BRPI0618482A2 - nucleobase contendo grupo perfluoroaquila e processo para a produção da mesma - Google Patents

nucleobase contendo grupo perfluoroaquila e processo para a produção da mesma Download PDF

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Publication number
BRPI0618482A2
BRPI0618482A2 BRPI0618482-0A BRPI0618482A BRPI0618482A2 BR PI0618482 A2 BRPI0618482 A2 BR PI0618482A2 BR PI0618482 A BRPI0618482 A BR PI0618482A BR PI0618482 A2 BRPI0618482 A2 BR PI0618482A2
Authority
BR
Brazil
Prior art keywords
nucleobase
production
perfluoroalkyl group
nucleobase containing
containing perfluoroalkyl
Prior art date
Application number
BRPI0618482-0A
Other languages
English (en)
Inventor
Tetsu Yamakawa
Kyoto Yamamoto
Daisuke Uraguchi
Kenji Tokuhisa
Original Assignee
Tosoh Corp
Tosoh F Tech Inc
Sagami Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tosoh Corp, Tosoh F Tech Inc, Sagami Chem Res filed Critical Tosoh Corp
Publication of BRPI0618482A2 publication Critical patent/BRPI0618482A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

NUCLEOBASE CONTENDO GRUPO PERFLUOROAQUILA E PROCESSO PARA A PRODUçãO DA MESMA. A presente invenção refere-se a um processo de produção simples e eficiente de uma nucleobase contendo um grupo perrluoroalquila. Uma nucleobase (por exemplo, uracilas, citosinas, adeninas,guaninas, hipoxantinas, xantinas, ou similares) é reagida com um haleto de perfluoroalquila na presença de um sulfóxido, um peróxido e um composto de ferro para produzir uma nucleobase substituida por períluoroalquila, que é útil como um intermediário para fármacos medicinais, economicamente.
BRPI0618482-0A 2005-11-09 2006-11-06 nucleobase contendo grupo perfluoroaquila e processo para a produção da mesma BRPI0618482A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005324943 2005-11-09
PCT/JP2006/322094 WO2007055170A1 (ja) 2005-11-09 2006-11-06 パーフルオロアルキル基を有する核酸塩基類およびその製造方法

Publications (1)

Publication Number Publication Date
BRPI0618482A2 true BRPI0618482A2 (pt) 2011-08-30

Family

ID=38023173

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0618482-0A BRPI0618482A2 (pt) 2005-11-09 2006-11-06 nucleobase contendo grupo perfluoroaquila e processo para a produção da mesma

Country Status (9)

Country Link
US (1) US7884202B2 (pt)
EP (1) EP1947092B1 (pt)
KR (1) KR101388688B1 (pt)
CN (1) CN101304977B (pt)
AU (1) AU2006313123B2 (pt)
BR (1) BRPI0618482A2 (pt)
CA (1) CA2631129A1 (pt)
RU (1) RU2436777C2 (pt)
WO (1) WO2007055170A1 (pt)

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SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US20140135497A1 (en) * 2012-11-13 2014-05-15 Boehringer Ingelheim International Gmbh Synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine
WO2014126954A1 (en) 2013-02-13 2014-08-21 OSI Pharmaceuticals, LLC Regioselective synthesis of substituted pyrimidines
CN103788095A (zh) * 2014-01-20 2014-05-14 四川大学华西医院 2,4(1h,3h)-嘧啶二酮衍生物及其制备方法
KR101763552B1 (ko) 2014-06-06 2017-07-31 론자 리미티드 불균일 촉매작용에 의한 플루오로 알킬화 화합물의 제조방법
CN105198946A (zh) * 2014-06-11 2015-12-30 江苏豪森药业股份有限公司 新的曲氟尿苷晶型及其制备方法
CN105175467B (zh) * 2014-06-11 2020-07-17 江苏豪森药业集团有限公司 曲氟尿苷的新晶型及其制备方法
CN104744466A (zh) * 2014-10-31 2015-07-01 合肥平光制药有限公司 一种高纯度茶碱的合成方法
US10968187B2 (en) * 2017-07-28 2021-04-06 Lonza Solutions Ag Method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by heterogeneous cobalt catalysis
WO2019020726A1 (en) 2017-07-28 2019-01-31 Lonza Ltd PROCESS FOR THE PREPARATION OF ALKYL OR FLUORO, CHLORO AND FLUOROCHLORO ALKYL COMPOUNDS BY COBALT HETEROGENEOUS CATALYSIS
CN107652341B (zh) * 2017-11-10 2019-10-11 上海兆维科技发展有限公司 一种制备“曲氟尿苷”的改进方法
CN112739352B (zh) * 2018-08-06 2024-01-23 斯凯拉克生物科技有限责任公司 活化amp-活化的蛋白激酶的化合物及其用途
US11827667B2 (en) 2018-09-14 2023-11-28 University Of Miyazaki Production method for guanosine derivative having fluorine atom-containing functional group at position 8 and application thereof
EP3917914A1 (en) 2019-02-01 2021-12-08 Fmc Corporation Diamino-substituted pyridines and pyrimidines as herbicides
CN109761914B (zh) * 2019-02-22 2021-03-05 北京瑞博奥生物科技有限公司 一种制备5-三氟甲基尿嘧啶的方法
WO2021183980A1 (en) 2020-03-13 2021-09-16 Fmc Corporation Substituted pyrimidines and triazines as herbicides
US11779590B2 (en) 2020-10-30 2023-10-10 Skylark Bioscience Llc AMP-activated protein kinase activating compounds and uses thereof

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CN101437778A (zh) 2006-11-06 2009-05-20 财团法人相模中央化学研究所 三氟甲基化用反应试剂

Also Published As

Publication number Publication date
RU2008122948A (ru) 2009-12-20
EP1947092A4 (en) 2009-12-09
KR101388688B1 (ko) 2014-04-24
AU2006313123B2 (en) 2012-01-12
KR20080066021A (ko) 2008-07-15
RU2436777C2 (ru) 2011-12-20
AU2006313123A1 (en) 2007-05-18
CN101304977B (zh) 2014-08-13
EP1947092B1 (en) 2015-04-15
CN101304977A (zh) 2008-11-12
US20090124796A1 (en) 2009-05-14
WO2007055170A1 (ja) 2007-05-18
EP1947092A1 (en) 2008-07-23
US7884202B2 (en) 2011-02-08
CA2631129A1 (en) 2007-05-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.