BRPI0612268A2 - Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus - Google Patents

Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus

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Publication number
BRPI0612268A2
BRPI0612268A2 BRPI0612268-0A BRPI0612268A BRPI0612268A2 BR PI0612268 A2 BRPI0612268 A2 BR PI0612268A2 BR PI0612268 A BRPI0612268 A BR PI0612268A BR PI0612268 A2 BRPI0612268 A2 BR PI0612268A2
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BR
Brazil
Prior art keywords
virus
influenza
producing
generating
cells
Prior art date
Application number
BRPI0612268-0A
Other languages
English (en)
Inventor
Gregory Duke
George Kemble
James Young
Zhaoti Wang
Original Assignee
Medimmune Vaccines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Vaccines Inc filed Critical Medimmune Vaccines Inc
Publication of BRPI0612268A2 publication Critical patent/BRPI0612268A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Biochemistry (AREA)
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  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

ÁCIDO NUCLEICO ISOLADO, VETOR DE EXPRESSçO, MÉTODOS PARA PRODUZIR UM RNA GENâMICO DA INIFLUENZA, PARA PRODUZIR UM VÍRUS DA INFLUENZA RECOMBINANTE, PARA GERAR UM VÍRUS DE RNA SEGMENTADO DE FILAMENTO NEGATIVO RECOMBINANTE NAS CÉLULAS CANINAS CULTIVADAS E PARA GERAR PARTÍCULAS VIRAIS DA INFLUENZA INFECCIOSA EM CÉLULAS CANiNAS CULTIVADAS, CÉLULA, E, VÍRUS. A presente invenção fornece novas sequências de ácido nucleico reguladoras da polimerase 1 canina, úteis para a expressão das sequências de ácido nucleico em células caninas tais como as células MDCK. A invenção ainda fornece vetores de expressão e células compreendendo tais ácidos nucleicos, bem como métodos de uso de tais ácidos nucleicos para produzir vírus da influenza, incluindo os vírus da influenza infecciosa.
BRPI0612268-0A 2005-06-21 2006-06-20 Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus BRPI0612268A2 (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US69296505P 2005-06-21 2005-06-21
US69297805P 2005-06-21 2005-06-21
US69955505P 2005-07-15 2005-07-15
US69955605P 2005-07-15 2005-07-15
US70200605P 2005-07-22 2005-07-22
US79352206P 2006-04-19 2006-04-19
US79352506P 2006-04-19 2006-04-19
PCT/US2006/023867 WO2007002008A2 (en) 2005-06-21 2006-06-20 Methods and compositions for expressing negative-sense viral rna in canine cells

Publications (1)

Publication Number Publication Date
BRPI0612268A2 true BRPI0612268A2 (pt) 2009-01-27

Family

ID=37595721

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0612268-0A BRPI0612268A2 (pt) 2005-06-21 2006-06-20 Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus

Country Status (11)

Country Link
US (4) US20060286591A1 (pt)
EP (2) EP1917352A4 (pt)
JP (2) JP2008543331A (pt)
KR (2) KR20080024212A (pt)
AU (2) AU2006262381A1 (pt)
BR (1) BRPI0612268A2 (pt)
CA (2) CA2613283A1 (pt)
IL (1) IL188202A0 (pt)
NO (1) NO20080358L (pt)
RU (1) RU2008101367A (pt)
WO (2) WO2007002008A2 (pt)

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US20060286591A1 (en) 2006-12-21
CA2613283A1 (en) 2007-01-04
AU2006262380A1 (en) 2007-01-04
WO2007002007A3 (en) 2007-06-21
AU2006262381A1 (en) 2007-01-04
WO2007002007A8 (en) 2007-05-10
US20100203641A1 (en) 2010-08-12
EP1917352A2 (en) 2008-05-07
JP2008546408A (ja) 2008-12-25
WO2007002008A2 (en) 2007-01-04
RU2008101367A (ru) 2009-08-10
NO20080358L (no) 2008-03-03
US8278433B2 (en) 2012-10-02
US20120329150A1 (en) 2012-12-27
IL188202A0 (en) 2008-03-20
CA2613284A1 (en) 2007-01-04
US8742089B2 (en) 2014-06-03
US20110045586A1 (en) 2011-02-24
WO2007002007A2 (en) 2007-01-04
EP1917361A4 (en) 2009-07-29
EP1917361A2 (en) 2008-05-07
KR20080025171A (ko) 2008-03-19
WO2007002008A3 (en) 2007-12-27
JP2008543331A (ja) 2008-12-04
KR20080024212A (ko) 2008-03-17
EP1917352A4 (en) 2009-03-25

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