BRPI0716477A2 - Derivados heteroarila como inibidores de quinase protéica - Google Patents

Derivados heteroarila como inibidores de quinase protéica

Info

Publication number: BRPI0716477A2
Authority: BR; Brazil
Prior art keywords: heteroaril; derivatives; protein kinase; kinase inhibitors; inhibitors
Prior art date: 2006-09-06

Application number

BRPI0716477-7A2A

Other languages

English (en)

Inventor

Konrad Honold

Wolfgang Schaefer

Stefan Scheiblich

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-06

Filing date

2007-09-04

Publication date

2014-03-18

2007-09-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2014-03-18 Publication of BRPI0716477A2 publication Critical patent/BRPI0716477A2/pt

Links

229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
239000003909 protein kinase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0716477-7A2A 2006-09-06 2007-09-04 Derivados heteroarila como inibidores de quinase protéica BRPI0716477A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06018627		2006-09-06
PCT/EP2007/007691 WO2008028617A1 (en)	2006-09-06	2007-09-04	Heteroaryl derivatives as protein kinase inhibitors

Publications (1)

Publication Number	Publication Date
BRPI0716477A2 true BRPI0716477A2 (pt)	2014-03-18

Family

ID=37668072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0716477-7A2A BRPI0716477A2 (pt)	2006-09-06	2007-09-04	Derivados heteroarila como inibidores de quinase protéica

Country Status (11)

Country	Link
US (1)	US8067599B2 (pt)
EP (1)	EP2064213A1 (pt)
JP (1)	JP2010502660A (pt)
KR (1)	KR101104666B1 (pt)
CN (1)	CN101511828A (pt)
AU (1)	AU2007294149A1 (pt)
BR (1)	BRPI0716477A2 (pt)
CA (1)	CA2662031A1 (pt)
IL (1)	IL196554A0 (pt)
MX (1)	MX2009002010A (pt)
WO (1)	WO2008028617A1 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2010502660A (ja)	2006-09-06	2010-01-28	エフ．ホフマン−ラロシュアーゲー	プロテインキナーゼインヒビターとしてのヘテロアリール誘導体
WO2008144253A1 (en) *	2007-05-14	2008-11-27	Irm Llc	Protein kinase inhibitors and methods for using thereof
PE20091561A1 (es)	2008-02-29	2009-10-30	Array Biopharma Inc	Compuestos inhibidores de raf y metodos para su uso
JP2011513332A (ja) *	2008-02-29	2011-04-28	アレイバイオファーマ、インコーポレイテッド	癌の治療のためのｒａｆ阻害剤としてのｎ−（６−アミノピリジン−３−イル）−３−（スルホンアミド）ベンズアミド誘導体
ES2392482T3 (es) *	2008-02-29	2012-12-11	Array Biopharma, Inc.	Derivados de imidazo[4,5-b] piridina usados como inhibidores de RAF
JP2011513331A (ja) *	2008-02-29	2011-04-28	アレイバイオファーマ、インコーポレイテッド	ピラゾール［３，４−ｂ］ピリジンＲＡＦ阻害剤
KR100970670B1 (ko)	2008-04-22	2010-07-15	계명대학교 산학협력단	세포증식 억제제로서 유용한 벤즈아미드 유도체 및 그제조방법
FR2941948B1 (fr) *	2009-02-12	2013-04-05	Nova Decision	Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
EP2470532A1 (en)	2009-08-28	2012-07-04	Array Biopharma, Inc.	1h-pyrazolo [ 3, 4-b]pyridine compounds for inhibiting raf kinase
US20130018033A1 (en)	2009-08-28	2013-01-17	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
WO2011025951A1 (en)	2009-08-28	2011-03-03	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
US20120157453A1 (en) *	2009-08-28	2012-06-21	Genentech, Inc.	Raf inhibitor compounds and methods of use thereof
CN102666498A (zh)	2009-08-28	2012-09-12	健泰科生物技术公司	Raf抑制剂化合物及其使用方法
CN102712646A (zh)	2009-08-28	2012-10-03	阵列生物制药公司	Raf抑制剂化合物及其使用方法
US8883819B2 (en) *	2011-09-01	2014-11-11	Irm Llc	Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
FR2984325A1 (fr) *	2011-12-14	2013-06-21	Sanofi Sa	Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
US10138235B2 (en)	2011-12-14	2018-11-27	Sanofi	Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof
US9273046B2 (en)	2011-12-31	2016-03-01	Beigene, Ltd.	Fused tricyclic compounds as Raf kinase inhibitors
CN102659778A (zh) *	2012-03-22	2012-09-12	盛世泰科生物医药技术(苏州)有限公司	6-氨基-2-甲基-3H-咪唑并[4,5-b]吡啶的合成新工艺
FR3000492B1 (fr) *	2012-12-28	2015-09-11	Oribase Pharma	Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000493A1 (fr) *	2012-12-28	2014-07-04	Oribase Pharma	Nouveaux inhibiteurs de proteines kinases
FR3000494B1 (fr)	2012-12-28	2015-08-21	Oribase Pharma	Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
WO2014134391A1 (en)	2013-02-28	2014-09-04	Bristol-Myers Squibb Company	Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
AR094929A1 (es)	2013-02-28	2015-09-09	Bristol Myers Squibb Co	Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
US9670231B2 (en)	2013-06-28	2017-06-06	Beigene, Ltd.	Fused tricyclic amide compounds as multiple kinase inhibitors
US9670203B2 (en)	2013-06-28	2017-06-06	Beigene, Ltd.	Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors
AU2016247768B2 (en) *	2015-04-17	2019-03-07	Corteva Agriscience Llc	Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
EP3365819B1 (en) *	2015-10-22	2023-06-07	Mangosuthu University Of Technology	Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of cyp17a1 and cyp19a1
TWI758313B (zh)	2016-10-12	2022-03-21	美商陶氏農業科學公司	一種用於製備(1r,3r)-及(1s,3s)-2,2-二鹵基-3-(經取代之苯基)環丙烷甲酸的方法
BR112019006746B8 (pt)	2016-10-12	2022-09-06	Dow Agrosciences Llc	Molécula apresentando utilidade pesticida, composição, e processos para controle de pragas
WO2019162458A1 (en)	2018-02-23	2019-08-29	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Novel inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases
TWI909513B (zh)	2019-01-25	2025-12-21	英屬開曼群島商百濟神州有限公司	作為ｂ-ｒａｆ激酶二聚體抑制劑之化合物及其製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ522839A (en) *	2000-06-27	2004-11-26	Genelabs Tech Inc	Novel compounds possessing antibacterial, antifungal or antitumor activity
TWI276631B (en)	2002-09-12	2007-03-21	Avanir Pharmaceuticals	Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
GB0330043D0 (en)	2003-12-24	2004-01-28	Pharmacia Italia Spa	Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
US7786113B2 (en) *	2004-12-23	2010-08-31	Hoffman-La Roche Inc.	Heterocyclic carbamate derivatives, their manufacture and use as pharmaceutical agents
US7618964B2 (en)	2004-12-23	2009-11-17	Hoffmann-La Roche Inc.	Benzamide derivatives, their manufacture and use as pharmaceutical agents
SG148192A1 (en) *	2005-07-29	2008-12-31	Hoffmann La Roche	Azabenzimidazole derivatives, their manufacture and use as anti-cancer agents
JP2010502660A (ja)	2006-09-06	2010-01-28	エフ．ホフマン−ラロシュアーゲー	プロテインキナーゼインヒビターとしてのヘテロアリール誘導体

2007
- 2007-09-04 JP JP2009527045A patent/JP2010502660A/ja active Pending
- 2007-09-04 EP EP07802106A patent/EP2064213A1/en not_active Withdrawn
- 2007-09-04 CN CNA2007800326413A patent/CN101511828A/zh active Pending
- 2007-09-04 US US12/374,682 patent/US8067599B2/en not_active Expired - Fee Related
- 2007-09-04 KR KR1020097004677A patent/KR101104666B1/ko not_active Expired - Fee Related
- 2007-09-04 MX MX2009002010A patent/MX2009002010A/es active IP Right Grant
- 2007-09-04 WO PCT/EP2007/007691 patent/WO2008028617A1/en not_active Ceased
- 2007-09-04 AU AU2007294149A patent/AU2007294149A1/en not_active Abandoned
- 2007-09-04 BR BRPI0716477-7A2A patent/BRPI0716477A2/pt not_active IP Right Cessation
- 2007-09-04 CA CA002662031A patent/CA2662031A1/en not_active Abandoned
2009
- 2009-01-15 IL IL196554A patent/IL196554A0/en unknown

Also Published As

Publication number	Publication date
KR101104666B1 (ko)	2012-01-13
IL196554A0 (en)	2009-11-18
US20090318428A1 (en)	2009-12-24
EP2064213A1 (en)	2009-06-03
CA2662031A1 (en)	2008-03-13
MX2009002010A (es)	2009-03-05
WO2008028617A1 (en)	2008-03-13
AU2007294149A1 (en)	2008-03-13
US8067599B2 (en)	2011-11-29
JP2010502660A (ja)	2010-01-28
KR20090038487A (ko)	2009-04-20
CN101511828A (zh)	2009-08-19

Legal Events

Date	Code	Title	Description
2014-08-26	B08L	Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]	Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 6A E 7A ANUIDADES.
2020-11-10	B08I	Publication cancelled [chapter 8.9 patent gazette]	Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA.
2020-11-17	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 6A, 7A, 8A, 9A, 10A, 11A, 12A E 13A ANUIDADES.
2021-03-09	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0716477A2 (pt)	2014-03-18	Derivados heteroarila como inibidores de quinase protéica
CY2019009I1 (el)	2019-11-27	Αναστολεις πρωτεϊνικων κινασων
BRPI0719991A2 (pt)	2014-03-18	Derivados de di-hidropiridina úteis como inibidores de proteína cinase
BRPI0910668A2 (pt)	2019-09-24	inibidores de proteína quinases
BRPI0719797A2 (pt)	2017-10-24	compostos e composições como inibidores de proteína cinase
ATE479434T1 (de)	2010-09-15	Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
BRPI0911228A2 (pt)	2017-05-30	compostos e composições como inibidores de proteínas quinase
BRPI0918846A2 (pt)	2019-09-24	inibidores de cinase heterocíclica
BRPI0920239A2 (pt)	2019-09-24	compostos heterocíclicos como inibidores de proteínas quinases
BRPI0820544A2 (pt)	2015-06-16	4-pirazolil-n-arilpirimidin-2-aminas e pirazolil-n-heteroarilpirimidin-2-aminas como inibidores de janus cinase
BRPI0714291A2 (pt)	2014-10-21	Derivados de [4,5']bipirimidinil-6-4'-diamina como inibidores de proteína cinase
BRPI0913879A2 (pt)	2019-09-24	fenilpirazinonas como inibidores de quinase
BRPI0811065A2 (pt)	2014-12-02	Indazóis 5-heteroaril substituídos como inibidores de quinase
ATE475662T1 (de)	2010-08-15	Dihydropyrazolopyrimidinonderivate
BRPI0920135A2 (pt)	2019-09-24	imidazopiridazinacarbonitrilos úteis como inibidores de quinase
ATE483711T1 (de)	2010-10-15	Spiroindolinonderivate
ATE488505T1 (de)	2010-12-15	Kinasehemmer auf hydantoinbasis
ATE469905T1 (de)	2010-06-15	Pyridopyrimidinonderivate
BRPI0716781A2 (pt)	2014-11-18	Inibidores da quinase
ATE506358T1 (de)	2011-05-15	2-benzylpyridazinonderivate als met-kinasehemmer
ATE512135T1 (de)	2011-06-15	Spiroindolinonderivate
BRPI0719389A2 (pt)	2014-10-07	Derivados de hidantoína utilizados como inibidores de mmp
CR10879A (es)	2009-08-05	Cyclized derivatives as eg-5 inhibitors
BRPI0720547A2 (pt)	2014-05-06	Inibidores de metaloprotease derivada de heterocíclico
ATE544764T1 (de)	2012-02-15	5-hydroxymethyloxazolidin-2-onderivate