BRPI0713738A2 - Biomarcadores para a progressão de doença alzheimer - Google Patents
Biomarcadores para a progressão de doença alzheimerInfo
- Publication number
- BRPI0713738A2 BRPI0713738A2 BRPI0713738-9A2A BRPI0713738A BRPI0713738A2 BR PI0713738 A2 BRPI0713738 A2 BR PI0713738A2 BR PI0713738 A BRPI0713738 A BR PI0713738A BR PI0713738 A2 BRPI0713738 A2 BR PI0713738A2
- Authority
- BR
- Brazil
- Prior art keywords
- biomarkers
- disease progression
- alzheimer disease
- alzheimer
- progression
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 239000000090 biomarker Substances 0.000 title 1
- 230000005750 disease progression Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81561006P | 2006-06-20 | 2006-06-20 | |
| PCT/US2007/071421 WO2007149798A2 (en) | 2006-06-20 | 2007-06-18 | Biomarkers for the progression of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0713738A2 true BRPI0713738A2 (pt) | 2014-06-24 |
Family
ID=38834281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0713738-9A2A BRPI0713738A2 (pt) | 2006-06-20 | 2007-06-18 | Biomarcadores para a progressão de doença alzheimer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100035251A1 (pt) |
| EP (1) | EP2035582A2 (pt) |
| JP (1) | JP2009541336A (pt) |
| KR (1) | KR20090019848A (pt) |
| CN (1) | CN101473044A (pt) |
| AU (1) | AU2007261095A1 (pt) |
| BR (1) | BRPI0713738A2 (pt) |
| CA (1) | CA2657980A1 (pt) |
| MX (1) | MX2008016524A (pt) |
| RU (1) | RU2009101384A (pt) |
| WO (1) | WO2007149798A2 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009042160B3 (de) * | 2009-09-11 | 2011-04-14 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Verfahren zur Diagnose und/oder Vorhersage der Entwicklung von neurodegenerativen Erkrankungen |
| ES2524892T3 (es) | 2010-09-02 | 2014-12-15 | Glaxosmithkline Intellectual Property Development Limited | 2-(Benciloxi)benzamidas como inhibidores de LRRK2 quinasa |
| RU2013129818A (ru) | 2010-11-30 | 2015-01-10 | Дженентек, Инк. | Способы анализа и биомаркеры для гена lrrk2 |
| WO2012135631A1 (en) * | 2011-03-30 | 2012-10-04 | Arrien Pharmaeuticals Llc | Substituted 5-(pyrazin-2-yl)-1h-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors |
| EA025186B1 (ru) | 2012-06-29 | 2016-11-30 | Пфайзер Инк. | НОВЫЕ 4-(ЗАМЕЩЕННЫЙ АМИНО)-7Н-ПИРРОЛО[2,3-d]ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ LRRK2 |
| GB201212084D0 (en) * | 2012-07-06 | 2012-08-22 | Randox Lab Ltd | Tropomyosin isoforms related to alzheimers disease and mild cognitive impairment |
| EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| CN105331721A (zh) * | 2015-11-27 | 2016-02-17 | 首都医科大学宣武医院 | 检测pd致病基因突变的方法,及其引物、试剂盒 |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| PT3472153T (pt) | 2016-06-16 | 2021-12-31 | Denali Therapeutics Inc | Pirimidin-2-ilamino-1h-pirazóis como inibidores de lrrk2 para uso no tratamento de distúrbios neurodegenerativos |
| CA3069554A1 (en) | 2017-07-14 | 2019-01-17 | Glaxosmithkline Intellectual Property Development Limited | Inhibitors of leucine rich repeat kinase 2 |
| EP3873471B1 (en) | 2018-10-31 | 2025-12-31 | Merck Sharp & Dohme LLC | N-HETEROARYL INDAZOLE DERIVATIVES AS LRRK2 INHIBITORS: PHARMACEUTICAL COMPOSITIONS AND THEIR USES |
| WO2020247298A2 (en) | 2019-06-06 | 2020-12-10 | Merck Sharp & Dohme Corp. | 1-pyrazolyl, 5-, 6- disubstituted indazole derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof |
| CN115243687A (zh) | 2019-10-25 | 2022-10-25 | 默沙东有限责任公司 | 作为lrrk2抑制剂的n-(杂芳基)喹唑啉-2-胺衍生物、药物组合物及其用途 |
| US12570640B2 (en) | 2020-09-02 | 2026-03-10 | Merck Sharp & Dohme Llc | 2-aminoquinazolines as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof |
| AU2021371136A1 (en) | 2020-10-29 | 2023-05-11 | Merck Sharp & Dohme Llc | N-linked isoquinoline amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof |
| CN114736959B (zh) * | 2022-05-09 | 2023-09-22 | 上海市精神卫生中心(上海市心理咨询培训中心) | 轻度认知功能损害诊断标志物、试剂盒及其应用 |
| WO2024182689A1 (en) | 2023-03-01 | 2024-09-06 | Vanderbilt University | Inhibitors of lrrk2 |
| CN117230184B (zh) * | 2023-11-13 | 2024-03-19 | 深圳康美生物科技股份有限公司 | 基于飞行时间核酸质谱技术检测阿尔兹海默病基因的核酸组合及应用 |
| WO2025190385A1 (zh) * | 2024-03-14 | 2025-09-18 | 上海拓界生物医药科技有限公司 | 靶向LRRK2的RNAi剂及其医药用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006045392A2 (en) * | 2004-10-21 | 2006-05-04 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Kaspp (lrrke) gene, its production and use for the detection and treatment of neurodegenerative disorders |
-
2007
- 2007-06-18 MX MX2008016524A patent/MX2008016524A/es not_active Application Discontinuation
- 2007-06-18 EP EP07798679A patent/EP2035582A2/en not_active Withdrawn
- 2007-06-18 JP JP2009516649A patent/JP2009541336A/ja active Pending
- 2007-06-18 AU AU2007261095A patent/AU2007261095A1/en not_active Abandoned
- 2007-06-18 RU RU2009101384/10A patent/RU2009101384A/ru unknown
- 2007-06-18 KR KR1020087030933A patent/KR20090019848A/ko not_active Withdrawn
- 2007-06-18 CN CNA2007800229023A patent/CN101473044A/zh active Pending
- 2007-06-18 CA CA002657980A patent/CA2657980A1/en not_active Abandoned
- 2007-06-18 US US12/305,053 patent/US20100035251A1/en not_active Abandoned
- 2007-06-18 BR BRPI0713738-9A2A patent/BRPI0713738A2/pt not_active IP Right Cessation
- 2007-06-18 WO PCT/US2007/071421 patent/WO2007149798A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009541336A (ja) | 2009-11-26 |
| AU2007261095A1 (en) | 2007-12-27 |
| MX2008016524A (es) | 2009-03-09 |
| CA2657980A1 (en) | 2007-12-27 |
| EP2035582A2 (en) | 2009-03-18 |
| WO2007149798A2 (en) | 2007-12-27 |
| WO2007149798A3 (en) | 2008-07-24 |
| US20100035251A1 (en) | 2010-02-11 |
| CN101473044A (zh) | 2009-07-01 |
| RU2009101384A (ru) | 2010-07-27 |
| KR20090019848A (ko) | 2009-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 4A, 5A, 6A E 7A ANUIDADES. |
|
| B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A, 6A, 7A, 8A, 9A, 10A, 11A, 12A E 13A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |