BRPI0412059A - método para a preparação de formulação de liberação controlada - Google Patents

método para a preparação de formulação de liberação controlada

Info

Publication number
BRPI0412059A
BRPI0412059A BRPI0412059-0A BRPI0412059A BRPI0412059A BR PI0412059 A BRPI0412059 A BR PI0412059A BR PI0412059 A BRPI0412059 A BR PI0412059A BR PI0412059 A BRPI0412059 A BR PI0412059A
Authority
BR
Brazil
Prior art keywords
controlled release
release compositions
bioactive agent
present
production
Prior art date
Application number
BRPI0412059-0A
Other languages
English (en)
Inventor
Gary P Cook
Original Assignee
Pr Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pr Pharmaceuticals Inc filed Critical Pr Pharmaceuticals Inc
Publication of BRPI0412059A publication Critical patent/BRPI0412059A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"MéTODO PARA A PREPARAçãO DE FORMULAçãO DE LIBERAçãO CONTROLADA". Mais precisamente, os métodos aqui apresentados são utilizados para a produção de composições de liberação controlada e compreendem a colocação de uma fase orgânica que contém um agente bioativo e um polímero em contato com uma fase aquosa que contém um íon orgânico para criar composições de liberação controlada que contêm agentes bioativos. A presente invenção também inclui composições de liberação controlada que incluem um polímero, um íon orgânico e um agente bioativo. A presente invenção também inclui métodos de utilização de tais composições de liberação controlada. A utilidade da presente invenção é que os métodos resultam na produção de composições de liberação controlada que contêm o agente bioativo que pode ser administrado em uma forma de baixa dosagem concentrada, que tem um baixo ponto de surtou e uma produção reduzida de agente bioativo degradado.
BRPI0412059-0A 2003-07-15 2004-07-15 método para a preparação de formulação de liberação controlada BRPI0412059A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48766303P 2003-07-15 2003-07-15
PCT/US2004/022816 WO2005009356A2 (en) 2003-07-15 2004-07-15 Method for the preparation of controlled release formulations

Publications (1)

Publication Number Publication Date
BRPI0412059A true BRPI0412059A (pt) 2006-09-05

Family

ID=34102710

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412059-0A BRPI0412059A (pt) 2003-07-15 2004-07-15 método para a preparação de formulação de liberação controlada

Country Status (9)

Country Link
US (1) US8871269B2 (pt)
EP (2) EP1651136B1 (pt)
JP (2) JP5165239B2 (pt)
CN (2) CN102935069A (pt)
AU (1) AU2004259208B2 (pt)
BR (1) BRPI0412059A (pt)
CA (1) CA2532302C (pt)
ES (1) ES2625343T3 (pt)
WO (1) WO2005009356A2 (pt)

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Also Published As

Publication number Publication date
US20060228414A1 (en) 2006-10-12
US8871269B2 (en) 2014-10-28
CA2532302C (en) 2016-12-20
AU2004259208B2 (en) 2011-04-28
WO2005009356A2 (en) 2005-02-03
WO2005009356A3 (en) 2005-06-09
EP1651136B1 (en) 2017-03-08
CN102935069A (zh) 2013-02-20
CN1852687B (zh) 2014-01-22
JP2011144207A (ja) 2011-07-28
AU2004259208A1 (en) 2005-02-03
ES2625343T3 (es) 2017-07-19
CN1852687A (zh) 2006-10-25
CA2532302A1 (en) 2005-02-03
JP5165239B2 (ja) 2013-03-21
EP2462896A1 (en) 2012-06-13
EP1651136A4 (en) 2009-07-08
JP2007524645A (ja) 2007-08-30
EP1651136A2 (en) 2006-05-03

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B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 7A ANUIDADE.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.