BRPI0809652A2 - Processo melhorado para a síntese de solifenacina - Google Patents

Processo melhorado para a síntese de solifenacina

Info

Publication number
BRPI0809652A2
BRPI0809652A2 BRPI0809652-0A2A BRPI0809652A BRPI0809652A2 BR PI0809652 A2 BRPI0809652 A2 BR PI0809652A2 BR PI0809652 A BRPI0809652 A BR PI0809652A BR PI0809652 A2 BRPI0809652 A2 BR PI0809652A2
Authority
BR
Brazil
Prior art keywords
solifenacin
synthesis
improved process
improved
solifenacin synthesis
Prior art date
Application number
BRPI0809652-0A2A
Other languages
English (en)
Inventor
Jordi Puig Serrano
Pelayo Camps
Original Assignee
Medichen S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichen S A filed Critical Medichen S A
Publication of BRPI0809652A2 publication Critical patent/BRPI0809652A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0809652-0A2A 2007-03-30 2008-03-28 Processo melhorado para a síntese de solifenacina BRPI0809652A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92102707P 2007-03-30 2007-03-30
US92819907P 2007-05-08 2007-05-08
PCT/IB2008/000749 WO2008120080A2 (en) 2007-03-30 2008-03-28 An improved process for the synthesis of solifenacin

Publications (1)

Publication Number Publication Date
BRPI0809652A2 true BRPI0809652A2 (pt) 2014-10-07

Family

ID=39735044

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809652-0A2A BRPI0809652A2 (pt) 2007-03-30 2008-03-28 Processo melhorado para a síntese de solifenacina

Country Status (10)

Country Link
US (1) US7741489B2 (pt)
EP (1) EP2142540A2 (pt)
JP (1) JP2010523539A (pt)
KR (1) KR20100016116A (pt)
CN (1) CN101711248A (pt)
AR (1) AR066206A1 (pt)
BR (1) BRPI0809652A2 (pt)
CA (1) CA2682381A1 (pt)
IL (1) IL201245A0 (pt)
WO (1) WO2008120080A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009087664A1 (en) * 2007-12-04 2009-07-16 Cadila Healthcare Limited Process for preparing chemically and chirally pure solifenacin base and its salts
WO2010103529A1 (en) * 2009-03-09 2010-09-16 Megafine Pharma(P) Ltd. A new method for the preparation of solifenacin and new intermediate thereof
AR080176A1 (es) * 2010-02-15 2012-03-21 Boehringer Ingelheim Int Sales e hidratos de la 4-((3-cloro-4-fluoro-fenil)amino)-6-(cis-4-(n-((morf-1-olin-4-il)carbonil)-n-metil-amino)-ciclohexan-1-iloxi)-7-metoxi-quinazolina, su uso como medicamento y su preparacion
WO2012062916A1 (de) 2010-11-11 2012-05-18 Hexal Ag Kristallines solifenacin-succinat
CN102199180B (zh) * 2011-04-12 2014-07-09 连云港杰瑞药业有限公司 一种卡培他滨的制备方法
EP2723734A1 (en) 2011-06-22 2014-04-30 Isochem Process for the preparation of solifenacin and salts thereof
CN102887894A (zh) * 2011-07-18 2013-01-23 天津市医药集团技术发展有限公司 一种琥珀酸索利那新晶型及其制备方法
KR101365849B1 (ko) 2012-03-28 2014-02-24 경동제약 주식회사 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체
EP2867210A1 (en) * 2012-07-02 2015-05-06 Pharmathen S.A. A process for the preparation of solifenacin or a salt thereof
CN103787969B (zh) 2012-10-30 2016-07-06 上海京新生物医药有限公司 一种(1s)-1-苯基-3,4-二氢-2（1h）-异喹啉甲酸酯的制备方法
DE102013113283A1 (de) † 2013-11-29 2015-06-03 Leonhard Kurz Stiftung & Co. Kg Mehrschichtkörper und Verfahren zu dessen Herstellung
CN103760286A (zh) * 2014-01-14 2014-04-30 北京万全德众医药生物技术有限公司 一种用高效液相色谱法测定琥珀酸索非那新中间体光学纯度的方法
CN105510458B (zh) * 2015-12-05 2019-03-08 迪沙药业集团有限公司 琥珀酸索利那新中r-3-奎宁醇的检测方法
CN108314681A (zh) * 2017-01-17 2018-07-24 北京蓝贝望生物医药科技股份有限公司 琥珀酸索利那新的新制备方法
CN110407808B (zh) * 2018-04-27 2022-04-15 燃点(南京)生物医药科技有限公司 (1s)-1-苯基-3,4-二氢-1h-异喹啉-2-羰基咪唑新晶型及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2005012I1 (no) * 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
EP1714965A4 (en) * 2004-02-09 2007-12-19 Astellas Pharma Inc COMPOSITION CONTAINING SOLIFENACINE SUCCINATE
JPWO2005087231A1 (ja) 2004-03-16 2008-01-24 アステラス製薬株式会社 ソリフェナシン含有組成物

Also Published As

Publication number Publication date
CA2682381A1 (en) 2008-10-09
EP2142540A2 (en) 2010-01-13
WO2008120080A3 (en) 2009-08-06
WO2008120080A2 (en) 2008-10-09
CN101711248A (zh) 2010-05-19
JP2010523539A (ja) 2010-07-15
US20080242697A1 (en) 2008-10-02
AR066206A1 (es) 2009-08-05
IL201245A0 (en) 2010-05-31
KR20100016116A (ko) 2010-02-12
US7741489B2 (en) 2010-06-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.