BRPI0720178B8 - derivados de 2,3-di-hidroimidazo[1,2-c]quinazolina substituída úteis para tratar distúrbios e doenças hiperproliferativos associados com angiogênese, e composições farmacêuticas - Google Patents

derivados de 2,3-di-hidroimidazo[1,2-c]quinazolina substituída úteis para tratar distúrbios e doenças hiperproliferativos associados com angiogênese, e composições farmacêuticas

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Publication number
BRPI0720178B8
BRPI0720178B8 BRPI0720178A BRPI0720178A BRPI0720178B8 BR PI0720178 B8 BRPI0720178 B8 BR PI0720178B8 BR PI0720178 A BRPI0720178 A BR PI0720178A BR PI0720178 A BRPI0720178 A BR PI0720178A BR PI0720178 B8 BRPI0720178 B8 BR PI0720178B8
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BR
Brazil
Prior art keywords
dihydroimidazo
angiogenesis
diseases associated
substituted
pharmaceutical compositions
Prior art date
Application number
BRPI0720178A
Other languages
English (en)
Inventor
Redman Aniko
Bullion Ann-Marie
Campbell Ann-Marie
Wood Jill
Hentemann Martin
Michels Martin
Bruce Rowley R
Scott William
Original Assignee
Bayer Ip Gmbh
Bayer Pharma AG
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39492563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0720178(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh, Bayer Pharma AG, Bayer Schering Pharma Ag filed Critical Bayer Ip Gmbh
Publication of BRPI0720178A2 publication Critical patent/BRPI0720178A2/pt
Publication of BRPI0720178B1 publication Critical patent/BRPI0720178B1/pt
Publication of BRPI0720178B8 publication Critical patent/BRPI0720178B8/pt

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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Abstract

derivados de 2,3-di-hidroimidazo[1,2-c]quinazolina substituída úteis para tratar distúrbios e doenças hiperproliferativos associados com angiogênese. esta invenção refere-se a novos compostos de 2,3-di-hidroimidazo[1,2-c]quinazolina, composições farmacêuticas contendo tais compostos e ao uso daqueles compostos ou composições para inibição da fosfotidilino- sitol-3-cinase (pi3k) e tratar doenças associadas à atividade de fosfotidilino-sitol-3-cinase (pi3k), em particular tratar distúrbios hiperproliferativos e/ou de angiogênese, como um agente exclusivo ou em combinação com outros ingredientes ativos.
BRPI0720178A 2006-12-05 2007-12-05 derivados de 2,3-di-hidroimidazo[1,2-c]quinazolina substituída úteis para tratar distúrbios e doenças hiperproliferativos associados com angiogênese, e composições farmacêuticas BRPI0720178B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87309006P 2006-12-05 2006-12-05
US60/873,090 2006-12-05
PCT/US2007/024985 WO2008070150A1 (en) 2006-12-05 2007-12-05 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

Publications (3)

Publication Number Publication Date
BRPI0720178A2 BRPI0720178A2 (pt) 2013-12-24
BRPI0720178B1 BRPI0720178B1 (pt) 2019-04-09
BRPI0720178B8 true BRPI0720178B8 (pt) 2021-05-25

Family

ID=39492563

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BRPI0720178A BRPI0720178B8 (pt) 2006-12-05 2007-12-05 derivados de 2,3-di-hidroimidazo[1,2-c]quinazolina substituída úteis para tratar distúrbios e doenças hiperproliferativos associados com angiogênese, e composições farmacêuticas

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AR (1) AR064106A1 (pt)
AU (1) AU2007328008B2 (pt)
BR (1) BRPI0720178B8 (pt)
CA (1) CA2671614C (pt)
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