BRPI0721136A8 - conjugado imunogênico, polissacarídeos de streptococcus pneumoniae sorotipo 1, composição imunogênica multivalente e seus métodos de produção - Google Patents
conjugado imunogênico, polissacarídeos de streptococcus pneumoniae sorotipo 1, composição imunogênica multivalente e seus métodos de produçãoInfo
- Publication number
- BRPI0721136A8 BRPI0721136A8 BRPI0721136A BRPI0721136A BRPI0721136A8 BR PI0721136 A8 BRPI0721136 A8 BR PI0721136A8 BR PI0721136 A BRPI0721136 A BR PI0721136A BR PI0721136 A BRPI0721136 A BR PI0721136A BR PI0721136 A8 BRPI0721136 A8 BR PI0721136A8
- Authority
- BR
- Brazil
- Prior art keywords
- streptococcus pneumoniae
- immunogenic composition
- polysaccharides
- pneumoniae serotype
- production methods
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 title abstract 6
- 241000193998 Streptococcus pneumoniae Species 0.000 title abstract 4
- 229940031000 streptococcus pneumoniae Drugs 0.000 title abstract 4
- 150000004676 glycans Chemical class 0.000 title abstract 3
- 229920001282 polysaccharide Polymers 0.000 title abstract 3
- 239000005017 polysaccharide Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 208000035109 Pneumococcal Infections Diseases 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
Abstract
conjugado imunogênico, polissacarídeos de streptococcus pneumoniae sorotipo 1, composição imunogênica mul tivalente e seus métodos de produção". é descrita uma composição imunogênica tendo 13 conjugados de polissacarídeo-proteína distintos e opcionalmente, um adjuvante à base de alumínio. cada conjugado contém um polissacarídeo capsular preparado a partir de um sorotipo diferente de streptococcus pneumoniae (1, 3, 4, 5, 6a, 68, 7f, 9v, 14, 18c, 19a, 19f e 23f) conjugado a uma proteína de veículo. a composição imunogênica, formulada como uma vacina, aumenta a cobertura contra doença pneumocócica em bebês e crianças pequenas globalmente, e e proporciona cobertura para os sorotipos 6a e 19a que não é dependente das limitações limitações de proteção cruzada do sorogrupo. também é descrito um método para produzir um conjugado imunogênico compreendendo polissacarídeo de streptococcus pneumoniae sorotipo 1 encadeado de modo covalente a uma proteína de veículo, o método incluindo de-0-acetilação parcial do polissacarídeo por hidrólise branda em um tampão de ph alcalino.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/644,207 US20070184072A1 (en) | 2005-04-08 | 2006-12-22 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US11/644,207 | 2006-12-22 | ||
| PCT/US2007/086976 WO2008079653A1 (en) | 2006-12-22 | 2007-12-10 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0721136A2 BRPI0721136A2 (pt) | 2014-04-01 |
| BRPI0721136A8 true BRPI0721136A8 (pt) | 2019-01-29 |
| BRPI0721136B1 BRPI0721136B1 (pt) | 2019-06-18 |
| BRPI0721136B8 BRPI0721136B8 (pt) | 2021-05-25 |
Family
ID=39386416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0721136A BRPI0721136B8 (pt) | 2006-12-22 | 2007-12-10 | método para produzir um conjugado imunogênico que compreende polissacarídeo de streptococcus pneumoniae sorotipo 1 encadeado de modo covalente a uma proteína de veículo |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20070184072A1 (pt) |
| EP (1) | EP2094304B1 (pt) |
| JP (2) | JP5815207B2 (pt) |
| KR (3) | KR20140130564A (pt) |
| CN (2) | CN101610788A (pt) |
| AU (1) | AU2007337214B9 (pt) |
| BR (1) | BRPI0721136B8 (pt) |
| CA (1) | CA2673558C (pt) |
| CL (1) | CL2007003781A1 (pt) |
| DK (1) | DK2094304T3 (pt) |
| ES (1) | ES2559060T3 (pt) |
| HK (1) | HK1215189A1 (pt) |
| HU (1) | HUE028421T2 (pt) |
| IL (1) | IL199324A (pt) |
| MX (1) | MX336934B (pt) |
| PL (1) | PL2094304T3 (pt) |
| PT (1) | PT2094304E (pt) |
| RU (1) | RU2484846C2 (pt) |
| SG (1) | SG177174A1 (pt) |
| SI (1) | SI2094304T1 (pt) |
| WO (1) | WO2008079653A1 (pt) |
| ZA (1) | ZA200904619B (pt) |
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|---|---|---|---|---|
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| KR102564388B1 (ko) | 2005-04-08 | 2023-08-08 | 와이어쓰 엘엘씨 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| AR056396A1 (es) | 2005-06-27 | 2007-10-10 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
| GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
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| TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
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