BRPI0714633A2 - extrusable detergent composition - Google Patents

Abstract

COMPOUNDS AND COMPOSITIONS AS HEDGEHOG MODULATORS. The present invention relates to a method for modulating hedgehog signaling pathway activity. In particular, the invention provides a method for inhibiting aberrant growth state resulting from phenotypes such as Ptc function loss, hedgehog function gain, smoothened function gain or smoothened function gain or function gain. Gly, which comprises contacting a cell with a sufficient amount of a compound of formula I.

Description

EXTRUSIBLE DETERGENT COMPOSITION The present invention relates to extrusable detergent compositions, in particular to bar-shaped detergent compositions and comprising beneficial agents, the bars of which are provided with enhanced tear strength and brittleness.

Detergent compositions are used by people around the world for skin care and cleansing. It is well known that detergents help in removing dirt from the skin, the mechanism of which is well understood. In addition to the use of detergents for their primary function ie cleansing, they are also useful as delivery vehicles for various benefit agents, for example, moisturizing agents and skin lightening additives, which are incorporated therein. for additional user benefits. Consumer research has shown that the presence of such beneficial agents added in detergent compositions has been of considerable consumer interest. Consumers are also interested in smoother ways to cleanse their skin which results in less damage to the skin's natural protective barrier and retains moisture in their skin. It can be seen that this consumer attraction is directly proportional to the number of different benefits provided by the detergent composition during use and after use. Therefore, detergent compositions capable of providing multiple benefits are highly desirable.

Skin whitening and humidification remain the most preferred benefits among others, which consumers seek in personal care compositions. Skin whitening is especially desired by people in the Asian subcontinent, while humidification is desired by people worldwide. Several skin whitening actives have been used and reported in the literature which include herbal extracts and

synthetic chemicals. Dicarboxylic acids, such as azelaic acid and its salts form a class of potent skin whitening agents, which are reported in the prior art. The use of dicarboxylic acids has also been reported in GB 2068997 (Colgate, 1981) for the prevention / reduction of Cimida rupture in detergent bars.

On the other hand, the benefits of alpha hydroxy acids are also

are well known which include skin lightening, humidification and chemical exfoliation. The benefit of humidification is generally achieved by the incorporation of high levels of alpha hydroxy acids. This has been described in GB 1417183 (Unilever, 1975), which claims specific humidification benefits without adversely affecting bar processing. It should be noted that in said publication the levels of alpha hydroxy acid are 20 - 55 wt%, preferably at least 20 wt% of the composition. GB 1460442 (Unilever, 1977) describes detergent bars for personal bath use containing soap, synthetic detergents and skin moisturizing compound selected from dicarboxylic acids, hydroxy acids, amino acids or combinations thereof. The level of incorporation is 5 - 55% by weight. Said bars provide humidification benefits due to the high levels of acids.

The present inventors have wished to combine the skin lightening benefits of dicarboxylic acids with the benefits of alpha-hydroxy acids and even to offer through a rinse detergent composition.

When the present inventors attempted to produce detergent compositions comprising the above two classes of beneficial agents, they surprisingly observed that when the composition was extruded into bars, the bars exhibited Cimida rupture. This was unexpected as dicarboxylic acids were added to the bars.

detergents formerly to make them resistant to breakage. Through extensive experimentation, the present inventors have observed that the same problem could be solved by incorporating a reduced amount of surfactants into the detergent composition.

It is therefore an object of the present invention to provide multiple benefit agents through the detergent composition.

Another object of the present invention is to produce breakthrough resistant extrusable detergent compositions having good ion use properties comprising a combination of dicarboxylic acid and alpha hydroxy acid.

According to one aspect, the present invention relates to a

extrudable detergent composition comprising, 20% to 80% by weight of soap; 0.5% to 5% by weight of surfactant selected from anionic, nonionic, amphoteric and zwitterionic surfactants; 0.1% to 10% by weight of water-soluble dicarboxylic acid salt having the formula COOH - (CH 2) n -COOH where "n" is an integer from 2 to 8; 0.1% to 10% by weight of water soluble alpha hydroxy acid salt.

According to a preferred aspect, the surfactant includes a mixture of anionic surfactant and nonionic surfactant, more preferably the anionic surfactant is present from 2% to 4% and the nonionic surfactant is present up to 1% by weight.

In a highly preferred aspect, the anionic surfactant is an alkali metal salt of C8 -C18 primary alcohol sulphate and the nonionic surfactant is an amine oxide. The term "extrudable" for the purpose of the present invention means that the composition is capable of being extruded through necessary dies in the form of chains which can be cut into pieces or bars which are ready for use.

The term "detergent composition" has been used herein as a

synonym for soaps, soap bars and personal bath bars. Other advantages of the invention will become more fully apparent from the detailed description of the preferred embodiments of the invention.

The present invention relates to extrusable detergent compositions comprising beneficial agents.

Limited rupture of soap, that is, the tendency of soap to crack when humidified and dried, particularly during use, has been a general problem. Cimped rupture refers to a known defect of soap bars in developing cracks when repeatedly moistened and dried. Cimida rupture detergent bars are not preferred by the user. The present inventors have provided a detergent composition that provides skin lightening and moisturizing benefits to the wearer without compromising the quality of the physical structure and integrity of the bar while in use. In the detergent compositions of the present invention, it is preferred

that the soap content is from 20 to 80% by weight, more preferably from 40 - 75%.

The predominant washing active agent in the detergent composition of the present invention may be any conventional soap, commonly referred to as a fatty acid salt. The soap may be derived from one or a mixture of C8 -C22 straight or branched chain, preferably C12 -C18 monocyclic, saturated or unsaturated monocarboxylic acids, of natural or synthetic origin. Natural sources, for example animal, marine or vegetable fats or oils, almost always produce mixtures of said fatty acids, all of which may be employed. Examples thereof include fatty acids derived from coconut oil, olive oil, palm oil, tallow oil, soybean oil, cottonseed oil,

peanuts, turmeric oil, sunflower seed oil, corn oil, fish oils, tallow, and the like. Illustratively, individual fatty acids include caprylic, lauric, myristic, stearic, oleic, palmitic, palmitoleic, ricinoleic, linoleic, and iminoleramic acid and the like. Fatty acids may also be synthetically derived by paraffin oxidation, Oxynthesis, or the like. The cation or salt portion of the soap is preferably an alkali metal such as potassium and especially sodium, but may alternatively be an alkaline earth metal such as calcium or magnesium, or ammonium, substituted ammonium, or organic amine such as an alkylamine. lower or lower alkanolamine. Tallow fatty acids can be derived from various

animal sources and generally comprise about 1 - 8% myristic acid, about 21 - 32% palmitic acid, about 14 - 31% stearic acid, about 0 - 4% palmitoleic acid, about 36 - 50% oleic acid and about 0 - 5% linoleic acid. A typical distribution is 2.5% myristic acid, 29% palmitic acid, 23% stearic acid, 2% palmitoleic acid, 41.5% oleic acid, and 3% linoleic acid. Other similar mixtures, such as those of palm oil and those derived from various animal fat and fat are also included. Coconut oil refers to fatty acid mixtures having an approximate carbon chain length distribution of 8% C8, 7% C10, 48% C12, 17% C14, 8% C16, 2 % C18, 7% oleic acid and 2% linoleic acid (the first six fatty acids listed). Coconut oil employed for soap may be replaced in whole or in part by other "higher lauric" oils, that is, oils or fats where at least 50% of the total fatty acids are composed of lauric or myristic acids and mixtures thereof. Said oils are generally exemplified by coconut oil class tropical oil oils. For example, they include: palm oil, oil

of babagu, ouricuri oil, tucum oil, cohune palm oil, murumuru oil, jaboty seed oil, khakan seed oil, walnut oil

de.dika, and ucuhuba butter.

A preferred soap is a mixture of about 30% to about 40% coconut oil and about 60% to about 70% tallow. Mixtures may also contain higher contents of tallow, for example 15% to 20% coconut and 80 to 85% tallow. Soaps may contain unsaturation according to commercially acceptable standards. Excessive unsaturation is usually avoided. Without intending to stick to a theory, the presence of strong electrolytes in the soap bar, however, can create processing problems as they break the liquid crystal phases of the soap matrix that binds insoluble soaps between Yes. Without said liquid crystal phases, soap cannot be extruded in any meaningful way. Therefore, it is preferred that the content of the additional inorganic electrolytes in the detergent composition be kept quite low and preferably less than 1% by weight of the composition. Electrolytes include sodium chloride, sodium sulfate, sodium sulfite and sodium bisulfite, which are generally added.

the detergent compositions.

It is preferred that the composition comprises from about 0.1% to 10%, more preferably 1% to 5% and more preferably 1% to 2% by weight of water-soluble dicarboxylic acid salt having the formula COOH- (CH 2 ) n-COOH where "n" is an integer from 2 to 8. More preferably, dicarboxylic acid is selected from adipic acid, azelaic acid or sebacic acid, more preferably sebacic acid. Water soluble salts include alkali metal salts, for example sodium or potassium salts, or alkanolamine or ammonium. Dicarboxylic acids are used here mainly as skin lightening benefit agents.

The water-soluble alpha hydroxy acid salt is preferably

present from 0.1% to 10%, more preferably from 1% to 5%, and more preferably from 1% to 2% by weight of the composition. Preferably 1 is alpha hydroxy acid and is selected from glycolic acid, lactic acid, malonic acid, citric acid or tartaric acid or mixtures thereof. Lactic acid is more preferred. Water soluble salts include alkali metal salts, for example sodium or potassium salts, or alkanolamine or ammonium salts.

Alpha-hydroxy acids (AHAs) are naturally occurring organic carboxylic acids such as glycolic acid, a natural constituent of sugarcane juice and lactic acid, found in whey and tomato juice. Topical formulations incorporating such acids are frequently used and are also present over a wide range of highly promoted cosmetic products. Among the many benefits reported are dead skin cell exfoliation, skin humidification, photodane reversal, and reduction in wrinkles, brown spots, and redness. The overall result is skin that looks and feels better.

According to the present invention, the detergent composition comprises 0.5% to 5%, more preferably from 0.5% to 2% by weight of surfactant selected from anionic, nonionic, amphoteric, betaine or zwitterionic surfactants. . Cationic surfactants are generally not suitable for the present invention as they are not compatible with the predominantly anionic atmosphere of the composition due to the relatively large proportion of fatty acid soaps. It is, however, determined that cations of cationic surfactants, when present in the composition as impurity, or when normally added, do not cause any notable undesirable effect.

The synthetic detergents contemplated as surfactants in the present invention are different soap compounds whose properties

Detersives such as soap are due to the presence of a hydrophilic group and a hydrophobe in the molecule.

The water-soluble anionic surfactants contemplated are the alkali metal salts (such as sodium and potassium) of the higher linear alkyl benzene sulfonates and the alkali metal salts of ethoxylated and non-ethoxylated fatty alcohols, and ethoxylated alkyl phenols.

Preferred sulfated surfactants which may be used in the compositions of the present invention include sulfated ethoxylated and non-ethoxylated fatty alcohols, preferably primary or secondary monohydric alcohols with C8 -C18 alkyl groups, preferably C12 -C16, and, if ethoxylated, on average about 1 -15 'preferably 3-12 moles of ethylene oxide (EO) per mole of alcohol, and ethoxylated alkylated sulfated alkoxyphenols with C8 -C16 alkyl groups, preferably C8 -C9 alkyl groups, and on average from 4-12 moles EO per mole of alkyl phenol.

The preferred class of sulfated ethoxylated surfactants are sulfated ethoxylated linear alcohols, such as C8 - C18 ethoxylated alcohols with an average of about 1 to about 12 moles of ethylene oxide. A more preferred ethoxylated detergent is produced by suffatating C12 -C15 ethoxylated alcohols with 3 moles of ethylene oxide.

The anionic surfactant may be, for example, an aliphatic sulfonate such as a primary alkane sulfonate (e.g. C8 -C22), primary alkane disulfonate (e.g. C8 -C22) 'C8 -C22 alkylene sulfonate, C8 -C22 hydroxyalkane or alkyl glyceryl ether sulfonate (AGS); or in aromatic sulfonate such as alkyl benzene sulfonate. The anionic may also be an alkyl sulfate (e.g. C12 -C18 alkyl sulfate) or ethereal alkyl sulfate (including ethereal glyceryl sulfates). Among the alkyl ether sulfates are those with the formula:

Where R is an alkyl or alkenyl having 8 to 18 carbons, preferably 12 to 18 carbons, η and having an average value greater than 1.0, preferably between 2 and 3; and M is a solubilization cation such as sodium, potassium, ammonium or substituted ammonium. Ammonium and ether lauryl

Sodium are preferred.

The anionic surfactant may also be alkyl sulfosuccinates including mono- and dialkyl, for example, C6 -C22 sulfosuccinates); alkyl and acyl taurates, alkyl and acyl sarcosinates, sulfoacetates. C8 - C22 alkyl phosphates and phosphates, alkyl phosphate esters and alkoxy alkyl phosphate esters, C8 - C22 monoalkyl succinates and maleates, sulfoacetates , and acyl isethionates.

Taurates are generally identified by the formula; R 2 CO 2 N 3 CH 2 CH 2 SO 3 M where R 2 ranges from C 8 -C 20 alkyl, R 3C 1 -C 4 alkyl range and M a solubilization cation. Acyl isethionates are prepared by reaction between alkali metal isethionate with mixed aliphatic fatty acids having from 6 to 18 carbon atoms and an iodine value of less than 20. At least 75% of the mixed fatty acids are provided with 12 to 18 carbon atoms. and up to 25% are endowed with 6 to 10 carbon atoms. Among the anionic surfactants, C8-C28 primary alcohol sulfates are most preferred.

Preferred amine oxides include dimethyldodecylamine oxide, oleyldi (2-hydroxyethyl) oxide, dimethyloctylamide oxide, dimethyldecylamine oxide, dimethyl tetradecylamine oxide, di (2-hydroxyethyl) tetradecylamine oxide, 3-dihydroxypropylamine oxide (3-hydroxypropyl) amine, and dimethylhexadecylamine oxide, more preferably C12-14 alkyl dimethyl amine oxide, such as hexadecyl dimethylamine oxide, octadecylamine oxide, lauryl dimethyl amine oxide and hydrates thereof. The group of N-

oxide and a weak base with a ρ Kb of about 9. amine oxides 15

20

25

Suitable for use herein are commercially produced by a number of suppliers, including Akzo Chemie and Ethyl Corp. More preferred amine oxides are selected from C 12-14 alkyl dimethyl amine oxide such as hexadecyl dimethylamine oxide, octadecylamine oxide, lauryl dimethyl amine oxide and its hydrates, more preferably lauryl dimethyl amine oxide.

Zwitterionic surfactants are exemplified by those which may be broadly described as derived from aliphatic quaternary ammonium, phosphonium, and sulfonium compounds, wherein the aliphatic radicals may be straight chain or branched, and where one of the aliphatic substituents contains from about 8 to about 10 to about 10 to about 10 to about 10 to about 10 to about 10% of the aliphatic substituents. about 18 carbon atoms and one contains an anionic group, for example carboxy, sulfonate, sulfate, phosphate, or phosphonate.

Examples of said preferred surfactants include: 4- [N, N-di (2-hydroxyethyl) -N-octadecylammonium] butane-1-carboxylate; 5- [S-3-hydroxypropyl-S-hexadecylsulfonio] -3-hydroxypentane-1-sulfate; 3- [P'P-diethyl-P-3'6,9-

trioxatotradexocylphosphonium] -2-hydroxypropane-1-phosphate; 3- [N, N-dipropyl-N-3-

dodecoxy-2-hydroxypropylammonium] propane-1-phosphonate; 3- (N, N-dimethyl-N-

hexadecylammonium) propane-1-sulfonate; 3- (N, N-dimethyl-N-hexadecylammonium) -2-hydroxypropane-1-sulfonate; 4- [N, N-di (2-hydroxyethyl) -N- (2-hydroxydodecyl) ammonium] butane-1-carboxylate; 3- [S-ethyl-S- (3-dodecoxy-2-hydroxypropyl) sulfonium] propane-1-phosphate; 3- [P, P-dimethyl-P-dodecylphosphonium] propane-1-phosphonate; and 5- [N, N-di (3-hydroxypropyl) -N-hexadecylammonium] -2-hydroxypentane-1-sulfate.

Amphoteric detergents that may be used in the present invention include at least one acidic group. It can be a carboxylic acid group or a sulfonic acid group. They include quaternary nitrogen and starch are quaternary acid starches. They should generally include an alkyl or alkenyl group of 7 to 18 carbon atoms.

Suitable amphoteric surfactants include betaine and sulfobetaine starch. Preferred examples of sulfobetaine include alkylminopropyl sulfobetaines, alkylhydroxy sulfobetaines, hydroxy sulfobetaine amide, and propyl sulfobetaine amide, of which lauryl dimethyl hydroxy sulfobetaine, myristyl dimethyl hydroxy sulfobetaine, N'N-dimethyl sulfobetaine, N'N-dimethyl sulfobetaine, propyl-2-hydroxy sulfobetaine are in particular preferred.

Of these, lauryl dimethyl hydroxy sulfobetaine and myristyl dimethyl hydroxy sulfobetaine are most preferred. Preferred examples of betaine starches include lauramide propyl betaine and cocamide propyl betaine.

The nonionic which may be used includes in particular reaction products of compounds having a hydrophobic group and a reactive hydrogen atom, for example aliphatic alcohols, acids, amides or alkylphenols with alkylene oxides, in particular 0xoxide. of ethylene either alone or with polypropylene oxide. Specific nonionic detergent compounds are ethylene oxide (C6 - C22) alkylene oxide condensates, the primary or secondary aliphatic (C8 - C18) aliphatic or branched alcohol condensation products, and the products produced by oxide condensation of ethylene with the polypropylene and ethylenediamine oxide reaction products. Other so-called nonionic detergent compounds included in long chain tertiary amine oxides, long chain tertiary phosphine oxides and dialkyl sulfoxides.

Nonionics can also be an agicating amide, such as a polysaccharide amide. Preferred alkyl polysaccharides are

alkyl polyglycosides of formula;

R20 (CnH2nO) t (glycosyl) x;

where R2 is selected from the group consisting of alkyl,

alkylphenyl, hydroxyalkyl, hydroxyalkylphenyl, and mixtures thereof wherein the alkyl groups contain from about 10 to about 18 ', preferably from about 12 to about 14, carbon atoms; η and O to 3, preferably 2; t is from 0 to about 10, preferably 0; and χ e from 1.3 to about 10 'preferably from 1.3 to about 2.7. Glycosyl is preferably derived from glucose. To prepare said compounds, the alcohol or alkyl polyethyl alcohol is formed first and then reacted with glucose or a glucose source to form the glycoside (fixed at position 1). The additional glycosyl moieties may then be fixed between their -1 positions and the preceding glycosyl moieties at 2-, 3-, 4- and / or 6-, preferably

predominantly position-2.

Preferred nonionic surfactants for use in the compositions of the present invention include ethoxylated fatty alcohols, preferably primary or secondary linear monohydric alcohols with C10 -C18 alkyl groups, preferably C12 -C16, and averaging about 1-15, preferably 3-12 moles. ethylene oxide (EO) per mole of alcohol, and ethoxylated alkylphenols with C8 -C16 alkyl groups, preferably C8 -C9 alkyl groups, and averaging about 4-12 moles EO per mole of alkyl phenol. The preferred class of compound nonionic surfactants are ethoxylated linear alcohols, such as C12 -C16 ethoxylated alcohols with an average of about 1 to about 12 moles of ethylene oxide. The most preferred nonionic detergent is a C12 -C15 ethoxylated alcohol with 3 moles of ethylene oxide. The nonionic surfactant must be capable of being liquefied, for

for example, at an elevated temperature of about 900 ° C, to facilitate processing of the bar-shaped soap composition. Other nonionic compounds which are suitable are polyoxyalkylene esters of organic acids such as higher fatty acids, resin acids, tallow oil acids, or acids from petroleum oxidation products. Said esters will generally contain from about 10 to about 22 carbon atoms in the acidic fragment and from about 12 to about 30 moles of ethylene oxide or its equivalent. Still other nonionic surfactants are alkylene oxide condensates with higher fatty acid amides. The fatty acid group will generally contain from about 8 to about 22 carbon atoms, and said will be condensed with from about 10 to about 50 moles of ethylene oxide. The corresponding carboxamides and sulfonamides may also be used as substantial equivalents.

Oxyalkylated higher aliphatic alcohols are the preferred nonionic surfactants for compositions according to the present invention. Fatty alcohols should contain at least 6 carbon atoms, and preferably at least about 8 carbon atoms. Most preferred alcohols are laurylal myristyl, cetyl, stearyl, and oleyl alcohols, and said alcohols should be condensed with at least about 6 moles of ethylene oxide. A typical non-ionic product is C12 - C13 aliphatic alcohol condensed with about 6.5 moles of ethylene oxide. Corresponding alkyl mercaptans when condensed with ethylene oxide are also suitable for the compositions of the present invention.

As an example of the exemplary specific nonionic surfactants, mention is made of dinonii phenol + 15 E.O. (1 mole dinonyl phenol reacted with 15 moles of ethylene oxide), dodecii mercaptan + 10 EO, lauramide + 8 EO, stearic acid + 20 EO, tetradecyl amine + 14 EO, dodecyi sulfonamide + 6 E. 0., and alcohol of myristyl -1-10 EO Preferred are condensations of one mole of an alkanol, preferably straight and primary chain, from about 9 to 20 ', especially 10 to 18, carbon atoms of about 4 to 20, especially 5 to 15' moles of oxide. ethylene, as represented, for example, by Neodol 23-65 (C12-13 alkanol + 6.5 EO) and Neodol 45-13 (C4-15 alkanol + 13 EO) ·

Mixtures of the aforementioned type of synthetic detergent from

Surfactants, for example, anionic and nonionic surfactants, or different specific anionic or nonionic surfactants, may be used to modify detergency, foam characteristics, and other properties of the composition. As indicated in the examples below, inclusion of said surfactants in the extrusable detergent compositions of the present invention allows to achieve better Omida rupture resistance and further provide

The desired foam profile is the composition.

Specific advantages have been observed when the detergent composition is extrusive when it is surfactant. It is preferred that the surfactant include a mixture of anionic and nonionic surfactants, in particular a mixture of an anionic surfactant, preferably an alkali metal sulfate salt.

of C 8 -C 18 primary alcohol and an amine oxide.

In addition to the above essential ingredients, the detergent composition of the present invention may also comprise any or all of the following ingredients used to increase their storage life, aesthetics or functionality ie; Vitamins such as vitamin A and E1 and vitamin alkyl esters such as vitamin C alkyl esters; Lipids such as cholesterol, cholesterol esters, lanolin, ceramides, sucrose esters, and pseudo ceramides; liposome forming materials such as phospholipids, and suitable "non-syphilic" molecules provided with two long hydrocarbon chains; essential fatty acids, polyunsaturated fatty acids, and sources of said materials; unsaturated fatty acid triglycerides such as sunflower oil, primrose oil, avocado oil, almond oil; vegetable butters formed from mixtures of saturated and unsaturated fatty acids such as shea butter; minerals such as sources of zinc, magnesium, and iron; skin conditioners such as silicone oils, gums and modifications thereof such as linear and cyclic polydimethylsiloxanes, amino, alkyl, and alkylaryl silicone oils; hydrocarbons such as petrolatum, petroleum wax, petroleum jelly, microcrystalline wax, ceresine, squalene, pristan, paraffin wax and mineral oil; conditioning proteins such as milk proteins, silk proteins and glutins; cationic polymers as conditioners that may be used include Quatrisoft type conditioners LM-200 Poliquaternium-24, Merquat Plus 3330 — Poliquatermium 39; and Jaguar®, humectants such as glycerol, sorbitol, and urea emollients such as long chain fatty acid esters,

such as isopropyl palmitate and cetyl lactate;

In addition to the above, the composition may also include a deep cleansing agent. Said are defined herein as ingredients that can either increase freshness after the cleansing or can provide a sustained effect on skin problems that are associated with incomplete cleansing. Deep cleansing agents include:

- antimicrobials such as 2-hydroxy-4,2'-4'-trichlorodiphenyl ether (DP300), 2,6-dimethyl-4-hydroxychlorobenzene (PCMX), 3,4,4'-tri chlorocarbanylide (TCC), 3-trifluoromethyl 4,4'-dichlorocarbanilide (TFC), benzoyl peroxide, zinc salts, tea tree oil. Additional optional agents include anti-acne agents such as salicylic acid, lactic acid, glycolic acid, and citric acid, and benzoyl peroxide (also an antimicrobial agent); oil control agents including tallow suppressants, opacifiers such as silica, titanium dioxide, oil absorbers such as microspheres; astringents including tannin, zinc and aluminum salts, plant extracts such as green tea and Witchhazel (Hammailes); exfoliating and friction particles such as polyethylene beads, agglomerated silica, sugar, pits, seeds, and crushed shells such as walnut, peach, avocado, and oats, salts; cooling agents such as menthol and its various derivatives and lower alcohols; fruit and herbal extracts; skin soothing agents such as aloe vera; essential oils such as mint, jasmine, camphor, white cedar, sour orange skin, ryu, turpentine, cinnamon, bergamot, citrus unshiu, calamus, pine, lavender, laurel, clove, hiba, eucalyptus, lemon, starflower, thyme mint, rose, sage, mint, cineol, eugenol, citral, citronella, borneol, linalool, geranoyl, evening primrose, camphor, thymol, spirantol, pinene, simonene and terpenoid oils; sunscreens such as 4-tertiary butyl-4'-methoxy dibenzoylmethane (offered under the trademark PARSOL 1789 by Givaudan) and / or 2-ethyl hexyl methoxy cinnamate (offered under the trademark PARSOL MCX by Givaudan) or other UV sunscreens -A and UV-B

may also be incorporated.

Other benefit agents that may be employed include

Anti-aging compounds and skin whitening agents, antioxidants such as, for example, butylated hydroxytoluene (BHT) may advantageously be used in amounts of about 0.01% or greater if appropriate.

Another ingredient that may be included are physical scrubs such as polyoxyethylene beads, walnut shells and apricot seeds. The incorporation of said physical exfoliators provides additional benefits over chemical exfoliation provided by alpha-hydroxy acids. Such additional benefits are highly desired by consumers. The particle size of the scrub preferably is between 50 microns to 1000 microns, more preferably 100 microns to 500 microns and most preferably 100 to 200 microns.

A final group of optional ingredients is optical modifiers that are defined as materials that modify the optical texture or introduce a pattern to increase bar distinction. Examples of

Suitable optical modifiers include:

- spots / dots such as crushed fruit pits, seeds, polyethylene beads, mineral-mineral-reflective T-and-loofhai-paFt-ieulas such as mica; pearling agents such as coated micas, and certain waxes; wax / plastic slices resembling, for example, fruit slices; vegetable or fruit slices g) opacifiers such as Ti02 and mixtures of the above. In addition, the bar composition of the invention may include 0 to 25% by weight of crystalline or amorphous aluminum hydroxide. Said aluminum hydroxide may be generated in situ by reacting fatty acids and / or mono- or polycarboxylic non-fatty acids with sodium aluminate, or may be prepared separately by reacting fatty and / or non-fatty acids. mono- or polycarboxylic acid with sodium aluminate and add the reaction product to the soap. Another class of hardening agents are inorganic solids or insoluble minerals that can structure the discontinuous phase by meshing or space filling. Said include fumed, precipitated or modified silica, alumina, calcium carbonate, kaolin, and talc. Aluminum silicate clays in particular synthetic or natural hectorites may also be used. In addition to the benefit agents, suitable bar builders that provide bar integrity may also be used. Water insoluble builders also have a melting point in the range of 40-100 ° C, more preferably at least 50 ° C, notably 50 ° C to 90 ° C. Suitable materials which are in particular contemplated are fatty acids, in particular those having a carbon chain of 12 to 24 carbon atoms. Examples are lauric, myristic, palmitic, strong, arachidic and behenic acid and mixtures thereof. Sources of said fatty acids are coconut, coconut with cover, palm, palm kernel, babassu and tallow fatty acids and partially or completely hardened fatty acids or distilled fatty acids. Other suitable water-insoluble builders include alkanols of 8 to 20 carbon atoms, in particular cetyl alcohol. Said materials generally have a water solubility of less than 5 g / liter at 20 ° C. Other builders may include particulate solids such as talc, starch (e.g. maltodextrin) or clay. The relative proportions of water-soluble and water-insoluble structures govern the coefficient at which the bar wears during use. The presence of the water-insoluble structuring tends to retard bar dissolution when exposed to water during use and therefore delays the

wear coefficient.

In addition, the composition can be produced in multicolored, for

example, in strips, through the judicious use of dye as is well known in the art.

Beneficial agents generally comprise about 0 - 25%

by weight of the composition, preferably 5-20%, and more preferably between 2 and 10%.

Finally, the bar compositions of the invention comprise about 1 to 15%, preferably 2 to 12%, more preferably 3 to 12% by weight of water. Bar compositions of the invention have a pH of about 6 to 11, preferably above 7.

The essential agents of benefit of the present invention may be added at any stage in bar processing provided that the component is not subjected to processing steps leading to its degradation. The components may be added as free acid or salt depending on the pH of the medium, ie with a very alkaline active material free acid may be added as long as the salt is formed in the bar. In preparing the detergent rods of the present invention, dicarboxylic acid, alpha hydroxy acid and non-cationic surfactant components may be incorporated into the soap at any stage of bar processing, preferably by mixing with the soap chips previously prepared in the process. crutcher or more preferably in the amalgamator. According to a further feature of the invention, the dicarboxylic acid and alpha hydroxy acid components are first dissolved or dispersed in the liquid or liquefied surfactant (e.g. by heating to about 90 ° C if necessary) and the resulting solution (or dispersion ) is then mixed with the soap composition-containing fatty acid salt, followed by conventional extrusion and bar pressing. The surfactant detergent composition of the present invention enhances their solubility and foam properties in use in water, especially cold and hard water, exerts an emollient or anti-irritant effect on the skin, and makes the soap composition more plastic and smoother. ready and economically processed in bars. Pre-dissolution of dicarboxylic acid and alpha hydroxy acid in the surfactant further facilitates uniform mixing in the soap composition.

Soap bars can be prepared by either neutralization or saponification. If fatty acid is used, it can be introduced into the mixture a number of times. Fatty acids, for example, can be added directly to the mixer and melted. A second approach to combining ingredients begins with the use of a preformed soap paste and mixing the ingredients well below the melting temperature of the soap (e.g. 50 ° C). The preformed soap paste can be added in a lâmina blade type mixer (or similar type mixer that provides sufficient mixing action to mix the materials) and subsequently add the alpha-hydroxy acid salt and salt. dicarboxylic acid as described above. Provided the ingredients are mixed until homogeneous, the material can be cooled, crushed, extruded and subsequently pressed. The procedure for combining these materials is quite

flexible. One way to combine the ingredients is to weigh a predetermined amount of soap paste (formed from a conventional process by mixing the ingredients, cooling and refining), heating and mixing them to about 40 ° C, adding the hydroxy acid salt (eg sodium lactate) followed by the dicarboxylic acid salt (eg dipotassium sebacate). The dough can then be ground and processed into bars.

The bar may be in the form of a single or multi-phase bar, commonly known as miscellaneous detergent bars, which generally have at least 2 visually distinct phases in the bar, which may be, for example, in the form of beads. co-extruded. Multistage or multicolored soaps have been described by several terms that include varied, marbled, striated, and striped.

-10 Another way to prepare the formulation is to prepare all the

mass in a single pot under melting conditions. The bars described in the present application may be prepared using the manufacturing techniques described in the literature and known in the art of toilet soap bar manufacturing. Examples of the types of manufacturing processes offered are given in the book Soap.

Technology for the 1990's (Edited by Luis Spitz, American Oil Chemist Society Champaign, and Illinois. 1990). Those broadly referred to include: melt forming, extrusion / stamping, and extrusion, quenching, and cutting. A preferred process is extrusion and stamping because of its ability to economically produce high quality bars suitable as toilet soaps.

The invention may be practiced in various ways and a

A number of specific embodiments will be described to illustrate the invention with reference to the accompanying examples.

All amounts and proportions referred to herein and in the appended claims are by weight unless otherwise indicated.

EXPERIMENT-1

Several detergent compositions 1-7 in the form of soap bars have been produced. The final composition of these bars is tabulated in table-1 below, while the scoring panel is tabulated in table-2. Table 1

Lot Numbers Ingredients (% by weight) 1 2 3 4 5 6 7 Soap 74 74 74 74 74 74 74 SLS 4 4 0 4 4 4 2.5 DMLO 2 2 2 0 2 2 1 Di-potassium Sebacate 2 1.5 2 2 1.5 1.5 1.5 Sodium lactate 2 2 2 2 2 2 2 Polymer Beads 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Sodium sulfite 0.3 0 0.3 0.3 0 0 0 Water and other smaller up to 100 100 100 100 100 100

- Soap paste containing 80 parts non-lauric soap and 20 parts

parts of lauric soaps, had 77% TFM1 16% moisture and volatiles and 0.4% insoluble alcohols. Ex-Jocil Industries, India.

- SLS is Sodium Lauryl Sulphate (90% pure) Ex-Galaxy

Surfactants

- DMLO is Dimethyl Lauryl Amine Oxide (28% aqueous solution) Ex-Galaxy Surfactants

- Sodium Lactate (60% aqueous solution) Ex Lactochem India

- Dipotassium Sebaeate powder Ex-FDL UK

- Polymer Beads - 100 mesh Polyethylene beads, offered by Micropowders INC USA.

Table 2

Lot number 1 2 3 4 5 6 7 Breakout score (0 6.1 3.3 0 0 1.6 1.7 0 -14) Score method

The soap bars were washed under conditions controlled by a team of 5 operators trained for 4 successive days, each operator manipulated each bar once a day. A single wash involved soaking the tablet in about 2 liters of water (changed for each tablet) for 15 seconds and then rubbing the tablet around the edges and hands 180 degrees, 40 times. The tablet was immersed for 15 seconds after the 20th time and was twisted again at the end of the operation. Daily readings after drying and reading on the last day were assessed for crack on a scale of 0-14 where 0 represents no breakage while 14 represents very severe breakage, with an increasing degree of breakage. A burst score of 0 is more desirable and is preferred over scores of 0.1 or 0.2 and higher.

From table 2 above, it is clear that when the compositions contained in the top surfactant or surfactant (6%), the breakthrough scores were unacceptable (lots 1, 2, 5 and 6).

However, the inventive batches 3, 4 and 7 had a rupture score of 0.

An illustrative procedure for producing detergent compositions in the form of heavily ground bars and extruded soap bars is offered below. The following ingredients were used to produce the soap bars, as in table-3 below. All ingredients are in Kg.

Table 3

Soap Mass 910 Glycerin 5 SLS 25 DMLO 10 Parsol MCX 1 Sodium Lactate 20 Di-Dotassium Sebacate 15 Titanium Dioxide 3 TinoDaI 0.2 Extracts 1 Perfume 15 Polymer Beads 1 Dye 0.7 Total 1000

- Soap mass containing 80 parts of non-lauric soap and 20 parts of lauric soap, showed 77% TFM1 16% moisture and volatiles and 0.4% insoluble alcohols. Ex-Jocil Industries, India.

- Glycerin (99% pure) Ex-Jocil Industries

- SLS is Sodium Lauryl Sulphate (90% pure) Ex-Galaxy

Surfactants

- DMLO is Dimethyl Lauryl Amine Oxide (28% aqueous solution) Ex-Galaxy Surfactants

- Sodium Laetate (60% aqueous solution) Ex Laetoehem India

- Dipotassium Sebaeate Powder Ex-FDL UK

- Polymer Beads - 100 mesh Polyethylene Beads, offered by Micropowders INC USA.

- Extracts - Mix of Fruit and Turmeric (Extrapone Curcuma) and (Extrapone fruits) extracts offered by Symrise India

Process: The soap paste was placed in a mixer and then mixed with SLS for 3 minutes. After it was converted to a fine powder, DMLO and polymer beads were added followed by sodium lactate and Parsol MCX. The dough was mixed for 3 minutes and solid additives such as titanium dioxide, Tinopal, and dipotassium sebacate were added.

d »1

mass. After mixing for 2 minutes extracts were added and mixed for another 2 minutes. Colorants and perfume were added and mixed for 2 minutes. The composition was then ground followed by

work and stamping.

The present invention thus provides a composition

an extrudable detergent comprising multiple benefit agents such as alpha hydroxy acids and dicarboxylic acids, the compositions of which, when extruded in bar form, remain resistant to wet breakage, a situation which is normally not acceptable to the consumer. Although the basic principles of the method of the present invention

have been illustrated and described herein, it will be appreciated by those skilled in the art that variations in the disclosed embodiment, both with regard to its details and the organization of said details, may be implemented without departing from the spirit and scope thereof. Thus, it is intended that the foregoing description and examples be considered as illustrative only of the principles of the invention and not construed in the limiting sense.

Claims (9)

1. EXTRUSTABLE DETERGENT COMPOSITION, comprising (i) 20% to 80% by weight of soap; (ii) 0.5% to 5% by weight of surfactant selected from anionic, nonionic, amphoteric, betain or zwitterionic surfactants; jü) 0.1% to 10% by weight of water soluble dicarboxylic acid salt having the formula COOH- (CH 2) n -COOH where "n" is an integer from 2 to 8; iv) 0.1% to 10% by weight of water-soluble alpha hydroxy acid salt. EXTRUSTABLE DETERGENT COMPOSITION as claimed in claim 1, wherein said surfactant includes a mixture of anionic surfactant and nonionic surfactant. EXTRUSTABLE DETERGENT COMPOSITION as claimed in claim 2, wherein in said mixture the anionic surfactant is present from 2% to 4% and the nonionic surfactant is present up to 1% by weight. EXTRUSTABLE DETERGENT COMPOSITION as claimed in claim 2 or claim 3, wherein said anionic surfactant is a C8 -C18 primary alcohol sulfate alkali metal salt and said nonionic surfactant is an amine oxide. EXTRUSTABLE DETERGENT COMPOSITION as claimed in any preceding claim, wherein said dicarboxylic acid is selected from adipic acid, azelaic acid or sebacic acid. EXTRUSTABLE DETERGENT COMPOSITION as claimed in claim 5, wherein said dicarboxylic acid is sebacic acid. EXTRUSTABLE DETERGENT COMPOSITION as claimed in any preceding claim, wherein said alpha hydroxy acid is selected from glycolic acid, lactic acid, malic acid, citric acid or tartaric acid. EXTRUSTABLE DETERGENT COMPOSITION as claimed in claim 7, wherein said alpha hydroxy acid is lactic acid. 9. EXTRUSIBLE DETERGENT COMPOSITION, substantially as described herein with reference to the accompanying examples.