ES2109516T3 - Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores. - Google Patents
Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores.Info
- Publication number
- ES2109516T3 ES2109516T3 ES93922849T ES93922849T ES2109516T3 ES 2109516 T3 ES2109516 T3 ES 2109516T3 ES 93922849 T ES93922849 T ES 93922849T ES 93922849 T ES93922849 T ES 93922849T ES 2109516 T3 ES2109516 T3 ES 2109516T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkyl
- chr13
- chr14
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 150000001875 compounds Chemical class 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical group O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
- OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010011562 aspartic acid receptor Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN COMPUESTO QUE TIENE LA FORMULA (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, EN LA QUE R ES HIDROGENO O HIDROXI; R1 ES HIDROGENO, ALQUILO, ARILALQUILO, (CH2)NOH O (CH2)NR7R8; R5 Y R6 SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, HALOGENO, NO2, CN, CF3, SO2NR7R8, PO3R9R10, ALQUILO, ALQUENILO, ALQUINILO, (CH2)NCONR7R8, (CH2)NCO2R10, NHCOR11, EN DONDE R7 Y R8 SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO O ALQUILO O R7 Y R8 JUNTOS FORMAN UN ANILLO DE TRES A SIETE ATOMOS, R9 ES HIDROGENO O ALQUILO, R10 ES HIDROGENO O ALQUILO, R11 ES HIDROGENO O ALQUILO Y N ES UN ENTERO DE CERO A CUATRO; A ES UN ANILLO DE CINCO A SIETE ATOMOS FUSIONADO CON EL ANILLO BENZO EN LAS POSICIONES MARCADAS A Y B Y ESTA FORMADO POR LOS SIGUIENTES RADICALES BIVALENTES: A-NR12-CHR13-CHR14-B, A-CHR13CHR14-NR12-B, A-CHR13-NR12-CHR14-B, A-CHR14-CH2-NR12-CHR13-B, ACHR13-NR12-CH2-CHR14-B, A-CH2-CH2-CHR13-NR12-B, A-NR12-CHR13-CH2-CH2B, A-CH2-CH2-NR12-CH2-CH2-B, A-CH2-CH2-CH2-NR12-CH2-B, A-CH2-NR12CH2-CH2-CH2-B, A-CH2-CH2-CH2-CH2-NR12-B, A-NR12-CH2-CH2-CH2-CH2-B, EN DONDE R12 ES HIDROGENO, CH2CH2OH O ALQUILO Y R13 Y R14 SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, CN, CONH2, CH2NH2, CH2OH, ALQUILO, ARILALQUILO, ALQUENILO O CO2R15, EN DONDE R15 ES HIDROGENO O ALQUILO. LOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS DE MAMIFEROS Y RESPONDEN AL BLOQUEO DE RECEPTORES DE ACIDO GLUTAMICO Y ASPARTICO. TAMBIEN SE PRESENTAN LOS PROCESOS PARA LA PREPARACION DE LOS COMPUESTOS Y NUEVOS INTERMEDIOS UTILES EN LOS PROCESOS.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96015792A | 1992-10-13 | 1992-10-13 | |
| US3433293A | 1993-03-22 | 1993-03-22 | |
| US12477093A | 1993-09-24 | 1993-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2109516T3 true ES2109516T3 (es) | 1998-01-16 |
Family
ID=27364627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93922849T Expired - Lifetime ES2109516T3 (es) | 1992-10-13 | 1993-10-08 | Derivados de quinoxalinodiona como antagonistas de aminoacidos excitadores. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6703391B2 (es) |
| EP (1) | EP0664807B1 (es) |
| JP (1) | JPH08502483A (es) |
| AT (1) | ATE157977T1 (es) |
| AU (1) | AU680632B2 (es) |
| DE (1) | DE69313866T2 (es) |
| DK (1) | DK0664807T3 (es) |
| ES (1) | ES2109516T3 (es) |
| GR (1) | GR3025257T3 (es) |
| WO (1) | WO1994009000A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2161783C (en) * | 1993-05-13 | 2006-08-15 | Frank Watjen | Ampa antagonists and a method of treatment therewith |
| US5843945A (en) * | 1993-05-13 | 1998-12-01 | Neurosearch A/S | AMPA antagonists and a method of treatment |
| EP0705834A1 (de) * | 1994-07-27 | 1996-04-10 | Ciba-Geigy Ag | Azaaliphatisch Überbrückte Chinoxalin-2,3-dione |
| EP0705835A1 (de) * | 1994-09-01 | 1996-04-10 | Ciba-Geigy Ag | Oxa- oder thiaaliphatisch überbrückte Chinoxalin-2,3-dione |
| AU687255B2 (en) * | 1994-09-14 | 1998-02-19 | Neurosearch A/S | Indole-2,3-dione-3-oxime derivatives, their preparation and use |
| US5801174A (en) * | 1994-09-14 | 1998-09-01 | Neurosearch A/S | Fused indole and quinoxaline derivatives, their preparation and use |
| WO1996028445A1 (en) * | 1995-03-14 | 1996-09-19 | Warner-Lambert Company | Novel glutamate (ampa/kainate) receptor antagonists: n-substituted fused azacycloalkylquinoxalinediones |
| WO1998005651A1 (en) * | 1996-08-01 | 1998-02-12 | Warner-Lambert Company | Novel glutamate receptor antagonists: fused cycloalkyl quinoxalinediones |
| WO2002014277A1 (en) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| WO2002014276A1 (en) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Benzoylaminoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| DE10121215A1 (de) * | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| WO2007059608A1 (en) | 2005-11-23 | 2007-05-31 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| WO2007115409A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| WO2012014910A1 (ja) * | 2010-07-29 | 2012-02-02 | 日本ケミファ株式会社 | Ｐ２ｘ４受容体拮抗剤 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK146787A (da) * | 1987-03-23 | 1988-09-24 | Ferrosan | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| DK160941C (da) | 1988-06-28 | 1991-10-21 | Novo Nordisk As | Kondenserede 2,3-dihydroxypyraziner, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar |
| DK716188D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Quinoxalinforbindelser, deres fremstilling og anvendelse |
| DK101290D0 (da) | 1990-04-24 | 1990-04-24 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| ATE194985T1 (de) | 1990-11-06 | 2000-08-15 | Yamanouchi Pharma Co Ltd | Kondensiertes pyrazinderivat |
| CA2076948C (en) | 1991-08-28 | 2002-04-16 | Frank Watjen | Isatineoxime derivatives, their preparation and use |
| WO1996028445A1 (en) * | 1995-03-14 | 1996-09-19 | Warner-Lambert Company | Novel glutamate (ampa/kainate) receptor antagonists: n-substituted fused azacycloalkylquinoxalinediones |
-
1993
- 1993-10-08 EP EP93922849A patent/EP0664807B1/en not_active Expired - Lifetime
- 1993-10-08 JP JP6510172A patent/JPH08502483A/ja active Pending
- 1993-10-08 AT AT93922849T patent/ATE157977T1/de active
- 1993-10-08 DE DE69313866T patent/DE69313866T2/de not_active Expired - Lifetime
- 1993-10-08 AU AU51715/93A patent/AU680632B2/en not_active Ceased
- 1993-10-08 ES ES93922849T patent/ES2109516T3/es not_active Expired - Lifetime
- 1993-10-08 WO PCT/US1993/009667 patent/WO1994009000A1/en not_active Ceased
- 1993-10-08 DK DK93922849.0T patent/DK0664807T3/da active
-
1995
- 1995-05-18 US US08/443,507 patent/US6703391B2/en not_active Expired - Fee Related
-
1997
- 1997-11-05 GR GR970402894T patent/GR3025257T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0664807B1 (en) | 1997-09-10 |
| US6703391B2 (en) | 2004-03-09 |
| DE69313866T2 (de) | 1998-03-05 |
| DE69313866D1 (de) | 1997-10-16 |
| US20030114422A1 (en) | 2003-06-19 |
| GR3025257T3 (en) | 1998-02-27 |
| AU680632B2 (en) | 1997-08-07 |
| JPH08502483A (ja) | 1996-03-19 |
| EP0664807A1 (en) | 1995-08-02 |
| WO1994009000A1 (en) | 1994-04-28 |
| AU5171593A (en) | 1994-05-09 |
| DK0664807T3 (da) | 1998-04-27 |
| ATE157977T1 (de) | 1997-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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