BRPI0810530B8 - composição, uso da mesma, biomaterial sintético, seu método de fabricação e kit para formar o mesmo - Google Patents

composição, uso da mesma, biomaterial sintético, seu método de fabricação e kit para formar o mesmo

Info

Publication number
BRPI0810530B8
BRPI0810530B8 BRPI0810530A BRPI0810530A BRPI0810530B8 BR PI0810530 B8 BRPI0810530 B8 BR PI0810530B8 BR PI0810530 A BRPI0810530 A BR PI0810530A BR PI0810530 A BRPI0810530 A BR PI0810530A BR PI0810530 B8 BRPI0810530 B8 BR PI0810530B8
Authority
BR
Brazil
Prior art keywords
biomaterials
composition
precursor molecule
kit
manufacturing
Prior art date
Application number
BRPI0810530A
Other languages
English (en)
Inventor
Rehor Annemie
Cerritelli Simona
Original Assignee
Kuros Biosurgery Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuros Biosurgery Ag filed Critical Kuros Biosurgery Ag
Publication of BRPI0810530A2 publication Critical patent/BRPI0810530A2/pt
Publication of BRPI0810530B1 publication Critical patent/BRPI0810530B1/pt
Publication of BRPI0810530B8 publication Critical patent/BRPI0810530B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
    • C08G65/33306—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3342—Polymers modified by chemical after-treatment with organic compounds containing sulfur having sulfur bound to carbon and hydrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/58—Ethylene oxide or propylene oxide copolymers, e.g. pluronics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Polyethers (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Surgical Instruments (AREA)
  • Sealing Material Composition (AREA)
  • Medicinal Preparation (AREA)
  • Laminated Bodies (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Details Of Garments (AREA)

Abstract

selante tecidual polimérico. a presente invenção refere-se a métodos para fabricação de biomateriais para uso como selante tecidual, a kits contendo precursores para formação dos biomateriais, e as biomateriais resultantes. os biomateriais são formados a partir de uma composição contendo pelo menos uma primeira e uma segunda moléculaa precursoraa, em que: i) a primeira molécula precursora é um polímero com base em poli(etileno glicol) tendo x grupos nucleofílicos selecionados no grupo que consiste em grupos tiol ou amino, em que x é igual a 2 ou maior que 2, preferivelmente 3, 4,5,6,7 0u 8; ii) a segunda molécula precursora é da fórmula geral: a-[(c3h6o)n-(c2h4o)m-b]i em que m e n são inteiros de 1 a 200 i é maior que 2, preferivelmente 3, 4, 5, 6,7 ou 8 a é um ponto de ramificação, b é um grupo conjugado insaturado.
BRPI0810530A 2007-04-13 2008-04-14 composição, uso da mesma, biomaterial sintético, seu método de fabricação e kit para formar o mesmo BRPI0810530B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91173707P 2007-04-13 2007-04-13
US60/911,737 2007-04-13
PCT/EP2008/054487 WO2008125655A1 (en) 2007-04-13 2008-04-14 Polymeric tissue sealant

Publications (3)

Publication Number Publication Date
BRPI0810530A2 BRPI0810530A2 (pt) 2014-10-07
BRPI0810530B1 BRPI0810530B1 (pt) 2018-07-17
BRPI0810530B8 true BRPI0810530B8 (pt) 2021-06-22

Family

ID=39671705

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810530A BRPI0810530B8 (pt) 2007-04-13 2008-04-14 composição, uso da mesma, biomaterial sintético, seu método de fabricação e kit para formar o mesmo

Country Status (14)

Country Link
US (2) US8961947B2 (pt)
EP (2) EP2136850B1 (pt)
JP (2) JP2010523243A (pt)
CN (1) CN101711168B (pt)
AT (1) ATE543520T1 (pt)
BR (1) BRPI0810530B8 (pt)
CA (1) CA2685807C (pt)
DK (1) DK2136850T3 (pt)
ES (2) ES2733276T3 (pt)
MX (1) MX2009011005A (pt)
PL (1) PL2136850T3 (pt)
PT (1) PT2136850E (pt)
RU (1) RU2453340C2 (pt)
WO (1) WO2008125655A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9211358B2 (en) * 2007-04-24 2015-12-15 Rutgers, The State University Of New Jersey Dressing compositions and methods
JP5588511B2 (ja) 2009-07-27 2014-09-10 エンドロジックス、インク ステントグラフト
RU2554854C9 (ru) 2009-07-31 2017-02-03 Асцендис Фарма Ас Биоразлагаемые нерастворимые в воде гидрогели на основе полиэтиленгликоля
SG178193A1 (en) 2009-07-31 2012-03-29 Sanofi Aventis Deutschland Prodrugs comprising an insulin linker conjugate
SG178195A1 (en) 2009-07-31 2012-03-29 Sanofi Aventis Deutschland Long acting insulin composition
EP2545100A2 (en) 2010-03-09 2013-01-16 Council of Scientific & Industrial Research A biodegradable polymeric hydrogel composition
CA2730598C (en) * 2010-03-16 2018-03-13 Confluent Surgical, Inc. Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels
US9119605B2 (en) 2010-05-06 2015-09-01 Zimmer, Inc. Synthetic polymer adhesives and methods for making, using and delivering the same
JP5827319B2 (ja) 2010-05-12 2015-12-02 セント ジュード メディカル インコーポレイテッドＳｔ． Ｊｕｄｅ Ｍｅｄｉｃａｌ， Ｉｎｃ． 生体接着剤アプリケーター及びそれを用いた組織穿刺孔の封止方法
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
US20140067082A1 (en) 2012-09-06 2014-03-06 Xinyin Liu Bioresorbable ceramic composition for forming a three dimensional scaffold
AU2013328785B2 (en) 2012-10-11 2016-07-21 Ascendis Pharma A/S Hydrogel prodrugs
WO2014160083A1 (en) * 2013-03-13 2014-10-02 Applied Cardiovascular Solutions, Llc. Methods, compositions, and devices for the occlusion of cavities and passageways
JP6325821B2 (ja) * 2014-01-08 2018-05-16 株式会社日本触媒 硫黄原子含有多分岐ポリアルキレングリコール系ブロック共重合体
EP3248622B1 (en) * 2015-01-20 2020-08-19 National Institute for Materials Science Surgical sealant
WO2017103914A1 (en) * 2015-12-17 2017-06-22 Regentis Biomaterials Ltd. Ready for use organic solvent free compositions comprising protein-polymer conjugates and uses thereof
WO2019099935A1 (en) * 2017-11-16 2019-05-23 Maculus Therapeutix Llc Materials and methods for administration to nasal cavity
EP3848066B1 (en) * 2018-09-05 2024-03-13 National Institute for Materials Science Adhesion prevention material
US10799289B2 (en) 2018-10-15 2020-10-13 Avent, Inc. Compositions, systems, kits, and methods for neural ablation
KR20230130049A (ko) * 2021-01-08 2023-09-11 시락 게엠베하 인터내셔날 생체흡수성 밀봉 분말
CN121154542B (zh) * 2025-11-24 2026-03-24 山东第一医科大学(山东省医学科学院) 用于负载疏水带正电荷药物的响应型胶束及其制备方法

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008341A (en) 1968-10-11 1977-02-15 W. R. Grace & Co. Curable liquid polymer compositions
US3908039A (en) 1973-10-25 1975-09-23 Grace W R & Co Photocurable polyene-polythiol lacquer composition
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
SE8200751L (sv) 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
DE3433210C1 (de) 1984-09-10 1986-06-05 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Mittel zur Fuellung von Knochen- und Zahndefekten,zum Knochenaufbau,fuer Knochenkontaktschichten und fuer Knochen- und Zahnwurzelersatz und Verwendung von Carbonatapatit fuer diesen Zweck
DE3543567A1 (de) 1985-12-10 1987-06-11 Degussa Verfahren zur herstellung von sulfensaeurechloriden und sulfensaeureestern
US4711903A (en) 1986-01-31 1987-12-08 G. D. Searle & Co. Phenolic thioethers as inhibitors of 5-lipoxygenase
AU2258788A (en) 1987-07-07 1989-01-30 Cytrx Biopool Ltd. Fibrin-binding compound and method
US5504001A (en) 1987-11-25 1996-04-02 Zymogenetics, Inc. Hybrid plasminogen activator
US4847325A (en) 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5100668A (en) 1988-06-14 1992-03-31 Massachusetts Institute Of Technology Controlled release systems containing heparin and growth factors
US5137819A (en) 1988-07-08 1992-08-11 University Of British Columbia Cellulose binding fusion proteins for immobilization and purification of polypeptides
AU630643B2 (en) 1988-11-09 1992-11-05 Protein Polymers Technologies, Inc. Functional recombinantly prepared synthetic protein polymer
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5475052A (en) 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5527856A (en) 1988-11-21 1996-06-18 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5247041A (en) 1989-02-22 1993-09-21 Toray Industries, Inc. Thiol methacrylate or acrylate resin obtained by polymerizing a thiol methacrylate or acrylate compound
US5171670A (en) 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
US5268305A (en) 1989-06-15 1993-12-07 Biocircuits Corporation Multi-optical detection system
US5330911A (en) 1989-09-28 1994-07-19 Board Of Regents, The University Of Texas System Surfaces having desirable cell adhesive effects
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5169764A (en) 1990-08-08 1992-12-08 Regeneron Pharmaceuticals, Inc. Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
EP0564502B1 (en) 1990-11-27 2002-01-30 The American National Red Cross Tissue sealant and growth factor containing compositions that promote accelerated wound healing
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
SE9101853D0 (sv) 1991-06-17 1991-06-17 Jonas Wadstroem Improved tissue ashesive
SE470006B (sv) 1991-09-26 1993-10-25 Corline Systems Ab Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
NZ249770A (en) 1992-02-28 1996-09-25 Univ Texas Biodegradable, polymerisable, substantially water soluble macromer comprising at least one water soluble region, at least one degradable region and at least two free radical polymerisable regions separated by at least one degradable region
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5814603A (en) 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5292514A (en) 1992-06-24 1994-03-08 Minnesota Mining And Manufacturing Company Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
CA2103400C (en) 1992-11-19 1998-08-25 Andrew T. C. Liu Abrasion resistant dental composition product and process
AU675252B2 (en) 1992-12-18 1997-01-30 Tremco, Inc. Fast-curing, high strength, two-part sealants using acetoacetate-amine cure chemistry
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
JP3746293B2 (ja) 1993-02-22 2006-02-15 アメリカン バイオサイエンス、インコーポレイテッド 生物製剤のインビボ送達の方法とそのための組成物
DE69433920T2 (de) 1993-03-12 2005-06-02 American National Red Cross Supplementierte verdichtungsmittel für gewebe, methoden für ihre herstellung und ihre verwendung
TW303299B (pt) 1993-07-22 1997-04-21 Lilly Co Eli
US5428014A (en) 1993-08-13 1995-06-27 Zymogenetics, Inc. Transglutaminase cross-linkable polypeptides and methods relating thereto
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5773577A (en) 1994-03-03 1998-06-30 Protein Polymer Technologies Products comprising substrates capable of enzymatic cross-linking
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
CA2155762C (en) 1994-08-23 2000-04-25 Haruya Sato Protein modification method
AU717906B2 (en) 1994-12-07 2000-04-06 American National Red Cross, The Supplemented and unsupplemented tissue sealants, methods of their production and use
US5747456A (en) 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5693341A (en) 1995-03-16 1997-12-02 Collagen Corporation Affinity bound collagen matrices for the delivery of biologically active agents
US5561982A (en) 1995-05-02 1996-10-08 Universal Vortex, Inc. Method for energy separation and utilization in a vortex tube which operates with pressure not exceeding atmospheric pressure
DE19624148A1 (de) * 1995-06-22 1997-01-02 Henkel Kgaa Masse zum Kleben, Dichten und Beschichten
JP2000500019A (ja) 1995-11-16 2000-01-11 ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング ストレプトアビジン融合タンパク質経由でのペプチドの生産方法
US7026292B1 (en) 1995-12-12 2006-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
PT876165E (pt) 1995-12-18 2006-10-31 Angiotech Biomaterials Corp Composicoes de polimeros reticulados e processos para a sua utilizacao
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5874308A (en) 1996-01-16 1999-02-23 University Of British Columbia Compositions and methods for modulating cell proliferation using growth factor-polysaccharide binding fusion proteins
BR9708589A (pt) 1996-04-05 1999-08-03 Minnesota Mining & Mfg Composição polimerizável por luz visível e processos para revestir um substrato com um revestimento protetor e para reparar um defeito em um substrato revestido
US5914182A (en) 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
US5877153A (en) 1996-06-11 1999-03-02 Commonwealth Biotechnologies Inc. Heparin-binding peptides
US6566406B1 (en) 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
AU4648697A (en) 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
EP0950665A4 (en) 1996-09-26 2004-05-06 Ajinomoto Kk PHYSIOLOGICALLY ACTIVE MODIFIED PROTEINS AND DRUG COMPOSITIONS CONTAINING THEM
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DE59807348D1 (de) 1997-02-05 2003-04-10 Rolic Ag Zug Photovernetzbare Silanderivate
DE19705963A1 (de) 1997-02-17 1998-08-20 Hoechst Ag Vernetzte Vinylpolymere mit Gallensäure-Adsorberwirkung
CA2307954C (en) 1997-04-03 2010-07-13 California Institute Of Technology Enzyme-medicated modification of fibrin for tissue engineering
WO1999031137A1 (en) 1997-12-18 1999-06-24 Eli Lilly And Company Crystalline teriparatide
US5958874A (en) 1998-02-18 1999-09-28 The Research Foundation Of State University Of New York Recombinant fibronectin-based extracellular matrix for wound healing
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
DZ2873A1 (fr) 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
US6894022B1 (en) 1998-08-27 2005-05-17 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
US7601685B2 (en) 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
US7241730B2 (en) 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
CA2359318C (en) 1999-02-01 2009-06-30 Universitat Zurich Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6312725B1 (en) * 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
WO2000064481A1 (en) 1999-04-22 2000-11-02 Eidgenössische Technische Hochschule (ETH) Controlled release of growth factors from heparin containing matrices
ES2200880T3 (es) 1999-04-26 2004-03-16 Akzo Nobel N.V. Composicion que comprende compuestos mercapto-funcionales.
KR100345214B1 (ko) 1999-08-17 2002-07-25 이강춘 생체적합성 고분자가 수식된 펩타이드의 비점막 전달
ATE434010T1 (de) 1999-08-27 2009-07-15 Angiodevice Internat Gmbh Interpenetrierende polymernetzwerke zur verwendung als hochfeste medizinische dichtungsmasse
CA2394653A1 (en) 2000-01-05 2001-07-12 Novartis Ag Hydrogels
WO2001054746A2 (en) 2000-01-31 2001-08-02 Advanced Research And Technology Institute, Inc. Composite biomaterial including anisometric calcium phosphate reinforcement particles
US7291673B2 (en) 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
EP1355965B1 (en) 2000-10-19 2012-09-19 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method of synthesizing block copolymers for multifunctional self-assembled systems
DE60218814T2 (de) 2001-01-03 2007-12-06 Santa Fe Science and Technology, Inc., Santa Fe Stabile, konjugiertes polymer enthaltende elektrochrome vorrichtungen mit ionischen flüssigkeiten
US20030044468A1 (en) * 2001-03-20 2003-03-06 Francesco Cellesi Two-phase processing of thermosensitive polymers for use as biomaterials
CA2367636C (en) 2001-04-12 2010-05-04 Lisa Mckerracher Fusion proteins
CA2681952A1 (en) 2001-04-25 2002-10-31 Eidgenoessische Technische Hochschule Zurich Drug delivery matrices to enhance wound healing
EP1446453A1 (en) 2001-11-07 2004-08-18 Universität Zürich Synthetic matrix for controlled cell ingrowth and tissue regeneration and endometriosis
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
ES2301697T3 (es) 2001-12-18 2008-07-01 Eidgenossisch Technische Hochschule Zurich Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos.
EP1494730B1 (en) 2002-03-22 2012-01-18 Kuros Biosurgery AG Composition for hard tissue augmentation
US20040002770A1 (en) 2002-06-28 2004-01-01 King Richard S. Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof
EP1562630A4 (en) 2002-10-31 2009-02-18 Univ Northwestern INJECTABLE BIOADHûSIVE POLYMERS HYDROGELES AND RELEVANT PROCESSES FOR ENZYMATIC PRODUCTION
US20040225077A1 (en) * 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US8013068B2 (en) 2003-01-02 2011-09-06 Rohm And Haas Company Michael addition compositions
AU2003203316B2 (en) 2003-02-13 2007-01-11 Synthes Gmbh Injectable bone-replacement mixture
US7273896B2 (en) 2003-04-10 2007-09-25 Angiotech Pharmaceuticals (Us), Inc. Compositions and methods of using a transient colorant
CN1626549A (zh) * 2003-12-11 2005-06-15 中国人民解放军军事医学科学院基础医学研究所 胸腺五肽的聚乙二醇化衍生物，含有它们的药物组合物及用途
EP1593727B1 (en) 2004-05-03 2008-08-06 Rohm And Haas Company Michael addition compositions
EP1593728B1 (en) 2004-05-03 2012-05-09 Rohm And Haas Company Michael addition compositions
EP1828244A2 (en) 2004-12-22 2007-09-05 Kuros Biosurgery AG Michael-type addition reaction functionalised peg hydrogels with factor xiiia incorporated biofactors
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
DE602006018023D1 (de) 2005-08-08 2010-12-16 Angstrom Medica Inc Zementprodukte sowie verfahren zu deren herstellung und verwendung

Also Published As

Publication number Publication date
JP2010523243A (ja) 2010-07-15
EP2136850A1 (en) 2009-12-30
US8961947B2 (en) 2015-02-24
CN101711168B (zh) 2013-05-01
EP2537539A1 (en) 2012-12-26
RU2009141875A (ru) 2011-05-20
ATE543520T1 (de) 2012-02-15
WO2008125655A1 (en) 2008-10-23
BRPI0810530A2 (pt) 2014-10-07
PL2136850T3 (pl) 2012-07-31
EP2537539B1 (en) 2019-04-03
US20150133579A1 (en) 2015-05-14
CA2685807A1 (en) 2008-10-23
BRPI0810530B1 (pt) 2018-07-17
CN101711168A (zh) 2010-05-19
PT2136850E (pt) 2012-04-27
RU2453340C2 (ru) 2012-06-20
JP5930336B2 (ja) 2016-06-08
JP2014176736A (ja) 2014-09-25
EP2136850B1 (en) 2012-02-01
ES2381639T3 (es) 2012-05-30
MX2009011005A (es) 2009-11-02
US9180222B2 (en) 2015-11-10
CA2685807C (en) 2016-04-12
DK2136850T3 (da) 2012-04-10
US20080253987A1 (en) 2008-10-16
ES2733276T3 (es) 2019-11-28

Similar Documents

Publication Publication Date Title
BRPI0810530A2 (pt) Selante tecidual polimérico
MY144221A (en) Biocompatible polymer compositions for dual or multistaged curing.
ES2192821T3 (es) Resinas de poliuretano modificadas con silano, procedimiento para su preparacion y su uso como resinas que se endurecen con humedad.
NO20013700D0 (no) GCSF-konjugater
BRPI0719499A8 (pt) Composição de poliolefina funcional
WO2008069919A3 (en) Methods & compositions for treating tissue using silk proteins
ATE419022T1 (de) Hydrophobe mehrkomponenten-heparinkonjugate, ein verfahren zur ihrer herstellung und verwendung
JO2707B1 (ar) مشتقات ثيوفين جليكوسايد جديدة, طرق تحضيرها, والادوية المحتوية على هذه المركبات واستخدامها
BR0308920A (pt) Composições nanoenchedoras reticuláveis e/ou reticuladas
DE602004013672D1 (de) Verfahren zur Herstellung eines modifizierten, konjugierten Dienpolymers und dieses enthaltende Elastomerzusammensetzung
BR0207502A (pt) Compostos, enanciÈmeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos
DE60229305D1 (de) Luftreinigungsfilter und verfahren zur herstellung desselben
NI200900190A (es) Derivados de sulfonil amida para el tratamiento del crecimiento celular anormal. pc33495a
BR0311612A (pt) Catalisador orgânico com solubilidade elevada, composição e aditivo de limpeza contendo o mesmo, processo de fabricação do mesmo, processo para a produção de sulfatos cìclicos e processo de limpeza de superfìcies ou tecidos
TW200613338A (en) Moisture-curable, silane crosslinking compositions
ATE361952T1 (de) Festigkeitsoptimierte polymere mit gemischten oxyalkyleneiheiten
BR0116332A (pt) Processo para o aumento da estabilidade
BRPI0413967A (pt) polìmero solúvel em água, processo para preparar um polìmero solúvel em água, composição e solução aquosa
ATE525438T1 (de) Flammwidrige flexible thermoplastische zusammensetzung, herstellungsverfahren und gegenstände daraus
DE60117651D1 (de) Bioabbaubare Zusammensetzung und Verfahren zur deren Herstellung
BRPI0516363A (pt) composição para cuidado dos cabelos e processo para preparação de uma composição
BRPI0403215A (pt) Composição de éter de celulose para a extrusão de artigos moldados minerais bem como processo para a extrusão de artigos moldados minerais com aplicação dessa composição de éter de celulose
BR0308690A (pt) Polisobutenaminas, processo para preparação e uso das mesmas, concentrado de aditivo, e, composição de combustìvel
ATE552286T1 (de) Verfahren zur herstellung von polyethylenglykolverbindungen
BRPI0714102A8 (pt) Composição de polietileno de alta densidade, processo para produzir uma composição de polietileno de alta densidade, dispositivo reservatório e método para confeccionar um dispositivo reservatório

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/04/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.