BRPI0716145A2 - formuaÇço de vacina, mÉtodo de adaptaÇço e propagaÇço do vÍrus chikungunya, mÉtodo de concentraÇço e purificaÇço de vÍrus, composiÇço potencialmente imunogÊnica, sequÊncia de nucleotÍdeo, contruto de dna recombinante, mÉtodo para produzir proteÍna recombinante, composiÇço farmacÊutica, mÉtodo in vitro ou in vivo e mÉtodo para elicitar resposta imune protetora - Google Patents
formuaÇço de vacina, mÉtodo de adaptaÇço e propagaÇço do vÍrus chikungunya, mÉtodo de concentraÇço e purificaÇço de vÍrus, composiÇço potencialmente imunogÊnica, sequÊncia de nucleotÍdeo, contruto de dna recombinante, mÉtodo para produzir proteÍna recombinante, composiÇço farmacÊutica, mÉtodo in vitro ou in vivo e mÉtodo para elicitar resposta imune protetoraInfo
- Publication number
- BRPI0716145A2 BRPI0716145A2 BRPI0716145-0A2A BRPI0716145A BRPI0716145A2 BR PI0716145 A2 BRPI0716145 A2 BR PI0716145A2 BR PI0716145 A BRPI0716145 A BR PI0716145A BR PI0716145 A2 BRPI0716145 A2 BR PI0716145A2
- Authority
- BR
- Brazil
- Prior art keywords
- vitro
- composition
- nucleotide sequence
- immune response
- dna construct
- Prior art date
Links
- 238000000338 in vitro Methods 0.000 title 3
- 238000000034 method Methods 0.000 title 3
- 239000000203 mixture Substances 0.000 title 3
- 241001502567 Chikungunya virus Species 0.000 title 1
- 108020004511 Recombinant DNA Proteins 0.000 title 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 230000006978 adaptation Effects 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 230000002163 immunogen Effects 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001681 protective effect Effects 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36161—Methods of inactivation or attenuation
- C12N2770/36163—Methods of inactivation or attenuation by chemical treatment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1583/CHE/2006 | 2006-09-01 | ||
| IN1583CH2006 | 2006-09-01 | ||
| PCT/IN2007/000383 WO2008026225A2 (en) | 2006-09-01 | 2007-08-31 | A vaccine for chikungunya virus infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0716145A2 true BRPI0716145A2 (pt) | 2013-09-17 |
| BRPI0716145B1 BRPI0716145B1 (pt) | 2021-06-22 |
Family
ID=39136377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0716145-0A BRPI0716145B1 (pt) | 2006-09-01 | 2007-08-31 | Composição de vacina e método para preparar uma composição de vacina para o vírus chikungunya |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8865184B2 (pt) |
| EP (1) | EP2073839B1 (pt) |
| CN (1) | CN101516395B (pt) |
| BR (1) | BRPI0716145B1 (pt) |
| WO (1) | WO2008026225A2 (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2545597A1 (en) * | 2006-03-15 | 2007-09-15 | Institut Pasteur | Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof |
| CA2598966A1 (en) * | 2007-09-07 | 2009-03-07 | Institut Pasteur | Anti-chikungunya monoclonal antibodies and uses thereof |
| ES2588738T3 (es) * | 2008-04-04 | 2016-11-04 | The Trustees Of The University Of Pennsylvania | Secuencias de consenso de proteínas del virus Chikungunya, moléculas de ácido nucleico que las codifican, y composiciones y métodos de uso de las mismas |
| EP3957754B1 (en) * | 2008-04-21 | 2026-01-28 | Gen-Probe Incorporated | Method for detecting chikungunya virus |
| SG171828A1 (en) | 2008-11-26 | 2011-07-28 | Us Gov Health & Human Serv | Virus like particle compositions and methods of use |
| DK2519266T3 (da) | 2009-12-31 | 2017-11-06 | Medigen Inc | Infektiøse DNA vacciner mod Chikungunya virus |
| WO2011124635A1 (en) | 2010-04-07 | 2011-10-13 | Humalys | Binding molecules against chikungunya virus and uses thereof |
| EP2374816B1 (en) * | 2010-04-07 | 2016-09-28 | Agency For Science, Technology And Research | Binding molecules against Chikungunya virus and uses thereof |
| JP2013523175A (ja) * | 2010-04-14 | 2013-06-17 | イーエムディー・ミリポア・コーポレーション | 高力価、高純度のウイルスストックの作製方法及びその使用方法 |
| CN103228293A (zh) * | 2010-11-30 | 2013-07-31 | 巴拉特生物技术国际有限公司 | 用于在哺乳动物中预防和治疗金迪普拉病毒感染的疫苗制剂 |
| WO2012078116A1 (en) * | 2010-12-10 | 2012-06-14 | Agency For Science, Technology And Research | Immunogenic chikungunya virus peptides |
| AU2012269907B2 (en) * | 2011-06-17 | 2017-05-18 | Bharat Biotech International Limited | Vaccine composition comprising an inactivated chikungunya virus strain |
| US10137186B2 (en) * | 2013-03-14 | 2018-11-27 | Takeda Vaccines, Inc. | Compositions and methods for live, attenuated alphavirus formulations |
| MA41517A (fr) * | 2015-04-14 | 2017-12-19 | Univ Vanderbilt | Neutralisation du virus du chikungunya à médiation par des anticorps |
| JP6896700B2 (ja) * | 2015-07-16 | 2021-06-30 | バハラ バイオテック インターナショナル リミテッド | ワクチン組成物 |
| EP4357355A3 (en) | 2015-12-23 | 2024-09-25 | Valneva SE | Virus purification |
| US20190054161A1 (en) * | 2016-01-13 | 2019-02-21 | United States, As Represented By The Secretary Of The Army | Inactivated vaccine for chikungunya virus |
| US10632184B2 (en) | 2016-03-31 | 2020-04-28 | Takeda Vaccines, Inc. | Compositions and methods for stabilizing alphaviruses with improved formulations |
| CN105906694B (zh) * | 2016-05-05 | 2019-05-14 | 中国人民解放军军事医学科学院微生物流行病研究所 | 基孔肯亚病毒特异性检测抗原及其应用 |
| AU2017261706B2 (en) | 2016-05-10 | 2024-10-31 | Najit Technologies, Inc. | Inactivating pathogens and producing highly immunogenic inactivated vaccines using a dual oxidation process |
| WO2017210215A1 (en) | 2016-05-31 | 2017-12-07 | The Government Of The United States Of America As Represented By The Secretary Of The Army | Zika virus vaccine and methods of production |
| AU2018298499B2 (en) * | 2017-07-03 | 2024-07-18 | Bharat Biotech International Limited | A synthetic polypeptide epitope based vaccine composition |
| KR102757369B1 (ko) | 2017-09-21 | 2025-01-20 | 발네바 에스이 | 면역원성 치쿤구니야 바이러스 chikv-델타5nsp3을 포함하는 약제학적 조성물의 생산 방법 |
| CA3081586A1 (en) | 2017-11-03 | 2019-05-09 | Takeda Vaccines, Inc. | Zika vaccines and immunogenic compositions, and methods of using the same |
| CN116983398A (zh) | 2017-11-30 | 2023-11-03 | 武田疫苗股份有限公司 | 寨卡疫苗和免疫原性组合物以及其使用方法 |
| US10718771B2 (en) | 2018-02-09 | 2020-07-21 | Chung Yuan Christian University | Recombinant baculoviruses and their uses in detecting arthropod-borne virus |
| EP3530668A1 (en) | 2018-02-22 | 2019-08-28 | Euroimmun Medizinische Labordiagnostika AG | A novel assay for the diagnosis of viral infections |
| EP3755709A1 (en) | 2018-02-22 | 2020-12-30 | Euroimmun Medizinische Labordiagnostika AG | Assay for the diagnosis of viral infections |
| CN113939311A (zh) * | 2019-05-08 | 2022-01-14 | 武田疫苗股份有限公司 | 灭活病毒组合物和寨卡疫苗制剂 |
| US11519919B2 (en) | 2019-07-02 | 2022-12-06 | Euroimmun Medizinische Labordiagnostika Ag | Assay for the diagnosis of nematode infections |
| IL292433A (en) * | 2019-10-25 | 2022-06-01 | Emergent Travel Health Inc | Chikungunya virus-like particle vaccine and methods of using the same |
| CN117771353B (zh) * | 2024-02-27 | 2024-05-14 | 中国医学科学院医学生物学研究所 | 一种以包膜蛋白为靶标的基孔肯雅病毒的mRNA疫苗及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1248471A (zh) * | 1998-09-23 | 2000-03-29 | 卫生部北京生物制品研究所 | Vero细胞乙型脑炎灭活疫苗及其制备方法 |
| WO2008030220A2 (en) * | 2005-08-11 | 2008-03-13 | The Board Of Regents Of The University Of Texas System | Chikungunya virus infectious clones and uses thereof |
| CA2545597A1 (en) * | 2006-03-15 | 2007-09-15 | Institut Pasteur | Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof |
-
2007
- 2007-08-31 CN CN200780035576.XA patent/CN101516395B/zh active Active
- 2007-08-31 BR BRPI0716145-0A patent/BRPI0716145B1/pt active IP Right Grant
- 2007-08-31 EP EP07827554.2A patent/EP2073839B1/en active Active
- 2007-08-31 WO PCT/IN2007/000383 patent/WO2008026225A2/en not_active Ceased
- 2007-08-31 US US12/439,509 patent/US8865184B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2073839B1 (en) | 2016-10-19 |
| EP2073839A2 (en) | 2009-07-01 |
| WO2008026225A2 (en) | 2008-03-06 |
| WO2008026225A3 (en) | 2008-09-25 |
| CN101516395B (zh) | 2014-03-26 |
| US20130022631A1 (en) | 2013-01-24 |
| CN101516395A (zh) | 2009-08-26 |
| US8865184B2 (en) | 2014-10-21 |
| BRPI0716145B1 (pt) | 2021-06-22 |
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| B65X | Notification of requirement for priority examination of patent application | ||
| B65Z | Priority examination of the patent application refused (request does not comply with dec. 132/06 of 20061117) | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
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| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/08/2007, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, , QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |