BRPI0613924A2 - Forma cristalina do ácido zoledrônico, processo para a obtenção deste e composição farmacêutica o compreendendo - Google Patents

Forma cristalina do ácido zoledrônico, processo para a obtenção deste e composição farmacêutica o compreendendo Download PDF

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Publication number
BRPI0613924A2
BRPI0613924A2 BRPI0613924-8A BRPI0613924A BRPI0613924A2 BR PI0613924 A2 BRPI0613924 A2 BR PI0613924A2 BR PI0613924 A BRPI0613924 A BR PI0613924A BR PI0613924 A2 BRPI0613924 A2 BR PI0613924A2
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BR
Brazil
Prior art keywords
crystalline form
obtaining
pharmaceutical composition
zoledronic acid
composition understanding
Prior art date
Application number
BRPI0613924-8A
Other languages
English (en)
Inventor
Alberto Labriola Rafael
Graciela Tombari Dora
Vecchioli Adriana
Original Assignee
Gador S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gador S.A. filed Critical Gador S.A.
Publication of BRPI0613924A2 publication Critical patent/BRPI0613924A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FORMA CRISTALINA DO áCIDO ZOLEDRÈNICO, PROCESSO PARA A OBTENçãO DESTE E COMPOSIçãO FARMACêUTICA O COMPREENDENDO. Esta invenção refere-se a uma nova forma cristalina do ácido zoledrónico, caracterizada por seu difratograma de Raio-X, bem como por sua distribuição espacial na rede cristalina e suas curvas de análise térmica. Estão também incluídos um método para a obtenção desta forma cristalina, o qual inclui a síntese do ácido correspondente, e uma composição farmacêutica compreendendo esta forma cristalina.
BRPI0613924-8A 2005-07-28 2006-05-12 Forma cristalina do ácido zoledrônico, processo para a obtenção deste e composição farmacêutica o compreendendo BRPI0613924A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ARP20050103131 2005-07-28
ARP050103131A AR054673A1 (es) 2005-07-28 2005-07-28 Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
PCT/EP2006/004473 WO2007016982A1 (en) 2005-07-28 2006-05-12 A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it

Publications (1)

Publication Number Publication Date
BRPI0613924A2 true BRPI0613924A2 (pt) 2012-03-20

Family

ID=36659934

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0613924-8A BRPI0613924A2 (pt) 2005-07-28 2006-05-12 Forma cristalina do ácido zoledrônico, processo para a obtenção deste e composição farmacêutica o compreendendo

Country Status (10)

Country Link
US (3) US20080090784A1 (pt)
EP (1) EP1924587B1 (pt)
KR (2) KR20080031475A (pt)
AR (1) AR054673A1 (pt)
AU (1) AU2006278951B2 (pt)
BR (1) BRPI0613924A2 (pt)
CA (1) CA2615418C (pt)
NZ (1) NZ565356A (pt)
WO (1) WO2007016982A1 (pt)
ZA (1) ZA200800729B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071574B2 (en) 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation
CN101262856A (zh) * 2005-09-12 2008-09-10 雷迪博士实验室有限公司 唑来膦酸的结晶三水合物
WO2007125521A2 (en) * 2006-05-02 2007-11-08 Ranbaxy Laboratories Limited Polymorphic form of zoledronic acid and processes for their preparation
EP1925621A1 (en) * 2006-11-27 2008-05-28 Novartis AG Crystalline forms of zoledronic acid
CA2769633C (en) 2009-07-31 2017-06-06 Thar Pharma, Llc Crystallization method and bioavailability
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
EA201270328A1 (ru) * 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
US8882740B2 (en) 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
WO2012071517A2 (en) 2010-11-24 2012-05-31 Thar Pharmaceuticals, Inc. Novel crystalline forms
HU230718B1 (hu) 2011-02-08 2017-11-28 Richter Gedeon Nyrt. Új eljárás dronsavak gyógyszeripari előállítására
CN102690288B (zh) * 2012-06-07 2015-06-17 吉林大学 一种双膦酸类化合物的制备方法
WO2017208070A1 (en) 2016-05-31 2017-12-07 Grünenthal GmbH Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis
CN110551152A (zh) * 2018-05-31 2019-12-10 四川科伦药物研究院有限公司 唑来膦酸一水合物及无水物晶型制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3626058A1 (de) 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3776880D1 (de) 1986-11-21 1992-04-02 Ciba Geigy Ag Neue substituierte alkandiphosphonsaeuren.
US4922007A (en) 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US6410520B2 (en) * 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
US20040230076A1 (en) * 2003-02-27 2004-11-18 Revital Lifshitz-Liron Process for purification of zoledronic acid
US20050054616A1 (en) 2003-07-03 2005-03-10 Judith Aronhime Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation
WO2005066188A1 (en) * 2003-10-17 2005-07-21 Sun Pharmaceutical Industries Limited A process for the preparation of 2-(imidazol-1-yl)-1-hydroxyethane-1, 1-diphosphonic acid
CA2551230A1 (en) * 2003-12-23 2005-07-14 Lyogen Limited A process for the preparation of alkyl- and aryl-diphosphonic acids and salts thereof
WO2005063717A1 (en) * 2003-12-26 2005-07-14 Natco Pharma Limited An improved process for the preparation of zoledronic acid
US20060178439A1 (en) * 2005-01-04 2006-08-10 Mohakhud Pradeep K Crystalline form of zoledronic acid

Also Published As

Publication number Publication date
CA2615418A1 (en) 2007-02-15
NZ565356A (en) 2010-01-29
AU2006278951B2 (en) 2012-01-12
US8338619B2 (en) 2012-12-25
CA2615418C (en) 2011-04-26
US20100197935A1 (en) 2010-08-05
ZA200800729B (en) 2009-08-26
KR20140023949A (ko) 2014-02-27
EP1924587A1 (en) 2008-05-28
AR054673A1 (es) 2007-07-11
KR20080031475A (ko) 2008-04-08
US20080090784A1 (en) 2008-04-17
AU2006278951A1 (en) 2007-02-15
EP1924587B1 (en) 2014-03-05
US20100197931A1 (en) 2010-08-05
US8952172B2 (en) 2015-02-10
WO2007016982A1 (en) 2007-02-15

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015.