BRPI0618452A2 - piridopirazinas e seu uso como moduladores de cinases - Google Patents

piridopirazinas e seu uso como moduladores de cinases Download PDF

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Publication number
BRPI0618452A2
BRPI0618452A2 BRPI0618452-9A BRPI0618452A BRPI0618452A2 BR PI0618452 A2 BRPI0618452 A2 BR PI0618452A2 BR PI0618452 A BRPI0618452 A BR PI0618452A BR PI0618452 A2 BRPI0618452 A2 BR PI0618452A2
Authority
BR
Brazil
Prior art keywords
pyridopyrazines
kinase modulators
malignant
medicament
modulators
Prior art date
Application number
BRPI0618452-9A
Other languages
English (en)
Inventor
Eckhard Claus
Irene Seipelt
Eckhard Guenther
Emmanuel Polymeropoulos
Michael Czech
Tilmann Schuster
Original Assignee
Aterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aterna Zentaris Gmbh filed Critical Aterna Zentaris Gmbh
Priority claimed from PCT/EP2006/068322 external-priority patent/WO2007054556A1/de
Publication of BRPI0618452A2 publication Critical patent/BRPI0618452A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PIRIDOPIRAZINAS E SEU USO COMO MODULADORES DE CINASES. A presente invenção refere-se a novos derivados de pirido[2,3- b]pirazina da fórmula geral (I), sua produção e uso como medicamento, especialmente para o tratamento de doenças malignas e outras, à base de proliferações de células patológicas.
BRPI0618452-9A 2005-11-11 2006-11-10 piridopirazinas e seu uso como moduladores de cinases BRPI0618452A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73569805P 2005-11-11 2005-11-11
EP05024693A EP1785423A1 (de) 2005-11-11 2005-11-11 Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen
US84976106P 2006-10-06 2006-10-06
PCT/EP2006/068322 WO2007054556A1 (de) 2005-11-11 2006-11-10 Neue pyridopyrazine und deren verwendung als modulatoren von kinasen

Publications (1)

Publication Number Publication Date
BRPI0618452A2 true BRPI0618452A2 (pt) 2011-08-30

Family

ID=36149056

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0618452-9A BRPI0618452A2 (pt) 2005-11-11 2006-11-10 piridopirazinas e seu uso como moduladores de cinases

Country Status (4)

Country Link
EP (1) EP1785423A1 (pt)
BR (1) BRPI0618452A2 (pt)
NZ (1) NZ595658A (pt)
TW (1) TWI392675B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2508184A1 (en) 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazine derivatives and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10323345A1 (de) * 2003-05-23 2004-12-16 Zentaris Gmbh Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
ES2316985T3 (es) * 2003-05-23 2009-04-16 Aterna Zentaris Gmbh Nuevas piridopirazidinas y su uso como moduladores de quinasas.
WO2005007099A2 (en) * 2003-07-10 2005-01-27 Imclone Systems Incorporated Pkb inhibitors as anti-tumor agents

Also Published As

Publication number Publication date
NZ595658A (en) 2013-03-28
EP1785423A1 (de) 2007-05-16
TW200736254A (en) 2007-10-01
TWI392675B (zh) 2013-04-11

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 10A ANUIDADE.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.