CN CN200680006116.XA patent/CN101128596B/zh not_active Expired - Fee Related
- 2006-02-23 JP JP2007556603A patent/JP5770411B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1851323B1 (en) | 2016-09-28 |
| JP5770411B2 (ja) | 2015-08-26 |
| AU2006217901B2 (en) | 2011-09-29 |
| EP1851323A1 (en) | 2007-11-07 |
| CN103463615B (zh) | 2016-09-07 |
| BRPI0608273B8 (pt) | 2021-07-27 |
| EA200701778A1 (ru) | 2008-02-28 |
| PL1851323T3 (pl) | 2017-02-28 |
| BRPI0608273B1 (pt) | 2017-04-04 |
| CN101128596B (zh) | 2014-07-23 |
| KR101244995B1 (ko) | 2013-03-18 |
| CN101128596A (zh) | 2008-02-20 |
| ES2599859T3 (es) | 2017-02-03 |
| JP2008537476A (ja) | 2008-09-18 |
| NZ560601A (en) | 2009-09-25 |
| US8088597B2 (en) | 2012-01-03 |
| CN103463615A (zh) | 2013-12-25 |
| KR20070114141A (ko) | 2007-11-29 |
| US20080161227A1 (en) | 2008-07-03 |
| WO2006089921A1 (en) | 2006-08-31 |
| AU2006217901A1 (en) | 2006-08-31 |
| EA016396B1 (ru) | 2012-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12P 21/02 , C12P 21/06 Ipc: C12P 21/02 (2006.01), C12P 21/06 (2006.01), A61K 3 |
|
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
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