BRPI0608322A2 - uso de um composto de sulfonamida para aperfeiçoamento da farmacocinética de um fármaco - Google Patents

uso de um composto de sulfonamida para aperfeiçoamento da farmacocinética de um fármaco

Info

Publication number
BRPI0608322A2
BRPI0608322A2 BRPI0608322-6A BRPI0608322A BRPI0608322A2 BR PI0608322 A2 BRPI0608322 A2 BR PI0608322A2 BR PI0608322 A BRPI0608322 A BR PI0608322A BR PI0608322 A2 BRPI0608322 A2 BR PI0608322A2
Authority
BR
Brazil
Prior art keywords
pharmacokinetics
drug
improve
sulfonamide compound
improving
Prior art date
Application number
BRPI0608322-6A
Other languages
English (en)
Inventor
Klooster Gerben Albert Eleutherius Van't
Piet Tom Bert Paul Wigerinck
Meyer Sandra De
Lieven Elvire Colette Baert
Kock Herman Augustinus De
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of BRPI0608322A2 publication Critical patent/BRPI0608322A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

USO DE UM COMPOSTO DE SULFONAMIDA PARA APERFEIçOAMENTO DA FARMACOCINéTICA DE UM FáRMACO. Método para aperfeiçoamento da farmacocinética de fármacos os quais são metabolizados pela monooxigenase de citocroma P450 é divulgado. Mais especificamente, ele refere-se a um método para aperfeiçoamento da farmacocinética de inibidores de protease retroviral e, em particular, para aperfeiçoamento da farmacocinética de inibidores de protease do vírus da imunodeficiência humana (HIV). Uma composição farmacéutica e seu uso na fabricação de um medicamento para a inibição ou tratamento de uma infecção pelo HIV ou AIDS em um ser humano também são parte da invenção.
BRPI0608322-6A 2005-04-15 2006-04-14 uso de um composto de sulfonamida para aperfeiçoamento da farmacocinética de um fármaco BRPI0608322A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05103035 2005-04-15
US68428305P 2005-05-25 2005-05-25
PCT/EP2006/061614 WO2006108879A2 (en) 2005-04-15 2006-04-14 Use of a sulfonamide compound for improving the pharmacokinetics of a drug

Publications (1)

Publication Number Publication Date
BRPI0608322A2 true BRPI0608322A2 (pt) 2009-12-29

Family

ID=35589560

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608322-6A BRPI0608322A2 (pt) 2005-04-15 2006-04-14 uso de um composto de sulfonamida para aperfeiçoamento da farmacocinética de um fármaco

Country Status (12)

Country Link
US (1) US8557854B2 (pt)
EP (1) EP1874307A2 (pt)
JP (1) JP2008535896A (pt)
CN (1) CN101175491B (pt)
AR (1) AR053845A1 (pt)
AU (1) AU2006234335B2 (pt)
BR (1) BRPI0608322A2 (pt)
CA (1) CA2604799C (pt)
EA (1) EA016340B1 (pt)
TW (1) TW200745100A (pt)
WO (1) WO2006108879A2 (pt)
ZA (1) ZA200708811B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027887A1 (de) 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
DE102005057421A1 (de) * 2005-11-30 2007-05-31 Bayer Schering Pharma Ag Heteroaromatische Sulfonamid-Prodrugs
WO2008115894A1 (en) * 2007-03-16 2008-09-25 Sequoia Pharmaceuticals Benzofuran-derived hiv protease inhibitors
AR069539A1 (es) * 2007-07-25 2010-02-03 Tibotec Pharm Ltd Avances respecto de las formulaciones de comprimidos contra el vih
US8569364B2 (en) * 2007-11-28 2013-10-29 Sequoia Pharmaceuticals, Inc. 5-substituted benzofurans as inhibitors of cytochrome P450 2D6
UA103013C2 (uk) * 2007-12-06 2013-09-10 Тиботек Фармасьютикелз Амідні сполуки як активатори противірусних препаратів
US8759379B2 (en) * 2008-01-04 2014-06-24 Gilead Sciences, Inc. Inhibitors of cytochrome P450
US20110195940A1 (en) * 2008-09-17 2011-08-11 Nektar Therapeutics Protease Inhibitors Having Enhanced Features
EP2346842A1 (en) * 2008-10-07 2011-07-27 Tibotec Pharmaceuticals New amide compounds as boosters of antivirals
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
US20110155359A1 (en) * 2009-12-16 2011-06-30 E. I. Du Pont De Nemours And Company Hollow structures and associated method for conveying refrigerant fluids
EP2528923B1 (en) 2010-01-28 2014-07-30 Mapi Pharma Limited Process for the preparation of darunavir and darunavir intermediates
AR080375A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
CN102080122B (zh) * 2010-11-26 2013-04-10 吉林大学 同时测定五种cyp450酶探针药代谢产物的检测方法
CN102175804B (zh) * 2010-12-30 2013-06-05 吉林大学 Cyp450酶亚型生物质谱绝对定量方法
CN104540813A (zh) * 2012-06-27 2015-04-22 默沙东公司 磺酰胺衍生物以及使用它们用于改善药物的药物动力学的方法
WO2014000178A1 (en) * 2012-06-27 2014-01-03 Merck Sharp & Dohme Corp. Sulfonamide derivatives and methods of use thereof for improving the pharmacokinetics of a drug
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug
WO2015070366A1 (en) 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug
WO2015070367A1 (en) 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Piperidine or piperazine linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug
CN111202723A (zh) * 2020-02-15 2020-05-29 江苏艾立康药业股份有限公司 一种达芦那韦吸入干粉药物组合物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033792A2 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
US7659404B2 (en) 2001-02-14 2010-02-09 Tibotec Pharmaceuticals Ltd. Broad spectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors
WO2002092595A1 (en) * 2001-05-11 2002-11-21 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
EP1304404A1 (en) 2001-10-17 2003-04-23 Milliken Europe N.V. Reinforcement fabrics having at least two reinforcement directions
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
WO2003091264A2 (en) 2002-04-26 2003-11-06 Gilead Sciences, Inc. Non nucleoside reverse transcriptase inhibitors
BRPI0414916A (pt) * 2003-09-30 2006-11-07 Tibotec Pharm Ltd métodos para a preparação de compostos de sulfonamida de benzoxazol e intermediários dos mesmos

Also Published As

Publication number Publication date
TW200745100A (en) 2007-12-16
AR053845A1 (es) 2007-05-23
EA016340B1 (ru) 2012-04-30
AU2006234335A1 (en) 2006-10-19
CN101175491A (zh) 2008-05-07
US20080287488A1 (en) 2008-11-20
CA2604799A1 (en) 2006-10-19
CA2604799C (en) 2015-06-09
AU2006234335B2 (en) 2011-09-29
US8557854B2 (en) 2013-10-15
ZA200708811B (en) 2009-01-28
EA200702242A1 (ru) 2008-02-28
JP2008535896A (ja) 2008-09-04
WO2006108879A2 (en) 2006-10-19
EP1874307A2 (en) 2008-01-09
CN101175491B (zh) 2011-07-27
WO2006108879A3 (en) 2008-01-10

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]