BRPI0716477A2 - Derivados heteroarila como inibidores de quinase protéica - Google Patents

Derivados heteroarila como inibidores de quinase protéica

Info

Publication number: BRPI0716477A2
Authority: BR; Brazil
Prior art keywords: heteroaril; derivatives; protein kinase; kinase inhibitors; inhibitors
Prior art date: 2006-09-06

Application number

BRPI0716477-7A2A

Other languages

English (en)

Inventor

Konrad Honold

Wolfgang Schaefer

Stefan Scheiblich

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-06

Filing date

2007-09-04

Publication date

2014-03-18

2007-09-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2014-03-18 Publication of BRPI0716477A2 publication Critical patent/BRPI0716477A2/pt

Links

229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
239000003909 protein kinase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0716477-7A2A 2006-09-06 2007-09-04 Derivados heteroarila como inibidores de quinase protéica BRPI0716477A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06018627		2006-09-06
PCT/EP2007/007691 WO2008028617A1 (en)	2006-09-06	2007-09-04	Heteroaryl derivatives as protein kinase inhibitors

Publications (1)

Publication Number	Publication Date
BRPI0716477A2 true BRPI0716477A2 (pt)	2014-03-18

Family

ID=37668072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0716477-7A2A BRPI0716477A2 (pt)	2006-09-06	2007-09-04	Derivados heteroarila como inibidores de quinase protéica

Country Status (11)

Country	Link
US (1)	US8067599B2 (pt)
EP (1)	EP2064213A1 (pt)
JP (1)	JP2010502660A (pt)
KR (1)	KR101104666B1 (pt)
CN (1)	CN101511828A (pt)
AU (1)	AU2007294149A1 (pt)
BR (1)	BRPI0716477A2 (pt)
CA (1)	CA2662031A1 (pt)
IL (1)	IL196554A0 (pt)
MX (1)	MX2009002010A (pt)
WO (1)	WO2008028617A1 (pt)

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KR101104666B1 (ko)	2006-09-06	2012-01-13	에프. 호프만-라 로슈 아게	단백질 키나제 억제제로서의 헤테로아릴 유도체
WO2008144253A1 (en) *	2007-05-14	2008-11-27	Irm Llc	Protein kinase inhibitors and methods for using thereof
JP2011513331A (ja)	2008-02-29	2011-04-28	アレイバイオファーマ、インコーポレイテッド	ピラゾール［３，４−ｂ］ピリジンＲＡＦ阻害剤
JP2011513332A (ja) *	2008-02-29	2011-04-28	アレイバイオファーマ、インコーポレイテッド	癌の治療のためのｒａｆ阻害剤としてのｎ−（６−アミノピリジン−３−イル）−３−（スルホンアミド）ベンズアミド誘導体
KR20100122505A (ko) *	2008-02-29	2010-11-22	어레이 바이오파마 인크.	Ｒａｆ 저해물질 화합물 및 이들의 이용 방법
CA2716947A1 (en) *	2008-02-29	2009-09-11	Array Biopharma Inc.	Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
KR100970670B1 (ko)	2008-04-22	2010-07-15	계명대학교 산학협력단	세포증식 억제제로서 유용한 벤즈아미드 유도체 및 그제조방법
FR2941948B1 (fr) *	2009-02-12	2013-04-05	Nova Decision	Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
JP2013503189A (ja)	2009-08-28	2013-01-31	アレイバイオファーマ、インコーポレイテッド	Ｒａｆ阻害化合物およびその使用方法
JP2013503190A (ja)	2009-08-28	2013-01-31	アレイバイオファーマ、インコーポレイテッド	Ｒａｆ阻害化合物およびその使用方法
WO2011025965A1 (en)	2009-08-28	2011-03-03	Genentech, Inc.	Raf inhibitor compounds and methods of use thereof
WO2011025968A1 (en)	2009-08-28	2011-03-03	Array Biopharma Inc.	1h-pyrazolo [ 3, 4-b] pyridine compounds for inhibiting raf kinase
CN102712646A (zh)	2009-08-28	2012-10-03	阵列生物制药公司	Raf抑制剂化合物及其使用方法
US20130018033A1 (en)	2009-08-28	2013-01-17	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
US8883819B2 (en) *	2011-09-01	2014-11-11	Irm Llc	Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
FR2984325A1 (fr) *	2011-12-14	2013-06-21	Sanofi Sa	Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
US10138235B2 (en)	2011-12-14	2018-11-27	Sanofi	Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof
PL2797888T3 (pl)	2011-12-31	2016-12-30		Połączone związki tricykliczne jako inhibitory kinazy raf
CN102659778A (zh) *	2012-03-22	2012-09-12	盛世泰科生物医药技术(苏州)有限公司	6-氨基-2-甲基-3H-咪唑并[4,5-b]吡啶的合成新工艺
FR3000494B1 (fr)	2012-12-28	2015-08-21	Oribase Pharma	Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000493A1 (fr) *	2012-12-28	2014-07-04	Oribase Pharma	Nouveaux inhibiteurs de proteines kinases
FR3000492B1 (fr) *	2012-12-28	2015-09-11	Oribase Pharma	Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
AR094929A1 (es)	2013-02-28	2015-09-09	Bristol Myers Squibb Co	Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
CN105102448B (zh)	2013-02-28	2018-03-06	百时美施贵宝公司	作为rock1和rock2抑制剂的苯基吡唑衍生物
EA029412B1 (ru)	2013-06-28	2018-03-30	Бейджин, Лтд.	Конденсированные трициклические соединения мочевины в качестве ингибиторов киназы raf и/или димера киназы raf
EP3013797B1 (en)	2013-06-28	2018-01-03	BeiGene, Ltd.	Fused tricyclic amide compounds as multiple kinase inhibitors
ES2735924T3 (es) *	2015-04-17	2019-12-20	Dow Agrosciences Llc	Moléculas que tienen utilidad plaguicida e intermediarios, composiciones y procesos, relacionados con ellas
EP3365819B1 (en) *	2015-10-22	2023-06-07	Mangosuthu University Of Technology	Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of cyp17a1 and cyp19a1
BR122020018163B8 (pt) *	2016-10-12	2022-09-06	Dow Agrosciences Llc	Moléculas tendo utilidade pesticida, e intermediários, composições, processos relacionados às mesmas e sementes resistentes a pragas
TWI758313B (zh)	2016-10-12	2022-03-21	美商陶氏農業科學公司	一種用於製備(1r,3r)-及(1s,3s)-2,2-二鹵基-3-(經取代之苯基)環丙烷甲酸的方法
BR112020017159A2 (pt) *	2018-02-23	2020-12-22	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Inibidores de glutaminil ciclases bacterianas para uso no tratamento de doenças periodontais e relacionadas
TWI849043B (zh)	2019-01-25	2024-07-21	英屬開曼群島商百濟神州有限公司	B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途
CN117924278A (zh) *	2024-01-19	2024-04-26	四川大学	一种二胺单体、聚酰亚胺聚合物、芳香族聚酰胺聚合物及其制备方法和用途

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KR20030011371A (ko) *	2000-06-27	2003-02-07	진랩스 테크놀러지스, 인크.	항세균, 항진균 또는 항암 활성을 갖는 신규 화합물
TWI276631B (en)	2002-09-12	2007-03-21	Avanir Pharmaceuticals	Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
GB0330043D0 (en)	2003-12-24	2004-01-28	Pharmacia Italia Spa	Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
CN101830899A (zh) *	2004-12-23	2010-09-15	霍夫曼-拉罗奇有限公司	杂环氨基甲酸酯衍生物,它们的制备及作为药剂的应用
JP2008525355A (ja)	2004-12-23	2008-07-17	エフ．ホフマン−ラロシュアーゲー	ベンズアミド誘導体、これらの製造及び医薬剤としての使用。
CN101208338B (zh) *	2005-07-29	2010-12-29	霍夫曼-拉罗奇有限公司	氮杂苯并咪唑衍生物，它们的制备以及作为抗癌剂的应用
KR101104666B1 (ko)	2006-09-06	2012-01-13	에프. 호프만-라 로슈 아게	단백질 키나제 억제제로서의 헤테로아릴 유도체

2007
- 2007-09-04 KR KR1020097004677A patent/KR101104666B1/ko not_active Expired - Fee Related
- 2007-09-04 EP EP07802106A patent/EP2064213A1/en not_active Withdrawn
- 2007-09-04 WO PCT/EP2007/007691 patent/WO2008028617A1/en not_active Ceased
- 2007-09-04 CA CA002662031A patent/CA2662031A1/en not_active Abandoned
- 2007-09-04 AU AU2007294149A patent/AU2007294149A1/en not_active Abandoned
- 2007-09-04 BR BRPI0716477-7A2A patent/BRPI0716477A2/pt not_active IP Right Cessation
- 2007-09-04 CN CNA2007800326413A patent/CN101511828A/zh active Pending
- 2007-09-04 US US12/374,682 patent/US8067599B2/en not_active Expired - Fee Related
- 2007-09-04 MX MX2009002010A patent/MX2009002010A/es active IP Right Grant
- 2007-09-04 JP JP2009527045A patent/JP2010502660A/ja active Pending
2009
- 2009-01-15 IL IL196554A patent/IL196554A0/en unknown

Also Published As

Publication number	Publication date
WO2008028617A1 (en)	2008-03-13
KR101104666B1 (ko)	2012-01-13
MX2009002010A (es)	2009-03-05
US20090318428A1 (en)	2009-12-24
EP2064213A1 (en)	2009-06-03
CN101511828A (zh)	2009-08-19
JP2010502660A (ja)	2010-01-28
KR20090038487A (ko)	2009-04-20
US8067599B2 (en)	2011-11-29
CA2662031A1 (en)	2008-03-13
IL196554A0 (en)	2009-11-18
AU2007294149A1 (en)	2008-03-13

Legal Events

Date	Code	Title	Description
2014-08-26	B08L	Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]	Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 6A E 7A ANUIDADES.
2020-11-10	B08I	Publication cancelled [chapter 8.9 patent gazette]	Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA.
2020-11-17	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 6A, 7A, 8A, 9A, 10A, 11A, 12A E 13A ANUIDADES.
2021-03-09	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0716477A2 (pt)	2014-03-18	Derivados heteroarila como inibidores de quinase protéica
CY2019009I1 (el)	2019-11-27	Αναστολεις πρωτεϊνικων κινασων
BRPI0719991A2 (pt)	2014-03-18	Derivados de di-hidropiridina úteis como inibidores de proteína cinase
BRPI0910668A2 (pt)	2019-09-24	inibidores de proteína quinases
BRPI0719797A2 (pt)	2017-10-24	compostos e composições como inibidores de proteína cinase
ATE479434T1 (de)	2010-09-15	Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
BRPI0911228A2 (pt)	2017-05-30	compostos e composições como inibidores de proteínas quinase
BRPI0918846A2 (pt)	2019-09-24	inibidores de cinase heterocíclica
BRPI0920239A2 (pt)	2019-09-24	compostos heterocíclicos como inibidores de proteínas quinases
BRPI0820544A2 (pt)	2015-06-16	4-pirazolil-n-arilpirimidin-2-aminas e pirazolil-n-heteroarilpirimidin-2-aminas como inibidores de janus cinase
BRPI0714291A2 (pt)	2014-10-21	Derivados de [4,5']bipirimidinil-6-4'-diamina como inibidores de proteína cinase
BRPI0913879A2 (pt)	2019-09-24	fenilpirazinonas como inibidores de quinase
BRPI0811065A2 (pt)	2014-12-02	Indazóis 5-heteroaril substituídos como inibidores de quinase
ATE475662T1 (de)	2010-08-15	Dihydropyrazolopyrimidinonderivate
BRPI0920135A2 (pt)	2019-09-24	imidazopiridazinacarbonitrilos úteis como inibidores de quinase
ATE483711T1 (de)	2010-10-15	Spiroindolinonderivate
ATE488505T1 (de)	2010-12-15	Kinasehemmer auf hydantoinbasis
ATE469905T1 (de)	2010-06-15	Pyridopyrimidinonderivate
BRPI0716781A2 (pt)	2014-11-18	Inibidores da quinase
ATE506358T1 (de)	2011-05-15	2-benzylpyridazinonderivate als met-kinasehemmer
ATE512135T1 (de)	2011-06-15	Spiroindolinonderivate
BRPI0719389A2 (pt)	2014-10-07	Derivados de hidantoína utilizados como inibidores de mmp
CR10879A (es)	2009-08-05	Cyclized derivatives as eg-5 inhibitors
BRPI0720547A2 (pt)	2014-05-06	Inibidores de metaloprotease derivada de heterocíclico
ATE544764T1 (de)	2012-02-15	5-hydroxymethyloxazolidin-2-onderivate