BRPI0700258A - sistema local de liberação de substáncia ativa e processo para sua preparação - Google Patents
sistema local de liberação de substáncia ativa e processo para sua preparaçãoInfo
- Publication number
- BRPI0700258A BRPI0700258A BRPI0700258-0A BRPI0700258A BRPI0700258A BR PI0700258 A BRPI0700258 A BR PI0700258A BR PI0700258 A BRPI0700258 A BR PI0700258A BR PI0700258 A BRPI0700258 A BR PI0700258A
- Authority
- BR
- Brazil
- Prior art keywords
- release system
- active substance
- polymethyl methacrylate
- local
- bodies
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 abstract 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 abstract 3
- 239000004926 polymethyl methacrylate Substances 0.000 abstract 3
- MCMNRKCIXSYSNV-UHFFFAOYSA-N ZrO2 Inorganic materials O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 abstract 2
- 239000012190 activator Substances 0.000 abstract 2
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 abstract 2
- 238000010526 radical polymerization reaction Methods 0.000 abstract 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229940125717 barbiturate Drugs 0.000 abstract 1
- 229910001385 heavy metal Inorganic materials 0.000 abstract 1
- 239000003999 initiator Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003505 polymerization initiator Substances 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/20—Extrusion means, e.g. for producing pharmaceutical forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
SISTEMA LOCAL DE LIBERAçãO DE SUBSTáNCIA ATIVA E PROCESSO PARA SUA PREPARAçãO. A presente invenção refere-se a um sistema local de liberação de substância ativa, que consiste aproximadamente de corpos esféricos ou de rotação simétrica, que são constituídos essencialmente de polimetilmetacrilato ou polimetilmetacrilato-co-metilacrilato, diáxido de zircónio ou sulfato de bário e uma ou mais substâncias farmacêuticas ativas, particularmente antibióticos, e que são preparados por polimerização radical, sendo que na faixa de temperatura de 10-80<198>C não estão contidos ativadores de polimerização por radical eficazes, ou radicais desses ativadores de polimerização dos grupos das aminas aromáticas, dos sais de metal pesado e dos barbituratos. Um processo para preparação do sistema de liberação local substância ativa, no qual a) é preparada uma pasta por misturação de metacrilato de metila, metacrilato de polimetila ou polimetilmetacrilato-co-metilacrilato, diáxido de zircónio, e/ou sulfato de bário, uma ou mais substâncias ativas farmacêuticas e um iniciador de radical termicamente decomponível, sendo que a pasta possui uma tal viscosidade, que não pode ser moldada à temperatura ambiente por atuação da força de cisalhamento, b) a pasta com um dispositivo de fundição por injeção sem aquecimento à temperatura ambiente é borrifada aproximadamente na forma de esferas ou corpos esféricos de rotação simétrica formando um fio; c) os corpos são aquecidos a uma temperatura na qual o iniciador de polimerização se decompõe.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006006510A DE102006006510A1 (de) | 2006-02-10 | 2006-02-10 | Lokales Wirkstofffreisetzungssystem und ein Verfahren zu seiner Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0700258A true BRPI0700258A (pt) | 2007-11-06 |
Family
ID=38080014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0700258-0A BRPI0700258A (pt) | 2006-02-10 | 2007-02-12 | sistema local de liberação de substáncia ativa e processo para sua preparação |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20070190105A1 (pt) |
| EP (1) | EP1818039B1 (pt) |
| JP (1) | JP4686488B2 (pt) |
| CN (1) | CN101015697B (pt) |
| AU (1) | AU2007200072B2 (pt) |
| BR (1) | BRPI0700258A (pt) |
| CA (1) | CA2572764A1 (pt) |
| DE (1) | DE102006006510A1 (pt) |
| ZA (1) | ZA200701174B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007050762B3 (de) * | 2007-10-22 | 2009-05-07 | Heraeus Medical Gmbh | Pastenförmiger Polymethylmethacrylat-Knochenzement und seine Verwendung |
| DE102007052116B4 (de) * | 2007-10-22 | 2013-02-21 | Heraeus Medical Gmbh | Einkomponenten-Knochenzementpasten, deren Verwendung und Verfahren zu deren Aushärtung |
| DE102008064657A1 (de) * | 2008-06-30 | 2010-04-08 | Heraeus Medical Gmbh | PMMA-Paste |
| DE102008030312A1 (de) * | 2008-06-30 | 2010-01-14 | Heraeus Medical Gmbh | PMMA-Paste |
| CA2797904C (en) * | 2011-12-20 | 2015-01-27 | Heraeus Medical Gmbh | Paste-like bone cement |
| EP2664349B1 (de) * | 2012-05-16 | 2016-02-03 | Heraeus Medical GmbH | Pastenförmiger Knochenzement |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US616033A (en) * | 1898-12-13 | sturcke | ||
| DE2320373B2 (de) * | 1973-04-21 | 1978-04-06 | Merck Patent Gmbh, 6100 Darmstadt | Antibioticahaltiges Mittel und seine Verwendung als chirurgisches Kunststoffmaterial |
| DE2651441C2 (de) * | 1976-11-11 | 1987-01-08 | Merck Patent Gmbh, 6100 Darmstadt | Antibioticahaltiges Mittel |
| AR216922A1 (es) * | 1976-11-11 | 1980-02-15 | Merck Patent Gmbh | Procedimiento para la fabricacion de un medio quirurgico |
| DE2917037C2 (de) * | 1979-04-27 | 1980-12-11 | Josef Dipl.-Chem. Dr. 8000 Muenchen Gaensheimer | Parenteral arzneimittelhaltige partiell resorbierbare Mehrkomponentenmasse auf Basis von polymeren Stoffen |
| EP0061108B1 (de) * | 1981-03-19 | 1986-12-30 | mundipharma GmbH | Knochenimplantat aus Tricalciumphosphat mit mikro-und makroporöser Struktur, Verfahren zu seiner Herstellung und seiner Verwendung |
| DE3669108D1 (de) * | 1985-06-20 | 1990-04-05 | Ceraver | Zement fuer die verankerung von knochenprothesen. |
| US5286791A (en) * | 1992-05-29 | 1994-02-15 | Himont Incorporated | Impact modified graft copolymer compositions containing broad molecular weight distribution polypropylene |
| KR0139235B1 (ko) * | 1994-01-29 | 1998-04-28 | 조세현 | 정형외과용 세멘트 비드조성물 및 그의 제조방법 |
| DE19606490A1 (de) * | 1996-02-22 | 1997-08-28 | Merck Patent Gmbh | Vorrichtung zur manuellen Herstellung von perlschnurförmigen pharmakahaltigen Implantaten |
| DE19641775A1 (de) * | 1996-08-22 | 1998-02-26 | Merck Patent Gmbh | Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen |
| US5968999A (en) * | 1997-10-28 | 1999-10-19 | Charlotte-Mecklenburg Hospital Authority | Bone cement compositions |
| JP4305594B2 (ja) * | 2000-11-28 | 2009-07-29 | 株式会社トクヤマ | 歯科用接着キット |
| US7670627B2 (en) * | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
-
2006
- 2006-02-10 DE DE102006006510A patent/DE102006006510A1/de not_active Ceased
-
2007
- 2007-01-03 CA CA002572764A patent/CA2572764A1/en not_active Abandoned
- 2007-01-05 US US11/620,172 patent/US20070190105A1/en not_active Abandoned
- 2007-01-08 AU AU2007200072A patent/AU2007200072B2/en not_active Ceased
- 2007-01-25 EP EP07001577.1A patent/EP1818039B1/de not_active Not-in-force
- 2007-02-09 ZA ZA200701174A patent/ZA200701174B/xx unknown
- 2007-02-09 JP JP2007030742A patent/JP4686488B2/ja not_active Expired - Fee Related
- 2007-02-09 CN CN200710084031XA patent/CN101015697B/zh not_active Expired - Fee Related
- 2007-02-12 BR BRPI0700258-0A patent/BRPI0700258A/pt not_active IP Right Cessation
-
2010
- 2010-11-18 US US12/949,260 patent/US8758827B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070190105A1 (en) | 2007-08-16 |
| EP1818039A3 (de) | 2012-07-04 |
| JP4686488B2 (ja) | 2011-05-25 |
| CA2572764A1 (en) | 2007-08-10 |
| CN101015697B (zh) | 2012-05-23 |
| JP2007209763A (ja) | 2007-08-23 |
| ZA200701174B (en) | 2008-07-30 |
| DE102006006510A1 (de) | 2007-08-23 |
| EP1818039A2 (de) | 2007-08-15 |
| CN101015697A (zh) | 2007-08-15 |
| EP1818039B1 (de) | 2013-07-31 |
| AU2007200072A1 (en) | 2007-08-30 |
| US8758827B2 (en) | 2014-06-24 |
| US20110062637A1 (en) | 2011-03-17 |
| AU2007200072B2 (en) | 2009-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2257 DE 08/04/2014. |