BRPI0611567A2 - composto e/ou sais farmaceuticamente aceitáveis dos mesmos, processo para síntese dos compostos, e formulação aerossol, e, uso de pelo menos uma pró-droga mútua de fenilfosfato - Google Patents

composto e/ou sais farmaceuticamente aceitáveis dos mesmos, processo para síntese dos compostos, e formulação aerossol, e, uso de pelo menos uma pró-droga mútua de fenilfosfato

Info

Publication number: BRPI0611567A2
Authority: BR; Brazil
Prior art keywords: compound; phenylphosphate; salts; pharmaceutically acceptable; aerosol formulation
Prior art date: 2005-06-14

Application number

BRPI0611567A

Other languages

English (en)

Inventor

Bruce Charles Girton

Marcin Stasiak

William R Baker

Original Assignee

Gilead Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-14

Filing date

2006-06-12

Publication date

2016-11-16

2006-06-12 Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc

2016-11-16 Publication of BRPI0611567A2 publication Critical patent/BRPI0611567A2/pt

Links

150000001875 compounds Chemical class 0.000 title 2
239000000443 aerosol Substances 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000009472 formulation Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
CMPQUABWPXYYSH-UHFFFAOYSA-N phenyl phosphate Chemical compound OP(O)(=O)OC1=CC=CC=C1 CMPQUABWPXYYSH-UHFFFAOYSA-N 0.000 title 1
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Otolaryngology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

BRPI0611567A 2005-06-14 2006-06-12 composto e/ou sais farmaceuticamente aceitáveis dos mesmos, processo para síntese dos compostos, e formulação aerossol, e, uso de pelo menos uma pró-droga mútua de fenilfosfato BRPI0611567A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US69054505P	2005-06-14	2005-06-14
PCT/US2006/022790 WO2006138212A1 (en)	2005-06-14	2006-06-12	SUBSTITUTED PHENYLPHOSPHATES AS MUTUAL PRODRUGS OF STEROIDS AND β -AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION

Publications (1)

Publication Number	Publication Date
BRPI0611567A2 true BRPI0611567A2 (pt)	2016-11-16

Family

ID=37570763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0611567A BRPI0611567A2 (pt)	2005-06-14	2006-06-12	composto e/ou sais farmaceuticamente aceitáveis dos mesmos, processo para síntese dos compostos, e formulação aerossol, e, uso de pelo menos uma pró-droga mútua de fenilfosfato

Country Status (14)

Country	Link
US (1)	US20100209508A1 (pt)
EP (1)	EP1893220A4 (pt)
JP (1)	JP2008546694A (pt)
KR (1)	KR20060130515A (pt)
CN (1)	CN101227912A (pt)
AR (1)	AR054475A1 (pt)
AU (1)	AU2006259604A1 (pt)
BR (1)	BRPI0611567A2 (pt)
CA (1)	CA2612364A1 (pt)
IL (1)	IL187816A0 (pt)
NO (1)	NO20080182L (pt)
RU (1)	RU2008100237A (pt)
TW (1)	TW200718707A (pt)
WO (1)	WO2006138212A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ575549A (en) *	2006-09-19	2012-06-29	Cipla Ltd	Processes for the preparation of ciclesonide and its crystal form
US20100112061A1 (en) *	2006-12-13	2010-05-06	William Baker	Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
US20100098641A1 (en) *	2006-12-13	2010-04-22	William Baker	Monophosphates as Mutual Prodrugs of Anti-Inflammatory Signal Transduction Modulators (AISTM's) and Beta-Agonists for the Treatment of Pulmonary Inflammation and Bronchoconstriction
CL2008003803A1 (es) *	2007-12-21	2010-02-19	Schering Corp	Compuestos derivados de esteroides c20-21 sustituidos, agonistas del receptor de glucocorticoide; composicion farmaceutica que comprende a dicho compuesto; y uso para tratar o prevenir una enfermedad o afeccion inmune, autoinmune o inflamatoria, tales como colitis inflamatoria y artritis reumatoide.
MX2010007024A (es) *	2007-12-21	2010-09-30	Schering Corp	Tioéteres c-21 como agonista del receptor de glucocorticoides.
EP2294077A1 (en) *	2008-06-10	2011-03-16	Gilead Sciences, Inc.	Corticosteroid linked beta-agonist compounds for use in therapy
WO2010126953A1 (en) *	2009-04-29	2010-11-04	Gilead Sciences, Inc.	Corticosteroid linked beta-agonist compounds for use in therapy
WO2010132743A1 (en) *	2009-05-15	2010-11-18	Gilead Sciences, Inc.	Corticosteroid beta-agonist compounds for use in therapy
AU2010260177A1 (en) *	2009-06-16	2011-12-15	Merck Sharp & Dohme Corp.	Novel [3,2-c] heteroaryl steroids as glucocorticoid receptor agonists, compositions and uses thereof
ME01331B (me) *	2009-09-11	2013-12-20	Chiesi Farm Spa	Derivati izoksazolidina
WO2011081937A1 (en)	2009-12-15	2011-07-07	Gilead Sciences, Inc.	Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy
JP6124176B2 (ja) *	2013-03-26	2017-05-10	株式会社伏見製薬所	樹脂成形体用組成物
CN104510726A (zh) *	2013-09-27	2015-04-15	张金华	一种用于清洁呼吸道系统的食盐干粉吸入剂
PT107567B (pt) *	2014-03-31	2019-02-13	Hovione Farm S A	Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
KR20220119529A (ko)	2016-06-02	2022-08-29	애브비 인코포레이티드	글루코코르티코이드 수용체 작용제 및 이의 면역접합체
SG10202104259RA (en) *	2016-11-08	2021-06-29	Regeneron Pharma	Steroids and protein-conjugates thereof
KR20200007905A (ko)	2017-05-18	2020-01-22	리제너론 파마슈티칼스 인코포레이티드	사이클로덱스트린 단백질 약물 접합체
EP3706805A2 (en)	2017-11-07	2020-09-16	Regeneron Pharmaceuticals, Inc.	Hydrophilic linkers for antibody drug conjugates
WO2019106609A1 (en)	2017-12-01	2019-06-06	Abbvie Inc.	Glucocorticoid receptor agonist and immunoconjugates thereof
MA50259A1 (fr)	2018-01-08	2021-07-29	Regeneron Pharma	Stéroïdes et leurs conjugués-anticorps
CA3098453A1 (en)	2018-05-09	2019-11-14	Regeneron Pharmaceuticals, Inc.	Anti-msr1 antibodies and methods of use thereof
IT201900014178A1 (it) *	2019-08-06	2021-02-06	Genetic S P A	Esteri del montelukast e loro formulazioni farmaceutiche
JP7656784B2 (ja) *	2020-11-26	2025-04-04	国立医薬品食品衛生研究所長	新規化合物及び抗コロナウイルス剤
CN112592280B (zh) *	2020-12-09	2023-05-23	青岛职业技术学院	一种消旋沙丁胺醇的制备方法
AR125084A1 (es)	2021-03-23	2023-06-07	Lilly Co Eli	Agonistas del receptor de glucocorticoides novedosos
TWI899455B (zh)	2021-03-23	2025-10-01	美商美國禮來大藥廠	糖皮質素受體激動劑
AR125079A1 (es)	2021-03-23	2023-06-07	Lilly Co Eli	Agonistas de receptores de glucocorticoides sustituidos con carboxi
WO2022268176A1 (zh) *	2021-06-24	2022-12-29	江苏先声药业有限公司	甾体类化合物、其药物组合物及其应用
WO2023040793A1 (zh) *	2021-09-14	2023-03-23	映恩生物制药（苏州）有限公司	一种抗炎症的化合物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB933868A (en) *	1958-12-08	1963-08-14	American Cyanamid Co	Process for fluorinating steroids
US4757079A (en) *	1986-06-24	1988-07-12	Dynamac Corporaton	Anti-hypertensive piperidine compounds
GR1001529B (el) *	1990-09-07	1994-03-31	Elmuquimica Farm Sl	Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
EP0701565B1 (de) *	1993-04-02	1998-10-28	Byk Gulden Lomberg Chemische Fabrik GmbH	Neue prednisolonderivate
US6300326B1 (en) *	1994-11-02	2001-10-09	Michael R. Dobbs	Composition and method for control and treatment of cutaneous inflammation
IT1303671B1 (it) *	1998-07-28	2001-02-23	Nicox Sa	Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio
US20060293293A1 (en) *	2003-05-22	2006-12-28	Altana Pharma Ag	Salmeterol and ciclesonide combination
WO2005028495A1 (en) *	2003-09-24	2005-03-31	Glaxo Group Limited	Anti-inflammatory glucocorticoids
WO2005063777A1 (en) *	2003-12-23	2005-07-14	Corus Pharma	Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation

2006
- 2006-06-12 CA CA002612364A patent/CA2612364A1/en not_active Abandoned
- 2006-06-12 BR BRPI0611567A patent/BRPI0611567A2/pt not_active IP Right Cessation
- 2006-06-12 US US11/922,258 patent/US20100209508A1/en not_active Abandoned
- 2006-06-12 JP JP2008516976A patent/JP2008546694A/ja active Pending
- 2006-06-12 AU AU2006259604A patent/AU2006259604A1/en not_active Abandoned
- 2006-06-12 RU RU2008100237/04A patent/RU2008100237A/ru not_active Application Discontinuation
- 2006-06-12 CN CNA2006800213783A patent/CN101227912A/zh active Pending
- 2006-06-12 WO PCT/US2006/022790 patent/WO2006138212A1/en not_active Ceased
- 2006-06-12 EP EP06784777A patent/EP1893220A4/en not_active Withdrawn
- 2006-06-14 TW TW095121230A patent/TW200718707A/zh unknown
- 2006-06-14 AR ARP060102527A patent/AR054475A1/es unknown
- 2006-06-14 KR KR1020060053519A patent/KR20060130515A/ko not_active Withdrawn
2007
- 2007-12-02 IL IL187816A patent/IL187816A0/en unknown
2008
- 2008-01-11 NO NO20080182A patent/NO20080182L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20080182L (no)	2008-02-21
WO2006138212A1 (en)	2006-12-28
IL187816A0 (en)	2008-08-07
EP1893220A1 (en)	2008-03-05
EP1893220A4 (en)	2011-06-15
KR20060130515A (ko)	2006-12-19
RU2008100237A (ru)	2009-07-20
CN101227912A (zh)	2008-07-23
TW200718707A (en)	2007-05-16
AR054475A1 (es)	2007-06-27
US20100209508A1 (en)	2010-08-19
CA2612364A1 (en)	2006-12-28
AU2006259604A1 (en)	2006-12-28
JP2008546694A (ja)	2008-12-25

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Legal Events

Date	Code	Title	Description
2010-11-16	B06G	Technical and formal requirements: other requirements [chapter 6.7 patent gazette]	Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA.
2011-12-06	B11Z	Dismissal: petition dismissal - article 216, par 2 of industrial property law	Free format text: REFERENTE A PETICAO 020070177258/RJ DE 13/12/2007.
2017-02-07	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2017-05-30	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]