BRPI0708909B8 - uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna - Google Patents

uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna

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Publication number
BRPI0708909B8
BRPI0708909B8 BRPI0708909A BRPI0708909A BRPI0708909B8 BR PI0708909 B8 BRPI0708909 B8 BR PI0708909B8 BR PI0708909 A BRPI0708909 A BR PI0708909A BR PI0708909 A BRPI0708909 A BR PI0708909A BR PI0708909 B8 BRPI0708909 B8 BR PI0708909B8
Authority
BR
Brazil
Prior art keywords
eculizumab
paroxysmal nocturnal
nocturnal hemoglobinuria
patients
hpn
Prior art date
Application number
BRPI0708909A
Other languages
English (en)
Inventor
Bell Leonard
P Rother Russel
Original Assignee
Alexion Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38222520&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0708909(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
Priority to BR122017024057A priority Critical patent/BR122017024057B8/pt
Publication of BRPI0708909A2 publication Critical patent/BRPI0708909A2/pt
Publication of BRPI0708909B1 publication Critical patent/BRPI0708909B1/pt
Publication of BRPI0708909B8 publication Critical patent/BRPI0708909B8/pt

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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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Abstract

composto ultilizado na preparação de um medicamento para tratamento de pacientes com hemoglobinúria paroxística noturna através de um inibidor de complemento. eculizumab, um anticorpo monoclonal humanizado contra c5 que inibe a ativação do complemento terminal, mostrou atividade em uma triagem de marcação aberta de 12 semanas preliminar em um pequeno grupo de pacientes com hemoglobinúria paroxísta noturna (hpn). o presente estudo examinou se a terapia crônica com eculizumab pode reduzir hemólise intravascular, estabilizar níveis de hemoglobina, reduzir requerimentos de transfusão, e melhorar a qualidade de vida em uma triagem global de fase iii do tipo duplo-cego, aleatória, placebo-controlado, multi-cêntrica. tem sido encontrado que eculizumab estabilizou os níveis de hemoglobina, diminui a necessidade de transfusões, e melhorou a qualidade de vida em pacientes hpn através de uma via de hemólise intravascular reduzida. tratamento crônico com eculizumab aparenta ser uma terapia segura e eficaz para pnh.
BRPI0708909A 2006-03-15 2007-03-15 uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna BRPI0708909B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122017024057A BR122017024057B8 (pt) 2006-03-15 2007-03-15 anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78307006P 2006-03-15 2006-03-15
US60/783,070 2006-03-15
PCT/US2007/006606 WO2007106585A1 (en) 2006-03-15 2007-03-15 Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement

Publications (3)

Publication Number Publication Date
BRPI0708909A2 BRPI0708909A2 (pt) 2011-06-14
BRPI0708909B1 BRPI0708909B1 (pt) 2021-02-09
BRPI0708909B8 true BRPI0708909B8 (pt) 2021-05-25

Family

ID=38222520

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122017024057A BR122017024057B8 (pt) 2006-03-15 2007-03-15 anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável
BRPI0708909A BRPI0708909B8 (pt) 2006-03-15 2007-03-15 uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122017024057A BR122017024057B8 (pt) 2006-03-15 2007-03-15 anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável

Country Status (16)

Country Link
US (8) US20090220508A1 (pt)
EP (5) EP3124029A1 (pt)
JP (9) JP2009530299A (pt)
KR (2) KR20140057635A (pt)
AU (1) AU2007225044C1 (pt)
BR (2) BR122017024057B8 (pt)
CA (2) CA2645810C (pt)
DK (1) DK2359834T5 (pt)
ES (2) ES2965283T3 (pt)
HU (2) HUE030105T2 (pt)
IL (4) IL302157A (pt)
MX (2) MX340784B (pt)
PL (2) PL2359834T3 (pt)
PT (1) PT2359834T (pt)
SI (1) SI2359834T1 (pt)
WO (1) WO2007106585A1 (pt)

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