BRPI0717035A2 - Moduladores de benzotriazol cinase - Google Patents

Moduladores de benzotriazol cinase

Info

Publication number: BRPI0717035A2
Authority: BR; Brazil
Prior art keywords: benzotriazol; kinase modulators; modulators; kinase; benzotriazol kinase
Prior art date: 2006-09-08

Application number

BRPI0717035-1A2A

Other languages

English (en)

Inventor

David Michael Goldstein

Leyi Gong

Christophe Michoud

Wylie Solang Palmer

Achyutharao Sidduri

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-08

Filing date

2007-08-30

Publication date

2014-11-25

2007-08-30 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2014-11-25 Publication of BRPI0717035A2 publication Critical patent/BRPI0717035A2/pt

2021-05-04 Publication of BRPI0717035B1 publication Critical patent/BRPI0717035B1/pt

2021-05-25 Publication of BRPI0717035B8 publication Critical patent/BRPI0717035B8/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0717035A 2006-09-08 2007-08-30 moduladores de benzotriazol cinase BRPI0717035B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US84309006P	2006-09-08	2006-09-08
US60/843,090		2006-09-08
PCT/EP2007/059040 WO2008028860A1 (en)	2006-09-08	2007-08-30	Benzotriazole kinase modulators

Publications (3)

Publication Number	Publication Date
BRPI0717035A2 true BRPI0717035A2 (pt)	2014-11-25
BRPI0717035B1 BRPI0717035B1 (pt)	2021-05-04
BRPI0717035B8 BRPI0717035B8 (pt)	2021-05-25

Family

ID=38893293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0717035A BRPI0717035B8 (pt)	2006-09-08	2007-08-30	moduladores de benzotriazol cinase

Country Status (17)

Country	Link
US (1)	US8962622B2 (pt)
EP (1)	EP2066319B1 (pt)
JP (1)	JP5325783B2 (pt)
KR (1)	KR101177729B1 (pt)
CN (1)	CN101511359B (pt)
AR (1)	AR062666A1 (pt)
AT (1)	ATE543498T1 (pt)
AU (1)	AU2007293917B2 (pt)
BR (1)	BRPI0717035B8 (pt)
CA (1)	CA2662998C (pt)
CL (1)	CL2007002572A1 (pt)
ES (1)	ES2378577T3 (pt)
IL (1)	IL197015A (pt)
MX (1)	MX2009002229A (pt)
PE (1)	PE20080659A1 (pt)
TW (1)	TW200819440A (pt)
WO (1)	WO2008028860A1 (pt)

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US8183339B1 (en)	1999-10-12	2012-05-22	Xigen S.A.	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20040082509A1 (en)	1999-10-12	2004-04-29	Christophe Bonny	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8080517B2 (en)	2005-09-12	2011-12-20	Xigen Sa	Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2007031098A1 (en)	2005-09-12	2007-03-22	Xigen S.A.	Cell-permeable peptide inhibitors of the jnk signal transduction pathway
BRPI0720003A2 (pt)	2006-12-08	2018-09-18	Hoffmann La Roche	pirimidinas substituídas e seu uso como moduladores de jnk
JP5587193B2 (ja) *	2007-10-23	2014-09-10	エフ．ホフマン−ラロシュアーゲー	新規なキナーゼ阻害剤
KR101368079B1 (ko) *	2008-05-16	2014-03-14	에프. 호프만-라 로슈 아게	Ｊｎｋ 의 억제제
WO2009143865A1 (en) *	2008-05-30	2009-12-03	Xigen S.A.	Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2009143864A1 (en)	2008-05-30	2009-12-03	Xigen S.A.	Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2010072228A1 (en)	2008-12-22	2010-07-01	Xigen S.A.	Novel transporter constructs and transporter cargo conjugate molecules
JP5518905B2 (ja)	2009-02-24	2014-06-11	エフ．ホフマン−ラロシュアーゲー	ＪＮＫモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン
IN2012DN01231A (pt) *	2009-08-10	2015-05-15	Hoffmann La Roche
CA2799328C (en) *	2010-06-04	2018-02-20	Humberto Bartolome Arzeno	2 -amino- pyrimidine derivatives useful as inhibitors of jnk
BR112012030814A2 (pt) *	2010-06-04	2019-09-24	Hoffmann La Roche	inibidores de jnk
WO2011160653A1 (en)	2010-06-21	2011-12-29	Xigen S.A.	Novel jnk inhibitor molecules
AU2010362444B2 (en)	2010-10-14	2015-08-06	Xigen Inflammation Ltd.	Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
EP2673347B1 (en) *	2011-02-09	2018-09-12	The Lubrizol Corporation	Asphaltene dispersant containing lubricating compositions
EP2567959B1 (en)	2011-09-12	2014-04-16	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013091670A1 (en)	2011-12-21	2013-06-27	Xigen S.A.	Novel jnk inhibitor molecules for treatment of various diseases
ES2694829T3 (es) *	2013-02-25	2018-12-27	Aurigene Discovery Technologies Limited	Derivados de benzotriazol trisustituido como inhibidores de dihidroorotato oxigenasa
EA201501080A1 (ru)	2013-06-26	2016-07-29	Ксижен Инфлемейшн Лтд.	Новое применение обладающих способностью проникать в клетку пептидных ингибиторов пути трансдукции сигнала jnk для лечения различных заболеваний
WO2014206427A1 (en)	2013-06-26	2014-12-31	Xigen Inflammation Ltd.	New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2015197097A1 (en)	2014-06-26	2015-12-30	Xigen Inflammation Ltd.	New use for jnk inhibitor molecules for treatment of various diseases
MX358346B (es)	2014-04-04	2018-08-15	Syros Pharmaceuticals Inc	Inhibidores de la quinasa dependiente de ciclina 7 (cdk7).
JP2017518333A (ja) *	2014-06-16	2017-07-06	アリンキーバイオファーマＡｌｌｉｎｋｙＢｉｏｐｈａｒｍａ	神経系の変性疾患を治療及び予防するためのｐ３８及びｊｎｋｍａｐｋ阻害剤
WO2017204626A1 (en)	2016-05-24	2017-11-30	Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis	Combination therapy - combined map2k4/map3k1 and mek/erk inhibition
WO2018029336A1 (en)	2016-08-12	2018-02-15	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway.
CN108117523B (zh) *	2016-11-29	2021-05-07	上海医药工业研究院	卤代尿嘧啶类化合物的制备方法
CA3060390A1 (en)	2017-04-24	2018-11-01	Aurigene Discovery Technologies Limited	Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
US20180369206A1 (en)	2017-04-24	2018-12-27	Aurigene Discovery Technologies Limited	Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
CA3091792A1 (en)	2018-02-20	2019-08-29	Agios Pharmaceuticals, Inc.	Methods of use for trisubstituted benzotriazole derivatives
KR20230069126A (ko) *	2020-09-15	2023-05-18	미쓰비시 타나베 파마 코퍼레이션	트리아진 화합물의 염, 그 결정형 및 제조 방법
CN114456126A (zh) *	2022-02-26	2022-05-10	郑州萃智医药科技有限公司	一种化合物的合成方法
CN115677595B (zh) *	2022-10-26	2024-06-14	江苏睿实生物科技有限公司	一种2,4,5-三氯嘧啶的制备方法

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US6329380B1 (en)	1999-06-30	2001-12-11	Merck & Co., Inc.	SRC kinase inhibitor compounds
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2007
- 2007-08-30 KR KR1020097004741A patent/KR101177729B1/ko active Active
- 2007-08-30 AU AU2007293917A patent/AU2007293917B2/en active Active
- 2007-08-30 JP JP2009527118A patent/JP5325783B2/ja active Active
- 2007-08-30 WO PCT/EP2007/059040 patent/WO2008028860A1/en not_active Ceased
- 2007-08-30 CA CA2662998A patent/CA2662998C/en active Active
- 2007-08-30 ES ES07803049T patent/ES2378577T3/es active Active
- 2007-08-30 AT AT07803049T patent/ATE543498T1/de active
- 2007-08-30 EP EP07803049A patent/EP2066319B1/en active Active
- 2007-08-30 BR BRPI0717035A patent/BRPI0717035B8/pt active IP Right Grant
- 2007-08-30 MX MX2009002229A patent/MX2009002229A/es active IP Right Grant
- 2007-08-30 CN CN2007800334496A patent/CN101511359B/zh active Active
- 2007-09-05 TW TW096133095A patent/TW200819440A/zh unknown
- 2007-09-05 CL CL200702572A patent/CL2007002572A1/es unknown
- 2007-09-06 AR ARP070103923A patent/AR062666A1/es active IP Right Grant
- 2007-09-06 PE PE2007001197A patent/PE20080659A1/es active IP Right Grant
- 2007-09-07 US US11/899,758 patent/US8962622B2/en active Active
2009
- 2009-02-12 IL IL197015A patent/IL197015A/en active IP Right Grant

Also Published As

Publication number	Publication date
TW200819440A (en)	2008-05-01
JP2010502668A (ja)	2010-01-28
CN101511359B (zh)	2012-09-05
AU2007293917A1 (en)	2008-03-13
BRPI0717035B1 (pt)	2021-05-04
CN101511359A (zh)	2009-08-19
EP2066319A1 (en)	2009-06-10
IL197015A (en)	2013-12-31
KR101177729B1 (ko)	2012-09-07
AU2007293917B2 (en)	2013-01-31
US20080103142A1 (en)	2008-05-01
CA2662998C (en)	2015-10-06
KR20090040908A (ko)	2009-04-27
AR062666A1 (es)	2008-11-26
CL2007002572A1 (es)	2008-04-18
US8962622B2 (en)	2015-02-24
JP5325783B2 (ja)	2013-10-23
PE20080659A1 (es)	2008-05-17
CA2662998A1 (en)	2008-03-13
WO2008028860A1 (en)	2008-03-13
BRPI0717035B8 (pt)	2021-05-25
MX2009002229A (es)	2009-03-16
IL197015A0 (en)	2009-11-18
ES2378577T3 (es)	2012-04-16
ATE543498T1 (de)	2012-02-15
EP2066319B1 (en)	2012-02-01

Legal Events

Date	Code	Title	Description
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-02	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2020-04-28	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-05-05	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-11-17	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2021-02-23	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2021-05-04	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/08/2007, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/08/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

Publication	Publication Date	Title
ATE543498T1 (de)	2012-02-15	Benzotriazol kinasemodulatoren
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EP2089308A4 (en)	2014-08-06	DONOR
CR10841A (es)	2009-06-30	Imidazotriazinas imidazopirimidinas inhibidores de cinasa
BRPI0813653A2 (pt)	2014-12-30	Compostos de imidazotiazol moduladores de sirtuína
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DE602006020192D1 (de)	2011-03-31	Riemenscheibenanorndung
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DE602007000495D1 (de)	2009-03-12	Flüssigkeit-Koinfusionsgerät
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EP2041570A4 (en)	2010-02-24	CellSpotTM APPLICATIONS
DE602006019150D1 (de)	2011-02-03	Riemenscheibenanorndung
DE502007001652D1 (de)	2009-11-12	Notöltank
DE502007006319D1 (de)	2011-03-03	Staubabsaugadaptervorrichtung
DE602006016174D1 (de)	2010-09-23	Blisterverpackungsverfahren
BRPI0719956A2 (pt)	2014-04-29	Radiofluoração
FI20060178A0 (fi)	2006-02-23	Pinnoitusmenetelmä