BRPI0810399B8 - composto, composição farmacêutica que o contém e uso do mesmo - Google Patents

composto, composição farmacêutica que o contém e uso do mesmo

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Publication number
BRPI0810399B8
BRPI0810399B8 BRPI0810399A BRPI0810399A BRPI0810399B8 BR PI0810399 B8 BRPI0810399 B8 BR PI0810399B8 BR PI0810399 A BRPI0810399 A BR PI0810399A BR PI0810399 A BRPI0810399 A BR PI0810399A BR PI0810399 B8 BRPI0810399 B8 BR PI0810399B8
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
composition containing
compounds
formula
Prior art date
Application number
BRPI0810399A
Other languages
English (en)
Inventor
Renneberg Dorte
Hubler Francis
Hilpert Kurt
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0810399A2 publication Critical patent/BRPI0810399A2/pt
Publication of BRPI0810399A8 publication Critical patent/BRPI0810399A8/pt
Publication of BRPI0810399B1 publication Critical patent/BRPI0810399B1/pt
Publication of BRPI0810399B8 publication Critical patent/BRPI0810399B8/pt

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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D491/04—Ortho-condensed systems

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Abstract

composto, composição farmacêutica que o contêm e uso do mesmo. a invenção refere-se a compostos da fórmula (i) em que r¹, r², r¹a, r²a, r³, r4, a, b, x, w e n são tais como definidos na descrição, e aos sais farmaceuticamente aceitáveis destes compostos. estes compostos são de de utilidade como bloqueadores de canais de cálcio.
BRPI0810399A 2007-04-27 2008-04-25 composto, composição farmacêutica que o contém e uso do mesmo BRPI0810399B8 (pt)

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IB2007051581 2007-04-27
PCT/IB2008/051599 WO2008132679A1 (en) 2007-04-27 2008-04-25 Bridged six-membered ring compounds

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BRPI0810399A8 BRPI0810399A8 (pt) 2017-12-26
BRPI0810399B1 BRPI0810399B1 (pt) 2019-12-17
BRPI0810399B8 true BRPI0810399B8 (pt) 2021-05-25

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KR101364909B1 (ko) * 2008-04-25 2014-02-21 액테리온 파마슈티칼 리미티드 칼슘 채널 차단제로서의 벤지미다졸 유도체
BRPI0920635B8 (pt) * 2008-10-22 2021-05-25 Actelion Pharmaceuticals Ltd sais do éster do ácido (1r*,2r*,4r*)-2-(2-{[3-(4,7-dimetoxi-1h-benzoilimidazol-2-il)-propil]-metil-amino}-etil)-5-fenil-biciclo[2.2.2]oct-5-en-2-il isobutírico, uso do mesmo, e, composição farmacêutica
US8314253B2 (en) 2008-10-22 2012-11-20 Actelion Pharmaceuticals Ltd. Bridged tetrahydronaphthalene derivatives
WO2010046729A2 (en) * 2008-10-23 2010-04-29 Actelion Pharmaceuticals Ltd Tetrahydronaphthalene compounds
WO2011148956A1 (ja) * 2010-05-24 2011-12-01 トーアエイヨー株式会社 縮合イミダゾール誘導体
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
ES2536897T3 (es) 2010-10-20 2015-05-29 Actelion Pharmaceuticals Ltd. Preparación de compuestos de biciclo[2,2,2]octan-2-ona
KR101836552B1 (ko) * 2010-10-20 2018-03-08 아이도시아 파마수티컬즈 리미티드 바이시클로[2.2.2]옥탄-2-온 화합물의 부분입체선택적 제조
CN102875474A (zh) * 2012-10-23 2013-01-16 中国科学院广州生物医药与健康研究院 用于抗变异流感病毒的新型环烷胺类化合物
MX385777B (es) * 2014-12-24 2025-03-04 Lg Chemical Ltd Derivado de biarilo como agonista de gpr120.
WO2021007487A1 (en) 2019-07-11 2021-01-14 Praxis Precision Medicines, Inc. Formulations of t-type calcium channel modulators and methods of use thereof

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CL2008001205A1 (es) 2008-11-14
TWI353837B (en) 2011-12-11
MY149400A (en) 2013-08-30
US8202885B2 (en) 2012-06-19
MA31383B1 (fr) 2010-05-03
JP2010527330A (ja) 2010-08-12
KR101114725B1 (ko) 2012-06-12
RU2009143752A (ru) 2011-06-10
CN101668742A (zh) 2010-03-10
WO2008132679A1 (en) 2008-11-06
NZ581388A (en) 2011-05-27
CN101668742B (zh) 2014-04-30
IL201730A (en) 2015-09-24
SI2152670T1 (sl) 2014-04-30
ES2449147T3 (es) 2014-03-18
BRPI0810399B1 (pt) 2019-12-17
AR066148A1 (es) 2009-07-29
BRPI0810399A8 (pt) 2017-12-26
RU2503663C2 (ru) 2014-01-10
PL2152670T3 (pl) 2014-05-30
TW200848040A (en) 2008-12-16
HRP20140273T1 (hr) 2014-04-25
EP2152670A1 (en) 2010-02-17
BRPI0810399A2 (pt) 2014-11-04
CA2683866C (en) 2016-01-26
KR20090125856A (ko) 2009-12-07
PT2152670E (pt) 2014-03-04
AU2008243860B2 (en) 2013-04-18
DK2152670T3 (en) 2014-02-24
JP4595040B2 (ja) 2010-12-08
ZA200908392B (en) 2011-02-23
AU2008243860A1 (en) 2008-11-06
IL201730A0 (en) 2010-06-16
HK1141296A1 (en) 2010-11-05
EP2152670B1 (en) 2013-12-25
CA2683866A1 (en) 2008-11-06
MX2009011365A (es) 2009-11-05
CY1115328T1 (el) 2017-01-04
US20100130545A1 (en) 2010-05-27

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