BRPI0810204A2 - Inibidores da enzina diacilglicerol o-aciltransferase tipo 1 - Google Patents

Inibidores da enzina diacilglicerol o-aciltransferase tipo 1

Info

Publication number
BRPI0810204A2
BRPI0810204A2 BRPI0810204-0A2A BRPI0810204A BRPI0810204A2 BR PI0810204 A2 BRPI0810204 A2 BR PI0810204A2 BR PI0810204 A BRPI0810204 A BR PI0810204A BR PI0810204 A2 BRPI0810204 A2 BR PI0810204A2
Authority
BR
Brazil
Prior art keywords
diacylglycerol
inhibitors
acyltransferase type
acyltransferase
type
Prior art date
Application number
BRPI0810204-0A2A
Other languages
English (en)
Inventor
Gang Liu
Zhili Xin
Philip R Kym
Andrew J Souers
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BRPI0810204A2 publication Critical patent/BRPI0810204A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0810204-0A2A 2007-04-30 2008-04-30 Inibidores da enzina diacilglicerol o-aciltransferase tipo 1 BRPI0810204A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91499907P 2007-04-30 2007-04-30
PCT/US2008/061948 WO2008134690A1 (en) 2007-04-30 2008-04-30 Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme

Publications (1)

Publication Number Publication Date
BRPI0810204A2 true BRPI0810204A2 (pt) 2014-10-14

Family

ID=39619098

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810204-0A2A BRPI0810204A2 (pt) 2007-04-30 2008-04-30 Inibidores da enzina diacilglicerol o-aciltransferase tipo 1

Country Status (16)

Country Link
US (2) US8076344B2 (pt)
EP (2) EP2142552B1 (pt)
JP (1) JP5383661B2 (pt)
KR (1) KR20100019470A (pt)
CN (1) CN101720327A (pt)
AU (1) AU2008245458B2 (pt)
BR (1) BRPI0810204A2 (pt)
CA (1) CA2685524A1 (pt)
ES (1) ES2392117T3 (pt)
IL (1) IL201752A0 (pt)
MX (1) MX2009011753A (pt)
NZ (2) NZ580662A (pt)
RU (1) RU2012122056A (pt)
SG (1) SG171586A1 (pt)
WO (1) WO2008134690A1 (pt)
ZA (2) ZA200907614B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0519058A2 (pt) 2004-12-14 2008-12-23 Astrazeneca Ab composto ou um sal prà-droga farmaceuticamente aceitÁvel do mesmo, mÉtodos para produzir uma inibiÇço da atividade de dgat1 e para tratar diabete melito e/ou obesidade em um animal de sangue quente, uso de um composto, composiÇço farmacÊutica, e, processo para preparar um composto
AR058562A1 (es) 2005-12-22 2008-02-13 Astrazeneca Ab Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1
PT2402319T (pt) 2006-03-31 2017-12-11 Novartis Ag Inibidores de dgat
AU2007266796B2 (en) 2006-05-30 2011-02-10 Astrazeneca Ab Substituted 5-phenylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
EP2408774B1 (en) 2009-03-20 2014-11-26 Metabasis Therapeutics, Inc. Inhibitors of diacylglycerol o-acyltransferase 1(dgat-1) and uses thereof
US8586581B2 (en) * 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
WO2014081996A1 (en) * 2012-11-23 2014-05-30 Glaxosmithkline Llc Novel compounds as diacylglycerol acyltransferase inhibitors
CA3087925A1 (en) * 2018-02-02 2019-08-08 Boehringer Ingelheim International Gmbh Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors
WO2021076817A2 (en) * 2019-10-16 2021-04-22 Ohio State Innovation Foundation Methods and compositions related to treatment and prevention of cancer by inhibition of dgat1 and dgat2
IL296788A (en) 2020-03-26 2022-11-01 Sinopia Biosciences Inc Isotopically labeled trepidil histories
US20230167121A1 (en) * 2020-04-14 2023-06-01 The Trustees Of The University Of Pennsylvania Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
WO2021233884A1 (en) 2020-05-22 2021-11-25 Boehringer Ingelheim International Gmbh Continuous process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate
JP2024177750A (ja) * 2023-06-12 2024-12-24 信越化学工業株式会社 二環式アセチレンアルコール化合物、付加硬化型シリコーン組成物、及び熱伝導性付加硬化型シリコーン組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2779799A (en) * 1953-05-12 1957-01-29 Abbott Lab 1-cyclobutyl-1-ethynyl-ethanol-1
US6100077A (en) 1998-10-01 2000-08-08 The Trustees Of Columbia University In The City Of New York Isolation of a gene encoding diacylglycerol acyltransferase
AU2321000A (en) 1999-01-29 2000-08-18 Sumitomo Chemical Company, Limited Fat accumulation inhibitory agents
DE60031714T2 (de) 1999-12-06 2007-09-06 Smithkline Beecham Corp. Thrombopoietin-mimetika
JP2003189895A (ja) * 2001-12-27 2003-07-08 Sumitomo Chem Co Ltd マラリア原虫増殖抑制能力の検定方法
AR044152A1 (es) * 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
AU2006206573B9 (en) * 2005-01-19 2011-09-29 Merck Sharp & Dohme Corp. Bicyclic pyrimidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
EP1856121A1 (de) 2005-03-01 2007-11-21 Basf Aktiengesellschaft 5,6-dialkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
WO2006092428A2 (de) * 2005-03-02 2006-09-08 Basf Aktiengesellschaft 2-substituierte 7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
NZ577112A (en) * 2006-11-29 2012-03-30 Abbott Lab Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme compirising substituted bicyclic pyrimidines

Also Published As

Publication number Publication date
WO2008134690A1 (en) 2008-11-06
IL201752A0 (en) 2010-06-16
RU2009144116A (ru) 2011-06-10
JP5383661B2 (ja) 2014-01-08
AU2008245458B2 (en) 2013-01-10
EP2142552B1 (en) 2012-08-01
NZ596724A (en) 2013-06-28
CN101720327A (zh) 2010-06-02
CA2685524A1 (en) 2008-11-06
NZ580662A (en) 2012-01-12
US20080293713A1 (en) 2008-11-27
US20120041003A1 (en) 2012-02-16
AU2008245458A1 (en) 2008-11-06
RU2012122056A (ru) 2013-12-10
ZA200907614B (en) 2013-06-26
MX2009011753A (es) 2009-12-01
US8557828B2 (en) 2013-10-15
ES2392117T3 (es) 2012-12-04
SG171586A1 (en) 2011-06-29
EP2142552A1 (en) 2010-01-13
ZA201202856B (en) 2015-01-28
EP2500347A1 (en) 2012-09-19
JP2010526083A (ja) 2010-07-29
KR20100019470A (ko) 2010-02-18
HK1133644A1 (en) 2010-04-01
US8076344B2 (en) 2011-12-13

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: ABBVIE INC. (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]