BRPI0713063B8 - dímero de polipeptídeo capaz de inibir a atividade do complexo agonístico il-6/sil-6r e compreendendo dois monômeros, composição farmacêutica e seus usos - Google Patents

dímero de polipeptídeo capaz de inibir a atividade do complexo agonístico il-6/sil-6r e compreendendo dois monômeros, composição farmacêutica e seus usos

Info

Publication number
BRPI0713063B8
BRPI0713063B8 BRPI0713063A BRPI0713063A BRPI0713063B8 BR PI0713063 B8 BRPI0713063 B8 BR PI0713063B8 BR PI0713063 A BRPI0713063 A BR PI0713063A BR PI0713063 A BRPI0713063 A BR PI0713063A BR PI0713063 B8 BRPI0713063 B8 BR PI0713063B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
sil
monomers
inhibiting
activity
Prior art date
Application number
BRPI0713063A
Other languages
English (en)
Inventor
Seegert Dirk
H Wätzig Georg
Original Assignee
Conaris Res Institute Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conaris Res Institute Ag filed Critical Conaris Res Institute Ag
Publication of BRPI0713063A2 publication Critical patent/BRPI0713063A2/pt
Publication of BRPI0713063B1 publication Critical patent/BRPI0713063B1/pt
Publication of BRPI0713063B8 publication Critical patent/BRPI0713063B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

dímeros sgp13ofc aperfeiçoados. a presente invenção refere-se a dímeros polipeptídeos compreendendo duas moléculas gp13o solúveis, em que cada uma das ditas moléculas é fundida a um domínio fc de uma proteína lgg1 e em que a região articulada do domínio fc é modificada resultando em vantajosas propriedades do dímero. em uma modalidade particularmente preferida, a região articulada compreende a motivo sequência de aminoácidos ala~ 234~-glu~ 235~-gly~ 236~- ala~ 237~. além disso, uma composição farmacêutica contendo o dito dímero e vários usos médicos são descritos.
BRPI0713063A 2006-06-30 2007-06-29 dímero de polipeptídeo capaz de inibir a atividade do complexo agonístico il-6/sil-6r e compreendendo dois monômeros, composição farmacêutica e seus usos BRPI0713063B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06013668.6 2006-06-30
EP06013668A EP1873166B1 (en) 2006-06-30 2006-06-30 Improved sgp 130Fc dimers
PCT/EP2007/005812 WO2008000516A2 (en) 2006-06-30 2007-06-29 Improved sgp130fc dimers

Publications (3)

Publication Number Publication Date
BRPI0713063A2 BRPI0713063A2 (pt) 2012-04-17
BRPI0713063B1 BRPI0713063B1 (pt) 2019-10-08
BRPI0713063B8 true BRPI0713063B8 (pt) 2021-05-25

Family

ID=37654867

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0713063A BRPI0713063B8 (pt) 2006-06-30 2007-06-29 dímero de polipeptídeo capaz de inibir a atividade do complexo agonístico il-6/sil-6r e compreendendo dois monômeros, composição farmacêutica e seus usos

Country Status (21)

Country Link
US (3) US8895012B2 (pt)
EP (1) EP1873166B1 (pt)
JP (1) JP5417171B2 (pt)
KR (1) KR101474817B1 (pt)
CN (1) CN101484472B (pt)
AT (1) ATE480568T1 (pt)
AU (1) AU2007263939B2 (pt)
BR (1) BRPI0713063B8 (pt)
CA (1) CA2656440C (pt)
CY (1) CY1110973T1 (pt)
DE (1) DE602006016765D1 (pt)
DK (1) DK1873166T3 (pt)
EA (1) EA015620B1 (pt)
ES (1) ES2352561T3 (pt)
HR (1) HRP20100663T1 (pt)
PL (1) PL1873166T3 (pt)
PT (1) PT1873166E (pt)
RS (1) RS51544B (pt)
SI (1) SI1873166T1 (pt)
UA (1) UA95636C2 (pt)
WO (1) WO2008000516A2 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2352561T3 (es) 2006-06-30 2011-02-21 Conaris Research Institute Ag Dímeros de sgp 130fc mejorados.
DK2160401T3 (da) 2007-05-11 2014-10-20 Altor Bioscience Corp Fusionsmolekyler og il-15-varianter
EP2050759A1 (en) * 2007-10-19 2009-04-22 CONARIS research institute AG Soluble gp 130 muteins with improved binding activity
EP2619229B1 (en) 2010-09-21 2016-04-06 Altor BioScience Corporation Multimeric il-15 soluble fusion molecules and methods of making and using same
US11053299B2 (en) 2010-09-21 2021-07-06 Immunity Bio, Inc. Superkine
CN106851720B (zh) * 2013-09-20 2020-12-11 英特尔公司 Ap位置查询的装置、方法和存储介质
KR102503476B1 (ko) 2014-06-30 2023-02-24 알토 바이오사이언스 코포레이션 Il-15-베이즈드 분자 및 이의 사용 방법
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
EP3226888B1 (en) * 2014-12-01 2021-04-21 Ferring B.V. Administration of a selective il-6-trans-signalling inhibitor
RS65665B1 (sr) * 2014-12-01 2024-07-31 Ferring Bv Selektivne kompozicije inhibitora il-6-trans-signalizacije
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
ES2874974T3 (es) 2016-05-11 2021-11-05 Cytiva Bioprocess R & D Ab Matriz de separación
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
JP7106187B2 (ja) 2016-05-11 2022-07-26 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックスを保存する方法
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
ES2909833T3 (es) 2016-05-11 2022-05-10 Cytiva Bioprocess R & D Ab Método de limpieza y/o desinfección de una matriz de separación
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
KR102392142B1 (ko) 2016-10-21 2022-04-28 알토 바이오사이언스 코포레이션 다량체 il-15 기반 분자
CN108593912A (zh) * 2018-04-09 2018-09-28 北京大学深圳研究生院 一种可溶性cd38浓度的检测方法
CN108318689A (zh) * 2018-04-09 2018-07-24 北京大学深圳研究生院 一种多发性骨髓瘤的诊断方法
WO2020006469A1 (en) * 2018-06-29 2020-01-02 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating and reducing traumatic brain injury-associated impairments using sgp130
GB2595299B (en) 2020-05-21 2022-08-03 Mabsolve Ltd Modified immunoglobulin FC regions
JP7781786B2 (ja) * 2020-06-10 2025-12-08 フェリング・ベー・フェー アテローム性動脈硬化性心血管疾患を治療するための医薬化合物
WO2022139580A1 (en) 2020-12-22 2022-06-30 Ferring B.V. Blood gene expression biomarkers to predict response in patients with inflammatory bowel diseases
CN114681592A (zh) * 2020-12-31 2022-07-01 天境生物科技(杭州)有限公司 包含可溶性gp130二聚体的制剂和使用方法
CA3229588A1 (en) * 2021-09-01 2023-03-09 Telix Pharmaceuticals (Innovations) Pty Ltd Aggregate separation method
WO2024011946A1 (en) * 2022-07-12 2024-01-18 I-Mab Biopharma (Hangzhou) Co., Ltd Polypeptide dimers for the treatment of systemic sclerosis
EP4570816A1 (en) 2023-12-14 2025-06-18 Consejo Superior De Investigaciones Científicas - CSIC Soluble gp130fc (sgp130fc) for use in the treatment of sars-cov-2

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
JPH04218000A (ja) 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
AU5670194A (en) 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
US5457035A (en) * 1993-07-23 1995-10-10 Immunex Corporation Cytokine which is a ligand for OX40
US5783672A (en) * 1994-05-26 1998-07-21 Immunex Corporation Receptor for oncostatin M
CN1204147C (zh) * 1998-02-25 2005-06-01 利思进药品公司 提高以抗体为基础的融合蛋白的循环半衰期的方法
US6472179B2 (en) * 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
DE19941897B4 (de) 1999-09-02 2006-06-14 GSF - Forschungszentrum für Umwelt und Gesundheit GmbH IL-6 Rezeptor-Protein, Beta-Kette (gp130) des IL-6 Rezeptor-Proteins, für diese Proteine kodierende DNA, davon abgeleitete RNA, Peptid mit den Aminosäuren 771-811 dieser Beta-Kette oder Teilen davon und deren Verwendungen
JP5179689B2 (ja) * 2000-02-11 2013-04-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗体ベース融合タンパク質の循環系内半減期の増強
ES2298106T3 (es) * 2000-04-21 2008-05-16 Conaris Research Institute Ag Proteinas de fusion que comprenden dos moleculas gp130 solubles.
CA2447236A1 (en) * 2001-05-21 2002-11-28 Nektar Therapeutics Pulmonary administration of chemically modified insulin
WO2003008454A2 (en) * 2001-07-18 2003-01-30 Merck Patent Gmbh Glycoprotein vi fusion proteins
US6887687B2 (en) * 2001-07-30 2005-05-03 Immunex Corporation Nucleic acids encoding human ataxin-1-like polypeptide IMX97018
PT1641483E (pt) * 2003-06-12 2008-04-29 Lilly Co Eli Proteínas de fusão
EP1491554A1 (en) * 2003-06-23 2004-12-29 CONARIS research institute AG PEGylated soluble gp130-dimers useful as a medicament
BRPI0417916A (pt) * 2003-12-31 2007-04-10 Merck Patent Gmbh proteìna de fusão de fc-eritropoietina com farmacocinética melhorada
EP1630232B1 (en) 2004-08-27 2008-07-02 CONARIS research institute AG Optimized nucleotide sequences encoding sgp130
EP1801121A1 (en) 2005-12-23 2007-06-27 CONARIS research institute AG Soluble gp130 molecule variants useful as a medicament
ES2352561T3 (es) 2006-06-30 2011-02-21 Conaris Research Institute Ag Dímeros de sgp 130fc mejorados.

Also Published As

Publication number Publication date
ATE480568T1 (de) 2010-09-15
KR101474817B1 (ko) 2014-12-22
US9034817B2 (en) 2015-05-19
KR20090037898A (ko) 2009-04-16
JP5417171B2 (ja) 2014-02-12
EA015620B1 (ru) 2011-10-31
CA2656440C (en) 2018-10-02
RS51544B (sr) 2011-06-30
EP1873166A1 (en) 2008-01-02
UA95636C2 (en) 2011-08-25
CA2656440A1 (en) 2008-01-03
CY1110973T1 (el) 2015-06-11
EA200802396A1 (ru) 2009-06-30
JP2009540843A (ja) 2009-11-26
SI1873166T1 (sl) 2011-01-31
WO2008000516A2 (en) 2008-01-03
EP1873166B1 (en) 2010-09-08
AU2007263939A1 (en) 2008-01-03
US20100028367A1 (en) 2010-02-04
CN101484472A (zh) 2009-07-15
BRPI0713063B1 (pt) 2019-10-08
WO2008000516B1 (en) 2008-05-08
US8895012B2 (en) 2014-11-25
DK1873166T3 (da) 2010-12-20
HRP20100663T1 (hr) 2011-01-31
WO2008000516A3 (en) 2008-03-27
US20140178378A1 (en) 2014-06-26
US20150361157A1 (en) 2015-12-17
CN101484472B (zh) 2013-07-24
BRPI0713063A2 (pt) 2012-04-17
DE602006016765D1 (de) 2010-10-21
AU2007263939B2 (en) 2011-11-24
PL1873166T3 (pl) 2011-03-31
US9573989B2 (en) 2017-02-21
ES2352561T3 (es) 2011-02-21
PT1873166E (pt) 2010-12-09

Similar Documents

Publication Publication Date Title
CY1110973T1 (el) Βελτιωμενα διμερη sgp130fc
US20260115254A1 (en) Immune-cell targeted bispecific chimeric proteins and uses thereof
DK1347730T4 (da) Rekombinante anti-CD30-antistoffer og anvendelser deraf
BRPI0411172A (pt) peptìdeo, dìmero de peptìdeo, seu uso e composição farmacêutica
NZ592509A (en) HLA-A*1101-restricted WTI peptide and pharmaceutical composition comprising the same
JP2019507589A5 (pt)
WO2004069876A3 (en) Trimeric polypeptide construct to induce an enduring t cell response
BRPI0511421A (pt) composições cosmética e farmacêutica para tratar materiais contendo queratina, uso de composições cosméticas, molécula efetora que liga queratina, uso da mesma, e, processo
BRPI0512286B8 (pt) proteínas quiméricas inibidoras da angiogênese e o uso
RU2009100884A (ru) Пептидные фрагменты для индукции синтеза белков внеклеточного матрикса
DE602008005596D1 (de) Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität
EA200701036A1 (ru) Лактамные соединения и их применение в качестве фармацевтических препаратов
BR112023023463A2 (pt) Inibidores da interação menin-mll
TW202128961A (zh) 細胞激素融合蛋白及其醫藥組合物及治療應用
MY209615A (en) Extracellular domain of alpha subunit of ige fc receptor, pharmaceutical composition comprising same and method for producing same
DE602007009116D1 (de) Zusammensetzungen und verfahren zur verabreichung anti-aktivierter ras-antikörper an zellen
EA201100459A1 (ru) Композиции, включающие интерлейкин-1 и пептиды
CA3210657A1 (en) Glucagon-like peptide-1 receptor antagonists
DK2212347T3 (da) Opløselige GP130-muteiner med forbedret bindingsaktivitet
Kim et al. A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity
ATE368687T1 (de) Thrombopoietinproteine mit verbesserten eigenschaften
US20130108580A1 (en) Fusion protein and its uses
Qvit et al. Peptides that target protein-protein interactions as an anti-parasite strategy
ATE540971T1 (de) Proteinkinase-c-inhibitoren zur prävention von insulinresistenz und typ-2-diabetes
US20210052701A1 (en) Methods of Treating Vascular Leakage Using CXCL12 Peptides

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/06/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF