BRPI0616729A2 - estrutura de agrecanase - Google Patents

estrutura de agrecanase

Info

Publication number
BRPI0616729A2
BRPI0616729A2 BRPI0616729-2A BRPI0616729A BRPI0616729A2 BR PI0616729 A2 BRPI0616729 A2 BR PI0616729A2 BR PI0616729 A BRPI0616729 A BR PI0616729A BR PI0616729 A2 BRPI0616729 A2 BR PI0616729A2
Authority
BR
Brazil
Prior art keywords
agrecanase
polypeptide
ligand complexes
polypeptides
crystals
Prior art date
Application number
BRPI0616729-2A
Other languages
English (en)
Inventor
Lidia Mosyak
Rush Iii Thomas Saltmarsh
Xiaotian Zhong
Thomas E Mcdonagh
Katy E Georgiadis
Phaik-Eng Sum
Lisa A Collins-Racie
Christopher John Corcoran
Ravindra Kumar
Tracy Hebert
Stephane Hubert Olland
Stewart Andrews Mackie
Edward R Lavallie
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0616729A2 publication Critical patent/BRPI0616729A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Metallurgy (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

ESTRUTURA DE AGRECANASE. A presente invenção refere-se a polipeptídios agrecanase e complexos de polipeptídio agrecanase/ligante, cristais de agrecanase e de complexos de polipeptídio agrecanase/ligante e métodos e sistemas de software relacionados.
BRPI0616729-2A 2005-08-25 2006-08-24 estrutura de agrecanase BRPI0616729A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71145805P 2005-08-25 2005-08-25
US71145705P 2005-08-25 2005-08-25
PCT/US2006/033498 WO2007025248A2 (en) 2005-08-25 2006-08-24 Aggrecanase structure

Publications (1)

Publication Number Publication Date
BRPI0616729A2 true BRPI0616729A2 (pt) 2009-11-03

Family

ID=37695961

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0616729-2A BRPI0616729A2 (pt) 2005-08-25 2006-08-24 estrutura de agrecanase

Country Status (7)

Country Link
EP (1) EP1917354A2 (pt)
JP (1) JP2009508474A (pt)
AU (1) AU2006282798A1 (pt)
BR (1) BRPI0616729A2 (pt)
CA (1) CA2619521A1 (pt)
MX (1) MX2008002323A (pt)
WO (1) WO2007025248A2 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160492A1 (en) * 2000-07-25 2002-10-31 Cook Michael N. Bovine aggrecanase-1
US7118902B2 (en) * 2002-07-29 2006-10-10 Wyeth Modified ADAMTS4 molecules and method of use thereof
EP1737973A1 (en) * 2004-04-16 2007-01-03 Wyeth Truncated adamts molecules

Also Published As

Publication number Publication date
WO2007025248A2 (en) 2007-03-01
CA2619521A1 (en) 2007-03-01
AU2006282798A1 (en) 2007-03-01
WO2007025248B1 (en) 2007-10-11
WO2007025248A3 (en) 2007-08-09
EP1917354A2 (en) 2008-05-07
JP2009508474A (ja) 2009-03-05
MX2008002323A (es) 2008-03-18

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired