BRPI0617412B8 - anticorpo antiglipicano-3, agente anticâncer compreendendo o mesmo, bem como seu uso e seu processo de produção - Google Patents

anticorpo antiglipicano-3, agente anticâncer compreendendo o mesmo, bem como seu uso e seu processo de produção

Info

Publication number
BRPI0617412B8
BRPI0617412B8 BRPI0617412A BRPI0617412A BRPI0617412B8 BR PI0617412 B8 BRPI0617412 B8 BR PI0617412B8 BR PI0617412 A BRPI0617412 A BR PI0617412A BR PI0617412 A BRPI0617412 A BR PI0617412A BR PI0617412 B8 BRPI0617412 B8 BR PI0617412B8
Authority
BR
Brazil
Prior art keywords
antibody
antiglypican
well
production process
amino acid
Prior art date
Application number
BRPI0617412A
Other languages
English (en)
Inventor
I Dahiyat Bassil
Okabe Hisafumi
Sugimoto Masamichi
Iijima Shigeyuki
Alan Lazar Gregory
Sugo Izumi
Original Assignee
Chugai Pharmaceutical Co Ltd
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd, Xencor Inc filed Critical Chugai Pharmaceutical Co Ltd
Publication of BRPI0617412A2 publication Critical patent/BRPI0617412A2/pt
Publication of BRPI0617412B1 publication Critical patent/BRPI0617412B1/pt
Publication of BRPI0617412B8 publication Critical patent/BRPI0617412B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

ANTICORPO ANTIGLIPICANO-3, AGENTE ANTI-CÂNCER COMPREENDENDO O MESMO, BEM COMO SEU USO E SEU PROCESSO DE PRODUÇÃO. A presente invenção refere-se a um anticorpo antiglipicano-3 compreendendo uma ou mais substituições de aminoácidos introduzidas na região Fc. Preferivelmente, no anticorpo antiglipicano-3, um ou mais dos resíduos de aminoácidos nas posições 239, 298, 326, 330 e 332 na região Fc estão substituídos com outros resíduos de aminoácidos. Uma vez que o anticorpo antiglipicano-3 com a Fc modificada da invenção exibe aumentada atividade ADCC, ele é útil no tratamento de cânceres, tal como câncer hepático. São também descritos um agente anticâncer compreendendo o anticorpo antiglipicano-3 da invenção e um veículo farmaceuticamente aceitável, assim como um processo de tratamento de um paciente com câncer compreendendo administração ao paciente do agente anticâncer da invenção.
BRPI0617412A 2005-10-14 2006-10-11 anticorpo antiglipicano-3, agente anticâncer compreendendo o mesmo, bem como seu uso e seu processo de produção BRPI0617412B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/251,561 2005-10-14
US11/251,561 US20070087005A1 (en) 2005-10-14 2005-10-14 Anti-glypican-3 antibody
PCT/US2006/039682 WO2007047291A2 (en) 2005-10-14 2006-10-11 Anti-glypican-3 antibody

Publications (3)

Publication Number Publication Date
BRPI0617412A2 BRPI0617412A2 (pt) 2011-07-26
BRPI0617412B1 BRPI0617412B1 (pt) 2020-11-17
BRPI0617412B8 true BRPI0617412B8 (pt) 2022-08-30

Family

ID=37890328

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0617412A BRPI0617412B8 (pt) 2005-10-14 2006-10-11 anticorpo antiglipicano-3, agente anticâncer compreendendo o mesmo, bem como seu uso e seu processo de produção

Country Status (11)

Country Link
US (3) US20070087005A1 (pt)
EP (1) EP1933872B1 (pt)
JP (1) JP5303274B2 (pt)
KR (1) KR101397858B1 (pt)
CN (2) CN102850455B (pt)
AU (1) AU2006304100C1 (pt)
BR (1) BRPI0617412B8 (pt)
CA (1) CA2624894C (pt)
ES (1) ES2470374T3 (pt)
IL (1) IL190472A (pt)
WO (1) WO2007047291A2 (pt)

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