BRPI0610876A2 - composto, mÉtodos de inibir uma atividade de uma jak cinase, de tratar uma doenÇa autoimune mediada por cÉlula t, de tratar ou prevenir rejeiÇço ao transplante de aloenxerto em um receptor de transplante, de inibir uma cascata de transduÇço de sinal que jak3 cinase desempenha um papel e de tratar ou prevenir uma doenÇa mediada por jak cinase, formulaÇço farmacÊutica, e, kit - Google Patents

composto, mÉtodos de inibir uma atividade de uma jak cinase, de tratar uma doenÇa autoimune mediada por cÉlula t, de tratar ou prevenir rejeiÇço ao transplante de aloenxerto em um receptor de transplante, de inibir uma cascata de transduÇço de sinal que jak3 cinase desempenha um papel e de tratar ou prevenir uma doenÇa mediada por jak cinase, formulaÇço farmacÊutica, e, kit

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Publication number
BRPI0610876A2
BRPI0610876A2 BRPI0610876-8A BRPI0610876A BRPI0610876A2 BR PI0610876 A2 BRPI0610876 A2 BR PI0610876A2 BR PI0610876 A BRPI0610876 A BR PI0610876A BR PI0610876 A2 BRPI0610876 A2 BR PI0610876A2
Authority
BR
Brazil
Prior art keywords
treating
inhibiting
jak kinase
jak
methods
Prior art date
Application number
BRPI0610876-8A
Other languages
English (en)
Inventor
Hui Li
Sambaiah Thota
David Carroll
Ankush Argade
Kin Tso
Arvinder Sran
Jeffrey Clough
Holger Keim
Somasekhar Bhamidipati
Vanessa Taylor
Robin Cooper
Rajinder Singh
Brian Wong
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of BRPI0610876A2 publication Critical patent/BRPI0610876A2/pt
Publication of BRPI0610876B1 publication Critical patent/BRPI0610876B1/pt
Publication of BRPI0610876B8 publication Critical patent/BRPI0610876B8/pt

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

COMPOSTO, MÉTODOS DE INIBIR UMA ATIVIDADE DE UMA JAK CINASE, DE TRATAR UMA DOENÇA AUTOIMUNE MEDIADA POR CÉLULA T, DE TRATAR OU PREVENIR REJEIÇçO AO TRANSPLANTE DE ALOENXERTO EM UM RECEPTOR DE TRANSPLANTE, DE INIBIR UMA CASCATA DE TRANSDUÇAO DE SINAL EM QUE JAK3 CINASE DESEMPENHA UM PAPEL E DE TRATAR OU PREVENIR UMA DOENÇA MEDIADA POR JAK CINASE, FORMULAÇçO FARMACÊUTICA, E, KIT. A invenção abrange compostos tendo a fórmula (I-V) e as composições e métodos usando estes compostos no tratamento de condições em que a modulação da via de JAK ou a inibição de JAK cinases, particularmente JAK3, podem ser terapeuticamente úteis.
BRPI0610876A 2005-06-08 2006-06-08 composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel BRPI0610876B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68903205P 2005-06-08 2005-06-08
US60/689,032 2005-06-08
US70663805P 2005-08-08 2005-08-08
US60/706,638 2005-08-08
US77663606P 2006-02-24 2006-02-24
US60/776,636 2006-02-24
PCT/US2006/022590 WO2006133426A2 (en) 2005-06-08 2006-06-08 Compositions and methods for inhibition of the jak pathway

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BRPI0610876A2 true BRPI0610876A2 (pt) 2008-12-02
BRPI0610876B1 BRPI0610876B1 (pt) 2020-12-29
BRPI0610876B8 BRPI0610876B8 (pt) 2021-05-25

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