BRPI0611811A2 - ligantes de ligaÇço À proteÍna - Google Patents

ligantes de ligaÇço À proteÍna

Info

Publication number
BRPI0611811A2
BRPI0611811A2 BRPI0611811-9A BRPI0611811A BRPI0611811A2 BR PI0611811 A2 BRPI0611811 A2 BR PI0611811A2 BR PI0611811 A BRPI0611811 A BR PI0611811A BR PI0611811 A2 BRPI0611811 A2 BR PI0611811A2
Authority
BR
Brazil
Prior art keywords
protein binding
alkyl group
binding binders
equal
binders
Prior art date
Application number
BRPI0611811-9A
Other languages
English (en)
Inventor
Jason Richard Betley
Helen Rosemary Tatton
Ben Martin Beacom
James Christopher Pearson
Original Assignee
Prometic Biosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0511799A external-priority patent/GB0511799D0/en
Application filed by Prometic Biosciences Ltd filed Critical Prometic Biosciences Ltd
Publication of BRPI0611811A2 publication Critical patent/BRPI0611811A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • C07D251/44—One nitrogen atom with halogen atoms attached to the two other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LIGANTES DE LIGAÇçO A PROTEÍNA. Compostos da fórmula geral (I): nos quais, inter alia, Q¹ representa -NR¹Rü, -OR¹ ou -SR¹ e Q² representa -NR²R^ 4^, -OR² ou -SR² e A representa o ponto de fixação a uma matriz de suporte, são úteis como ligantes de ligação à proteína quando: (a) pelo menos um de R¹, R¹, R¹ e R^ 4^ inclui um grupo alquila -C~ n~H~ 2n+1~ no qual n é maior ou igual a 7; (b) pelo menos dois de R¹, R², Rü e R^ 4^ incluem, independentemente, um grupo alquila -C~ n~H~ 2n+1~ ou um grupo cicloalquila -C~ n~H~ 2n-1~ no qual n é maior do que ou igual a 4; ou (c) pelo menos três de R¹, R², Rü e R^ 4^ incluem, independentemente, um grupo C~ 1-12~ alquila substituído por - NR^ 5^R^ 6^ ou arila.
BRPI0611811-9A 2005-06-10 2006-06-08 ligantes de ligaÇço À proteÍna BRPI0611811A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0511799A GB0511799D0 (en) 2005-06-10 2005-06-10 Protein binding ligands
US69028705P 2005-06-14 2005-06-14
PCT/GB2006/050146 WO2006131768A2 (en) 2005-06-10 2006-06-08 Triazines as protein binding ligands

Publications (1)

Publication Number Publication Date
BRPI0611811A2 true BRPI0611811A2 (pt) 2008-12-09

Family

ID=37498810

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0611811-9A BRPI0611811A2 (pt) 2005-06-10 2006-06-08 ligantes de ligaÇço À proteÍna

Country Status (6)

Country Link
US (1) US8501939B2 (pt)
EP (1) EP1899308B1 (pt)
JP (1) JP5614930B2 (pt)
BR (1) BRPI0611811A2 (pt)
CA (1) CA2611734A1 (pt)
WO (1) WO2006131768A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1891088E (pt) * 2005-06-10 2011-12-19 Ares Trading Sa Processo para a purificação da proteína de ligação il-18
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
WO2010144468A1 (en) 2009-06-10 2010-12-16 Abbott Laboratories 2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors
CN112649517B (zh) * 2019-10-12 2021-10-15 中国科学院大连化学物理研究所 一种从生物体代谢物中筛选靶蛋白配体的方法
GB2609185A (en) * 2021-05-24 2023-02-01 Astrea Uk Services Ltd Scaffold for isolation of a biomolecule

Family Cites Families (32)

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GB814947A (en) * 1954-08-16 1959-06-17 Geigy Ag J R Improvements in and relating to plant growth influencing compositions
NL208063A (pt) * 1956-06-15
DE1302636B (pt) * 1961-07-07 1971-09-16
US3850918A (en) * 1970-06-17 1974-11-26 Ciba Geigy Corp 2-amino-4,6-disalicyloyl-hydrazino-s-triazines
US3931165A (en) * 1973-05-16 1976-01-06 Barer Sol J Tri-substituted triazines
US4204060A (en) * 1974-10-04 1980-05-20 Akzona Incorporated Novel monochloro-s-triazine derivatives
NL7500890A (nl) * 1975-01-25 1976-07-27 Akzo Nv Werkwijze voor de bereiding van nieuwe u.v.- -stabilisatoren.
US4229537A (en) 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4261892A (en) * 1978-04-12 1981-04-14 American Cyanamid Company 2,4,6-Tris-(substituted-amino)-s-triazines
GB8911287D0 (en) * 1989-05-17 1989-07-05 Ciba Geigy Ag Lubricant compositions
NZ246059A (en) 1991-12-03 1995-08-28 Proteus Molecular Design Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits
WO1993023432A1 (en) 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
US5283274A (en) * 1992-06-19 1994-02-01 Uniroyal Chemical Company, Inc. Substituted pyrimidines and substituted triazines as rubber-to-metal adhesion promoters
US5441563A (en) 1993-07-06 1995-08-15 Armstrong World Industries, Inc. Highly insoluble azole embossing inhibitor and the use thereof
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
GB9519197D0 (en) 1995-09-20 1995-11-22 Affinity Chromatography Ltd Novel affinity ligands and their use
US5750361A (en) 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
US5874576A (en) * 1995-12-19 1999-02-23 Givaudan-Roure (International) Sa Light screening agents
US5808011A (en) 1996-07-01 1998-09-15 Biopure Corporation Method for chromatographic removal of prions
AU738606B2 (en) 1997-02-06 2001-09-20 Enfer Technology Limited Immunological assay for spongiform encephalopathies
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Also Published As

Publication number Publication date
EP1899308A2 (en) 2008-03-19
WO2006131768A3 (en) 2007-09-27
US8501939B2 (en) 2013-08-06
US20080207876A1 (en) 2008-08-28
JP2008545868A (ja) 2008-12-18
EP1899308B1 (en) 2012-11-07
WO2006131768A2 (en) 2006-12-14
JP5614930B2 (ja) 2014-10-29
CA2611734A1 (en) 2006-12-14

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]