BRPI0713693A2 - composição, utilização de uma composição, e, produto - Google Patents

composição, utilização de uma composição, e, produto Download PDF

Info

Publication number: BRPI0713693A2
Authority: BR; Brazil
Prior art keywords: pain; disorders; composition according; muscle; morphine
Prior art date: 2006-06-16

Application number

BRPI0713693-5A

Other languages

English (en)

Portuguese (pt)

Inventor

Michel Auguet

Christine Favre

De Lassauniere Pierre-Etienne Chabrier

Original Assignee

Soc Conseils Rech Applic Scientifique Scras

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-16

Filing date

2007-06-11

Publication date

2012-10-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37616909&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0713693(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-06-11 Application filed by Soc Conseils Rech Applic Scientifique Scras filed Critical Soc Conseils Rech Applic Scientifique Scras

2012-10-30 Publication of BRPI0713693A2 publication Critical patent/BRPI0713693A2/pt

Links

239000000203 mixture Substances 0.000 title claims abstract description 67
-1 and Substances 0.000 title abstract description 7
108030001720 Bontoxilysin Proteins 0.000 claims abstract description 63
208000002193 Pain Diseases 0.000 claims abstract description 62
230000036407 pain Effects 0.000 claims abstract description 61
239000000047 product Substances 0.000 claims abstract description 34
231100001103 botulinum neurotoxin Toxicity 0.000 claims abstract description 31
150000003839 salts Chemical class 0.000 claims abstract description 30
229940127240 opiate Drugs 0.000 claims abstract description 28
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 20
238000011282 treatment Methods 0.000 claims abstract description 17
208000035475 disorder Diseases 0.000 claims abstract description 16
230000002265 prevention Effects 0.000 claims abstract description 11
230000001225 therapeutic effect Effects 0.000 claims abstract description 10
239000013066 combination product Substances 0.000 claims abstract description 5
229940127555 combination product Drugs 0.000 claims abstract description 5
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 63
229960005181 morphine Drugs 0.000 claims description 28
150000004676 glycans Chemical class 0.000 claims description 17
229920001282 polysaccharide Polymers 0.000 claims description 17
239000005017 polysaccharide Substances 0.000 claims description 17
230000037303 wrinkles Effects 0.000 claims description 17
239000003814 drug Substances 0.000 claims description 13
208000007101 Muscle Cramp Diseases 0.000 claims description 12
208000005392 Spasm Diseases 0.000 claims description 12
239000004094 surface-active agent Substances 0.000 claims description 11
208000030507 AIDS Diseases 0.000 claims description 10
208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims description 10
208000008454 Hyperhidrosis Diseases 0.000 claims description 10
208000019695 Migraine disease Diseases 0.000 claims description 10
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 10
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims description 10
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 10
206010027599 migraine Diseases 0.000 claims description 10
208000001640 Fibromyalgia Diseases 0.000 claims description 9
206010044074 Torticollis Diseases 0.000 claims description 9
229960004715 morphine sulfate Drugs 0.000 claims description 9
GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 claims description 9
201000004384 Alopecia Diseases 0.000 claims description 8
206010065390 Inflammatory pain Diseases 0.000 claims description 8
208000000112 Myalgia Diseases 0.000 claims description 8
210000004709 eyebrow Anatomy 0.000 claims description 8
230000003676 hair loss Effects 0.000 claims description 8
201000008482 osteoarthritis Diseases 0.000 claims description 8
208000004550 Postoperative Pain Diseases 0.000 claims description 7
210000003205 muscle Anatomy 0.000 claims description 7
208000004296 neuralgia Diseases 0.000 claims description 7
239000002537 cosmetic Substances 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 6
208000018360 neuromuscular disease Diseases 0.000 claims description 6
208000021722 neuropathic pain Diseases 0.000 claims description 6
TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims description 5
DYUTXEVRMPFGTH-UHFFFAOYSA-N 4-(2,5-dimethylphenyl)-5-methyl-1,3-thiazol-2-amine Chemical compound S1C(N)=NC(C=2C(=CC=C(C)C=2)C)=C1C DYUTXEVRMPFGTH-UHFFFAOYSA-N 0.000 claims description 5
206010058019 Cancer Pain Diseases 0.000 claims description 5
208000017667 Chronic Disease Diseases 0.000 claims description 5
206010010774 Constipation Diseases 0.000 claims description 5
XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims description 5
208000008238 Muscle Spasticity Diseases 0.000 claims description 5
208000029578 Muscle disease Diseases 0.000 claims description 5
208000021642 Muscular disease Diseases 0.000 claims description 5
IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical group C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims description 5
BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 5
ZTVQQQVZCWLTDF-UHFFFAOYSA-N Remifentanil Chemical compound C1CN(CCC(=O)OC)CCC1(C(=O)OC)N(C(=O)CC)C1=CC=CC=C1 ZTVQQQVZCWLTDF-UHFFFAOYSA-N 0.000 claims description 5
208000034189 Sclerosis Diseases 0.000 claims description 5
229960001391 alfentanil Drugs 0.000 claims description 5
201000008907 algoneurodystrophy Diseases 0.000 claims description 5
206010005159 blepharospasm Diseases 0.000 claims description 5
230000000744 blepharospasm Effects 0.000 claims description 5
229960001736 buprenorphine Drugs 0.000 claims description 5
RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 5
229960004126 codeine Drugs 0.000 claims description 5
229960004193 dextropropoxyphene Drugs 0.000 claims description 5
XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims description 5
206010012601 diabetes mellitus Diseases 0.000 claims description 5
229960000920 dihydrocodeine Drugs 0.000 claims description 5
RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 claims description 5
229960002428 fentanyl Drugs 0.000 claims description 5
PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims description 5
LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 5
229960000240 hydrocodone Drugs 0.000 claims description 5
229960002738 hydromorphone hydrochloride Drugs 0.000 claims description 5
230000037315 hyperhidrosis Effects 0.000 claims description 5
208000018197 inherited torticollis Diseases 0.000 claims description 5
230000003902 lesion Effects 0.000 claims description 5
229960000805 nalbuphine Drugs 0.000 claims description 5
NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 claims description 5
229960002085 oxycodone Drugs 0.000 claims description 5
229960000482 pethidine Drugs 0.000 claims description 5
229920000136 polysorbate Polymers 0.000 claims description 5
229950008882 polysorbate Drugs 0.000 claims description 5
229960003394 remifentanil Drugs 0.000 claims description 5
208000018198 spasticity Diseases 0.000 claims description 5
GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 claims description 5
230000035900 sweating Effects 0.000 claims description 5
230000000542 thalamic effect Effects 0.000 claims description 5
229960004380 tramadol Drugs 0.000 claims description 5
TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims description 5
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims description 5
208000002874 Acne Vulgaris Diseases 0.000 claims description 4
206010002153 Anal fissure Diseases 0.000 claims description 4
208000016583 Anus disease Diseases 0.000 claims description 4
206010056948 Automatic bladder Diseases 0.000 claims description 4
206010048994 Bladder spasm Diseases 0.000 claims description 4
208000010392 Bone Fractures Diseases 0.000 claims description 4
208000020401 Depressive disease Diseases 0.000 claims description 4
208000012661 Dyskinesia Diseases 0.000 claims description 4
208000017701 Endocrine disease Diseases 0.000 claims description 4
201000009273 Endometriosis Diseases 0.000 claims description 4
201000011275 Epicondylitis Diseases 0.000 claims description 4
208000000289 Esophageal Achalasia Diseases 0.000 claims description 4
206010068737 Facial asymmetry Diseases 0.000 claims description 4
206010016059 Facial pain Diseases 0.000 claims description 4
206010063006 Facial spasm Diseases 0.000 claims description 4
208000009531 Fissure in Ano Diseases 0.000 claims description 4
201000005569 Gout Diseases 0.000 claims description 4
206010019233 Headaches Diseases 0.000 claims description 4
208000004095 Hemifacial Spasm Diseases 0.000 claims description 4
208000007353 Hip Osteoarthritis Diseases 0.000 claims description 4
208000023178 Musculoskeletal disease Diseases 0.000 claims description 4
206010028980 Neoplasm Diseases 0.000 claims description 4
208000012902 Nervous system disease Diseases 0.000 claims description 4
208000025966 Neurological disease Diseases 0.000 claims description 4
208000008589 Obesity Diseases 0.000 claims description 4
206010030136 Oesophageal achalasia Diseases 0.000 claims description 4
206010033645 Pancreatitis Diseases 0.000 claims description 4
208000036496 Pelvic floor dyssynergia Diseases 0.000 claims description 4
201000004681 Psoriasis Diseases 0.000 claims description 4
206010039085 Rhinitis allergic Diseases 0.000 claims description 4
208000008765 Sciatica Diseases 0.000 claims description 4
208000004350 Strabismus Diseases 0.000 claims description 4
206010046543 Urinary incontinence Diseases 0.000 claims description 4
201000000621 achalasia Diseases 0.000 claims description 4
206010000496 acne Diseases 0.000 claims description 4
201000010105 allergic rhinitis Diseases 0.000 claims description 4
201000002898 anismus Diseases 0.000 claims description 4
239000002246 antineoplastic agent Substances 0.000 claims description 4
206010003246 arthritis Diseases 0.000 claims description 4
201000011510 cancer Diseases 0.000 claims description 4
206010008129 cerebral palsy Diseases 0.000 claims description 4
230000007547 defect Effects 0.000 claims description 4
230000004064 dysfunction Effects 0.000 claims description 4
208000010118 dystonia Diseases 0.000 claims description 4
230000001815 facial effect Effects 0.000 claims description 4
230000008921 facial expression Effects 0.000 claims description 4
208000024963 hair loss Diseases 0.000 claims description 4
231100000869 headache Toxicity 0.000 claims description 4
WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims description 4
229960001410 hydromorphone Drugs 0.000 claims description 4
208000014674 injury Diseases 0.000 claims description 4
230000035987 intoxication Effects 0.000 claims description 4
231100000566 intoxication Toxicity 0.000 claims description 4
208000013465 muscle pain Diseases 0.000 claims description 4
201000001119 neuropathy Diseases 0.000 claims description 4
230000007823 neuropathy Effects 0.000 claims description 4
239000002736 nonionic surfactant Substances 0.000 claims description 4
235000020824 obesity Nutrition 0.000 claims description 4
230000007170 pathology Effects 0.000 claims description 4
208000020016 psychiatric disease Diseases 0.000 claims description 4
206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
206010039083 rhinitis Diseases 0.000 claims description 4
210000004514 sphincter of oddi Anatomy 0.000 claims description 4
230000008733 trauma Effects 0.000 claims description 4
210000001364 upper extremity Anatomy 0.000 claims description 4
208000014001 urinary system disease Diseases 0.000 claims description 4
210000002700 urine Anatomy 0.000 claims description 4
206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 3
229920001612 Hydroxyethyl starch Polymers 0.000 claims description 3
206010036376 Postherpetic Neuralgia Diseases 0.000 claims description 3
208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 3
206010037779 Radiculopathy Diseases 0.000 claims description 3
206010043248 Tendon rupture Diseases 0.000 claims description 3
238000002266 amputation Methods 0.000 claims description 3
230000001684 chronic effect Effects 0.000 claims description 3
229940050526 hydroxyethylstarch Drugs 0.000 claims description 3
210000003141 lower extremity Anatomy 0.000 claims description 3
230000014759 maintenance of location Effects 0.000 claims description 3
210000000513 rotator cuff Anatomy 0.000 claims description 3
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
125000000129 anionic group Chemical group 0.000 claims description 2
239000003945 anionic surfactant Substances 0.000 claims description 2
125000002091 cationic group Chemical group 0.000 claims description 2
239000003093 cationic surfactant Substances 0.000 claims description 2
230000002980 postoperative effect Effects 0.000 claims description 2
229960004739 sufentanil Drugs 0.000 claims description 2
208000035985 Body Odor Diseases 0.000 claims 1
206010055000 Bromhidrosis Diseases 0.000 claims 1
210000002435 tendon Anatomy 0.000 claims 1
230000002232 neuromuscular Effects 0.000 abstract 1
229940053031 botulinum toxin Drugs 0.000 description 31
239000000679 carrageenan Substances 0.000 description 24
235000010418 carrageenan Nutrition 0.000 description 24
229920001525 carrageenan Polymers 0.000 description 24
229940113118 carrageenan Drugs 0.000 description 24
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 24
239000007924 injection Substances 0.000 description 21
238000002347 injection Methods 0.000 description 21
208000004454 Hyperalgesia Diseases 0.000 description 19
208000035154 Hyperesthesia Diseases 0.000 description 19
230000000694 effects Effects 0.000 description 19
108090000623 proteins and genes Proteins 0.000 description 16
102000004169 proteins and genes Human genes 0.000 description 16
108010079650 abobotulinumtoxinA Proteins 0.000 description 12
229940098753 dysport Drugs 0.000 description 12
241000700159 Rattus Species 0.000 description 10
239000003981 vehicle Substances 0.000 description 9
239000004480 active ingredient Substances 0.000 description 8
230000000202 analgesic effect Effects 0.000 description 8
108010057266 Type A Botulinum Toxins Proteins 0.000 description 6
238000002474 experimental method Methods 0.000 description 6
108090000765 processed proteins & peptides Proteins 0.000 description 6
239000003053 toxin Substances 0.000 description 6
231100000765 toxin Toxicity 0.000 description 6
108700012359 toxins Proteins 0.000 description 6
238000012360 testing method Methods 0.000 description 5
101000794261 Clostridium botulinum Botulinum neurotoxin type A Proteins 0.000 description 4
231100000111 LD50 Toxicity 0.000 description 4
230000008901 benefit Effects 0.000 description 4
230000004071 biological effect Effects 0.000 description 4
201000010099 disease Diseases 0.000 description 4
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 4
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
229920000053 polysorbate 80 Polymers 0.000 description 4
229940068968 polysorbate 80 Drugs 0.000 description 4
102000004196 processed proteins & peptides Human genes 0.000 description 4
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
229940094657 botulinum toxin type a Drugs 0.000 description 3
210000002683 foot Anatomy 0.000 description 3
108020001507 fusion proteins Proteins 0.000 description 3
102000037865 fusion proteins Human genes 0.000 description 3
230000002757 inflammatory effect Effects 0.000 description 3
239000007927 intramuscular injection Substances 0.000 description 3
238000010255 intramuscular injection Methods 0.000 description 3
238000007912 intraperitoneal administration Methods 0.000 description 3
239000000178 monomer Substances 0.000 description 3
229920001184 polypeptide Polymers 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000007929 subcutaneous injection Substances 0.000 description 3
238000010254 subcutaneous injection Methods 0.000 description 3
230000002195 synergetic effect Effects 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
208000003508 Botulism Diseases 0.000 description 2
241000193155 Clostridium botulinum Species 0.000 description 2
101710154606 Hemagglutinin Proteins 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
206010033799 Paralysis Diseases 0.000 description 2
101710176177 Protein A56 Proteins 0.000 description 2
208000027520 Somatoform disease Diseases 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
229940089093 botox Drugs 0.000 description 2
150000001720 carbohydrates Chemical class 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
230000000536 complexating effect Effects 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
238000000855 fermentation Methods 0.000 description 2
230000004151 fermentation Effects 0.000 description 2
235000013305 food Nutrition 0.000 description 2
239000000185 hemagglutinin Substances 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
239000007788 liquid Substances 0.000 description 2
208000027753 pain disease Diseases 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
239000000126 substance Substances 0.000 description 2
208000011580 syndromic disease Diseases 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
101710117542 Botulinum neurotoxin type A Proteins 0.000 description 1
101710156708 Botulinum neurotoxin type A2 Proteins 0.000 description 1
101710117524 Botulinum neurotoxin type B Proteins 0.000 description 1
101710117523 Botulinum neurotoxin type C Proteins 0.000 description 1
101710117518 Botulinum neurotoxin type D Proteins 0.000 description 1
101710117520 Botulinum neurotoxin type F Proteins 0.000 description 1
101710117519 Botulinum neurotoxin type G Proteins 0.000 description 1
208000000094 Chronic Pain Diseases 0.000 description 1
101000985023 Clostridium botulinum C phage Botulinum neurotoxin type C Proteins 0.000 description 1
206010010305 Confusional state Diseases 0.000 description 1
208000019505 Deglutition disease Diseases 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
208000032131 Diabetic Neuropathies Diseases 0.000 description 1
206010015995 Eyelid ptosis Diseases 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
208000021965 Glossopharyngeal Nerve disease Diseases 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
229930186217 Glycolipid Natural products 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
208000012659 Joint disease Diseases 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
208000010428 Muscle Weakness Diseases 0.000 description 1
206010028372 Muscular weakness Diseases 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
206010028813 Nausea Diseases 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
239000008896 Opium Substances 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
229920001219 Polysorbate 40 Polymers 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
229920002651 Polysorbate 85 Polymers 0.000 description 1
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
206010039424 Salivary hypersecretion Diseases 0.000 description 1
206010039897 Sedation Diseases 0.000 description 1
208000008630 Sialorrhea Diseases 0.000 description 1
206010041349 Somnolence Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
206010047700 Vomiting Diseases 0.000 description 1
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
229960004373 acetylcholine Drugs 0.000 description 1
125000003158 alcohol group Chemical group 0.000 description 1
230000001093 anti-cancer Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
108010069023 botulinum toxin type E Proteins 0.000 description 1
XNVWFBHTEBDKCA-UHFFFAOYSA-N butanedioic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CCC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O XNVWFBHTEBDKCA-UHFFFAOYSA-N 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000000470 constituent Substances 0.000 description 1
239000001177 diphosphate Substances 0.000 description 1
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
235000011180 diphosphates Nutrition 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000002996 emotional effect Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000012634 fragment Substances 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
201000005442 glossopharyngeal neuralgia Diseases 0.000 description 1
239000008103 glucose Substances 0.000 description 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
239000008187 granular material Substances 0.000 description 1
210000000548 hind-foot Anatomy 0.000 description 1
206010020718 hyperplasia Diseases 0.000 description 1
229960004716 idoxuridine Drugs 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000005847 immunogenicity Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
238000013101 initial test Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
231100000518 lethal Toxicity 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000002502 liposome Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
238000005259 measurement Methods 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
230000001394 metastastic effect Effects 0.000 description 1
206010061289 metastatic neoplasm Diseases 0.000 description 1
238000000034 method Methods 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
235000019426 modified starch Nutrition 0.000 description 1
230000004118 muscle contraction Effects 0.000 description 1
230000008693 nausea Effects 0.000 description 1
230000025743 negative regulation of exocytosis Effects 0.000 description 1
239000002858 neurotransmitter agent Substances 0.000 description 1
230000001473 noxious effect Effects 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
229960001027 opium Drugs 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000002245 particle Substances 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
229940068977 polysorbate 20 Drugs 0.000 description 1
229940101027 polysorbate 40 Drugs 0.000 description 1
229940113124 polysorbate 60 Drugs 0.000 description 1
229940113171 polysorbate 85 Drugs 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
201000003004 ptosis Diseases 0.000 description 1
230000005180 public health Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
230000036280 sedation Effects 0.000 description 1
230000001953 sensory effect Effects 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
206010044652 trigeminal neuralgia Diseases 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
230000008673 vomiting Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Zoology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Emergency Medicine (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Cardiology (AREA)

BRPI0713693-5A 2006-06-16 2007-06-11 composição, utilização de uma composição, e, produto BRPI0713693A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0605368A FR2902341B1 (fr)	2006-06-16	2006-06-16	Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR0605368		2006-06-16
PCT/FR2007/000956 WO2007144493A2 (fr)	2006-06-16	2007-06-11	Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace

Publications (1)

Publication Number	Publication Date
BRPI0713693A2 true BRPI0713693A2 (pt)	2012-10-30

Family

ID=37616909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0713693-5A BRPI0713693A2 (pt)	2006-06-16	2007-06-11	composição, utilização de uma composição, e, produto

Country Status (16)

Country	Link
US (1)	US9080220B2 (fr)
EP (1)	EP2037956B1 (fr)
JP (1)	JP5425622B2 (fr)
CN (1)	CN101466401A (fr)
AU (1)	AU2007259122B2 (fr)
BR (1)	BRPI0713693A2 (fr)
CA (1)	CA2655488C (fr)
DK (1)	DK2037956T3 (fr)
ES (1)	ES2399661T3 (fr)
FR (1)	FR2902341B1 (fr)
IL (1)	IL195254A (fr)
MX (1)	MX2008015254A (fr)
PL (1)	PL2037956T3 (fr)
PT (1)	PT2037956E (fr)
RU (1)	RU2434637C2 (fr)
WO (1)	WO2007144493A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7780967B2 (en) *	2000-02-08	2010-08-24	Allergan, Inc.	Reduced toxicity Clostridial toxin pharmaceutical compositions
FR2902341B1 (fr)	2006-06-16	2011-02-25	Scras	Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR2907680B1 (fr)	2006-10-27	2012-12-28	Scras	Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur induite par au moins un agent anti-cancereux
FR2910327B1 (fr)	2006-12-22	2013-04-26	Scras	Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
FR2930447B1 (fr)	2008-04-25	2010-07-30	Sod Conseils Rech Applic	Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique
ES2356883B1 (es) *	2008-07-24	2012-02-22	Bcn Peptides, S.A.	Composición para el tratamiento del dolor y/o la inflamación.
UA116985C2 (uk)	2012-05-30	2018-06-11	Президент Енд Феллоуз Оф Гарвард Колледж	Рекомбінантний ботулінічний нейротоксин
MX370929B (es)	2012-10-28	2020-01-08	Revance Therapeutics Inc	Composiciones y usos de las mismas para el tratamiento seguro de la rinitis.
US20160375112A1 (en) *	2013-07-03	2016-12-29	Toxcure, LLC	Reducing Adverse Side Effects of a Compound by a Neurotoxin
US11484580B2 (en)	2014-07-18	2022-11-01	Revance Therapeutics, Inc.	Topical ocular preparation of botulinum toxin for use in ocular surface disease
JP2017526715A (ja) *	2014-09-12	2017-09-14	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	変形性関節症の痛みの治療方法
PT3274364T (pt)	2015-03-26	2021-11-05	Harvard College	Neurotoxina botulínica manipulada
PL3463432T3 (pl)	2016-05-27	2021-04-19	Ipsen Biopharm Limited	Ciekła formulacja neurotoksyny stabilizowana tryptofanem lub tyrozyną
EP3504226A1 (fr)	2016-08-24	2019-07-03	President and Fellows of Harvard College	Neurotoxine botulique manipulée
CA3068292A1 (fr) *	2017-06-26	2019-01-03	Bonti, Inc.	Formulations de neurotoxine clostridiale et utilisation
KR102088104B1 (ko) *	2018-06-29	2020-03-11	호서대학교 산학협력단	개망초 꽃 에센셜 오일을 포함하는 신경 근육 관련 질환 예방 및 치료용 조성물
EP3860640A1 (fr)	2018-10-02	2021-08-11	Merz Pharma GmbH & Co. KGaA	Nouvelles utilisations de neurotoxine botulique pour le traitement d'un lipoedème

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4457916A (en) *	1982-08-31	1984-07-03	Asahi Kasei Kogyo Kabushiki Kaisha	Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
DE69428813T2 (de)	1993-12-28	2002-04-04	Allergan Sales Inc	Verwendung von Botulinustoxin zur Behandlung von Spannungs-Kopfschmerz
US6136551A (en) *	1995-04-24	2000-10-24	Allergan, Inc.	Assay for detecting the presence of botulinum toxin neutralizing antibodies in a patient serum sample
US6113915A (en)	1999-10-12	2000-09-05	Allergan Sales, Inc.	Methods for treating pain
US6139845A (en) *	1999-12-07	2000-10-31	Allergan Sales, Inc.	Method for treating cancer with a neurotoxin
AU4904101A (en)	1999-12-08	2001-07-09	Fluoro Probe, Inc.	Method for relieving pain associated with an internal disease site
US7780967B2 (en) *	2000-02-08	2010-08-24	Allergan, Inc.	Reduced toxicity Clostridial toxin pharmaceutical compositions
DK1398038T4 (da)	2000-02-08	2011-03-28	Allergan Inc	Lægemidler med botulinustoxin
US20060269575A1 (en) *	2000-02-08	2006-11-30	Allergan, Inc.	Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
US20010036943A1 (en)	2000-04-07	2001-11-01	Coe Jotham W.	Pharmaceutical composition for treatment of acute, chronic pain and/or neuropathic pain and migraines
US6464986B1 (en)	2000-04-14	2002-10-15	Allegan Sales, Inc.	Method for treating pain by peripheral administration of a neurotoxin
US20020192239A1 (en) *	2001-01-09	2002-12-19	Borodic Gary E.	Use of botulinum toxin for the treatment of chronic facial pain
KR20030018827A (ko)	2001-08-31	2003-03-06	서구일	Ａ형 보툴리눔 독소를 유효성분으로 포함하는 신경차단제,및 이를 이용한 교감신경절 차단의 적응질환 치료제
US7022329B2 (en) *	2002-02-25	2006-04-04	Allergan, Inc.	Method for treating neurogenic inflammation pain with botulinum toxin and substance P components
US20040009180A1 (en)	2002-07-11	2004-01-15	Allergan, Inc.	Transdermal botulinum toxin compositions
US20050152905A1 (en) *	2002-08-22	2005-07-14	Omoigui Osemwota S.	Method of biochemical treatment of persistent pain
WO2004075832A2 (fr)	2003-02-27	2004-09-10	Lucas John M	Methodes et compositions de traitement de douleurs chroniques au moyen de la dhea et de derives de celle-ci
WO2004084839A2 (fr) *	2003-03-24	2004-10-07	Cady Roger K	Methode et article pour le traitement de troubles associes a des neurones sensoriels par une application transdermique de toxine botulinique
US7270287B2 (en) *	2004-01-06	2007-09-18	Allergan, Inc.	Botulinum toxin treatment for kinesia
US20050191321A1 (en) *	2004-02-26	2005-09-01	Allergan, Inc.	Methods for treating headache
GB2416122A (en)	2004-07-12	2006-01-18	Ipsen Ltd	Botulinum neurotoxin composition
GB2417419A (en) *	2004-07-12	2006-03-01	Ipsen Ltd	Therapeutic use of Botulinum toxin
GB2416692A (en)	2004-08-04	2006-02-08	Ipsen Ltd	Pharmaceutical composition containing botulinum neurotoxin
GB2419526A (en) *	2004-10-28	2006-05-03	Ipsen Ltd	Pharmaceutical composition containing botulinum neurotoxin
US20060240043A1 (en) *	2004-10-08	2006-10-26	Meyerson Laurence R	Methods and compositions for treating migraine pain
PE20060723A1 (es)	2004-11-04	2006-08-29	Toray Industries	Derivados de morfina como agentes analgesicos
US20090232849A1 (en) *	2005-03-03	2009-09-17	Universite Catholique De Louvain	Methods and compositions for the treatment of cancer
US20090214466A1 (en) *	2005-05-09	2009-08-27	Levin Bruce H	Methods of Alleviating Disorders and Their Associated Pain
KR100726441B1 (ko)	2005-11-22	2007-06-11	삼성전자주식회사	현상장치 및 이를 이용한 화상형성장치
FR2902341B1 (fr)	2006-06-16	2011-02-25	Scras	Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR2907680B1 (fr) *	2006-10-27	2012-12-28	Scras	Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur induite par au moins un agent anti-cancereux
FR2910327B1 (fr) *	2006-12-22	2013-04-26	Scras	Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
FR2930447B1 (fr) *	2008-04-25	2010-07-30	Sod Conseils Rech Applic	Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique

2006
- 2006-06-16 FR FR0605368A patent/FR2902341B1/fr not_active Expired - Fee Related
2007
- 2007-06-11 DK DK07788861.8T patent/DK2037956T3/da active
- 2007-06-11 CN CNA2007800220160A patent/CN101466401A/zh active Pending
- 2007-06-11 JP JP2009514842A patent/JP5425622B2/ja not_active Expired - Fee Related
- 2007-06-11 US US12/305,191 patent/US9080220B2/en not_active Expired - Fee Related
- 2007-06-11 AU AU2007259122A patent/AU2007259122B2/en not_active Ceased
- 2007-06-11 PT PT77888618T patent/PT2037956E/pt unknown
- 2007-06-11 EP EP07788861A patent/EP2037956B1/fr not_active Not-in-force
- 2007-06-11 RU RU2009101152/15A patent/RU2434637C2/ru active
- 2007-06-11 CA CA2655488A patent/CA2655488C/fr not_active Expired - Fee Related
- 2007-06-11 PL PL07788861T patent/PL2037956T3/pl unknown
- 2007-06-11 MX MX2008015254A patent/MX2008015254A/es active IP Right Grant
- 2007-06-11 BR BRPI0713693-5A patent/BRPI0713693A2/pt not_active Application Discontinuation
- 2007-06-11 ES ES07788861T patent/ES2399661T3/es active Active
- 2007-06-11 WO PCT/FR2007/000956 patent/WO2007144493A2/fr not_active Ceased
2008
- 2008-11-12 IL IL195254A patent/IL195254A/en active IP Right Grant

Also Published As

Publication number	Publication date
US20090232851A1 (en)	2009-09-17
JP2009539948A (ja)	2009-11-19
HK1130011A1 (en)	2009-12-18
MX2008015254A (es)	2008-12-17
CN101466401A (zh)	2009-06-24
EP2037956B1 (fr)	2012-12-12
RU2434637C2 (ru)	2011-11-27
US9080220B2 (en)	2015-07-14
WO2007144493A2 (fr)	2007-12-21
JP5425622B2 (ja)	2014-02-26
AU2007259122B2 (en)	2012-11-01
CA2655488A1 (fr)	2007-12-21
EP2037956A2 (fr)	2009-03-25
WO2007144493A3 (fr)	2008-04-17
DK2037956T3 (da)	2013-02-04
PT2037956E (pt)	2013-02-06
CA2655488C (fr)	2016-11-01
FR2902341A1 (fr)	2007-12-21
IL195254A (en)	2012-03-29
RU2009101152A (ru)	2010-07-27
PL2037956T3 (pl)	2013-04-30
FR2902341B1 (fr)	2011-02-25
IL195254A0 (en)	2011-08-01
ES2399661T3 (es)	2013-04-02
AU2007259122A1 (en)	2007-12-21

Legal Events

Date	Code	Title	Description
2016-04-19	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-01-02	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-12-26	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2019-08-13	B09B	Patent application refused [chapter 9.2 patent gazette]
2019-10-29	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL

Publication	Publication Date	Title
BRPI0713693A2 (pt)	2012-10-30	composição, utilização de uma composição, e, produto
US8679486B2 (en)	2014-03-25	High-potency botulinum toxin formulations
CN100438905C (zh)	2008-12-03	稳定的肉毒毒素液体制剂
US8273359B2 (en)	2012-09-25	Therapeutic use of at least one botulinum neurotoxin in the treatment of pain induced by at least one anti-neoplastic agent
CN112367967B (zh)	2023-04-04	肌肉松弛用组合物
US20050214325A1 (en)	2005-09-29	Compositions and methods to increase the effect of a neurotoxin treatment
BRPI0720730A2 (pt)	2014-04-08	Composições e métodos de aplicação tópica e liberação transdérmica de toxinas botulínicas estabilizadas com fragmentos de polipeptídeo derivados de hiv-tat.
ES2371785T3 (es)	2012-01-10	Utilización de al menos una neurotoxina botulínica para tratar el dolor causado por los tratamientos terapéuticos del virus del sida.
US12036263B2 (en)	2024-07-16	Topical compositions
KR20070091630A (ko)	2007-09-11	표정 주름을 이완시키는데 적합한 피부 적용을 위한 미용조성물
CN106170309A (zh)	2016-11-30	用于维持填充剂功效的组合物
KR20080086522A (ko)	2008-09-25	수종의 보툴리눔 독소를 함유하는 조성물
WO2008127419A2 (fr)	2008-10-23	Compositions et procédés pour augmenter l'effet d'un traitement neurotoxique
CA3238234A1 (fr)	2023-05-19	Composition de neurotoxine botulique
JP2023519935A (ja)	2023-05-15	皮膚症状に用いるためのアセチルコリンエステラーゼのｃ末端に由来するポリペプチド
CN100486557C (zh)	2009-05-13	一种美容肉毒素膏剂
HK1130011B (en)	2013-07-19	Simultaneous, separate or sequential therapeutic use of at least one botulinum neurotoxin and of at least one opiate derivative
BR112020026825B1 (pt)	2025-05-27	Composição para relaxamento muscular
KR20260035937A (ko)	2026-03-13	보툴리눔 독소 단백질 조성물 및 이의 용도
HK40040803B (en)	2023-06-16	Composition for muscle relaxation
EA045063B1 (ru)	2023-10-27	Композиция для расслабления мышц
BRPI1014922B1 (pt)	2026-01-21	Uso de uma composição tópica, emplastro para pele e kit para tratar o distúrbio da pele