BRPI0707190A2 - método para a produção de partìculas, partìcula, agente de contraste, composição terapêutica, e, composição de partìcula - Google Patents

método para a produção de partìculas, partìcula, agente de contraste, composição terapêutica, e, composição de partìcula

Info

Publication number
BRPI0707190A2
BRPI0707190A2 BRPI0707190-6A BRPI0707190A BRPI0707190A2 BR PI0707190 A2 BRPI0707190 A2 BR PI0707190A2 BR PI0707190 A BRPI0707190 A BR PI0707190A BR PI0707190 A2 BRPI0707190 A2 BR PI0707190A2
Authority
BR
Brazil
Prior art keywords
particle
composition
particles
contrast agent
production
Prior art date
Application number
BRPI0707190-6A
Other languages
English (en)
Inventor
Marcel R Bohmer
Winter Suzanna H P M De
William T Shi
Christopher Hall
Jong Nico De
Wamel Johanna E T Van
Marcia Emmer
Original Assignee
Koninkl Philips Electronics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Electronics Nv filed Critical Koninkl Philips Electronics Nv
Publication of BRPI0707190A2 publication Critical patent/BRPI0707190A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

MéTODO PARA A PRODUçãO DE PARTìCULAS, PARTìCULA, AGENTE DE CONTRASTE, COMPOSIçãO TERAPêUTICA, E, COMPOSIçãO DE PARTìCULA. A invenção se refere a um método para a preparação de partículas compreendendo um núcleo de gás e um envoltório, partículas essas que são adequadas para uso como agente de contraste e como parte de uma composição terapêutica, especialmente para dispensação de droga. Essas partículas mostram um nível de ativação surpreendentemente alto no fornecimento de energia de ultra-som.
BRPI0707190-6A 2006-01-24 2007-01-19 método para a produção de partìculas, partìcula, agente de contraste, composição terapêutica, e, composição de partìcula BRPI0707190A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100743 2006-01-24
PCT/IB2007/050186 WO2007085990A1 (en) 2006-01-24 2007-01-19 Method for producing a particle comprising a gas core and a shell and particles thus obtained

Publications (1)

Publication Number Publication Date
BRPI0707190A2 true BRPI0707190A2 (pt) 2011-04-26

Family

ID=36572207

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0707190-6A BRPI0707190A2 (pt) 2006-01-24 2007-01-19 método para a produção de partìculas, partìcula, agente de contraste, composição terapêutica, e, composição de partìcula

Country Status (7)

Country Link
US (1) US20100221190A1 (pt)
EP (1) EP1978945A1 (pt)
JP (1) JP2009524602A (pt)
CN (1) CN101374506B (pt)
BR (1) BRPI0707190A2 (pt)
RU (1) RU2008134466A (pt)
WO (1) WO2007085990A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009077921A2 (en) * 2007-12-18 2009-06-25 Koninklijke Philips Electronics, N.V. Antimicrobial filled capsules in an ultrasound field for treatment of dental biofilm
EP2103313A1 (en) * 2008-03-19 2009-09-23 Koninklijke Philips Electronics N.V. Method for the synthesis of hollow spheres
US8323685B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
CN102470100B (zh) * 2009-07-31 2015-02-18 皇家飞利浦电子股份有限公司 用于制备并入了有效生物活性分子的微粒的方法
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
CN116917029A (zh) * 2021-03-01 2023-10-20 国立大学法人东京大学 微颗粒和微颗粒分散液

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19648664A1 (de) * 1996-11-14 1998-05-28 Schering Ag Wirkstoffhaltige Mikropartikel, diese enthaltende Mittel, deren Verwendung zur ultraschallgesteuerten Freisetzung von Wirkstoffen sowie Verfahren zu deren Herstellung
EP0979071B1 (en) * 1997-04-30 2007-11-07 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents and for delivery of drugs into the bloodstream
US6896659B2 (en) * 1998-02-06 2005-05-24 Point Biomedical Corporation Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility
JP2007509989A (ja) * 2003-10-31 2007-04-19 ポイント バイオメディカル コーポレイション 超音波造影剤として有用な再構成可能なミクロスフィア組成物
EP1763397A1 (en) * 2004-06-29 2007-03-21 Koninklijke Philips Electronics N.V. System for manufacturing micro-spheres

Also Published As

Publication number Publication date
US20100221190A1 (en) 2010-09-02
EP1978945A1 (en) 2008-10-15
CN101374506A (zh) 2009-02-25
WO2007085990A1 (en) 2007-08-02
JP2009524602A (ja) 2009-07-02
CN101374506B (zh) 2013-09-18
RU2008134466A (ru) 2010-02-27

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: KONINKLIJKE PHILIPS N.V. (NL)

B25G Requested change of headquarter approved

Owner name: KONINKLIJKE PHILIPS N.V. (NL)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]