BRPI0619493A2 - forma cristalina purificada de cci-779, processo para a purificação de cc-779, produto, método para monitorar a cristalização de cci-779, kit, composição farmacêutica, método para o tratamento de câncer, e, uso de um cci-779 purificado - Google Patents

forma cristalina purificada de cci-779, processo para a purificação de cc-779, produto, método para monitorar a cristalização de cci-779, kit, composição farmacêutica, método para o tratamento de câncer, e, uso de um cci-779 purificado

Info

Publication number: BRPI0619493A2
Authority: BR; Brazil
Prior art keywords: cci; purified; purifying; kit; pharmaceutical composition
Prior art date: 2005-12-07

Application number

BRPI0619493A

Other languages

English (en)

Inventor

Adam P Michaud

Chunhao Zhang

Clifford William Coughlin

Lynn M Phelan

Subodh S Deshmukh

Wei Tong

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-07

Filing date

2006-12-06

Publication date

2016-09-06

2006-12-06 Application filed by Wyeth Corp filed Critical Wyeth Corp

2016-09-06 Publication of BRPI0619493A2 publication Critical patent/BRPI0619493A2/pt

Links

CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title 3
238000000034 method Methods 0.000 title 3
229960000235 temsirolimus Drugs 0.000 title 3
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
238000002425 crystallisation Methods 0.000 title 1
230000008025 crystallization Effects 0.000 title 1
238000012544 monitoring process Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Cardiology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0619493A 2005-12-07 2006-12-06 forma cristalina purificada de cci-779, processo para a purificação de cc-779, produto, método para monitorar a cristalização de cci-779, kit, composição farmacêutica, método para o tratamento de câncer, e, uso de um cci-779 purificado BRPI0619493A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US74800605P	2005-12-07	2005-12-07
PCT/US2006/046444 WO2007067565A1 (en)	2005-12-07	2006-12-06	Process for the preparation of purified crystalline cci-779

Publications (1)

Publication Number	Publication Date
BRPI0619493A2 true BRPI0619493A2 (pt)	2016-09-06

Family

ID=37891446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0619493A BRPI0619493A2 (pt)	2005-12-07	2006-12-06	forma cristalina purificada de cci-779, processo para a purificação de cc-779, produto, método para monitorar a cristalização de cci-779, kit, composição farmacêutica, método para o tratamento de câncer, e, uso de um cci-779 purificado

Country Status (18)

Country	Link
US (1)	US7553843B2 (pt)
EP (1)	EP1957500A1 (pt)
JP (1)	JP2009518413A (pt)
KR (1)	KR20080077618A (pt)
CN (1)	CN101321769A (pt)
AR (1)	AR058282A1 (pt)
AU (1)	AU2006322029A1 (pt)
BR (1)	BRPI0619493A2 (pt)
CA (1)	CA2630784A1 (pt)
CR (1)	CR9988A (pt)
EC (1)	ECSP088517A (pt)
GT (1)	GT200800089A (pt)
IL (1)	IL191546A0 (pt)
NO (1)	NO20082379L (pt)
PE (1)	PE20071041A1 (pt)
RU (1)	RU2008121240A (pt)
TW (1)	TW200732342A (pt)
WO (1)	WO2007067565A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011051960A2 (en)	2009-09-25	2011-05-05	Cadila Healthcare Limited	Process for the preparation of rapamycin derivatives
CN109020995A (zh) *	2017-06-12	2018-12-18	鲁南制药集团股份有限公司	一种替西罗莫司的晶型物

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5358909A (en) *	1991-02-27	1994-10-25	Nippon Steel Corporation	Method of manufacturing field-emitter
US5358908A (en) *	1992-02-14	1994-10-25	Micron Technology, Inc.	Method of creating sharp points and other features on the surface of a semiconductor substrate
US5385909A (en)	1993-11-22	1995-01-31	American Home Products Corporation	Heterocyclic esters of rapamycin
US5385908A (en)	1993-11-22	1995-01-31	American Home Products Corporation	Hindered esters of rapamycin
US5362718A (en) *	1994-04-18	1994-11-08	American Home Products Corporation	Rapamycin hydroxyesters
US6277983B1 (en) *	2000-09-27	2001-08-21	American Home Products Corporation	Regioselective synthesis of rapamycin derivatives
EP1319008B1 (en)	2000-09-19	2008-10-15	Wyeth	Water soluble rapamycin esters
FR2826961B1 (fr) *	2001-07-06	2005-09-30	Atofina	Procede de preparation d'anhydride (meth) acrylique
WO2005010010A1 (en) *	2003-07-16	2005-02-03	Wyeth	Cci-779 isomer c
KR20060057605A (ko)	2003-08-07	2006-05-26	와이어쓰	Ｃｃｉ-779의 위치선택적 합성 방법
RU2345999C2 (ru) *	2003-09-03	2009-02-10	Уайт	Аморфный 42-эфир рапамицина и 3-гидрокси-2(гидроксиметил)-2-метилпропионовой кислоты и содержащие его фармацевтические композиции
JP4224115B2 (ja) *	2004-04-14	2009-02-12	ワイス	ラパマイシン４２−エステル誘導体の位置特異的合成
AU2005238432A1 (en) *	2004-04-14	2005-11-10	Wyeth	Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
MX2007001676A (es) *	2004-08-10	2007-04-12	Wyeth Corp	Derivados de 42-ester de rapamicina con acido 2,2-bis(hidroximetil)propionico y metodos para hacer los mismos.
CA2590254A1 (en) *	2004-12-20	2006-06-29	Wyeth	Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
AU2005319454B2 (en) *	2004-12-20	2012-08-09	Wyeth	Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders
CA2595766A1 (en) *	2005-02-09	2006-08-17	Wyeth	Cci-779 polymorph and use thereof
CA2599580A1 (en) *	2005-03-02	2006-09-08	Wyeth	Recovery of cci-779 from mother liquors
US7241771B2 (en) *	2005-03-07	2007-07-10	Wyeth	Oxepane isomer of 42-O-(2-hydroxy)ethyl-rapamycin

2006
- 2006-12-06 AR ARP060105388A patent/AR058282A1/es unknown
- 2006-12-06 TW TW095145388A patent/TW200732342A/zh unknown
- 2006-12-06 PE PE2006001556A patent/PE20071041A1/es not_active Application Discontinuation
- 2006-12-06 CN CNA2006800458140A patent/CN101321769A/zh not_active Withdrawn
- 2006-12-06 WO PCT/US2006/046444 patent/WO2007067565A1/en not_active Ceased
- 2006-12-06 BR BRPI0619493A patent/BRPI0619493A2/pt not_active IP Right Cessation
- 2006-12-06 US US11/634,774 patent/US7553843B2/en not_active Expired - Fee Related
- 2006-12-06 EP EP06839039A patent/EP1957500A1/en not_active Withdrawn
- 2006-12-06 RU RU2008121240/04A patent/RU2008121240A/ru not_active Application Discontinuation
- 2006-12-06 AU AU2006322029A patent/AU2006322029A1/en not_active Abandoned
- 2006-12-06 CA CA002630784A patent/CA2630784A1/en not_active Abandoned
- 2006-12-06 KR KR1020087013678A patent/KR20080077618A/ko not_active Withdrawn
- 2006-12-06 JP JP2008544450A patent/JP2009518413A/ja active Pending
2008
- 2008-05-19 IL IL191546A patent/IL191546A0/en unknown
- 2008-05-19 CR CR9988A patent/CR9988A/es not_active Application Discontinuation
- 2008-05-26 NO NO20082379A patent/NO20082379L/no not_active Application Discontinuation
- 2008-06-05 GT GT200800089A patent/GT200800089A/es unknown
- 2008-06-09 EC EC2008008517A patent/ECSP088517A/es unknown

Also Published As

Publication number	Publication date
WO2007067565A1 (en)	2007-06-14
AR058282A1 (es)	2008-01-30
JP2009518413A (ja)	2009-05-07
TW200732342A (en)	2007-09-01
CN101321769A (zh)	2008-12-10
AU2006322029A1 (en)	2007-06-14
ECSP088517A (es)	2008-07-30
NO20082379L (no)	2008-09-04
EP1957500A1 (en)	2008-08-20
GT200800089A (es)	2008-12-04
US20070129395A1 (en)	2007-06-07
PE20071041A1 (es)	2007-12-07
RU2008121240A (ru)	2010-01-20
US7553843B2 (en)	2009-06-30
CA2630784A1 (en)	2007-06-14
IL191546A0 (en)	2008-12-29
KR20080077618A (ko)	2008-08-25
CR9988A (es)	2008-07-29

Legal Events

Date	Code	Title	Description
2012-02-07	B06G	Technical and formal requirements: other requirements [chapter 6.7 patent gazette]	Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 PAR 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA.
2012-12-25	B11Z	Dismissal: petition dismissal - article 216, par 2 of industrial property law	Free format text: REFERENTE A PETICAO NO 20080085052/RJ DE 09/06/2008.
2016-08-23	B11M	Decision cancelled [chapter 11.13 patent gazette]	Free format text: O DESPACHO 11.6.1 ESTA SENDO ANULADO TENDO POR BASE A DETERMINACAO DO DIRETOR DE PATENTES, A QUAL E CALCADA NO PARECER NO 0003-2014 AGU/PGF/PFE/INPI/COOPHI-LBC-1.0.
2016-08-30	B06H	Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]	Free format text: O DESPACHO 6.7 ESTA SENDO ANULADO TENDO POR BASE A DETERMINACAO DO DIRETOR DE PATENTES, A QUAL E CALCADA NO PARECER NO 0003-2014 AGU/PGF/PFE/INPI/COOPHI-LBC-1.0.
2017-02-07	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2017-05-30	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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