BRPI0612456A2 - compositions and methods for the treatment of malaria with cupredoxin and cytochrome - Google Patents
compositions and methods for the treatment of malaria with cupredoxin and cytochromeInfo
- Publication number
- BRPI0612456A2 BRPI0612456A2 BRPI0612456-9A BRPI0612456A BRPI0612456A2 BR PI0612456 A2 BRPI0612456 A2 BR PI0612456A2 BR PI0612456 A BRPI0612456 A BR PI0612456A BR PI0612456 A2 BRPI0612456 A2 BR PI0612456A2
- Authority
- BR
- Brazil
- Prior art keywords
- cytochrome
- malaria
- cupredoxin
- compositions
- methods
- Prior art date
Links
- 201000004792 malaria Diseases 0.000 title abstract 6
- 108010052832 Cytochromes Proteins 0.000 title abstract 3
- 102000018832 Cytochromes Human genes 0.000 title abstract 3
- 108010092351 cupredoxin Proteins 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 102100030497 Cytochrome c Human genes 0.000 abstract 2
- 108010075031 Cytochromes c Proteins 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 208000009182 Parasitemia Diseases 0.000 abstract 2
- 208000030852 Parasitic disease Diseases 0.000 abstract 2
- 210000003743 erythrocyte Anatomy 0.000 abstract 2
- 241000238631 Hexapoda Species 0.000 abstract 1
- 241000223960 Plasmodium falciparum Species 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/80—Cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
COMPOSIÇÕES E MÉTODOS PARA O TRATAMENTO DA MALÁRIA COM CUPREDOXINA E CITOCROMO. Mais particularmente a invenção se refere à cupredoxina e ao citocromo, bem como a seu uso separado ou em conjunto para inibir a disseminação da parasitemia das hemácias de mamíferos e em outros tecidos infectados pelo parasita da malária e, em especial, a parasitemia das hemácias humanas pelo P. falciparum. A invenção provê peptídeos isolados que são variantes, derivados ou equivalentes estruturais das cupredoxinas ou do citocromo c, e composições que compreendem as cupredoxinas e/ou o citocrorno c, ou suas variantes, derivados ou equivalentes estruturais, que forem úteis para o tratamento ou prevenção da infecção por malária em mamíferos. Além disso, a invenção provê métodos para o tratamento de pacientes mamíferos de maneira a prevenir ou inibir o crescimento da infecção da malária em mamíferos. A invenção também provê métodos para evitar o crescimento da infecção da malária em vetores insetos.COMPOSITIONS AND METHODS FOR TREATING MALARIA WITH CUPREDOXIN AND CYTOCHROME. More particularly the invention relates to cupredoxin and cytochrome as well as their separate or combined use to inhibit the spread of mammalian red blood cell parasitemia and other malaria parasite-infected tissues and in particular human red blood cell parasitemia. by P. falciparum. The invention provides isolated peptides which are structural variants, derivatives or equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and / or cytochrome c, or variants, derivatives or structural equivalents thereof which are useful for treatment or prevention. of malaria infection in mammals. In addition, the invention provides methods for treating mammalian patients in order to prevent or inhibit the growth of malaria infection in mammals. The invention also provides methods for preventing the growth of malaria infection in insect vectors.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68281305P | 2005-05-20 | 2005-05-20 | |
| US11/244,105 US7691383B2 (en) | 2004-10-07 | 2005-10-06 | Cupredoxin derived transport agents and methods of use thereof |
| US78086806P | 2006-03-10 | 2006-03-10 | |
| PCT/US2006/019492 WO2006127477A2 (en) | 2005-05-20 | 2006-05-19 | Compositions and methods for treating malaria with cupredoxin and cytochrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0612456A2 true BRPI0612456A2 (en) | 2009-02-17 |
Family
ID=37452644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0612456-9A BRPI0612456A2 (en) | 2005-05-20 | 2006-05-19 | compositions and methods for the treatment of malaria with cupredoxin and cytochrome |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1882039A4 (en) |
| JP (1) | JP2009504567A (en) |
| KR (1) | KR20080019615A (en) |
| AU (2) | AU2006251742A1 (en) |
| BR (1) | BRPI0612456A2 (en) |
| CA (1) | CA2607739A1 (en) |
| IL (1) | IL187161A0 (en) |
| MX (1) | MX2007014597A (en) |
| NO (1) | NO20076390L (en) |
| WO (1) | WO2006127477A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491394B2 (en) | 2001-02-15 | 2009-02-17 | The Board Of Trustees Of The University Of Illinois | Cytotoxic factors for modulating cell death |
| MX2007014599A (en) * | 2005-05-20 | 2008-02-07 | Univ Illinois | Compositions and methods for treating hiv infection with cupredoxin and cytochrome c. |
| MX2008000993A (en) * | 2005-07-19 | 2008-03-19 | Univ Illinois | Compositions and methods to control angiogenesis with cupredoxins. |
| AU2006269879A1 (en) | 2005-07-19 | 2007-01-25 | The Board Of Trustees Of The University Of Illinois | Transport agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491394B2 (en) * | 2001-02-15 | 2009-02-17 | The Board Of Trustees Of The University Of Illinois | Cytotoxic factors for modulating cell death |
| WO2002070542A2 (en) * | 2001-03-02 | 2002-09-12 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Band 3 antigenic peptides, malaria polypeptides and uses thereof |
-
2006
- 2006-05-19 KR KR1020077028985A patent/KR20080019615A/en not_active Ceased
- 2006-05-19 AU AU2006251742A patent/AU2006251742A1/en not_active Abandoned
- 2006-05-19 BR BRPI0612456-9A patent/BRPI0612456A2/en not_active IP Right Cessation
- 2006-05-19 JP JP2008512549A patent/JP2009504567A/en active Pending
- 2006-05-19 MX MX2007014597A patent/MX2007014597A/en active IP Right Grant
- 2006-05-19 EP EP06770687A patent/EP1882039A4/en not_active Withdrawn
- 2006-05-19 CA CA002607739A patent/CA2607739A1/en not_active Abandoned
- 2006-05-19 WO PCT/US2006/019492 patent/WO2006127477A2/en not_active Ceased
-
2007
- 2007-11-05 IL IL187161A patent/IL187161A0/en unknown
- 2007-12-11 NO NO20076390A patent/NO20076390L/en not_active Application Discontinuation
-
2010
- 2010-04-06 AU AU2010201360A patent/AU2010201360A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006127477A2 (en) | 2006-11-30 |
| IL187161A0 (en) | 2008-02-09 |
| JP2009504567A (en) | 2009-02-05 |
| MX2007014597A (en) | 2008-01-21 |
| EP1882039A4 (en) | 2008-08-20 |
| KR20080019615A (en) | 2008-03-04 |
| AU2010201360A1 (en) | 2010-04-29 |
| CA2607739A1 (en) | 2006-11-30 |
| NO20076390L (en) | 2008-02-15 |
| WO2006127477A3 (en) | 2007-03-08 |
| EP1882039A2 (en) | 2008-01-30 |
| AU2006251742A1 (en) | 2006-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA30063B1 (en) | PYRIMIDINYL-ARYLUREE DERIVATIVES COMPRISING INHIBITORS OF FIBROBLAST GROWTH FACTORS (FCG) | |
| BRPI0921999B8 (en) | use of a therapeutically effective amount of placental stem cells | |
| BRPI0912411B8 (en) | use of a human interleukin-2 mutein (hil-2 mutein) and pharmaceutical composition for the treatment and/or prophylaxis of an autoimmune disease | |
| UY33034A (en) | MATERIALS AND METHODS FOR THE TREATMENT OR PREVENTION OF DISEASES ASSOCIATED WITH HER-3 | |
| BRPI0412343A (en) | pyridazine derivatives and their use as therapeutic agents | |
| BRPI0515482A (en) | heterocyclic derivatives and their uses as therapeutic agents | |
| EA200600076A1 (en) | COMPOSITIONS AND METHODS OF INCREASING THE ACTIVITY OF TELOMERASE | |
| BR112013003186A2 (en) | compositions and methods for treating cardiovascular disease | |
| EA200970446A1 (en) | CONNECTING WITH ALBUMIN MOLECULES AND THEIR APPLICATION | |
| BRPI0606817A2 (en) | pyridazine derivatives and their use as therapeutic agents | |
| CY1111446T1 (en) | COMPOSITIONS OF CRYSTALL SUMMARY TRANS- (+/-) - DELTA-9-tetrahydrocannabinol | |
| NO20064584L (en) | Tetrahydropyridoindolderivater | |
| EA201270666A1 (en) | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR REDUCING URIC ACID LEVEL | |
| NO20100301L (en) | Improved brimonidine compositions for the treatment of erythema | |
| Langleben et al. | STRIDE 1: effects of the selective ETA receptor antagonist, sitaxsentan sodium, in a patient population with pulmonary arterial hypertension that meets traditional inclusion criteria of previous pulmonary arterial hypertension trials | |
| NO20073765L (en) | Compounds for the treatment of flaviviridae | |
| UY28443A1 (en) | SUBSTITUTED DERIVATIVES OF THE TIAZOL-BENZOISOTIAZOL DIOXIDE, PROCEDURE FOR PREPARATION AND USE. | |
| DE602005021770D1 (en) | INDOLE-1-YL-ACETIC DERIVATIVES | |
| Vathsala et al. | Immunomodulatory and antiparasitic effects of garlic–arteether combination via nitric oxide pathway in Plasmodium berghei-infected mice | |
| EA200600468A1 (en) | BIPOLAR TRANS-CAROTINOID SALTS AND THEIR APPLICATION | |
| BR112022015768A2 (en) | METHODS OF TREATMENT AND PREVENTION OF GRAFT ARRHYTHMIAS | |
| NO20076405L (en) | Use of 24-nor-UDCA | |
| Burman et al. | Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice | |
| BR0309421A (en) | Oily Body Associated Protein Compositions and Methods of Using These to Reduce the Risk of Cardiovascular Disease | |
| BRPI0612456A2 (en) | compositions and methods for the treatment of malaria with cupredoxin and cytochrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |