BRPI0613004A2 - expandase mutante, polinucleotÍdeo, vetor ou cassete de expressço, cÉlula hospedeira, mÉtodo de produzir uma expandase mutante e mÉtodo de produzir um composto á-lactÂmico de interesse - Google Patents

expandase mutante, polinucleotÍdeo, vetor ou cassete de expressço, cÉlula hospedeira, mÉtodo de produzir uma expandase mutante e mÉtodo de produzir um composto á-lactÂmico de interesse Download PDF

Info

Publication number: BRPI0613004A2
Authority: BR; Brazil
Prior art keywords: expandase; mutant; amino acid; positions; group
Prior art date: 2005-07-12

Application number

BRPI0613004-6A

Other languages

English (en)

Portuguese (pt)

Inventor

Dick Schipper

Richard Kerkman

Roelof Ary Lans Bovenberg

Lourina Madeleine Raamsdonk

Original Assignee

Dms Ip Assets B V

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-12

Filing date

2006-04-10

Publication date

2010-12-14

2006-04-10 Application filed by Dms Ip Assets B V filed Critical Dms Ip Assets B V

2010-12-14 Publication of BRPI0613004A2 publication Critical patent/BRPI0613004A2/pt

Links

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108010072986 threonyl-seryl-lysine Proteins 0.000 description 1
238000004448 titration Methods 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
239000012137 tryptone Substances 0.000 description 1
239000007160 ty medium Substances 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
229960004295 valine Drugs 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
239000002132 β-lactam antibiotic Substances 0.000 description 1
229940124586 β-lactam antibiotics Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BRPI0613004-6A 2005-07-12 2006-04-10 expandase mutante, polinucleotÍdeo, vetor ou cassete de expressço, cÉlula hospedeira, mÉtodo de produzir uma expandase mutante e mÉtodo de produzir um composto á-lactÂmico de interesse BRPI0613004A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05106347.7		2005-07-12
EP05106347		2005-07-12
PCT/EP2006/061479 WO2007006593A2 (fr)	2005-07-12	2006-04-10	Expandases mutantes

Publications (1)

Publication Number	Publication Date
BRPI0613004A2 true BRPI0613004A2 (pt)	2010-12-14

Family

ID=34940295

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0613004-6A BRPI0613004A2 (pt)	2005-07-12	2006-04-10	expandase mutante, polinucleotÍdeo, vetor ou cassete de expressço, cÉlula hospedeira, mÉtodo de produzir uma expandase mutante e mÉtodo de produzir um composto á-lactÂmico de interesse

Country Status (5)

Country	Link
EP (1)	EP1902140A2 (fr)
KR (1)	KR20080028924A (fr)
CN (1)	CN101300360A (fr)
BR (1)	BRPI0613004A2 (fr)
WO (1)	WO2007006593A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN104805047B (zh) *	2014-01-23	2017-09-22	中国科学院微生物研究所	产头孢菌素g的重组菌及其构建方法与应用
CN114958877B (zh) *	2022-06-14	2024-02-20	河南省健康元生物医药研究院有限公司	去乙酰氧基头孢菌素c合成酶突变体及其编码基因与应用
CN117363591B (zh) *	2023-10-10	2026-04-10	上海邦林生物科技有限公司	用于合成g-7-adca的扩环酶突变体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2323361A (en) *	1995-11-27	1998-09-23	Gist Brocades Bv	Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin G
GB0011185D0 (en) *	2000-05-09	2000-06-28	Synpac Pharmaceuticals Limited	Protein

2006
- 2006-04-10 EP EP06725677A patent/EP1902140A2/fr not_active Withdrawn
- 2006-04-10 BR BRPI0613004-6A patent/BRPI0613004A2/pt not_active IP Right Cessation
- 2006-04-10 CN CNA2006800255771A patent/CN101300360A/zh active Pending
- 2006-04-10 WO PCT/EP2006/061479 patent/WO2007006593A2/fr not_active Ceased
- 2006-04-10 KR KR1020087000778A patent/KR20080028924A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
EP1902140A2 (fr)	2008-03-26
WO2007006593A2 (fr)	2007-01-18
WO2007006593A3 (fr)	2007-04-12
CN101300360A (zh)	2008-11-05
KR20080028924A (ko)	2008-04-02

Legal Events

Date	Code	Title	Description
2012-06-05	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A E 6A ANUIDADES.
2013-03-19	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.

Publication	Publication Date	Title
FI106965B (fi)	2001-05-15	Uusia biologisia menetelmiä 7-ACA:n ja 7-ADAC:n valmistamiseksi
Kennedy et al.	1996	δ-(L-α-Aminoadipyl)-L-cysteinyl-D-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans
Crawford et al.	1995	Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity
US5318896A (en)	1994-06-07	Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
WO1997020053A2 (fr)	1997-06-05	Procede ameliore de production de cephalosporines semi-synthetiques par l'activite de l'expandase sur la penicilline g
EP1799817B1 (fr)	2012-11-21	Expandases mutantes
BRPI0613004A2 (pt)	2010-12-14	expandase mutante, polinucleotÍdeo, vetor ou cassete de expressço, cÉlula hospedeira, mÉtodo de produzir uma expandase mutante e mÉtodo de produzir um composto á-lactÂmico de interesse
HK1125973A (en)	2009-08-21	Mutant expandases and their use in the production of beta-lactam compounds
Yeh	1997	Evolving enzyme technology for pharmaceutical applications: case studies
RU2202616C2 (ru)	2003-04-20	Способ получения 7-аминоцефалоспорановой кислоты, вектор экспрессии, рекомбинантный штамм
PL172155B1 (pl)	1997-08-29	Sposób biotechnologiczny wytwarzania pochodnych kwasu cefalosporanowego
Hollingsworth	2002	Genetic engineering of cephalosporin biosynthesis
Skatrud et al.	1992	Genetic Manipulation of the β-lactam Antibiotic Biosynthetic Pathway