BRPI0717363B8 - imunoglobina humanizada que liga especificamente cd20, composição, vetor recombinante, métodos para obter uma célula hospedeira, de produção de uma imunoglobina que liga especificamente cd20, in viro para inibir o crescimento ou diferenciação de uma célula b humana normal e usos de imunoglobina e de uma quantidade efetiva de imunoglobina - Google Patents

imunoglobina humanizada que liga especificamente cd20, composição, vetor recombinante, métodos para obter uma célula hospedeira, de produção de uma imunoglobina que liga especificamente cd20, in viro para inibir o crescimento ou diferenciação de uma célula b humana normal e usos de imunoglobina e de uma quantidade efetiva de imunoglobina

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Publication number
BRPI0717363B8
BRPI0717363B8 BRPI0717363A BRPI0717363A BRPI0717363B8 BR PI0717363 B8 BRPI0717363 B8 BR PI0717363B8 BR PI0717363 A BRPI0717363 A BR PI0717363A BR PI0717363 A BRPI0717363 A BR PI0717363A BR PI0717363 B8 BRPI0717363 B8 BR PI0717363B8
Authority
BR
Brazil
Prior art keywords
immunoglobulin
specifically binds
cell
methods
compositions
Prior art date
Application number
BRPI0717363A
Other languages
English (en)
Inventor
S Smith Ernest
L Jr Fisher Terrence
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of BRPI0717363A2 publication Critical patent/BRPI0717363A2/pt
Publication of BRPI0717363B1 publication Critical patent/BRPI0717363B1/pt
Publication of BRPI0717363B8 publication Critical patent/BRPI0717363B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/72—Increased effector function due to an Fc-modification
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
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Abstract

imunoglobulina que liga especificamente cd20, composição, poltnucleo-tídeo isolado, vetor, métodos para obter uma célula hospedeira, de pro-dução de uma imunoglobulina que liga especificamente cd20, para inibir o crescimento ou diferenciação de uma célula b humana normal, usos de imunoglobulina e de uma quantidade efetiva de imunoglobulina, e compo-sição farmacêutica. composições e métodos são fornecidos para o tratamento de doenças associadas à cd20, incluindo linfomas, doenças autoimunes, transplante e rejeições. composições incluem anticor-pos anti-cd20 capazes de se ligar a um antígeno cd20 humano localizado na superfície de uma célula humana expressando cd20, em que o anticorpo aumentou a citotoxicidade depen-dente de complemento mediada por células (cdc), que é alcançado por ter pelo menos uma cdr otimizada engendrada dentro da região variável do anticorpo. composições também in-cluem fragmentos ligadores de antígenos, variantes, e derivados dos anticorpos monoclonais, linhagens de células produtoras destas composições de anticorpos, e moléculas de ácido nu-cleico isoladas codificadoras das seqüências de aminoácidos dos anticorpos. a invenção tam-bém inclui composições farmacêuticas compreendendo os anticorpos anti-cd20 da invenção, ou fragmentos ligadores de antígenos, variantes, ou seus derivados, em transportadores farma-ceuticamente aceitáveis, e métodos de utilização desses anticorpos anti-cd20.
BRPI0717363A 2006-10-10 2007-10-10 imunoglobina humanizada que liga especificamente cd20, composição, vetor recombinante, métodos para obter uma célula hospedeira, de produção de uma imunoglobina que liga especificamente cd20, in viro para inibir o crescimento ou diferenciação de uma célula b humana normal e usos de imunoglobina e de uma quantidade efetiva de imunoglobina BRPI0717363B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US85060406P 2006-10-10 2006-10-10
US60/850,604 2006-10-10
US11/869,170 2007-10-09
US11/869,170 US9382327B2 (en) 2006-10-10 2007-10-09 Anti-CD20 antibodies and methods of use
PCT/US2007/080925 WO2008063771A2 (en) 2006-10-10 2007-10-10 Anti-cd20 antibodies and methods of use

Publications (3)

Publication Number Publication Date
BRPI0717363A2 BRPI0717363A2 (pt) 2013-10-22
BRPI0717363B1 BRPI0717363B1 (pt) 2019-05-21
BRPI0717363B8 true BRPI0717363B8 (pt) 2021-05-25

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BRPI0717363A BRPI0717363B8 (pt) 2006-10-10 2007-10-10 imunoglobina humanizada que liga especificamente cd20, composição, vetor recombinante, métodos para obter uma célula hospedeira, de produção de uma imunoglobina que liga especificamente cd20, in viro para inibir o crescimento ou diferenciação de uma célula b humana normal e usos de imunoglobina e de uma quantidade efetiva de imunoglobina

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US (2) US9382327B2 (pt)
EP (1) EP2084189B1 (pt)
JP (1) JP5129818B2 (pt)
KR (2) KR101197542B1 (pt)
CN (1) CN101583626B (pt)
AU (1) AU2007324130B2 (pt)
BR (1) BRPI0717363B8 (pt)
CA (1) CA2665728C (pt)
DK (1) DK2084189T3 (pt)
ES (1) ES2632390T3 (pt)
IL (1) IL198020A (pt)
MX (1) MX2009003838A (pt)
NZ (1) NZ576081A (pt)
PT (1) PT2084189T (pt)
WO (1) WO2008063771A2 (pt)

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