BRPI0720748A2 - Processo para a síntese de derivados de ácido 3-amino-tetra-hidrofurano-3-carboxílico e uso dos mesmos como medicamentos - Google Patents

Processo para a síntese de derivados de ácido 3-amino-tetra-hidrofurano-3-carboxílico e uso dos mesmos como medicamentos

Info

Publication number
BRPI0720748A2
BRPI0720748A2 BRPI0720748-4A BRPI0720748A BRPI0720748A2 BR PI0720748 A2 BRPI0720748 A2 BR PI0720748A2 BR PI0720748 A BRPI0720748 A BR PI0720748A BR PI0720748 A2 BRPI0720748 A2 BR PI0720748A2
Authority
BR
Brazil
Prior art keywords
medicines
tetrahydrofuran
synthesis
amino
carboxylic acid
Prior art date
Application number
BRPI0720748-4A
Other languages
English (en)
Inventor
Zhengxu Han
Kai Gerlach
Dhileepkumar Krishnamurthy
Burkhard Matthes
Herbert Nar
Roland Pfau
Henning Priepke
Annette Schuler-Metz
Chris H Senanayake
Peter Sieger
Wenjun Tang
Wolfgang Wienen
Yibo Xu
Nathan K Yee
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0720748A2 publication Critical patent/BRPI0720748A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BRPI0720748-4A 2006-12-31 2007-12-21 Processo para a síntese de derivados de ácido 3-amino-tetra-hidrofurano-3-carboxílico e uso dos mesmos como medicamentos BRPI0720748A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88293706P 2006-12-31 2006-12-31
PCT/EP2007/064406 WO2008080891A2 (en) 2006-12-31 2007-12-21 Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

Publications (1)

Publication Number Publication Date
BRPI0720748A2 true BRPI0720748A2 (pt) 2015-05-19

Family

ID=39253961

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0720748-4A BRPI0720748A2 (pt) 2006-12-31 2007-12-21 Processo para a síntese de derivados de ácido 3-amino-tetra-hidrofurano-3-carboxílico e uso dos mesmos como medicamentos

Country Status (23)

Country Link
US (2) US20100317848A1 (pt)
EP (1) EP2114909A2 (pt)
JP (1) JP2010514729A (pt)
KR (1) KR20090097208A (pt)
CN (1) CN101573346B (pt)
AR (1) AR064708A1 (pt)
AU (1) AU2007341335A1 (pt)
BR (1) BRPI0720748A2 (pt)
CA (1) CA2674168A1 (pt)
CL (1) CL2007003875A1 (pt)
EA (1) EA200900797A1 (pt)
EC (1) ECSP099406A (pt)
MA (1) MA31116B1 (pt)
MY (1) MY148769A (pt)
NO (1) NO20091782L (pt)
NZ (1) NZ578715A (pt)
PE (1) PE20081834A1 (pt)
TN (1) TN2009000276A1 (pt)
TW (1) TW200846345A (pt)
UA (1) UA96973C2 (pt)
UY (1) UY30851A1 (pt)
WO (1) WO2008080891A2 (pt)
ZA (1) ZA200902451B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
US8741890B2 (en) * 2007-11-15 2014-06-03 Boehringer Ingelheim International Gmbh Substituted amides, manufacturing and use thereof as medicaments
ES2646191T3 (es) * 2011-03-09 2017-12-12 Csl Behring Gmbh Inhibidores de Factor XII para la administración con procedimientos médicos que comprenden contacto con superficies artificiales
EP2497489A1 (en) * 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
WO2014060575A2 (en) * 2012-10-19 2014-04-24 Medichem S.A. Process for the enantioselective synthesis of a tetrahydrobenzazepine compound
RU2520134C1 (ru) * 2013-02-27 2014-06-20 Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения
JP6636334B2 (ja) 2013-03-08 2020-01-29 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 遠隔虚血再灌流傷害の治療および予防
EP2999692A1 (en) * 2013-05-20 2016-03-30 LEK Pharmaceuticals d.d. Novel synthetic processes to 8-chloro-3-benzo[d]azepine via friedel-crafts alkylation of olefin
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007537181A (ja) * 2004-05-13 2007-12-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換されたチオフェン−カルボン酸アミド、医薬品の形態におけるこれらの製造及び使用
CA2562714A1 (en) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituted thiophene-2-carboxylic acid amides, the production thereof and the use thereof as drugs
WO2005111029A1 (de) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Neue substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
DE102004047840A1 (de) * 2004-09-29 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
PE20070171A1 (es) * 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa

Also Published As

Publication number Publication date
UY30851A1 (es) 2008-07-31
CN101573346A (zh) 2009-11-04
CN101573346B (zh) 2013-01-09
WO2008080891A3 (en) 2008-10-02
PE20081834A1 (es) 2009-01-16
AU2007341335A1 (en) 2008-07-10
AR064708A1 (es) 2009-04-22
EA200900797A1 (ru) 2009-12-30
US20130005962A1 (en) 2013-01-03
NO20091782L (no) 2009-06-10
JP2010514729A (ja) 2010-05-06
TN2009000276A1 (fr) 2010-10-18
MY148769A (en) 2013-05-31
WO2008080891A2 (en) 2008-07-10
US20100317848A1 (en) 2010-12-16
CL2007003875A1 (es) 2008-04-18
UA96973C2 (ru) 2011-12-26
MA31116B1 (fr) 2010-01-04
CA2674168A1 (en) 2008-07-10
ZA200902451B (en) 2010-05-26
EP2114909A2 (en) 2009-11-11
ECSP099406A (es) 2009-07-31
TW200846345A (en) 2008-12-01
NZ578715A (en) 2012-06-29
KR20090097208A (ko) 2009-09-15

Similar Documents

Publication Publication Date Title
BRPI0720748A2 (pt) Processo para a síntese de derivados de ácido 3-amino-tetra-hidrofurano-3-carboxílico e uso dos mesmos como medicamentos
BRPI0815405A2 (pt) Compostos derivados de purina, processo para a preparação de uma composição farmacêutica e uso dos mesmos
BRPI0817747A2 (pt) Processo para a preparação de derivados de ácido 2-di-halogenoacil-3-amino-acrílico
BRPI0920812A2 (pt) processo para a preparação de policondensados fosfatados e uso dos mesmos
BRPI0818533A2 (pt) composto, composição farmacêutica, e, processo para a preparação de um composto
BR112012006404A2 (pt) derivados de di-hidropteridinona, processo de preparação e uso farmacêutico dos mesmos
BRPI0820520A2 (pt) processo para a fabricação de formas de dosagem mastigáveis para a liberação de fármacos e produtos dos mesmos
BRPI0812064A2 (pt) Formulação farmacêutica, tabletes, e, processo para a produção de uma formulação farmacêutica
DK3421471T3 (da) Purin- og deazapurinderivater som farmaceutiske forbindelser
BRPI0920414A2 (pt) Processo para a produção de alfa-tocotrienal e seus derivados
BRPI0810632A2 (pt) Derivados de piridopirazina, processo de fabricação e usos dos mesmos
BRPI1006162A2 (pt) "composto,processo para preparar um composto,formulação farmacêutica,e uso de um composto".
PT1896065E (pt) Processo para a preparação de vacinas
BRPI0814457A2 (pt) Derivados de imidazolona, composições farmacêuticas, utilização de derivados de imidazolona, e, processo de síntese de derivados de imidazolona
BRPI0819991A2 (pt) Derivados de indolinona e processo para fabricação dos mesmos
BRPI0719955A2 (pt) Processo para síntese de derivados de fenóxi diaminopirimidina
BRPI0818541A2 (pt) Processo para a produção de um produto farmacêutico
BRPI0905847A2 (pt) "composição farmacêutica injetável e processo para preparar a composição"
BRPI0814821A2 (pt) Composto, composição farmacêutica, e, processo para preparar um composto
BRPI0908738A2 (pt) composto, medicamento, uso de um composto, e, processo para preparar os compostos
BRPI0922714A2 (pt) composto, processo para preparar um compsoto, medicamento, uso de um composto, e, composição farmacêutica
BR112012016201A2 (pt) ''composto, processo para a preparação de um composto, composição farmacêutica e uso de um composto''
BRPI0822946A2 (pt) Derivado de carboxiamida, processo para preparação de derivado de carboxiamida, composição farmacêutica e uso do derivado de carboxiamida
BRPI0818820A2 (pt) Processo para continuamente produzir derivados de 3-isotiazoinona e produtos intermediários dos mesmos
BRPI0917492A2 (pt) Processos para preparação de metil éster de ácido 4-oxo-octa-hidro-indol-1-carboxílio e derivados dos mesmos

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.