BRPI1012078A2 - construto de proteína, composição imunogênica, molécula de ácido nucleico , métodos de induzir uma resposta imune a casb7439 e de tratar um animal humano ou não-humano, e, uso de uma composição imunogênica - Google Patents

construto de proteína, composição imunogênica, molécula de ácido nucleico , métodos de induzir uma resposta imune a casb7439 e de tratar um animal humano ou não-humano, e, uso de uma composição imunogênica

Info

Publication number: BRPI1012078A2
Authority: BR; Brazil
Prior art keywords: immunogenic composition; casb7439; inducing; treating; human
Prior art date: 2009-05-27

Application number

BRPI1012078A

Other languages

English (en)

Inventor

Pilorget Anthony

Rioux Clément

Harvey Martine

Blais Normand

Original Assignee

Glaxosmithkline Biologicals Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-27

Filing date

2010-05-25

Publication date

2019-09-24

2010-05-25 Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa

2019-09-24 Publication of BRPI1012078A2 publication Critical patent/BRPI1012078A2/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Microbiology (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cell Biology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI1012078A 2009-05-27 2010-05-25 construto de proteína, composição imunogênica, molécula de ácido nucleico , métodos de induzir uma resposta imune a casb7439 e de tratar um animal humano ou não-humano, e, uso de uma composição imunogênica BRPI1012078A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US18138009P	2009-05-27	2009-05-27
US22039609P	2009-06-25	2009-06-25
PCT/EP2010/057141 WO2010136443A1 (en)	2009-05-27	2010-05-25	Casb7439 constructs

Publications (1)

Publication Number	Publication Date
BRPI1012078A2 true BRPI1012078A2 (pt)	2019-09-24

Family

ID=42556967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1012078A BRPI1012078A2 (pt)	2009-05-27	2010-05-25	construto de proteína, composição imunogênica, molécula de ácido nucleico , métodos de induzir uma resposta imune a casb7439 e de tratar um animal humano ou não-humano, e, uso de uma composição imunogênica

Country Status (19)

Country	Link
US (1)	US8916514B2 (pt)
EP (1)	EP2435469A1 (pt)
JP (1)	JP2012528106A (pt)
KR (1)	KR20120014054A (pt)
CN (1)	CN102459324B (pt)
AU (1)	AU2010252012A1 (pt)
BR (1)	BRPI1012078A2 (pt)
CA (1)	CA2763486A1 (pt)
CL (1)	CL2011002994A1 (pt)
CO (1)	CO6400229A2 (pt)
DO (1)	DOP2011000348A (pt)
EA (1)	EA020617B1 (pt)
IL (1)	IL216351A0 (pt)
MA (1)	MA33409B1 (pt)
MX (1)	MX2011012623A (pt)
NZ (1)	NZ596501A (pt)
PE (1)	PE20120400A1 (pt)
SG (1)	SG176220A1 (pt)
WO (1)	WO2010136443A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1254541C (zh)	2000-02-23	2006-05-03	史密丝克莱恩比彻姆生物有限公司	新化合物
DK1889630T3 (da) *	2000-10-18	2012-03-05	Glaxosmithkline Biolog Sa	Vacciner omfattende MAGE-antigen koblet til protein D-fragment
US20140171626A1 (en) *	2012-12-19	2014-06-19	Glaxosmithkline Llc	Protein purification
WO2016146143A1 (en)	2015-03-16	2016-09-22	Amal Therapeutics Sa	Cell penetrating peptides and complexes comprising the same
GB201520592D0 (en) *	2015-11-23	2016-01-06	Immunocore Ltd & Adaptimmune Ltd	Peptides
GB201520550D0 (en)	2015-11-23	2016-01-06	Immunocore Ltd & Adaptimmune Ltd	Peptides
GB201520568D0 (en)	2015-11-23	2016-01-06	Immunocore Ltd	Peptides
PT3429618T (pt)	2016-03-16	2024-04-02	Amal Therapeutics Sa	Combinação de um modulador de ponto de controlo imunitário e um complexo que compreende um péptido de penetração celular, uma carga e um agonistra peptídico de tlr para utilização em medicina
IL265479B (en)	2016-09-21	2022-09-01	Amal Therapeutics Sa	A fusion containing a cell-penetrating peptide, a multiple epitope, and a peptide tlr agonist for cancer therapy

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MX9300883A (es)	1992-02-18	1994-08-31	Smithkline Beecham Corp	Polipeptidos de vacuna.
WO1995014772A1 (en)	1993-11-12	1995-06-01	Kenichi Matsubara	Gene signature
GB9326253D0 (en)	1993-12-23	1994-02-23	Smithkline Beecham Biolog	Vaccines
WO1996002555A1 (en)	1994-07-15	1996-02-01	The University Of Iowa Research Foundation	Immunomodulatory oligonucleotides
US6030945A (en) *	1996-01-09	2000-02-29	Genentech, Inc.	Apo-2 ligand
ES2301175T3 (es)	1996-02-09	2008-06-16	Smithkline Beecham Biologicals S.A.	Vacunas contra el producto del gen 63 del virus de la varicela zoster.
ATE513042T1 (de)	1998-02-05	2011-07-15	Glaxosmithkline Biolog Sa	Tumorassoziierte antigenderivate der mage-familie,nukleinsäuresequenzen, die dafür kodieren, zur herstellung von fusionsproteinen und zusammensetzungen zur impfung
US6551795B1 (en)	1998-02-18	2003-04-22	Genome Therapeutics Corporation	Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
DE69933200T2 (de)	1998-03-09	2007-02-22	Glaxosmithkline Biologicals S.A.	Kombinierte impfstoffzusammensetzungen
US6087168A (en)	1999-01-20	2000-07-11	Cedars Sinai Medical Center	Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
TR200102781T2 (tr)	1999-03-11	2002-01-21	Smithkline Beecham Biologicals S. A.	Yeni bileşikler
AU5788900A (en)	1999-07-07	2001-01-22	Tularik Inc.	Diagnosis of cancer by detecting ash2 polypeptides or polynucleotides
US20020081590A1 (en)	2000-02-04	2002-06-27	Aeomica, Inc.	Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
US7811574B2 (en) *	2000-02-23	2010-10-12	Glaxosmithkline Biologicals S.A.	Tumour-specific animal proteins
CN1254541C (zh) *	2000-02-23	2006-05-03	史密丝克莱恩比彻姆生物有限公司	新化合物
UA79735C2 (uk) *	2000-08-10	2007-07-25	Глаксосмітклайн Байолоджікалз С.А.	Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах
US8039602B2 (en)	2000-10-31	2011-10-18	Ryogen Llc	Isolated genomic polynucleotide fragments from the p15 region of chromosome 11
GB0104259D0 (en) *	2001-02-21	2001-04-11	Smithkline Beecham Biolog	Novel compounds
GB0111974D0 (en) *	2001-05-16	2001-07-04	Glaxosmithkline Biolog Sa	Novel Compounds
MXPA05002287A (es)	2002-08-29	2005-08-18	Genentech Inc	2 polipeptidos similares a achaete-scute y acidos nucleicos de codificacion, y metodos para el diagnostico y tratamiento de tumores.
WO2008030559A2 (en) *	2006-09-08	2008-03-13	Corixa Corporation	Methods, compositions, and kits for the detection and monitoring of colon cancer
GB0700284D0 (en) *	2007-01-08	2007-02-14	Glaxosmithkline Biolog Sa	Combination therapy

2010
- 2010-05-25 NZ NZ596501A patent/NZ596501A/xx not_active IP Right Cessation
- 2010-05-25 CA CA2763486A patent/CA2763486A1/en not_active Abandoned
- 2010-05-25 EA EA201190274A patent/EA020617B1/ru not_active IP Right Cessation
- 2010-05-25 MX MX2011012623A patent/MX2011012623A/es active IP Right Grant
- 2010-05-25 PE PE2011002023A patent/PE20120400A1/es not_active Application Discontinuation
- 2010-05-25 AU AU2010252012A patent/AU2010252012A1/en not_active Abandoned
- 2010-05-25 KR KR1020117031060A patent/KR20120014054A/ko not_active Withdrawn
- 2010-05-25 CN CN201080033569.8A patent/CN102459324B/zh not_active Expired - Fee Related
- 2010-05-25 US US13/322,282 patent/US8916514B2/en not_active Expired - Fee Related
- 2010-05-25 MA MA34476A patent/MA33409B1/fr unknown
- 2010-05-25 EP EP10721024A patent/EP2435469A1/en not_active Withdrawn
- 2010-05-25 BR BRPI1012078A patent/BRPI1012078A2/pt not_active IP Right Cessation
- 2010-05-25 WO PCT/EP2010/057141 patent/WO2010136443A1/en not_active Ceased
- 2010-05-25 SG SG2011086840A patent/SG176220A1/en unknown
- 2010-05-25 JP JP2012512340A patent/JP2012528106A/ja active Pending
2011
- 2011-11-11 DO DO2011000348A patent/DOP2011000348A/es unknown
- 2011-11-14 IL IL216351A patent/IL216351A0/en unknown
- 2011-11-25 CL CL2011002994A patent/CL2011002994A1/es unknown
- 2011-12-01 CO CO11165849A patent/CO6400229A2/es active IP Right Grant

Also Published As

Publication number	Publication date
EP2435469A1 (en)	2012-04-04
CO6400229A2 (es)	2012-03-15
IL216351A0 (en)	2012-01-31
MX2011012623A (es)	2011-12-14
MA33409B1 (fr)	2012-07-03
US8916514B2 (en)	2014-12-23
US20120070491A1 (en)	2012-03-22
CL2011002994A1 (es)	2012-07-20
EA201190274A1 (ru)	2012-06-29
PE20120400A1 (es)	2012-05-04
NZ596501A (en)	2013-11-29
CN102459324B (zh)	2014-07-09
DOP2011000348A (es)	2012-01-15
WO2010136443A1 (en)	2010-12-02
JP2012528106A (ja)	2012-11-12
SG176220A1 (en)	2011-12-29
EA020617B1 (ru)	2014-12-30
CA2763486A1 (en)	2010-12-02
CN102459324A (zh)	2012-05-16
KR20120014054A (ko)	2012-02-15
AU2010252012A1 (en)	2011-12-22

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0716145A2 (pt)	2013-09-17	formuaÇço de vacina, mÉtodo de adaptaÇço e propagaÇço do vÍrus chikungunya, mÉtodo de concentraÇço e purificaÇço de vÍrus, composiÇço potencialmente imunogÊnica, sequÊncia de nucleotÍdeo, contruto de dna recombinante, mÉtodo para produzir proteÍna recombinante, composiÇço farmacÊutica, mÉtodo in vitro ou in vivo e mÉtodo para elicitar resposta imune protetora
BRPI0906997A2 (pt)	2015-07-07	Proteína, uso da proteína combinante ou fragmento da mesma, método para induzir uma resposta imune em um individuo, método para tratar um paceinte, construção de ácido nicleico, vetor de ezpressão o ucélula hospedeira, vacina, anticorpo, e, composição farmaceutica
BRPI0919531A2 (pt)	2015-12-08	anticorpos contra il17 humana e usos dos mesmos
DK2358756T4 (da)	2023-09-04	Humane antistoffer med høj affinitet til PCSK9
CO6680687A2 (es)	2013-05-31	Inmunoglobinas con dominio variable dual capaces de unirse a il 1 beta e il-17, composiciones farmaceúticas y conjugados de proteína de unión de las mismas
SG10201401995UA (en)	2014-08-28	Stable high protein concentration formulations of human anti-tnf-alpha-antibodies
BRPI1012340A (pt)	2017-07-25	proteínas de ligação específica e usos das mesmas
EP2342336A4 (en)	2012-05-02	CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS
EA201490393A1 (ru)	2015-01-30	Соматотропный гормон пролонгированного действия и способы его получения
BRPI0920026A2 (pt)	2015-12-15	método de tratamento de infecção pulmonar, composição farmacêutica e respectivos usos.
BR112013018932A2 (pt)	2017-05-02	polipeptídeo de interleucina-2 mutante, imunoconjugado, polinucleotídeo isolado, vetor de expressão, célula hospedeira, método de produção de um polipeptídeo de il-2 mutante ou um imunoconjugado do mesmo, composição farmacêutica, uso, método de tratamento de uma doença em um indivíduo e método de estimulação do sistema imunológico de um indivíduo
CL2014000927A1 (es)	2014-11-14	Proteinas naglu humana recombinante y usos de la misma
EA201270571A1 (ru)	2012-09-28	Человеческие il-23-антигенсвязывающие белки
BR112012027055A2 (pt)	2017-07-11	agente estabilizante para proteínas farmacêuticas.
BRPI0820068A2 (pt)	2015-09-01	Composição para nutrição humana e/ou animal, usos derivados e leveduras
BR112012013868A2 (pt)	2017-01-10	composição, proteína de fusão, polinucelotídeo, vetor ou constructo de gene, célula hospedeira , composição farmacêutica, método in vitro e uso de uma composição.
AR090047A1 (es)	2014-10-15	Dominio variable dual de inmunoglobulinas y sus usos
ATE492639T1 (de)	2011-01-15	Multimer zur immunstimulation
BRPI0920246A2 (pt)	2017-06-27	método de preparação de alfa-beta peptídios biologicamente ativos.
MX2009004243A (es)	2009-05-14	Nuevas proteinas h5, moleculas de acido nucleico y vectores que las codifican y su uso medicinal.
SMT201600147B (it)	2016-07-01	Metodi per migliorare l'espressione di proteine ricombinanti
BR112012027531A2 (pt)	2017-08-08	método de tratamento e/ou prevenção de progresso e/ou atraso de desenvolvimento de hepatite em um indivíduo, uso de uma molécula imunológica anti-cd3 e composição farmacêutica
BRPI0820258A2 (pt)	2017-04-04	composto, composições de vacina e farmacêutica, e , métodos para estimular uma resposta imune em um indivíduo e para tratar um indivíduo
CL2011002994A1 (es)	2012-07-20	Construccion de proteina que comprende polipeptido casb7439; composicion inmunogenica que comprende dicha construccion; uso de la composicion porque sirve para inducir respuesta inmunitaria al casb7439 en un animal.
EA201171232A1 (ru)	2012-05-30	Способ переноса полипептидов в клетки