BRPI0714399B8 - composição farmacêutica líquida oral - Google Patents
composição farmacêutica líquida oralInfo
- Publication number
- BRPI0714399B8 BRPI0714399B8 BRPI0714399A BRPI0714399A BRPI0714399B8 BR PI0714399 B8 BRPI0714399 B8 BR PI0714399B8 BR PI0714399 A BRPI0714399 A BR PI0714399A BR PI0714399 A BRPI0714399 A BR PI0714399A BR PI0714399 B8 BRPI0714399 B8 BR PI0714399B8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- oral liquid
- liquid pharmaceutical
- composition
- oral
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 239000007788 liquid Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 2
- 229960001802 phenylephrine Drugs 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
composição farmacêutica líquida oral; método de tratamento de um mamífero em necessidade de tratamento; e composição farmacêutica oral, aquosa. trata-se de uma composição farmacêutica líquida, oral. a composição compreende fenilefrina e polietileno glicol substancialmente isento de aldeído. a composição tem estabilidade de fenilefrina compatível com a estabilidade exigida para preparações comerciais. a composição pode compreender, opcionalmente, um ou mais agentes ativos adicionais.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/487,120 US20080014274A1 (en) | 2006-07-14 | 2006-07-14 | Enhanced stability phenylephrine liquid compositions |
| US487,120 | 2006-07-14 | ||
| US11/487,120 | 2006-07-14 | ||
| PCT/US2007/015771 WO2008008364A2 (en) | 2006-07-14 | 2007-07-11 | Enhanced stability phenylephrine liquid compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0714399A2 BRPI0714399A2 (pt) | 2013-03-12 |
| BRPI0714399B1 BRPI0714399B1 (pt) | 2020-11-17 |
| BRPI0714399B8 true BRPI0714399B8 (pt) | 2021-05-25 |
Family
ID=38814551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0714399A BRPI0714399B8 (pt) | 2006-07-14 | 2007-07-11 | composição farmacêutica líquida oral |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20080014274A1 (pt) |
| EP (2) | EP2351554B1 (pt) |
| JP (1) | JP2009543777A (pt) |
| KR (2) | KR20140088234A (pt) |
| CN (2) | CN101500539A (pt) |
| AR (1) | AR061985A1 (pt) |
| AU (1) | AU2007272961B2 (pt) |
| BR (1) | BRPI0714399B8 (pt) |
| CA (1) | CA2657611A1 (pt) |
| CO (1) | CO6180496A2 (pt) |
| EC (1) | ECSP099072A (pt) |
| ES (2) | ES2537761T3 (pt) |
| HK (1) | HK1205933A1 (pt) |
| HU (2) | HUE025790T2 (pt) |
| IL (1) | IL196447A (pt) |
| MX (1) | MX2009000530A (pt) |
| NZ (1) | NZ574148A (pt) |
| PE (1) | PE20081003A1 (pt) |
| PL (2) | PL2040672T3 (pt) |
| PT (2) | PT2040672E (pt) |
| RU (1) | RU2468787C2 (pt) |
| SG (2) | SG10201408522UA (pt) |
| TW (1) | TW200812640A (pt) |
| UY (1) | UY30484A1 (pt) |
| WO (1) | WO2008008364A2 (pt) |
| ZA (1) | ZA200900315B (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070249727A1 (en) | 2006-04-21 | 2007-10-25 | The Proctor & Gamble Company | Compositions and kits useful for treatment of respiratory illness |
| US10022339B2 (en) | 2006-04-21 | 2018-07-17 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
| CN104161736A (zh) * | 2006-06-01 | 2014-11-26 | Msd消费保健品公司 | 包含去氧肾上腺素的缓释药物制剂 |
| NZ573174A (en) * | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
| CA2653950A1 (en) * | 2006-06-01 | 2007-12-13 | Schering Corporation | Phenylephrine pulsed release formulations and pharmaceutical compositions |
| JP5121824B2 (ja) * | 2006-06-01 | 2013-01-16 | メルク・シャープ・アンド・ドーム・コーポレーション | フェニレフリンの徐放のための薬学的組成物 |
| MX2009013054A (es) * | 2007-06-01 | 2010-01-15 | Schering Plough Healthcare | Composicion farmaceutica que comprende un sustrato y un revestimiento que contiene un ingrediente activo y alcohol polivinilico. |
| PE20091084A1 (es) * | 2007-12-07 | 2009-07-23 | Schering Plough Healthcare | Formulaciones farmaceuticas de fenilefrina y composiciones para absorcion transmucosal |
| US8518439B2 (en) * | 2008-12-03 | 2013-08-27 | Novartis Ag | Liquid therapeutic composition |
| CA2690488C (en) * | 2010-01-19 | 2013-06-11 | Accucaps Industries Limited | Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof |
| CA2802362C (en) * | 2010-06-11 | 2017-11-21 | Gm Pharmaceuticals, Inc. | Pharmaceutical compositions for alleviating upper respiratory and oral-pharyngeal congestion |
| KR20140012029A (ko) | 2010-10-21 | 2014-01-29 | 알티유 파머수티컬즈, 엘엘시 | 즉시 사용가능한 케토로락 제제 |
| FR2987268B1 (fr) | 2012-02-28 | 2014-07-11 | Ammtek | Formulations liquides de sulfamides hypoglycemiants |
| EP2961377B1 (en) * | 2013-02-28 | 2020-03-18 | PF Consumer Healthcare 1 LLC | Enhanced stability of novel liquid compositions |
| AU2014306759B2 (en) | 2013-08-12 | 2018-04-26 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
| GB201506755D0 (en) * | 2015-04-21 | 2015-06-03 | Reckitt Benckiser Llc | Novel pharmaceutical formulation |
| JP5918895B1 (ja) * | 2015-05-21 | 2016-05-18 | 富士カプセル株式会社 | ナルフラフィン塩酸塩含有カプセル製剤 |
| BR112017025527A2 (pt) * | 2015-05-29 | 2018-08-07 | Kiel Laboratories Inc | preparação farmacêutica líquida, e, método para fabricar uma suspensão de celocoxibe. |
| US11278506B2 (en) | 2015-10-09 | 2022-03-22 | Rb Health (Us) Llc | Pharmaceutical formulation |
| US20180055938A1 (en) * | 2016-09-01 | 2018-03-01 | The Procter & Gamble Company | Medication With Improved Taste And Sensory Experience |
| CN109789101A (zh) | 2016-09-26 | 2019-05-21 | 宝洁公司 | 延长缓解剂型 |
| CN110115708A (zh) * | 2018-02-07 | 2019-08-13 | 保瑞药业股份有限公司 | 乙酰胺酚及曲马多共溶复方止痛口服液 |
| CA3100314A1 (en) | 2018-05-16 | 2019-11-21 | Bayer Healthcare Llc | High concentration suspension formulation for cold and flu soft gel capsule medications |
| CN108434097A (zh) * | 2018-06-22 | 2018-08-24 | 南京济群医药科技股份有限公司 | 一种稳定的含盐酸曲普利啶口服溶液剂及其制备方法 |
| CN109010341A (zh) * | 2018-10-29 | 2018-12-18 | 南京济群医药科技股份有限公司 | 一种含有氢溴酸右美沙芬的复方口服溶液及其制备方法 |
| WO2020210723A1 (en) | 2019-04-11 | 2020-10-15 | R.P. Scherer Technologies, Llc | Formulation for oral delivery of proteins, peptides and small molecules with poor permeability |
| MA58173B1 (fr) | 2019-12-23 | 2024-03-29 | Nutra Essential Otc S L | Composition liquide comprenant de l'ibuprofène et de la phényléphrine |
| WO2021150747A1 (en) * | 2020-01-22 | 2021-07-29 | Nevakar Inc. | Phenylephrine hydrochloride compositions and containers |
| CN111773203B (zh) * | 2020-05-15 | 2024-11-26 | 北京博智绿洲医药科技有限公司 | 一种包含盐酸去氧肾上腺素组合物的制备工艺 |
| CN111803452B (zh) * | 2020-07-08 | 2026-02-06 | 北京博智绿洲医药科技有限公司 | 一种包含盐酸去氧肾上腺素组合物的泡腾颗粒剂制备工艺 |
| CN114533664B (zh) * | 2022-01-29 | 2023-03-31 | 江苏广承药业有限公司 | 一种氢溴酸右美沙芬和愈创木酚甘油醚复方口服液体制剂 |
| WO2026015096A1 (en) * | 2024-07-09 | 2026-01-15 | Humanis Sağlik A.Ş. | Paraben free syrup compositions |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3515781A (en) * | 1967-10-12 | 1970-06-02 | Johnson & Johnson | Cold capsule |
| US5616621A (en) * | 1995-01-30 | 1997-04-01 | American Home Products Corporation | Taste masking liquids |
| US5759579A (en) | 1996-12-05 | 1998-06-02 | American Home Products Corporation | Pharmaceutical suspension systems |
| DE69815003T2 (de) * | 1997-09-10 | 2004-04-01 | Takeda Chemical Industries, Ltd. | Stabilisierte pharmazeutische Zusammensetzung |
| US6287597B1 (en) | 1999-03-12 | 2001-09-11 | Carter-Wallace, Inc. | Antihistaminic/decongestant compositions |
| JP3450805B2 (ja) * | 2000-08-08 | 2003-09-29 | わかもと製薬株式会社 | 水性医薬組成物 |
| WO2003011306A1 (en) | 2001-07-31 | 2003-02-13 | Wyeth | Sucralose formulations to mask unpleasant tastes |
| US6462094B1 (en) * | 2001-08-22 | 2002-10-08 | Medpointe Healthcare Inc. | Decongestant/expectorant compositions |
| US6509492B1 (en) * | 2001-08-31 | 2003-01-21 | First Horizon Pharmaceutical Corporation | Tannate compositions and methods of treatment |
| US20030060422A1 (en) * | 2001-08-31 | 2003-03-27 | Balaji Venkataraman | Tannate compositions and methods of treatment |
| US20040132827A1 (en) | 2001-10-26 | 2004-07-08 | Pediamed Pharmaceuticals, Inc. | Phenylephrine tannate, pyrilamine tannate and dextromethorphan tannate salts in pharmaceutical compositions |
| US7101572B2 (en) * | 2001-12-07 | 2006-09-05 | Unilab Pharmatech, Ltd. | Taste masked aqueous liquid pharmaceutical composition |
| US20050267222A1 (en) * | 2002-10-22 | 2005-12-01 | Dainippon Pharmaceutical Co. Ltd. | Stabilized composition |
| US6979689B2 (en) | 2002-12-20 | 2005-12-27 | Pediamed Pharmaceuticals, Inc. | Compositions and methods for treating upper respiratory congestion |
| JP2004300138A (ja) * | 2003-03-18 | 2004-10-28 | Takeda Chem Ind Ltd | 安定化された経口固形製剤 |
| US20050152967A1 (en) | 2003-03-28 | 2005-07-14 | Pfab, Lp | Dynamic variable release |
| DE10358213A1 (de) | 2003-12-12 | 2005-07-28 | Clariant Gmbh | Polyethylenglykol und dessen Herstellung |
| US20050266031A1 (en) | 2004-05-25 | 2005-12-01 | Jay Dickerson | Pharmaceutical suspension composition |
| WO2006022996A2 (en) | 2004-08-04 | 2006-03-02 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
| US20060148837A1 (en) | 2005-01-04 | 2006-07-06 | Everett Laboratories, Inc. | Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| US20070098785A1 (en) * | 2005-11-02 | 2007-05-03 | Tim Clarot | Medicant delivery system and device |
| US20070160689A1 (en) * | 2006-01-12 | 2007-07-12 | Everett Laboratories, Inc. | Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| US20070254027A1 (en) * | 2006-04-28 | 2007-11-01 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
-
2006
- 2006-07-14 US US11/487,120 patent/US20080014274A1/en not_active Abandoned
-
2007
- 2007-07-11 KR KR1020147017566A patent/KR20140088234A/ko not_active Withdrawn
- 2007-07-11 CN CNA2007800297124A patent/CN101500539A/zh active Pending
- 2007-07-11 SG SG10201408522UA patent/SG10201408522UA/en unknown
- 2007-07-11 KR KR1020097003036A patent/KR20090040334A/ko not_active Ceased
- 2007-07-11 HU HUE11163553A patent/HUE025790T2/hu unknown
- 2007-07-11 AU AU2007272961A patent/AU2007272961B2/en active Active
- 2007-07-11 WO PCT/US2007/015771 patent/WO2008008364A2/en not_active Ceased
- 2007-07-11 CA CA002657611A patent/CA2657611A1/en not_active Abandoned
- 2007-07-11 NZ NZ574148A patent/NZ574148A/en unknown
- 2007-07-11 EP EP11163553.8A patent/EP2351554B1/en active Active
- 2007-07-11 PL PL07836046T patent/PL2040672T3/pl unknown
- 2007-07-11 PL PL11163553T patent/PL2351554T3/pl unknown
- 2007-07-11 EP EP07836046.8A patent/EP2040672B1/en active Active
- 2007-07-11 RU RU2009101295/15A patent/RU2468787C2/ru active
- 2007-07-11 BR BRPI0714399A patent/BRPI0714399B8/pt active IP Right Grant
- 2007-07-11 ES ES07836046.8T patent/ES2537761T3/es active Active
- 2007-07-11 PT PT78360468T patent/PT2040672E/pt unknown
- 2007-07-11 PT PT111635538T patent/PT2351554E/pt unknown
- 2007-07-11 HU HUE07836046A patent/HUE025694T2/hu unknown
- 2007-07-11 MX MX2009000530A patent/MX2009000530A/es not_active Application Discontinuation
- 2007-07-11 CN CN201410790976.3A patent/CN104546671A/zh active Pending
- 2007-07-11 JP JP2009519504A patent/JP2009543777A/ja active Pending
- 2007-07-11 ES ES11163553.8T patent/ES2550036T3/es active Active
- 2007-07-11 SG SG2011049558A patent/SG173354A1/en unknown
- 2007-07-12 UY UY30484A patent/UY30484A1/es unknown
- 2007-07-12 PE PE2007000893A patent/PE20081003A1/es not_active Application Discontinuation
- 2007-07-13 TW TW096125692A patent/TW200812640A/zh unknown
- 2007-07-13 AR ARP070103111A patent/AR061985A1/es unknown
-
2009
- 2009-01-11 IL IL196447A patent/IL196447A/en active IP Right Grant
- 2009-01-14 EC EC2009009072A patent/ECSP099072A/es unknown
- 2009-01-14 ZA ZA200900315A patent/ZA200900315B/xx unknown
- 2009-01-14 CO CO09002495A patent/CO6180496A2/es not_active Application Discontinuation
- 2009-11-25 HK HK15106451.2A patent/HK1205933A1/xx unknown
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