BRPI0809600A2 - vírus atenuado útil para vacinas - Google Patents

vírus atenuado útil para vacinas

Info

Publication number
BRPI0809600A2
BRPI0809600A2 BRPI0809600A BRPI0809600A BRPI0809600A2 BR PI0809600 A2 BRPI0809600 A2 BR PI0809600A2 BR PI0809600 A BRPI0809600 A BR PI0809600A BR PI0809600 A BRPI0809600 A BR PI0809600A BR PI0809600 A2 BRPI0809600 A2 BR PI0809600A2
Authority
BR
Brazil
Prior art keywords
vaccines
attenuated virus
virus useful
useful
attenuated
Prior art date
Application number
BRPI0809600A
Other languages
English (en)
Inventor
Coleman John Robert
Futcher Bruce
Mueller Steffen
Papamichail Dimitris
Skiena Steve
Wimmer Eckhard
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39808891&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0809600(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Publication of BRPI0809600A2 publication Critical patent/BRPI0809600A2/pt
Publication of BRPI0809600B1 publication Critical patent/BRPI0809600B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/13—Poliovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12361—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16162—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32621—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32661—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32661—Methods of inactivation or attenuation
    • C12N2770/32662—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32671—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32711—Rhinovirus
    • C12N2770/32721—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32711—Rhinovirus
    • C12N2770/32761—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32711—Rhinovirus
    • C12N2770/32761—Methods of inactivation or attenuation
    • C12N2770/32762—Methods of inactivation or attenuation by genetic engineering
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BRPI0809600-7A 2007-03-30 2008-03-31 Vírus atenuado útil para vacinas BRPI0809600B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US90938907P 2007-03-30 2007-03-30
US60/909,389 2007-03-30
US6866608P 2008-03-07 2008-03-07
US61/068,666 2008-03-07
PCT/US2008/058952 WO2008121992A2 (en) 2007-03-30 2008-03-31 Attenuated viruses useful for vaccines

Publications (2)

Publication Number Publication Date
BRPI0809600A2 true BRPI0809600A2 (pt) 2016-07-12
BRPI0809600B1 BRPI0809600B1 (pt) 2023-01-24

Family

ID=39808891

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809600-7A BRPI0809600B1 (pt) 2007-03-30 2008-03-31 Vírus atenuado útil para vacinas

Country Status (13)

Country Link
US (5) US9476032B2 (pt)
EP (3) EP4368202A3 (pt)
JP (2) JP5733976B2 (pt)
KR (1) KR101621100B1 (pt)
CN (1) CN103476425B (pt)
AU (1) AU2008232491B2 (pt)
BR (1) BRPI0809600B1 (pt)
CA (1) CA2682089C (pt)
DK (1) DK2139515T4 (pt)
HR (1) HRP20181319T4 (pt)
MX (2) MX349825B (pt)
PL (1) PL2139515T5 (pt)
WO (1) WO2008121992A2 (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9476032B2 (en) 2007-03-30 2016-10-25 The Research Foundation For The State University Of New York Attenuated viruses useful for vaccines
US9052321B2 (en) * 2008-10-03 2015-06-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Flavivirus-based system for production of hepatitis C virus (HCV)
EP2391713A1 (en) 2009-01-30 2011-12-07 The Board Of Regents For Oklahoma State University Immunogenic compositions, vaccines and diagnostics based on canine distemper viruses circulating in north american dogs
CA2754826A1 (en) * 2009-03-06 2010-09-10 Mount Sinai School Of Medicine Live attenuated influenza virus vaccines comprising microrna response elements
TW201125984A (en) * 2009-10-09 2011-08-01 Univ New York State Res Found Attenuated influenza viruses and vaccines
EP2490268A1 (en) * 2011-02-03 2012-08-22 Imec Method for fabricating photovoltaic cells
EP2751260A2 (en) * 2011-09-02 2014-07-09 Westfälische Wilhelms-Universität Münster Live attenuated influenza virus
US20140356962A1 (en) * 2011-12-16 2014-12-04 The Research Foundation For The State University Of New York Novel attenuated poliovirus: pv-1 mono-cre-x
US20140363469A1 (en) * 2012-01-19 2014-12-11 Alnylam Pharmaceuticals, Inc. Viral attenuation and vaccine production
HRP20230694T1 (hr) * 2013-02-08 2023-10-13 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Smanjenje ljudskog respiratornog sincicijskog virusa prema ljestvici genoma deoptimizacijom kodon-para
CN113322264B (zh) * 2013-03-14 2024-05-31 爱默蕾大学 具有沉默突变的重组rsv、其相关疫苗和方法
EP3653701A1 (en) 2013-03-15 2020-05-20 The Research Foundation for The State University of New York Attenuated influenza viruses and vaccines
CN104056276B (zh) * 2013-03-20 2017-05-10 上海生物制品研究所有限责任公司 一种流感病毒减毒活疫苗及其制备方法
CN104419687B (zh) * 2013-09-03 2017-03-15 中国农业大学 重组PRRS病毒HV‑nsp29及其应用
WO2016037187A1 (en) * 2014-09-05 2016-03-10 The Research Foundation For The State University Of New York Recoded arbovirus and vaccines
WO2017099801A1 (en) * 2015-12-11 2017-06-15 The Trustees Of The University Of Pennsylvania Compositions, kits, and methods to detect hiv virus
US10731227B2 (en) 2014-12-12 2020-08-04 The Trustees Of The University Of Pennsylvania Compositions, kits, and methods to detect HIV virus
EP3050962A1 (en) * 2015-01-28 2016-08-03 Institut Pasteur RNA virus attenuation by alteration of mutational robustness and sequence space
CN107949636B (zh) * 2015-06-04 2021-11-09 香港大学 活减毒病毒以及生产和使用方法
WO2017056094A1 (en) 2015-09-30 2017-04-06 Ramot At Tel-Aviv University Ltd. Attenuated virus mutated at sites of evolutionarily conserved rna structure
MX2018005462A (es) 2015-10-29 2018-08-01 Univ Emory Composiciones inmunogénicas de rsv quimérico y métodos de uso.
CN105821009B (zh) * 2016-04-05 2019-07-26 中国人民解放军第三〇二医院 靶向肝癌溶瘤流感病毒的构建及其应用
WO2017218727A1 (en) 2016-06-15 2017-12-21 President And Fellows Of Harvard College Methods for rule-based genome design
US10809266B2 (en) * 2016-07-22 2020-10-20 Verily Life Sciences Llc Quantitative massively parallel proteomics
US11149255B2 (en) * 2016-09-06 2021-10-19 Bioventures, Llc Compositions and methods for generating reversion free attenuated and/or replication incompetent vaccine vectors
CN106650307B (zh) * 2016-09-21 2019-04-05 武汉伯远生物科技有限公司 一种基于密码子对使用频度的基因密码子优化方法
JP7198759B2 (ja) 2016-09-23 2023-01-04 ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンテッド・バイ・ザ・セクレタリー・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシーズ 弱毒化表現型を有するヒト呼吸器多核体ウイルス（ｒｓｖ）のためのワクチン候補
CN106520832B (zh) * 2016-11-17 2020-02-18 新乡医学院 双顺反子表达载体、表达系统、制备方法及应用
JP2020502080A (ja) * 2016-11-30 2020-01-23 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 弱毒ブタインフルエンザワクチン並びにその作製および使用方法
AR111770A1 (es) 2017-05-05 2019-08-21 Elanco Us Inc Vacuna para enfermedad respiratoria bovina
EP3655536A1 (en) 2017-07-17 2020-05-27 GlaxoSmithKline Biologicals SA Lyssavirus antigen constructs
US12178869B2 (en) 2017-12-22 2024-12-31 Codagenix Inc. Recombinant virus with codon-pair deoptimized region and uses thereof for the treatment of cancer
RU2020132280A (ru) 2018-03-08 2022-04-11 Кодадженикс Инк. Аттенуированные флавивирусы
CN108586608A (zh) * 2018-04-13 2018-09-28 四川农业大学 一种dhav-1 2c蛋白多克隆抗体、重组融合蛋白及其制备方法
US11039856B2 (en) 2018-05-10 2021-06-22 Verily Life Sciences Llc Surgical laparoscopic ports for implanting medical systems
CN109504662B (zh) * 2018-11-09 2022-06-10 浙江天元生物药业有限公司 一种柯萨奇病毒减毒株及其应用
CN113194988A (zh) 2018-12-14 2021-07-30 葛兰素史密斯克莱生物公司 异源初次免疫加强疫苗组合物及方法
WO2020167813A1 (en) 2019-02-11 2020-08-20 Emory University Chimeric rsv and hmpv f proteins, immunogenic compositions, and methods of use
CN114040979B (zh) * 2019-06-21 2024-06-28 国立大学法人大阪大学 稳定地保持外源基因的人工重组rna病毒的制作方法
CN114302738A (zh) 2019-06-25 2022-04-08 科达金尼克斯有限公司 减毒登革病毒
IL295112A (en) * 2020-01-28 2022-09-01 Codagenix Inc Sars-cov-2 polynucleotides and viruses that are deoptimized and uses thereof
CN111321125B (zh) * 2020-02-03 2022-07-19 广州医科大学 重组流感病毒及其在疫苗中的应用
CN111269895B (zh) * 2020-02-03 2022-09-27 广州医科大学 甲型流感病毒减毒株及其作为骨架病毒和疫苗的应用
WO2021191342A1 (de) * 2020-03-27 2021-09-30 Reinmueller Johannes Virustatisches mittel
CN111481663B (zh) * 2020-04-09 2022-12-09 广州医科大学 一种流感病毒活疫苗及其制备方法
EP4138906A4 (en) 2020-04-20 2024-10-30 Tran, Lloyd Hung Loi METHODS FOR THE PROPHYLAXIS AND TREATMENT OF COVID AND COVID-19
WO2021216743A2 (en) * 2020-04-21 2021-10-28 Emory University Coronavirus vaccines, compositions, and methods related thereto
AU2021282245A1 (en) * 2020-05-27 2023-01-19 Codagenix Inc. Live attenuated strains of foot and mouth disease modified by deoptimization and uses thereof
CN116249708A (zh) * 2020-05-27 2023-06-09 美国农业部 通过去优化修饰的口蹄疫活减毒毒株及其用途
WO2022011032A1 (en) * 2020-07-07 2022-01-13 Codagenix Inc. Method of producing modified virus genomes and producing modified viruses
WO2022011428A1 (en) * 2020-07-16 2022-01-20 Griffith University Live-attenuated virus vaccine
US20240018609A1 (en) * 2020-08-19 2024-01-18 City Of Hope Lamp detection of sars-cov-2 in saliva for the rapid diagnosis of covid-19
CN112662633A (zh) * 2020-12-28 2021-04-16 中国水产科学研究院珠江水产研究所 II型草鱼呼肠孤病毒冷适应株GCRV-GD108ca及其应用
PE20241321A1 (es) * 2021-06-23 2024-06-26 Univ Of Lancaster Atenuacion de virus
US20230274791A1 (en) * 2021-11-29 2023-08-31 The Chinese University Of Hong Kong Codon de-optimization or optimization using genetic architecture
EP4569104A2 (en) * 2022-08-12 2025-06-18 Fred Hutchinson Cancer Center Barcoded influenza viruses and mutational scanning libraries including the same
CN117153270B (zh) * 2023-10-30 2024-02-02 吉林华瑞基因科技有限公司 一种基因二代测序数据处理方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004147A1 (en) 1993-08-02 1995-02-09 Chiron Corp Recombinant constructs using replacement sequences in hypervariable regions
US20040023327A1 (en) 1995-12-07 2004-02-05 Short Jay M. End selection in directed evolution
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6238884B1 (en) 1995-12-07 2001-05-29 Diversa Corporation End selection in directed evolution
US6352842B1 (en) 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6764835B2 (en) 1995-12-07 2004-07-20 Diversa Corporation Saturation mutageneis in directed evolution
US6562594B1 (en) 1999-09-29 2003-05-13 Diversa Corporation Saturation mutagenesis in directed evolution
ATE451451T1 (de) 1996-07-15 2009-12-15 Us Gov Health & Human Serv Herstellung von attenuierten respiratorischen syncytialvirus-impfstoffen aus klonierten nukleotidsequenzen
GB9705669D0 (en) † 1997-03-19 1997-05-07 British Tech Group Attenuated polioviruses
US6410023B1 (en) 1997-05-23 2002-06-25 United States Of America Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene
BR9806084A (pt) * 1997-08-07 2001-09-18 Altwell Biotech Inc Vetor de poliovirus sabin tipo i, recombinante ou quimérico de replicação competente, seus métodos de produção e célula hospedeira
EP1690868A1 (en) 1997-10-31 2006-08-16 Maxygen, Inc. Modification of virus tropism and host range by viral genome shuffling
GB9817082D0 (en) † 1998-08-06 1998-10-07 Btg Int Ltd Attenuated poliovirus vaccine
CA2331335A1 (en) 1998-09-29 2000-04-06 Maxygen, Inc. Shuffling of codon altered genes
CA2361927A1 (en) 1999-03-09 2000-09-14 Diversa Corporation End selection in directed evolution
CA2329122A1 (en) 1999-03-26 2000-10-05 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
CA2291367A1 (en) * 1999-12-06 2001-06-06 Isabelle Henry Genetic constructions having a reduced or an increased number of epigenetic control regions and methods of use thereof
US20020076415A1 (en) 1999-12-14 2002-06-20 Jing-Hsiung Ou Hepatitis C virus gene products
AUPQ776100A0 (en) 2000-05-26 2000-06-15 Australian National University, The Synthetic molecules and uses therefor
GB0017990D0 (en) 2000-07-21 2000-09-13 Glaxo Group Ltd Papilloma virus sequences
DE60124918T2 (de) 2000-07-21 2007-08-02 Glaxo Group Ltd., Greenford Kodon-optimierte papillomavirussequenzen
IL155154A0 (en) 2000-09-30 2003-10-31 Diversa Corp Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
US20030041354A1 (en) 2000-10-17 2003-02-27 Novozymes A/S Transgenic plants
ATE403152T1 (de) 2000-10-17 2008-08-15 Besst Test Aps Test zum direkten nachweisen einer biologischen zelle in einer körperflüssigkeitsprobe
AU2002326303A1 (en) * 2001-05-25 2002-12-03 Tao Biosciences, Llc Methods for attenuation of virulence in bacteria
PT2311848E (pt) * 2002-12-23 2013-10-03 Vical Inc Vacinas à base de polinucleótido optimizadas por codão contra a infecção do citomegalovírus humano
AU2004262624B2 (en) 2003-02-28 2009-11-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinant human metapneumovirus and its use
WO2005024012A1 (en) 2003-09-11 2005-03-17 Novozymes A/S Increased expression of a modified polypeptide
WO2005098003A1 (en) 2004-04-07 2005-10-20 Novozymes A/S Mutated prokaryotic cells with high secretion-levels
WO2005115448A2 (en) 2004-05-24 2005-12-08 Medimmune Vaccines, Inc. Multi plasmid system for the production of influenza virus
KR20070058440A (ko) 2004-07-02 2007-06-08 헨리 엘 니만 복제 선택 재조합 및 그것의 용도
CA2574511A1 (en) 2004-07-20 2006-02-16 Novozymes, Inc. Methods of producing mutant polynucleotides
JP2008508879A (ja) 2004-08-03 2008-03-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 多様性タンパク質配列を生成するための部位特異的系
CA2587084C (en) * 2004-10-08 2019-07-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Modulation of replicative fitness by using less frequently used synonym ous codons
US8168771B2 (en) 2005-01-31 2012-05-01 The Johns Hopkins University Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants
CN101287838B (zh) 2005-10-14 2016-03-30 美国政府健康及人类服务部，疾病控制和预防中心 狂犬病病毒组合物和方法
EP2062023B2 (en) 2006-08-25 2016-11-09 The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus
WO2008027472A2 (en) 2006-08-29 2008-03-06 Danisco Us, Inc., Genencor Division Compositions and methods for improved protein production
PL2082045T3 (pl) 2006-10-24 2015-07-31 Basf Se Sposób zmniejszania ekspresji genów poprzez modyfikację częstości występowania kodonów
EP2082044B1 (en) 2006-10-24 2016-06-01 Basf Se Method of increasing gene expression using modified codon usage
WO2008121487A2 (en) 2007-03-29 2008-10-09 The Govt. Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Sevices. Live attenuated virus vaccines for la crosse virus and other bunyaviridae
US9476032B2 (en) 2007-03-30 2016-10-25 The Research Foundation For The State University Of New York Attenuated viruses useful for vaccines
EP2215231A4 (en) 2007-10-15 2010-12-01 Univ Queensland EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE
WO2017056094A1 (en) 2015-09-30 2017-04-06 Ramot At Tel-Aviv University Ltd. Attenuated virus mutated at sites of evolutionarily conserved rna structure
US10538786B2 (en) 2016-04-13 2020-01-21 Janssen Pharmaceuticals, Inc. Recombinant arterivirus replicon systems and uses thereof
US11821111B2 (en) 2019-11-15 2023-11-21 Fred Hutchinson Cancer Center Barcoded influenza viruses and deep mutational scanning libraries including the same

Also Published As

Publication number Publication date
US10023845B2 (en) 2018-07-17
EP2139515B2 (en) 2023-12-20
BRPI0809600B1 (pt) 2023-01-24
US20220298492A1 (en) 2022-09-22
MX2009010549A (es) 2010-03-15
PL2139515T5 (pl) 2024-04-08
KR101621100B1 (ko) 2016-05-13
JP2015091247A (ja) 2015-05-14
EP2139515B1 (en) 2018-06-13
US20170067030A1 (en) 2017-03-09
AU2008232491A1 (en) 2008-10-09
US11162080B2 (en) 2021-11-02
MX349825B (es) 2017-08-15
DK2139515T4 (da) 2024-03-04
EP4368202A3 (en) 2024-08-21
HRP20181319T4 (hr) 2024-02-16
EP4368202A2 (en) 2024-05-15
WO2008121992A2 (en) 2008-10-09
DK2139515T3 (en) 2018-08-27
EP3431099B1 (en) 2024-01-03
PL2139515T3 (pl) 2018-11-30
EP2139515A4 (en) 2011-07-06
US20100209454A1 (en) 2010-08-19
KR20100019423A (ko) 2010-02-18
EP3431099A1 (en) 2019-01-23
US20240228981A1 (en) 2024-07-11
JP2010523086A (ja) 2010-07-15
CN103476425B (zh) 2015-07-15
US20190010469A1 (en) 2019-01-10
AU2008232491B2 (en) 2014-05-22
EP2139515A2 (en) 2010-01-06
CA2682089A1 (en) 2008-10-09
JP5733976B2 (ja) 2015-06-10
HRP20181319T1 (hr) 2018-10-19
CA2682089C (en) 2019-03-12
WO2008121992A3 (en) 2009-02-26
US9476032B2 (en) 2016-10-25
CN103476425A (zh) 2013-12-25

Similar Documents

Publication Publication Date Title
BRPI0809600A2 (pt) vírus atenuado útil para vacinas
IL269427B (en) Vaccine nanotechnology
DK3192874T3 (da) Virusoprensning
PT2144998T (pt) Métodos e composições para vírus vivos atenuados
DK2200646T3 (da) RNA-Vacciner
DK2114993T3 (da) Vaccine
DK2049559T3 (da) Forbedrede HPV vacciner
ATE450271T1 (de) Impfstoff
BR112012004807A2 (pt) vacina para pcsk9
CR10571A (es) Vacuna virica recombinante
PT2656823E (pt) Dispositivo cirúrgico oftálmico para capsulotomia
BRPI0919250A2 (pt) métodos para a purificação de vírus
DK2242752T3 (da) Imidazolyl-biphenylimidazoler som hepatitis C-virus-inhibitorer
PT2427212T (pt) Anticorpos anti-cd100 e métodos para utilização dos mesmos
BRPI0917205A2 (pt) vacina polivalente
HRP20151000T8 (hr) Antivirusni spojevi
BRPI0909246A2 (pt) Embalagens para artigos fumáveis
BRPI0821034A2 (pt) Vírus influenza modificado
BRPI0818354A2 (pt) vacina preventiva do hiv baseada em anticorpos específicos para o hiv
EP2516629A4 (en) VACCINES AGAINST HERPES SIMPLEX VIRUS
DK2422810T3 (da) Influenzavaccine
BRPI0921578A2 (pt) vacinas unitemporais
PT3957754T (pt) Método para detetar o vírus chikungunya
BRPI0923034A2 (pt) terapia de combinação para virus da hepatite c
BRPI0919102A2 (pt) vacinas de salmonella não-tifóide

Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority

Free format text: PERDA DA PRIORIDADE US 61/068,666 DE 07/03/2008, CONFORME AS DISPOSICOES PREVISTAS NA LEI 9.279 DE 14/05/1996 (LPI) ART. 16 7O E NO ART. 28 DO ATO NORMATIVO 128/1997, POR NAO ATENDER AO DISPOSTO NO ART. 27 DO ATO NORMATIVO 128/1997, POIS NAO FOI APRESENTADA CESSAO DA REFERIDA PRIORIDADE, QUE POSSUI DEPOSITANTE DIFERENTE DO DEPOSITANTE DA FASE NACIONAL.

B12F Other appeals [chapter 12.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 31/03/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.