BRPI0620694A2 - composto, composição farmacêutica, processo para a preparação do composto, método para o tratamento de doenças inflamatórias mediado pela ativação de p38 map quinase e uso do composto - Google Patents
composto, composição farmacêutica, processo para a preparação do composto, método para o tratamento de doenças inflamatórias mediado pela ativação de p38 map quinase e uso do composto Download PDFInfo
- Publication number
- BRPI0620694A2 BRPI0620694A2 BRPI0620694-8A BRPI0620694A BRPI0620694A2 BR PI0620694 A2 BRPI0620694 A2 BR PI0620694A2 BR PI0620694 A BRPI0620694 A BR PI0620694A BR PI0620694 A2 BRPI0620694 A2 BR PI0620694A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- preparation process
- inflammatory diseases
- map kinase
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000004913 activation Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title 1
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA A PREPARAçãO DO COMPOSTO, MéTODO PARA O TRATAMENTO DE DOENçAS INFLAMATóRIAS MEDIADO PELA ATIVAçãO DE P38 MAP QUINASE E USO DO COMPOSTO. A presente invenção se refere a novos compostos de fórmula geral (1), aos seus regiosómeros, formas tautoméricas, novos intermediários envolvidos em sua síntese, os sais farmaceuticamente aceitáveis dos mesmos e composições farmacêuticas contendo os mesmos. A presente invenção se refere ainda a um processo para a preparação dos compostos de fórmula geral (1), seus regioisómeros, suas formas tautoméricas, os sais farmaceuticamente aceitáveis dos mesmos, composições farmacêuticas contendo os mesmos, e novos intermediários envolvidos em sua síntese.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1551/MUM/2005 | 2005-12-13 | ||
| IN1551MU2005 | 2005-12-13 | ||
| PCT/IN2006/000490 WO2007077574A2 (en) | 2005-12-13 | 2006-12-11 | SULFOXIMINE DERIVATIVES AS p38 MAP KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0620694A2 true BRPI0620694A2 (pt) | 2012-03-13 |
Family
ID=38173564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0620694-8A BRPI0620694A2 (pt) | 2005-12-13 | 2006-12-11 | composto, composição farmacêutica, processo para a preparação do composto, método para o tratamento de doenças inflamatórias mediado pela ativação de p38 map quinase e uso do composto |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100240709A1 (pt) |
| EP (1) | EP1971603B1 (pt) |
| JP (1) | JP4955698B2 (pt) |
| KR (1) | KR101091796B1 (pt) |
| AT (1) | ATE549331T1 (pt) |
| BR (1) | BRPI0620694A2 (pt) |
| CA (1) | CA2633083C (pt) |
| EA (1) | EA015497B1 (pt) |
| IL (1) | IL191929A0 (pt) |
| UA (1) | UA90038C2 (pt) |
| WO (1) | WO2007077574A2 (pt) |
| ZA (1) | ZA200804858B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2198710A1 (de) | 2008-12-19 | 2010-06-23 | Bayer CropScience AG | Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze |
| EP2917185B1 (en) * | 2012-11-09 | 2017-05-10 | Evotec International GmbH | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| KR101742226B1 (ko) | 2015-12-24 | 2017-05-31 | 강원대학교산학협력단 | 신규한 ｎ-이미다졸릴 설폭시민 유도체 및 이의 제조방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001074811A2 (en) * | 2000-03-30 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Substituted 1,3-thiazole compounds, their production and use |
-
2006
- 2006-12-11 BR BRPI0620694-8A patent/BRPI0620694A2/pt not_active IP Right Cessation
- 2006-12-11 AT AT06849043T patent/ATE549331T1/de active
- 2006-12-11 EA EA200870045A patent/EA015497B1/ru not_active IP Right Cessation
- 2006-12-11 WO PCT/IN2006/000490 patent/WO2007077574A2/en not_active Ceased
- 2006-12-11 EP EP06849043A patent/EP1971603B1/en active Active
- 2006-12-11 KR KR1020087016767A patent/KR101091796B1/ko not_active Expired - Fee Related
- 2006-12-11 CA CA2633083A patent/CA2633083C/en not_active Expired - Fee Related
- 2006-12-11 JP JP2008545254A patent/JP4955698B2/ja not_active Expired - Fee Related
- 2006-12-11 UA UAA200808221A patent/UA90038C2/ru unknown
- 2006-12-11 US US12/086,282 patent/US20100240709A1/en not_active Abandoned
-
2008
- 2008-06-03 IL IL191929A patent/IL191929A0/en unknown
- 2008-06-04 ZA ZA200804858A patent/ZA200804858B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007077574A2 (en) | 2007-07-12 |
| KR101091796B1 (ko) | 2011-12-08 |
| JP4955698B2 (ja) | 2012-06-20 |
| ATE549331T1 (de) | 2012-03-15 |
| JP2009519322A (ja) | 2009-05-14 |
| UA90038C2 (en) | 2010-03-25 |
| IL191929A0 (en) | 2009-08-03 |
| EA200870045A1 (ru) | 2009-02-27 |
| KR20080077280A (ko) | 2008-08-21 |
| US20100240709A1 (en) | 2010-09-23 |
| EA015497B1 (ru) | 2011-08-30 |
| EP1971603A2 (en) | 2008-09-24 |
| CA2633083A1 (en) | 2007-07-12 |
| WO2007077574A3 (en) | 2007-08-23 |
| WO2007077574A8 (en) | 2008-07-24 |
| EP1971603B1 (en) | 2012-03-14 |
| ZA200804858B (en) | 2010-10-27 |
| CA2633083C (en) | 2011-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2261 DE 06/05/2014. |