BRPI0415230A - anticorpo biespecìfico de substituição de proteìnas funcionais - Google Patents

anticorpo biespecìfico de substituição de proteìnas funcionais

Info

Publication number
BRPI0415230A
BRPI0415230A BRPI0415230-1A BRPI0415230A BRPI0415230A BR PI0415230 A BRPI0415230 A BR PI0415230A BR PI0415230 A BRPI0415230 A BR PI0415230A BR PI0415230 A BRPI0415230 A BR PI0415230A
Authority
BR
Brazil
Prior art keywords
blood coagulation
bispecific antibody
functional proteins
coagulation factor
antibody replacement
Prior art date
Application number
BRPI0415230-1A
Other languages
English (en)
Inventor
Kunihiro Hattori
Tetsuo Kojima
Taro Miyazaki
Tetsuhiro Soeda
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2003/013123 external-priority patent/WO2005035754A1/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BRPI0415230A publication Critical patent/BRPI0415230A/pt
Publication of BRPI0415230B1 publication Critical patent/BRPI0415230B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"ANTICORPO BIESPECìFICO DE SUBSTITUIçãO DE PROTEìNAS FUNCIONAIS". A presente invenção foi bem sucedida na construção de anticorpos biespecíficos, os quais se ligam a ambos o fator IX de coagulação sangüínea/fator IX de coagulação sangüínea ativado e fator X de coagulação sangüínea, e funcionalmente substituto para fator Vill de coagulação sangüínea/fator VIII de coagulação sangüínea ativado que aumenta a reação enzimática.
BRPI0415230-1A 2003-10-10 2004-10-08 Anticorpo biespecífico de substituição de proteínas funcionais, composição e seu uso BRPI0415230B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JPPCT/JP2003/013062 2003-10-10
PCT/JP2003/013062 WO2005035753A1 (ja) 2003-10-10 2003-10-10 機能蛋白質を代替する二重特異性抗体
JPPCT/JP2003/013123 2003-10-14
PCT/JP2003/013123 WO2005035754A1 (ja) 2003-10-14 2003-10-14 機能蛋白質を代替する二重特異性抗体
PCT/JP2004/014911 WO2005035756A1 (ja) 2003-10-10 2004-10-08 機能蛋白質を代替する二種特異性抗体

Publications (2)

Publication Number Publication Date
BRPI0415230A true BRPI0415230A (pt) 2006-12-12
BRPI0415230B1 BRPI0415230B1 (pt) 2023-01-10

Family

ID=34430861

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415230-1A BRPI0415230B1 (pt) 2003-10-10 2004-10-08 Anticorpo biespecífico de substituição de proteínas funcionais, composição e seu uso

Country Status (23)

Country Link
US (1) US8062635B2 (pt)
EP (3) EP1688488B9 (pt)
JP (2) JP5438880B2 (pt)
KR (2) KR101361437B1 (pt)
CN (1) CN1890369B (pt)
AT (1) ATE518952T1 (pt)
AU (2) AU2003271174A1 (pt)
BR (1) BRPI0415230B1 (pt)
CA (1) CA2541671C (pt)
DK (2) DK3085783T3 (pt)
ES (2) ES2865152T3 (pt)
HU (1) HUE053833T2 (pt)
IL (1) IL174794A (pt)
MX (1) MXPA06003831A (pt)
NO (2) NO345624B1 (pt)
NZ (1) NZ546509A (pt)
PL (1) PL3085783T3 (pt)
PT (1) PT3085783T (pt)
RU (1) RU2339696C2 (pt)
SI (1) SI3085783T1 (pt)
TW (1) TW200514790A (pt)
UA (1) UA95438C2 (pt)
WO (2) WO2005035753A1 (pt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11612562B2 (en) 2010-01-20 2023-03-28 Chugai Seiyaku Kabushiki Kaisha Solution preparation containing stabilized antibody
US12558423B2 (en) 2020-05-29 2026-02-24 Chugai Seiyaku Kabushiki Kaisha Antibody-containing formulation

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