BRPI0716539A2 - métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste - Google Patents
métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio desteInfo
- Publication number
- BRPI0716539A2 BRPI0716539A2 BRPI0716539A BRPI0716539A BRPI0716539A2 BR PI0716539 A2 BRPI0716539 A2 BR PI0716539A2 BR PI0716539 A BRPI0716539 A BR PI0716539A BR PI0716539 A BRPI0716539 A BR PI0716539A BR PI0716539 A2 BRPI0716539 A2 BR PI0716539A2
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxybenzoyl
- synthesizing
- amino
- methods
- sodium salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/04—Sodium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84277506P | 2006-09-07 | 2006-09-07 | |
| PCT/EP2007/059037 WO2008028859A1 (en) | 2006-09-07 | 2007-08-30 | A process for the manufacture of snac (salcaprozate sodium) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0716539A2 true BRPI0716539A2 (pt) | 2016-11-01 |
Family
ID=38702068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0716539A BRPI0716539A2 (pt) | 2006-09-07 | 2007-08-30 | métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7544833B2 (pt) |
| EP (1) | EP2064175B1 (pt) |
| JP (1) | JP5021033B2 (pt) |
| KR (1) | KR101081149B1 (pt) |
| CN (1) | CN101506147B (pt) |
| AU (1) | AU2007293916B2 (pt) |
| BR (1) | BRPI0716539A2 (pt) |
| CA (1) | CA2662080C (pt) |
| ES (1) | ES2498519T3 (pt) |
| IL (1) | IL197014A (pt) |
| MX (1) | MX2009002121A (pt) |
| WO (1) | WO2008028859A1 (pt) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027958A2 (en) | 2006-08-31 | 2008-03-06 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| BRPI0716539A2 (pt) * | 2006-09-07 | 2016-11-01 | Emisphere Tech Inc | métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste |
| PL2651398T3 (pl) | 2010-12-16 | 2018-05-30 | Novo Nordisk A/S | Stałe kompozycje zawierające agonistę GLP-1 i sól kwasu N-(8-(2-hydroksybenzoilo)amino)kaprylowego |
| DK2696687T3 (en) | 2011-04-12 | 2017-02-06 | Novo Nordisk As | Double-acylated GLP-1 derivatives |
| PL3542790T3 (pl) | 2012-03-22 | 2024-02-26 | Novo Nordisk A/S | Kompozycje zawierające substancję dostarczającą i ich przygotowanie |
| HUE042757T2 (hu) | 2012-03-22 | 2019-07-29 | Novo Nordisk As | Szállító szert tartalmazó készítmények és elõállításuk |
| EP4324475A1 (en) | 2012-03-22 | 2024-02-21 | Novo Nordisk A/S | Compositions of glp-1 peptides and preparation thereof |
| JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー／エス | ペプチド及び送達剤を含む錠剤製剤 |
| KR20210086717A (ko) | 2013-05-02 | 2021-07-08 | 노보 노르디스크 에이/에스 | Glp-1 화합물의 경구 투여 |
| DK3284797T3 (da) * | 2014-09-25 | 2021-02-01 | Daikin Ind Ltd | Sammensætning, der omfatter hfc og hfo |
| CN105566141B (zh) * | 2015-12-17 | 2018-01-26 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸缩合物的制备方法 |
| AR112015A1 (es) | 2017-06-09 | 2019-09-11 | Novo Nordisk As | Composiciones sólidas para administración oral |
| JP2020527159A (ja) | 2017-07-19 | 2020-09-03 | ノヴォ ノルディスク アー／エス | Ｅｇｆ（ａ）類似体、その製造、製剤および使用 |
| WO2019149880A1 (en) | 2018-02-02 | 2019-08-08 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| CN108689876B (zh) * | 2018-06-28 | 2020-11-27 | 苏州东南药业股份有限公司 | 一种8-(2-羟基苯甲酰胺基)辛酸钠的制备方法 |
| BR112022000529A2 (pt) | 2019-08-07 | 2022-03-03 | Novo Nordisk As | Composição farmacêutica |
| ES3006288T3 (en) | 2019-09-06 | 2025-03-18 | Novo Nordisk As | Method and equipment for fractionation of granules for use in pharmaceutical compositions |
| HRP20241052T1 (hr) | 2019-11-06 | 2024-11-08 | Novo Nordisk A/S | Semaglutid, namijenjen liječenju alzheimerove demencije |
| MX2022004718A (es) | 2019-11-07 | 2022-06-08 | Novo Nordisk As | Omposiciones sólidas que comprenden un inhibidor de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9) y una sal de ácido n-(8-(2-hidroxibenzoil)amino)caprílico. |
| CN114641276A (zh) | 2019-11-07 | 2022-06-17 | 诺和诺德股份有限公司 | 包含glp-1激动剂、sglt2抑制剂和n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐的固体组合物 |
| IT202000003251A1 (it) | 2020-02-18 | 2021-08-18 | Dipharma Francis Srl | Preparazione di un analgesico non steroideo |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| US20230165939A1 (en) | 2020-04-29 | 2023-06-01 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
| CN112661663B (zh) * | 2020-05-29 | 2021-09-17 | 杭州先为达生物科技有限公司 | N-[8-(2-羟基苯甲酰基)氨基]辛酸钾晶体多晶型物及其制备方法和用途 |
| US12410123B2 (en) | 2020-05-29 | 2025-09-09 | Sciwind Biosciences Co., Ltd. | N-[8-(2-hydroxybenzoyl)amino]potassium octanoate crystal polymorph, and preparation method therefor and use thereof |
| CN116507364A (zh) | 2020-10-16 | 2023-07-28 | 学校法人常翔学园 | 组合物 |
| CR20230308A (es) | 2020-12-11 | 2023-09-08 | Civi Biopharma Inc | Entrega oral de conjugados antisentido que tienen por blanco a pcsk9 |
| ES3023951T3 (en) * | 2021-01-29 | 2025-06-03 | Novo Nordisk As | Novel synthesis of salcaprozic acid by amide formation |
| US11667614B2 (en) | 2021-04-16 | 2023-06-06 | Navinta III Inc. | Process for the preparation of highly pure Salcaprozic Acid and pharmaceutically acceptable salts thereof |
| ES3064753T3 (en) | 2021-04-16 | 2026-04-28 | Navinta Iii Inc | Process for the preparation of highly pure salcaprozic acid and pharmaceutically acceptable salts thereof |
| PE20240640A1 (es) | 2021-04-22 | 2024-04-04 | Civi Biopharma Inc | Administracion oral de oligonucleotidos |
| WO2022264166A1 (en) | 2021-06-14 | 2022-12-22 | Mylan Laboratories Limited | Process for the preparation of pure salcaprozate sodium |
| US20250276043A1 (en) | 2021-06-25 | 2025-09-04 | Gan & Lee Pharmaceuticals Co., Ltd. | Pharmaceutical Composition Containing GLP-1 Compound |
| CA3223236A1 (en) | 2021-07-15 | 2023-01-19 | Thomas Kvistgaard Vilhelmsen | Tablet comprising a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| EP4370499A1 (en) | 2021-07-16 | 2024-05-22 | Novo Nordisk A/S | Sodium n-(8-(2- hydroxybenzoyl)amino)caprylate polymorphic form a |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| EP4534553A1 (en) | 2022-05-27 | 2025-04-09 | Hangzhou Sciwind Biosciences Co., Ltd. | Human amylin analog, and derivative and use thereof |
| CN115108936A (zh) * | 2022-07-29 | 2022-09-27 | 成都普康唯新生物科技有限公司 | 无水体系制备8-(2-羟基苯甲酰胺基)辛酸钠无水晶型的方法 |
| CN115160178A (zh) * | 2022-07-29 | 2022-10-11 | 成都普康唯新生物科技有限公司 | 一种8-(2-羟基苯甲酰胺基)辛酸钠无水晶型的制备方法 |
| TW202421645A (zh) | 2022-11-25 | 2024-06-01 | 丹麥商諾佛 儂迪克股份有限公司 | 如ｇｌｐ—１之肽治療劑的口服投與 |
| JP2026502943A (ja) | 2022-12-30 | 2026-01-27 | アルギファルマ エーエス | 経口投与されるポリペプチド治療剤の全身バイオアベイラビリティを高める組成物および方法 |
| EP4721754A1 (en) | 2023-05-29 | 2026-04-08 | Hangzhou Sciwind Biosciences Co., Ltd. | Polypeptide derivative for oral delivery |
| CN117402073B (zh) * | 2023-07-26 | 2025-12-02 | 扬州市普林斯医药科技有限公司 | 一种8-(2-羟基苯甲酰胺基)辛酸的制备方法 |
| CN117466765B (zh) * | 2023-12-27 | 2024-03-15 | 成都道合尔医药技术有限公司 | 8-(2-羟基苯甲酰胺基)辛酸钠及其合成方法 |
| WO2025169190A2 (en) | 2024-02-06 | 2025-08-14 | Opko Biologics Ltd. | Modified oxyntomodulin and methods of use thereof |
| WO2026017601A1 (en) | 2024-07-15 | 2026-01-22 | F. Hoffmann-La Roche Ag | Novel formulations for oral administration of oligonucleotides |
| CN118561711B (zh) * | 2024-07-31 | 2024-11-22 | 爱斯特（成都）生物制药股份有限公司 | 一种制备n-[8-(2-羟基苯甲酰基)氨基]辛酸及其盐的方法 |
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| BRPI0716539A2 (pt) * | 2006-09-07 | 2016-11-01 | Emisphere Tech Inc | métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste |
| FR2912145B1 (fr) | 2007-02-02 | 2009-03-06 | Servier Lab | Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
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| KR101534881B1 (ko) | 2007-07-31 | 2015-07-07 | 가부시키가이샤 도우사 고가쿠 겐큐쇼 | 펩티드의 제조방법 |
| CN101367750B (zh) | 2007-08-14 | 2012-05-23 | 中国人民解放军军事医学科学院毒物药物研究所 | (1s,2s,3s,4r)-3-[(1s)-1-乙酰氨-2-乙基-丁基]-4-胍基-2-羟基-环戊基-1-羧酸水合物及其医药用途 |
-
2007
- 2007-08-30 BR BRPI0716539A patent/BRPI0716539A2/pt not_active Application Discontinuation
- 2007-08-30 AU AU2007293916A patent/AU2007293916B2/en active Active
- 2007-08-30 WO PCT/EP2007/059037 patent/WO2008028859A1/en not_active Ceased
- 2007-08-30 EP EP07803046.7A patent/EP2064175B1/en active Active
- 2007-08-30 US US11/847,415 patent/US7544833B2/en active Active
- 2007-08-30 CN CN2007800316394A patent/CN101506147B/zh active Active
- 2007-08-30 JP JP2009527117A patent/JP5021033B2/ja active Active
- 2007-08-30 CA CA2662080A patent/CA2662080C/en not_active Expired - Fee Related
- 2007-08-30 KR KR1020097004631A patent/KR101081149B1/ko active Active
- 2007-08-30 US US16/490,424 patent/US10875826B2/en active Active
- 2007-08-30 ES ES07803046.7T patent/ES2498519T3/es active Active
- 2007-08-30 MX MX2009002121A patent/MX2009002121A/es active IP Right Grant
-
2009
- 2009-02-12 IL IL197014A patent/IL197014A/en active IP Right Grant
-
2020
- 2020-11-23 US US17/101,375 patent/US20210070691A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007293916A1 (en) | 2008-03-13 |
| IL197014A0 (en) | 2009-11-18 |
| US20200071263A1 (en) | 2020-03-05 |
| KR101081149B1 (ko) | 2011-11-07 |
| US20210070691A1 (en) | 2021-03-11 |
| EP2064175A1 (en) | 2009-06-03 |
| US10875826B2 (en) | 2020-12-29 |
| US7544833B2 (en) | 2009-06-09 |
| AU2007293916B2 (en) | 2011-02-03 |
| ES2498519T3 (es) | 2014-09-24 |
| US20080064890A1 (en) | 2008-03-13 |
| CA2662080C (en) | 2012-07-17 |
| CN101506147A (zh) | 2009-08-12 |
| CN101506147B (zh) | 2012-03-21 |
| KR20090060997A (ko) | 2009-06-15 |
| CA2662080A1 (en) | 2008-03-13 |
| WO2008028859A1 (en) | 2008-03-13 |
| JP5021033B2 (ja) | 2012-09-05 |
| IL197014A (en) | 2013-01-31 |
| MX2009002121A (es) | 2009-05-20 |
| EP2064175B1 (en) | 2014-08-06 |
| JP2010502667A (ja) | 2010-01-28 |
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