BRPI0810357A2 - Método para aumentar a secreção de uma poi a partir de uma célula eucariótica, uso de uma sequência de nucleotídeo, sequência de nucleotídeo, sequência promotora de levedura, vetor de expressão eucariótico, e, usos de um vetor de expressão e de uma sequência promotora de levedura. - Google Patents
Método para aumentar a secreção de uma poi a partir de uma célula eucariótica, uso de uma sequência de nucleotídeo, sequência de nucleotídeo, sequência promotora de levedura, vetor de expressão eucariótico, e, usos de um vetor de expressão e de uma sequência promotora de levedura.Info
- Publication number
- BRPI0810357A2 BRPI0810357A2 BRPI0810357-7A2A BRPI0810357A BRPI0810357A2 BR PI0810357 A2 BRPI0810357 A2 BR PI0810357A2 BR PI0810357 A BRPI0810357 A BR PI0810357A BR PI0810357 A2 BRPI0810357 A2 BR PI0810357A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleotide sequence
- yeast
- sequence
- eukaryotic
- poi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07008051 | 2007-04-20 | ||
| PCT/EP2008/003076 WO2008128701A2 (en) | 2007-04-20 | 2008-04-17 | Yeast expression systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0810357A2 true BRPI0810357A2 (pt) | 2014-10-07 |
Family
ID=39800700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0810357-7A2A BRPI0810357A2 (pt) | 2007-04-20 | 2008-04-17 | Método para aumentar a secreção de uma poi a partir de uma célula eucariótica, uso de uma sequência de nucleotídeo, sequência de nucleotídeo, sequência promotora de levedura, vetor de expressão eucariótico, e, usos de um vetor de expressão e de uma sequência promotora de levedura. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100297738A1 (pt) |
| EP (1) | EP2140008A2 (pt) |
| JP (1) | JP2010524440A (pt) |
| KR (1) | KR20100016170A (pt) |
| CN (1) | CN101679992A (pt) |
| AU (1) | AU2008241061A1 (pt) |
| BR (1) | BRPI0810357A2 (pt) |
| CA (1) | CA2684650A1 (pt) |
| EA (1) | EA017803B1 (pt) |
| WO (1) | WO2008128701A2 (pt) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258854A1 (en) * | 2009-05-20 | 2010-12-08 | FH Campus Wien | Eukaryotic host cell comprising an expression enhancer |
| EP2258855A1 (en) | 2009-05-28 | 2010-12-08 | Universität für Bodenkultur Wien | Expression sequences |
| WO2012109220A2 (en) * | 2011-02-08 | 2012-08-16 | Merck Sharp & Dohme Corp. | Cell cycle control for improving process performance and recombinant expression in fungal host cells |
| AU2012320421B2 (en) | 2011-10-07 | 2017-03-02 | Lonza Ltd | Regulatable promoter |
| CN104837857B (zh) | 2012-10-29 | 2018-11-06 | 龙沙有限公司 | 表达序列 |
| CN102977206B (zh) * | 2012-11-19 | 2014-10-01 | 中国农业科学院生物技术研究所 | 细胞色素结合结构域蛋白作为助分泌因子提高外源基因在毕赤酵母中分泌表达量的用途 |
| CN102994541B (zh) * | 2012-12-19 | 2015-04-15 | 江南大学 | 一种共表达upr关键基因和下游靶基因增强葡萄糖氧化酶分泌的方法 |
| PL2964765T3 (pl) | 2013-03-08 | 2019-10-31 | Keck Graduate Inst Of Applied Life Sciences | Promotory drożdżowe z pichia pastoris |
| DK2964775T3 (en) | 2013-03-08 | 2019-04-15 | Biogrammatics Inc | Yeast promoters for protein expression |
| CA2948369C (en) * | 2014-04-17 | 2023-09-26 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Recombinant host cell engineered to overexpress helper proteins |
| SG11201608080RA (en) | 2014-04-17 | 2016-10-28 | Boehringer Ingelheim Rcv Gmbh | Recombinant host cell for expressing proteins of interest |
| EP2952584A1 (en) | 2014-06-04 | 2015-12-09 | Boehringer Ingelheim RCV GmbH & Co KG | Improved protein production |
| CN104357416A (zh) * | 2014-10-22 | 2015-02-18 | 江南大学 | 一种改造蛋白折叠分泌途径增强葡萄糖氧化酶分泌的方法 |
| RU2683549C1 (ru) * | 2015-12-29 | 2019-03-28 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | СИСТЕМА ДЛЯ ЭКСПРЕССИИ FAB-ФРАГМЕНТОВ АНТИТЕЛ В МЕТИЛОТРОФНЫХ ДРОЖЖАХ PICHIAPASTORIS, НА ОСНОВЕ РЕКОМБИНАНТНЫХ ПЛАЗМИДНЫХ ДНК Ab-HCh-HIS/pPICZ_α_A И Ab-LCh-LAMBDA/pPICZα_A, ПРЕДНАЗНАЧЕННЫХ ДЛЯ КЛОНИРОВАНИЯ ВАРИАБЕЛЬНЫХ ДОМЕНОВ ТЯЖЕЛОЙ И ЛЕГКОЙ ЦЕПЕЙ АНТИТЕЛ, СООТВЕТСТВЕННО |
| CN105802867B (zh) * | 2016-05-23 | 2019-09-17 | 江南大学 | 一种碱性果胶酶分泌增强型菌株及其应用 |
| SG11201908079SA (en) | 2017-03-29 | 2019-10-30 | Boehringer Ingelheim Rcv Gmbh | Recombinant host cell with altered membrane lipid composition |
| US20210285062A1 (en) * | 2017-05-16 | 2021-09-16 | The Regents Of The University Of California | Fluorescence detection in yeast colonies |
| US20200181629A1 (en) | 2017-05-31 | 2020-06-11 | Universität Für Bodenkultur Wien | Yeast expressing a synthetic calvin cycle |
| CN107043757B (zh) * | 2017-06-01 | 2020-07-07 | 江苏师范大学 | 一株异源高效表达米黑根毛霉脂肪酶的重组毕赤酵母及其应用 |
| FR3068368A1 (fr) * | 2017-06-30 | 2019-01-04 | Compagnie Generale Des Etablissements Michelin | Utilisation des polyketide synthases de type iii de bacteries comme phloroglucinol synthases |
| US12404309B2 (en) | 2018-02-12 | 2025-09-02 | Lonza Ltd | Host cell for producing a protein of interest |
| EP3536784A1 (en) | 2018-03-05 | 2019-09-11 | ACIB GmbH | Host cell engineered for improved metabolite production |
| CA3103988A1 (en) | 2018-06-27 | 2020-01-02 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Means and methods for increased protein expression by use of transcription factors |
| CN113056554A (zh) * | 2018-11-19 | 2021-06-29 | 巴斯夫欧洲公司 | 重组酵母细胞 |
| CN115838754A (zh) * | 2018-12-27 | 2023-03-24 | 中国医学科学院药物研究所 | 生产达玛烯二醇-ii糖苷的重组菌及其应用 |
| DK3874047T4 (da) | 2019-01-11 | 2025-02-03 | Lonza Ag | Karbonkilde-reguleret proteinproduktion i en rekombinant værtscelle |
| HUE064229T2 (hu) | 2019-04-01 | 2024-02-28 | Univ Wien Bodenkultur | Mut-metilotróf élesztõ |
| WO2020200415A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Mut- methylotrophic yeast |
| WO2020200414A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Protein production in mut-methylotrophic yeast |
| WO2021014470A1 (en) * | 2019-07-25 | 2021-01-28 | Council Of Scientific And Industrial Research | Recombinant vector for high-expression of proteins in yeasts |
| CN110592090A (zh) * | 2019-10-30 | 2019-12-20 | 福建师范大学 | Ssa4基因启动子及利用该启动子驱动外源基因转录的毕赤酵母表达载体 |
| RU2728033C1 (ru) * | 2019-12-11 | 2020-07-28 | Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт"-ГосНИИгенетика) | Трансформант дрожжей Pichia pastoris, продуцирующий эндо-1,4-β-ксиланазу из Paenibacillus brasilensis |
| MX2022009958A (es) * | 2020-02-13 | 2022-10-07 | Univ Danmarks Tekniske | Cepas de produccion adictas a cargas. |
| EP4127185B1 (en) | 2020-04-01 | 2025-06-04 | Lonza Ltd. | Helper factors for expressing proteins in yeast |
| EP4222266A1 (en) | 2020-09-30 | 2023-08-09 | Lonza Ltd. | Host cells overexpressing translational factors |
| CN112280700B (zh) * | 2020-10-19 | 2022-09-06 | 中国石油化工股份有限公司 | 一株耐乙酸和甲酸的发酵菌株及其构建方法 |
| CN117120618A (zh) | 2021-02-12 | 2023-11-24 | 勃林格殷格翰 Rcv 两合公司 | 用于增加蛋白质分泌的信号肽 |
| CN113088533B (zh) * | 2021-04-15 | 2023-03-24 | 华中科技大学 | 一种高效表达藤壶粘胶蛋白的酵母工程菌及其制备方法 |
| CN114657190B (zh) * | 2022-04-06 | 2023-08-29 | 暨南大学 | Msn2p作为负调控因子在提高宿主细胞中蛋白表达中的应用 |
| CN114657197B (zh) * | 2022-04-06 | 2023-07-21 | 暨南大学 | Gsm1p作为正调控因子在提高宿主细胞中蛋白表达中的应用 |
| AU2023394995A1 (en) | 2022-12-16 | 2025-05-29 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Means and methods for increased protein expression by use of a combination of transport proteins and either chaperones or transcription factors |
| WO2024133538A1 (en) | 2022-12-20 | 2024-06-27 | Lonza Ltd | Host cells with pat1 knockout for increased specific protein productivity |
| CN116970503B (zh) * | 2023-07-25 | 2024-08-02 | 江南大学 | 一种强化囊泡转运的产乳铁蛋白毕赤酵母及促进胞外分泌的方法 |
| CN117467695B (zh) * | 2023-12-27 | 2024-05-03 | 南京鸿瑞杰生物医疗科技有限公司 | 过表达毕赤酵母分子伴侣提高报告蛋白分泌的方法 |
| WO2026027251A1 (en) | 2024-08-01 | 2026-02-05 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Signal peptides for increased protein secretion |
| CN119464103B (zh) * | 2025-01-17 | 2025-05-09 | 上海昌进生物科技有限公司 | 高效表达β-乳球蛋白的菌株及其构建方法和应用 |
| CN120574696B (zh) * | 2025-05-28 | 2026-02-17 | 引加(上海)生物医药科技有限公司 | 一种高表达梭菌蛋白酶的基因工程菌及其应用 |
-
2008
- 2008-04-17 WO PCT/EP2008/003076 patent/WO2008128701A2/en not_active Ceased
- 2008-04-17 JP JP2010503409A patent/JP2010524440A/ja active Pending
- 2008-04-17 KR KR1020097022964A patent/KR20100016170A/ko not_active Withdrawn
- 2008-04-17 CA CA002684650A patent/CA2684650A1/en not_active Abandoned
- 2008-04-17 CN CN200880012875A patent/CN101679992A/zh active Pending
- 2008-04-17 US US12/450,705 patent/US20100297738A1/en not_active Abandoned
- 2008-04-17 EP EP08748955A patent/EP2140008A2/en not_active Ceased
- 2008-04-17 BR BRPI0810357-7A2A patent/BRPI0810357A2/pt not_active IP Right Cessation
- 2008-04-17 EA EA200970985A patent/EA017803B1/ru not_active IP Right Cessation
- 2008-04-17 AU AU2008241061A patent/AU2008241061A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA200970985A1 (ru) | 2010-04-30 |
| AU2008241061A1 (en) | 2008-10-30 |
| JP2010524440A (ja) | 2010-07-22 |
| WO2008128701A2 (en) | 2008-10-30 |
| WO2008128701A3 (en) | 2009-03-12 |
| US20100297738A1 (en) | 2010-11-25 |
| CN101679992A (zh) | 2010-03-24 |
| EP2140008A2 (en) | 2010-01-06 |
| CA2684650A1 (en) | 2008-10-30 |
| EA017803B1 (ru) | 2013-03-29 |
| KR20100016170A (ko) | 2010-02-12 |
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Legal Events
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |