BRPI0809208A2 - ácidos poliglutâmicos funcionalizados por grupos catiônicos e grupos hidrofóbios e aplicações dos mesmos, em particular, aplicações terapêuticas dos mesmos. - Google Patents
ácidos poliglutâmicos funcionalizados por grupos catiônicos e grupos hidrofóbios e aplicações dos mesmos, em particular, aplicações terapêuticas dos mesmos.Info
- Publication number
- BRPI0809208A2 BRPI0809208A2 BRPI0809208A BRPI0809208A BRPI0809208A2 BR PI0809208 A2 BRPI0809208 A2 BR PI0809208A2 BR PI0809208 A BRPI0809208 A BR PI0809208A BR PI0809208 A BRPI0809208 A BR PI0809208A BR PI0809208 A2 BRPI0809208 A2 BR PI0809208A2
- Authority
- BR
- Brazil
- Prior art keywords
- applications
- groups
- polyglutamic acids
- acids functionalized
- therapeutic applications
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/48—Polymers modified by chemical after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Polyamides (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0703185A FR2915748B1 (fr) | 2007-05-03 | 2007-05-03 | Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques |
| PCT/EP2008/055507 WO2008135563A1 (fr) | 2007-05-03 | 2008-05-05 | Acides polyglutamiques fonctionnalises par des groupements cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0809208A2 true BRPI0809208A2 (pt) | 2016-11-16 |
Family
ID=38792517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0809208A BRPI0809208A2 (pt) | 2007-05-03 | 2008-05-05 | ácidos poliglutâmicos funcionalizados por grupos catiônicos e grupos hidrofóbios e aplicações dos mesmos, em particular, aplicações terapêuticas dos mesmos. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8716217B2 (pt) |
| EP (1) | EP2152782A1 (pt) |
| JP (1) | JP2010529214A (pt) |
| KR (1) | KR20100016280A (pt) |
| CN (1) | CN101663346B (pt) |
| AU (1) | AU2008248604B2 (pt) |
| BR (1) | BRPI0809208A2 (pt) |
| CA (1) | CA2683741A1 (pt) |
| EA (1) | EA016911B1 (pt) |
| FR (1) | FR2915748B1 (pt) |
| IL (1) | IL201017A (pt) |
| MX (1) | MX2009011813A (pt) |
| NZ (1) | NZ580906A (pt) |
| WO (1) | WO2008135563A1 (pt) |
| ZA (1) | ZA200906941B (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2822834B1 (fr) | 2001-04-02 | 2005-02-25 | Flamel Tech Sa | Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation |
| FR2840614B1 (fr) * | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
| FR2843117B1 (fr) | 2002-07-30 | 2004-10-15 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques |
| FR2860516B1 (fr) * | 2003-10-03 | 2006-01-13 | Flamel Tech Sa | Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
| FR2862536B1 (fr) | 2003-11-21 | 2007-11-23 | Flamel Tech Sa | Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques |
| FR2915684B1 (fr) | 2007-05-03 | 2011-01-14 | Flamel Tech Sa | Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules |
| FR2915683B1 (fr) | 2007-05-03 | 2009-08-07 | Flamel Technologies Sa | Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif |
| GB0814519D0 (en) * | 2008-08-08 | 2008-09-17 | Imp Innovations Ltd | Process |
| GB0820865D0 (en) * | 2008-11-14 | 2008-12-24 | Membrane Extraction Tech Ltd | Degradable supports for tide synthesis |
| FR2940619B1 (fr) | 2008-12-31 | 2012-02-10 | Flamel Technologies Sa | Composition comprenant un actif de solubilite aqueuse faible ou moyenne |
| US20110256227A1 (en) * | 2010-04-14 | 2011-10-20 | Intezyne Technologies, Inc. | Controlled polyplex assembly |
| JP2013234207A (ja) * | 2010-08-31 | 2013-11-21 | Jsr Corp | 新規重合体及び新規ｎ−カルボキシアミノ酸無水物、ならびにそれらの製造方法 |
| US20120093762A1 (en) * | 2010-10-14 | 2012-04-19 | Nitto Denko Corporation | Nucleic acid delivery compounds |
| FR2968994B1 (fr) | 2010-12-17 | 2012-12-28 | Flamel Tech Sa | Procede de preparation de nanoparticules |
| FR2968993B1 (fr) | 2010-12-17 | 2012-12-28 | Flamel Tech Sa | Nanoparticules comportant au moins un actif et au moins deux polyelectrolytes |
| WO2012159945A1 (en) * | 2011-05-20 | 2012-11-29 | Ares Trading S.A. | Ifn-beta compositions, preparation methods and uses thereof |
| FR2975912B1 (fr) | 2011-05-30 | 2013-06-14 | Flamel Tech Sa | Composition a liberation controlee de buprenorphine |
| EP2554161A1 (en) * | 2011-08-02 | 2013-02-06 | LFB Biotechnologies | Pharmaceutical composition comprising factor VII encapsulated in micelles |
| CN102698279B (zh) * | 2012-07-03 | 2013-12-04 | 南京医科大学 | 一种两亲性γ-聚谷氨酸纳米药物载体的制备方法 |
| US9999633B2 (en) | 2013-04-09 | 2018-06-19 | International Business Machines Corporation | Antimicrobial cationic polycarbonates |
| US9357772B2 (en) | 2013-04-09 | 2016-06-07 | International Business Machines Corporation | Antimicrobial cationic polycarbonates |
| WO2014169153A1 (en) * | 2013-04-10 | 2014-10-16 | Echogen, Inc. | Peptide complexes and therapeutic uses |
| KR101507119B1 (ko) * | 2013-05-31 | 2015-03-30 | 주식회사 바이오리더스 | 점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체 |
| CN103590133B (zh) * | 2013-10-11 | 2015-09-16 | 华东理工大学 | 一种利用静电纺丝制备聚肽共聚物多孔纳米纤维的方法 |
| WO2015133449A1 (ja) * | 2014-03-07 | 2015-09-11 | 日本化薬株式会社 | 核酸送達のための組成物 |
| WO2015146731A1 (ja) * | 2014-03-26 | 2015-10-01 | 日本化薬株式会社 | 核酸送達用組成物及び核酸含有医薬組成物 |
| CN111698999A (zh) * | 2017-12-06 | 2020-09-22 | 阿道恰公司 | 包含至少一种pi在5.8与8.5之间的基础胰岛素和带有羧酸根电荷及疏水基的共聚氨基酸的ph为7的可注射溶液 |
| CN111683674A (zh) * | 2017-12-07 | 2020-09-18 | 阿道恰公司 | 包含胰淀素、胰淀素激动剂受体或胰淀素类似物和共聚氨基酸的可注射水溶液形式的组合物 |
| CN108465104A (zh) * | 2018-03-07 | 2018-08-31 | 佛山实瑞先导材料研究院（普通合伙） | 一种生长激素控释包衣及其制备方法 |
| JP7568511B2 (ja) | 2018-04-27 | 2024-10-16 | ジーンエディット インコーポレイテッド | カチオン性ポリマーおよびその生体分子送達のための使用 |
| WO2020067142A1 (en) | 2018-09-25 | 2020-04-02 | The University Of Tokyo | Amphiphilic poly(amino acid), block copolymer using the amphiphilic poly(amino acid), and complex including the amphiphilic poly(amino acid) or the block copolymer and nucleic acid |
| CN110903410B (zh) * | 2019-12-05 | 2021-07-23 | 南京大学 | 聚阳离子型多糖及其应用 |
| CN111804151B (zh) * | 2020-07-27 | 2021-08-27 | 上海恩捷新材料科技有限公司 | 一种用于生活污水处理的mbr平板滤膜及其制备方法 |
| CN115975185B (zh) * | 2022-12-15 | 2024-07-26 | 广州微冠生物科技有限公司 | 一种含多肽的可溶性微针贴及其制备方法 |
| CN119081105A (zh) * | 2024-11-01 | 2024-12-06 | 浙江大学长三角智慧绿洲创新中心 | 一种聚谷氨酸-维生素e两亲性偶联物及其制备方法和应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4351337A (en) | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| DE3581471D1 (de) | 1984-10-19 | 1991-02-28 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
| KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
| US6153193A (en) | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
| FR2732218B1 (fr) | 1995-03-28 | 1997-08-01 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation |
| US6686446B2 (en) * | 1998-03-19 | 2004-02-03 | The Regents Of The University Of California | Methods and compositions for controlled polypeptide synthesis |
| EP0963758A3 (en) | 1998-05-07 | 2000-03-22 | Universiteit Gent | Synthetic polyaminoacid complexes for delivery of nucleic acids to target cells |
| GB9811059D0 (en) | 1998-05-23 | 1998-07-22 | Univ Strathclyde | Polyamino acid vesicles |
| FR2786098B1 (fr) | 1998-11-20 | 2003-05-30 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication |
| FR2801226B1 (fr) | 1999-11-23 | 2002-01-25 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation |
| JP2002069177A (ja) * | 2000-06-12 | 2002-03-08 | Mitsui Chemicals Inc | 重合体及びその製造方法 |
| JP4585114B2 (ja) * | 2000-12-27 | 2010-11-24 | 三井化学株式会社 | 重合体及びその製造方法 |
| FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
| FR2843117B1 (fr) * | 2002-07-30 | 2004-10-15 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques |
| DE60321816D1 (de) | 2002-12-04 | 2008-08-07 | Flamel Tech Sa | Polyaminosäuren, funktionalisiert durch mindestens eine (oligo-)aminosäure und ihre, insbesondere therapeutische, anwendung |
| FR2855521B1 (fr) | 2003-05-28 | 2005-08-05 | Flamel Tech Sa | Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques. |
| FR2873703B1 (fr) * | 2004-07-30 | 2006-12-08 | Flamel Technologies Sa | Polyaminoacides branches, fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques |
| JP4735933B2 (ja) | 2004-09-03 | 2011-07-27 | 独立行政法人産業技術総合研究所 | ｐＨ応答性両性イオン微粒子状ポリマー及びその用途 |
| FR2892725B1 (fr) * | 2005-10-31 | 2011-03-04 | Flamel Tech Sa | Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques |
| DE602006007177D1 (de) * | 2005-12-05 | 2009-07-16 | Nitto Denko Corp | Polyglutamat-aminosäure-konjugate und verfahren |
| JP2009007547A (ja) * | 2007-05-25 | 2009-01-15 | Tokyo Metropolitan Univ | 核酸キャリア及び核酸デリバリー方法 |
-
2007
- 2007-05-03 FR FR0703185A patent/FR2915748B1/fr not_active Expired - Fee Related
-
2008
- 2008-05-05 US US12/149,542 patent/US8716217B2/en not_active Expired - Fee Related
- 2008-05-05 CN CN2008800125724A patent/CN101663346B/zh not_active Expired - Fee Related
- 2008-05-05 EP EP08750064A patent/EP2152782A1/fr not_active Withdrawn
- 2008-05-05 WO PCT/EP2008/055507 patent/WO2008135563A1/fr not_active Ceased
- 2008-05-05 CA CA002683741A patent/CA2683741A1/fr not_active Abandoned
- 2008-05-05 AU AU2008248604A patent/AU2008248604B2/en not_active Ceased
- 2008-05-05 KR KR1020097023191A patent/KR20100016280A/ko not_active Abandoned
- 2008-05-05 MX MX2009011813A patent/MX2009011813A/es active IP Right Grant
- 2008-05-05 BR BRPI0809208A patent/BRPI0809208A2/pt not_active IP Right Cessation
- 2008-05-05 EA EA200901481A patent/EA016911B1/ru not_active IP Right Cessation
- 2008-05-05 JP JP2010504757A patent/JP2010529214A/ja active Pending
- 2008-05-05 NZ NZ580906A patent/NZ580906A/en not_active IP Right Cessation
-
2009
- 2009-09-17 IL IL201017A patent/IL201017A/en not_active IP Right Cessation
- 2009-10-06 ZA ZA2009/06941A patent/ZA200906941B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101663346A (zh) | 2010-03-03 |
| FR2915748A1 (fr) | 2008-11-07 |
| FR2915748B1 (fr) | 2012-10-19 |
| KR20100016280A (ko) | 2010-02-12 |
| WO2008135563A1 (fr) | 2008-11-13 |
| US20090012028A1 (en) | 2009-01-08 |
| AU2008248604B2 (en) | 2012-11-08 |
| NZ580906A (en) | 2011-07-29 |
| EP2152782A1 (fr) | 2010-02-17 |
| US8716217B2 (en) | 2014-05-06 |
| EA200901481A1 (ru) | 2010-04-30 |
| CN101663346B (zh) | 2012-03-21 |
| IL201017A0 (en) | 2010-05-17 |
| JP2010529214A (ja) | 2010-08-26 |
| EA016911B1 (ru) | 2012-08-30 |
| CA2683741A1 (fr) | 2008-11-13 |
| IL201017A (en) | 2013-03-24 |
| ZA200906941B (en) | 2010-12-29 |
| AU2008248604A1 (en) | 2008-11-13 |
| MX2009011813A (es) | 2009-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |