DK3421471T3 - Purin- og deazapurinderivater som farmaceutiske forbindelser - Google Patents
Purin- og deazapurinderivater som farmaceutiske forbindelser Download PDFInfo
- Publication number
- DK3421471T3 DK3421471T3 DK18182786.6T DK18182786T DK3421471T3 DK 3421471 T3 DK3421471 T3 DK 3421471T3 DK 18182786 T DK18182786 T DK 18182786T DK 3421471 T3 DK3421471 T3 DK 3421471T3
- Authority
- DK
- Denmark
- Prior art keywords
- deazapurin
- purin
- derivatives
- pharmaceutical compounds
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0608179A GB0608179D0 (en) | 2006-04-25 | 2006-04-25 | Pharmaceutical compounds |
| GB0608176A GB0608176D0 (en) | 2006-04-25 | 2006-04-25 | Pharmaceutical Compounds |
| EP07732555A EP2043655A2 (en) | 2006-04-25 | 2007-04-25 | Purine and deazapurine derivatives as pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3421471T3 true DK3421471T3 (da) | 2021-06-14 |
Family
ID=38255445
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18182786.6T DK3421471T3 (da) | 2006-04-25 | 2007-04-25 | Purin- og deazapurinderivater som farmaceutiske forbindelser |
| DK19216213.9T DK3719018T3 (da) | 2006-04-25 | 2007-04-25 | Purin og deazapurinderivater som farmaceutiske forbindelser |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19216213.9T DK3719018T3 (da) | 2006-04-25 | 2007-04-25 | Purin og deazapurinderivater som farmaceutiske forbindelser |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8796293B2 (da) |
| EP (3) | EP3421471B1 (da) |
| JP (1) | JP5606734B2 (da) |
| DK (2) | DK3421471T3 (da) |
| ES (2) | ES2878130T3 (da) |
| FI (1) | FI3719018T3 (da) |
| WO (1) | WO2007125321A2 (da) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| JP5606734B2 (ja) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| US8227603B2 (en) | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| DK2069352T5 (da) | 2006-08-02 | 2017-04-03 | Cytokinetics Inc | Bestemte kemiske enheder, sammensætninger og fremgangsmåder |
| EP2139478A4 (en) | 2007-03-30 | 2010-05-05 | Cytokinetics Inc | CHEMICAL ENTITIES, COMPOSITIONS AND METHODS |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| BRPI0818533B8 (pt) | 2007-10-11 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto |
| US8173635B2 (en) * | 2007-11-02 | 2012-05-08 | Vertex Pharmaceuticals Incorporated | Kinase inhibitors |
| CN101959887B (zh) | 2008-01-08 | 2013-07-31 | 阵列生物制药公司 | 作为激酶抑制剂的吡咯并吡啶 |
| EP2242757B1 (en) | 2008-01-09 | 2012-08-01 | Array Biopharma, Inc. | Pyrazolopyridines as kinase inhibitors |
| EP2297153B1 (en) * | 2008-04-21 | 2015-05-27 | Lexicon Pharmaceuticals, Inc. | Limk2 inhibitors, compositions comprising them, and methods of their use |
| AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
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| AU2010310786B2 (en) | 2009-10-23 | 2014-03-27 | Eli Lilly And Company | AKT inhibitors |
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| JP5927201B2 (ja) * | 2010-12-16 | 2016-06-01 | カルチャン リミテッド | Ask1阻害ピロロピリミジン誘導体 |
| WO2012131399A1 (en) | 2011-04-01 | 2012-10-04 | Astrazeneca Ab | Therapeutic treatment |
| US10272082B2 (en) | 2011-07-13 | 2019-04-30 | Cytokinetics, Inc. | Combination ALS therapy |
| SG2014009260A (en) * | 2011-09-12 | 2014-09-26 | Merck Patent Gmbh | Aminopyrimidine derivatives for use as modulators of kinase activity |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| PT2785349T (pt) | 2011-11-30 | 2019-12-11 | Astrazeneca Ab | Tratamento combinado de cancro |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| JP6139690B2 (ja) * | 2012-10-26 | 2017-05-31 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルートンチロシンキナーゼの阻害剤 |
| WO2014086453A1 (en) * | 2012-12-07 | 2014-06-12 | Merck Patent Gmbh | Azaheterobicyclic compounds |
| MX368286B (es) | 2013-04-17 | 2019-09-27 | Signal Pharm Llc | Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer. |
| EA030726B1 (ru) | 2013-04-17 | 2018-09-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | ФАРМАЦЕВТИЧЕСКИЕ СОСТАВЫ, СПОСОБЫ, ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ПРИМЕНЕНИЯ, ОТНОСЯЩИЕСЯ К 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1H-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1H)-ОНУ |
| AU2014254059B2 (en) | 2013-04-17 | 2019-06-06 | Signal Pharmaceuticals, Llc | Combination therapy comprising a TOR kinase inhibitor and a cytidine analog for treating cancer |
| CA2908957C (en) | 2013-04-17 | 2021-05-18 | Signal Pharmaceuticals, Llc | Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer |
| US9505764B2 (en) | 2013-04-17 | 2016-11-29 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| HK1221168A1 (zh) | 2013-04-17 | 2017-05-26 | 西格诺药品有限公司 | 用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法 |
| CA2908353C (en) | 2013-04-17 | 2021-11-02 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| HK1223286A1 (zh) | 2013-05-29 | 2017-07-28 | 西格诺药品有限公司 | 7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3,4-二氢吡嗪并[2,3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法 |
| JP2017511367A (ja) | 2014-04-16 | 2017-04-20 | シグナル ファーマシューティカルズ,エルエルシー | 1−エチル−7−(2−メチル−6−(1H−1,2,4−トリアゾール−3−イル)ピリジン−3−イル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン及び共形成物を含む固体形態、その組成物及び使用方法 |
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| EP3265464A1 (en) * | 2015-03-04 | 2018-01-10 | F. Hoffmann-La Roche AG | Triazolopyridine compounds and methods of use thereof |
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| JP7392164B2 (ja) | 2020-01-16 | 2023-12-05 | 浙江海正薬業股▲ふん▼有限公司 | ヘテロアリール誘導体、その製造方法およびその使用 |
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| AU2020480829A1 (en) | 2020-12-07 | 2023-07-20 | Kimberly-Clark Worldwide, Inc. | Methods and consumer products for detecting a metabolite |
| AU2023240170A1 (en) * | 2022-03-24 | 2024-10-31 | Curasen Therapeutics, Inc. | Alpha 1a-adrenergic receptor agonists and methods of use |
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| BRPI0818533B8 (pt) | 2007-10-11 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto |
-
2007
- 2007-04-25 JP JP2009507156A patent/JP5606734B2/ja active Active
- 2007-04-25 EP EP18182786.6A patent/EP3421471B1/en active Active
- 2007-04-25 FI FIEP19216213.9T patent/FI3719018T3/fi active
- 2007-04-25 ES ES18182786T patent/ES2878130T3/es active Active
- 2007-04-25 US US12/298,462 patent/US8796293B2/en active Active
- 2007-04-25 ES ES19216213T patent/ES3043833T3/es active Active
- 2007-04-25 DK DK18182786.6T patent/DK3421471T3/da active
- 2007-04-25 EP EP07732555A patent/EP2043655A2/en not_active Withdrawn
- 2007-04-25 DK DK19216213.9T patent/DK3719018T3/da active
- 2007-04-25 WO PCT/GB2007/001518 patent/WO2007125321A2/en not_active Ceased
- 2007-04-25 EP EP19216213.9A patent/EP3719018B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3421471A1 (en) | 2019-01-02 |
| US8796293B2 (en) | 2014-08-05 |
| EP2043655A2 (en) | 2009-04-08 |
| DK3719018T3 (da) | 2025-09-29 |
| EP3719018B1 (en) | 2025-08-27 |
| WO2007125321A3 (en) | 2007-12-27 |
| HK1257844A1 (en) | 2019-11-01 |
| ES2878130T3 (es) | 2021-11-18 |
| WO2007125321A2 (en) | 2007-11-08 |
| JP2009534455A (ja) | 2009-09-24 |
| JP5606734B2 (ja) | 2014-10-15 |
| EP3719018A1 (en) | 2020-10-07 |
| FI3719018T3 (fi) | 2025-10-07 |
| EP3421471B1 (en) | 2021-05-26 |
| US20100022564A1 (en) | 2010-01-28 |
| ES3043833T3 (en) | 2025-11-25 |
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