BRPI0615781A2 - compostos inibidores de raf e métodos de uso destes - Google Patents

compostos inibidores de raf e métodos de uso destes

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Publication number
BRPI0615781A2
BRPI0615781A2 BRPI0615781-5A BRPI0615781A BRPI0615781A2 BR PI0615781 A2 BRPI0615781 A2 BR PI0615781A2 BR PI0615781 A BRPI0615781 A BR PI0615781A BR PI0615781 A2 BRPI0615781 A2 BR PI0615781A2
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BR
Brazil
Prior art keywords
methods
compounds
raf inhibitor
inhibitor compounds
formula
Prior art date
Application number
BRPI0615781-5A
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English (en)
Inventor
Greg Mikinis
Joseph L Lyssikatos
Eugene Tarlton
Alexandre J Buckmelter
Li Ren
Bryson Rast
Stephen T Schlachter
Steven Mark Wenglowsky
Ellen Laird
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of BRPI0615781A2 publication Critical patent/BRPI0615781A2/pt

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

COMPOSTOS INIBIDORES DE RAF E MéTODOS DE USO DESTES. A presente invenção refere-se a compostos da fórmula I, que são úteis para inibir Raf cinase e para tratar distúrbios por ela mediados. Métodos de usar compostos da fórmula 1, e estereoisómeros, isómeros geométricos, tautómeros, solvatos e sais farmaceuticamente aceitáveis destes, para diagnose in vitro, in situ e in vivo, prevenção ou tratamento de tais distúrbios em células mamíferas, ou condições patológicas associadas, são revelados.
BRPI0615781-5A 2005-09-01 2006-08-31 compostos inibidores de raf e métodos de uso destes BRPI0615781A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71363005P 2005-09-01 2005-09-01
PCT/US2006/033976 WO2007027855A2 (en) 2005-09-01 2006-08-31 Raf inhibitor compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0615781A2 true BRPI0615781A2 (pt) 2009-06-16

Family

ID=37744290

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0615781-5A BRPI0615781A2 (pt) 2005-09-01 2006-08-31 compostos inibidores de raf e métodos de uso destes

Country Status (13)

Country Link
US (1) US20070049603A1 (pt)
EP (1) EP1934228A2 (pt)
JP (1) JP2009507024A (pt)
KR (1) KR20080052630A (pt)
CN (1) CN101305010A (pt)
AU (1) AU2006284751A1 (pt)
BR (1) BRPI0615781A2 (pt)
CA (1) CA2620864A1 (pt)
IL (1) IL189771A0 (pt)
NO (1) NO20081595L (pt)
RU (1) RU2008112313A (pt)
WO (1) WO2007027855A2 (pt)
ZA (1) ZA200802822B (pt)

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