NO20092529L - Substituerte 2,3-dihydroimidazo[1,2-c]kinazolinderivater som er anvendbare for behandling av hyperproliferative forstyrrelser og sykdommer assosiert med angiogenese - Google Patents

Substituerte 2,3-dihydroimidazo[1,2-c]kinazolinderivater som er anvendbare for behandling av hyperproliferative forstyrrelser og sykdommer assosiert med angiogenese

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Publication number
NO20092529L
NO20092529L NO20092529A NO20092529A NO20092529L NO 20092529 L NO20092529 L NO 20092529L NO 20092529 A NO20092529 A NO 20092529A NO 20092529 A NO20092529 A NO 20092529A NO 20092529 L NO20092529 L NO 20092529L
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Norway
Prior art keywords
treatment
dihydroimidazo
angiogenesis
diseases associated
substituted
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NO20092529A
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English (en)
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NO342348B1 (no
Inventor
Martin Michels
Martin Hentemann
Jill Wood
William Scott
Ann-Marie Campbell
Ann-Marie Bullion
R Bruce Rowley
Aniko Redman
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Bayer Ip Gmbh
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Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of NO20092529L publication Critical patent/NO20092529L/no
Publication of NO342348B1 publication Critical patent/NO342348B1/no

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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Abstract

Foreliggende oppfinnelse gjelder nye 2,3-dihydroimidazo-[1,2-c] kinazolinforbindelser, farmasøytiske preparater som inneholder slike forbindelser og anvendelse av forbindelsene eller preparatene for inhibering av fosfatidylinositol-3-kinase (PI3K) og behandling av sykdommer som er forbundet med fosfatidylinositol-3-kinase (PI3K) -aktivitet, fortrinnsvis behandling av hyperproliferative forstyrrelser og/eller angiogeneseforstyrrelser, som eneste middel eller i kombinasjon med andre aktive bestanddeler.
NO20092529A 2006-12-05 2009-07-03 Substituerte 2,3-dihydroimidazo[1,2-c]kinazolinderivater, og anvendelse derav ved behandling av hyper-proliferative og/eller angiogeneseforstyrrelser, samt farmasøytise sammensetninger derav NO342348B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87309006P 2006-12-05 2006-12-05
PCT/US2007/024985 WO2008070150A1 (en) 2006-12-05 2007-12-05 Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

Publications (2)

Publication Number Publication Date
NO20092529L true NO20092529L (no) 2009-08-27
NO342348B1 NO342348B1 (no) 2018-05-07

Family

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NO20092529A NO342348B1 (no) 2006-12-05 2009-07-03 Substituerte 2,3-dihydroimidazo[1,2-c]kinazolinderivater, og anvendelse derav ved behandling av hyper-proliferative og/eller angiogeneseforstyrrelser, samt farmasøytise sammensetninger derav

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US (3) US8466283B2 (no)
EP (1) EP2096919B1 (no)
JP (1) JP5326092B2 (no)
KR (1) KR101501785B1 (no)
CN (4) CN108774232B (no)
AR (1) AR064106A1 (no)
AU (1) AU2007328008B2 (no)
BR (1) BRPI0720178B8 (no)
CA (1) CA2671614C (no)
CL (1) CL2007003508A1 (no)
CO (1) CO6220908A2 (no)
CR (1) CR10838A (no)
CU (1) CU23796B7 (no)
DK (1) DK2096919T3 (no)
DO (1) DOP2009000135A (no)
EA (1) EA018839B1 (no)
EC (1) ECSP099387A (no)
ES (1) ES2572189T3 (no)
GT (1) GT200900154A (no)
HN (1) HN2009001131A (no)
HU (1) HUE028773T2 (no)
IL (1) IL198273A (no)
JO (1) JO3147B1 (no)
MA (1) MA31283B1 (no)
MX (1) MX2009006001A (no)
MY (1) MY157944A (no)
NO (1) NO342348B1 (no)
NZ (1) NZ577342A (no)
PA (1) PA8759601A1 (no)
PE (1) PE20081444A1 (no)
PL (1) PL2096919T3 (no)
RS (1) RS56045B1 (no)
SG (1) SG177170A1 (no)
SI (1) SI2096919T1 (no)
SV (1) SV2009003288A (no)
TN (1) TN2009000137A1 (no)
TW (1) TWI406662B (no)
UA (1) UA96965C2 (no)
UY (1) UY30761A1 (no)
WO (1) WO2008070150A1 (no)
ZA (1) ZA200904691B (no)

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JO3733B1 (ar) 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
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EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP6427097B2 (ja) 2012-06-15 2018-11-21 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． 癌を処置するための組成物および該組成物を製造するための方法
WO2014068070A1 (en) 2012-10-31 2014-05-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preventing antiphospholipid syndrome (aps)
KR102185175B1 (ko) * 2012-11-02 2020-12-02 티지 쎄라퓨틱스, 인코포레이티드 항cd20 항체와 pi3 키나아제 선택적 억제제의 조합물
CN103214489B (zh) * 2013-02-25 2016-10-26 中国人民解放军第二军医大学 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法
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CN104557955B (zh) * 2013-10-23 2017-05-03 上海汇伦生命科技有限公司 作为PI3K/mTOR抑制剂的三环类化合物，其制备方法和用途
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