BRPI0618863A2 - métodos de modular a atividade de um canal iônico dependente e de tratar dor, uma transtorno associado aos sistemas genitourinário ou gastrointestinal em um indivíduo e, composto - Google Patents

métodos de modular a atividade de um canal iônico dependente e de tratar dor, uma transtorno associado aos sistemas genitourinário ou gastrointestinal em um indivíduo e, composto

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Publication number
BRPI0618863A2
BRPI0618863A2 BRPI0618863A BRPI0618863A BRPI0618863A2 BR PI0618863 A2 BRPI0618863 A2 BR PI0618863A2 BR PI0618863 A BRPI0618863 A BR PI0618863A BR PI0618863 A BRPI0618863 A BR PI0618863A BR PI0618863 A2 BRPI0618863 A2 BR PI0618863A2
Authority
BR
Brazil
Prior art keywords
genitourinary
modulating
activity
individual
methods
Prior art date
Application number
BRPI0618863A
Other languages
English (en)
Inventor
Joachim Demnitz
Nachhttarpal Gill
Philip K Ahring
Rahul Vohra
Original Assignee
Painceptor Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Painceptor Pharma Corp filed Critical Painceptor Pharma Corp
Publication of BRPI0618863A2 publication Critical patent/BRPI0618863A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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  • Health & Medical Sciences (AREA)
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  • Pain & Pain Management (AREA)
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  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Dermatology (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
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BRPI0618863A 2005-11-23 2006-11-22 métodos de modular a atividade de um canal iônico dependente e de tratar dor, uma transtorno associado aos sistemas genitourinário ou gastrointestinal em um indivíduo e, composto BRPI0618863A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73960005P 2005-11-23 2005-11-23
PCT/CA2006/001897 WO2007059608A1 (en) 2005-11-23 2006-11-22 Compositions and methods for modulating gated ion channels

Publications (1)

Publication Number Publication Date
BRPI0618863A2 true BRPI0618863A2 (pt) 2016-09-13

Family

ID=38066867

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0618863A BRPI0618863A2 (pt) 2005-11-23 2006-11-22 métodos de modular a atividade de um canal iônico dependente e de tratar dor, uma transtorno associado aos sistemas genitourinário ou gastrointestinal em um indivíduo e, composto

Country Status (9)

Country Link
US (2) US7718641B2 (pt)
EP (1) EP1957486A4 (pt)
JP (1) JP2009516712A (pt)
KR (1) KR20080070749A (pt)
CN (1) CN101346375B (pt)
AU (1) AU2006317545B2 (pt)
BR (1) BRPI0618863A2 (pt)
CA (1) CA2630617C (pt)
WO (1) WO2007059608A1 (pt)

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EP1183025B1 (en) * 1999-05-19 2009-01-14 PainCeptor Pharma Corp. Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
US8377691B2 (en) * 2006-01-26 2013-02-19 Integral Molecular, Inc. Lipoparticles comprising ion channels, methods of making and using the same
US8618113B2 (en) 2006-07-14 2013-12-31 Medical Research Council Treatment for demyelinating disease
WO2008144931A1 (en) * 2007-05-30 2008-12-04 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US20110262395A1 (en) * 2008-05-08 2011-10-27 University Of Utah Research Foundation Sensory receptors for chronic fatigue and pain and uses thereof
WO2010073128A2 (en) * 2008-12-26 2010-07-01 Glenmark Pharmaceuticals, S.A. Fused imidazole derivatives as trpv3 antagonist
US9211313B2 (en) * 2011-01-14 2015-12-15 The Research Foundation Of State University Of New York Methods and compound to inhibit Ca2+ permeable cation conductance
JP5971657B2 (ja) 2011-04-20 2016-08-17 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素環誘導体
JO3154B1 (ar) * 2011-06-17 2017-09-20 Glaxosmithkline Llc عوامل مضادة لـ trpv4
WO2013146754A1 (ja) 2012-03-27 2013-10-03 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素５員環誘導体
WO2015021988A1 (en) 2013-08-12 2015-02-19 Aros Pharma Aps Pyrrolo-isoquinoline compounds for treatment of pain associated with interstitial cystitis/bladder pain syndrome
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
JPWO2015046193A1 (ja) 2013-09-25 2017-03-09 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体
WO2018151239A1 (ja) * 2017-02-17 2018-08-23 第一三共株式会社 ３，６－ジヒドロ－２Ｈ－フロ［２，３－ｅ］インドール化合物
WO2018151240A1 (ja) * 2017-02-17 2018-08-23 第一三共株式会社 ３，６，７，８－テトラヒドロシクロペンタ［ｅ］インドール化合物
CN109364248B (zh) * 2018-10-16 2021-05-18 哈尔滨医科大学 ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用

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US20070191418A1 (en) 2007-08-16
EP1957486A1 (en) 2008-08-20
WO2007059608A1 (en) 2007-05-31
CA2630617A1 (en) 2007-05-31
JP2009516712A (ja) 2009-04-23
EP1957486A4 (en) 2009-11-11
KR20080070749A (ko) 2008-07-30
US20100197721A1 (en) 2010-08-05
CN101346375B (zh) 2013-04-10
CA2630617C (en) 2014-03-25
CN101346375A (zh) 2009-01-14
AU2006317545A1 (en) 2007-05-31
US7718641B2 (en) 2010-05-18
AU2006317545B2 (en) 2012-04-12

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