BRPI0810653A2 - Derivados de ácido nicotínico como moduladores do receptor metabotrópico de glutamato-5. - Google Patents
Derivados de ácido nicotínico como moduladores do receptor metabotrópico de glutamato-5.Info
- Publication number
- BRPI0810653A2 BRPI0810653A2 BRPI0810653-3A2A BRPI0810653A BRPI0810653A2 BR PI0810653 A2 BRPI0810653 A2 BR PI0810653A2 BR PI0810653 A BRPI0810653 A BR PI0810653A BR PI0810653 A2 BRPI0810653 A2 BR PI0810653A2
- Authority
- BR
- Brazil
- Prior art keywords
- glutamat
- modulators
- acid derivatives
- nicotinic acid
- metabotropic receptor
- Prior art date
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title 1
- 102000006239 metabotropic receptors Human genes 0.000 title 1
- 108020004083 metabotropic receptors Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07106537 | 2007-04-19 | ||
| PCT/EP2008/054682 WO2008128968A1 (en) | 2007-04-19 | 2008-04-17 | Nicotinic acid derivatives as modulators of metabotropic glutamate receptor-5 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0810653A2 true BRPI0810653A2 (pt) | 2014-11-04 |
Family
ID=38654771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0810653-3A2A BRPI0810653A2 (pt) | 2007-04-19 | 2008-04-17 | Derivados de ácido nicotínico como moduladores do receptor metabotrópico de glutamato-5. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20090105266A1 (pt) |
| EP (1) | EP2146969A1 (pt) |
| JP (1) | JP2010524892A (pt) |
| KR (1) | KR20090130141A (pt) |
| CN (1) | CN101679299A (pt) |
| AR (1) | AR068072A1 (pt) |
| AU (1) | AU2008240790A1 (pt) |
| BR (1) | BRPI0810653A2 (pt) |
| CA (1) | CA2682676A1 (pt) |
| CL (1) | CL2008001114A1 (pt) |
| EA (1) | EA200901379A1 (pt) |
| MX (1) | MX2009011208A (pt) |
| PE (1) | PE20090074A1 (pt) |
| TW (1) | TW200904425A (pt) |
| WO (1) | WO2008128968A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0606774D0 (en) * | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
| WO2010135493A2 (en) * | 2009-05-20 | 2010-11-25 | Emory University | Alzheimer's disease imaging agents |
| EP2390245A1 (en) * | 2010-05-26 | 2011-11-30 | Nabriva Therapeutics AG | Enantiomerically pure amines |
| US20140228398A1 (en) | 2011-03-18 | 2014-08-14 | Novartis Ag | COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE |
| WO2013081094A1 (ja) * | 2011-11-30 | 2013-06-06 | 東レ株式会社 | イミダゾ［１，２－ａ］ピリジン誘導体及びその医薬用途 |
| TW201341367A (zh) | 2012-03-16 | 2013-10-16 | Axikin Pharmaceuticals Inc | ３，５－二胺基吡唑激酶抑制劑 |
| US9296754B2 (en) | 2013-03-15 | 2016-03-29 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| US9233961B2 (en) | 2013-03-15 | 2016-01-12 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2014151729A1 (en) | 2013-03-15 | 2014-09-25 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| US10939682B2 (en) | 2013-07-02 | 2021-03-09 | Syngenta Participations Ag | Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| MY175865A (en) | 2013-12-19 | 2020-07-14 | Novartis Ag | [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis |
| JP6689821B2 (ja) | 2014-08-12 | 2020-04-28 | シンジェンタ パーティシペーションズ アーゲー | 硫黄含有置換基を有する殺有害生物的に活性な複素環式誘導体 |
| ES2806598T3 (es) | 2014-12-11 | 2021-02-18 | Syngenta Participations Ag | Derivados tetracíclicos activos como plaguicidas con sustituyentes que contienen azufre |
| HUE049801T2 (hu) | 2014-12-23 | 2020-10-28 | Sma Therapeutics Inc | 3,5-diaminopirazol kináz inhibitorok |
| EP3286186B1 (en) | 2015-04-24 | 2020-05-06 | Syngenta Participations AG | Pesticidally active polycyclic derivatives with sulfur substituted five membered ring heterocyles |
| JP2018513870A (ja) | 2015-04-24 | 2018-05-31 | シンジェンタ パーティシペーションズ アーゲー | 硫黄置換５員環複素環を有する殺有害生物的に活性な多環式誘導体 |
| US10202380B2 (en) | 2015-07-01 | 2019-02-12 | Syngenta Participations Ag | Pesticidally active tetracyclic derivatives with sulfur containing substituents |
| CN107735396B (zh) | 2015-07-01 | 2021-03-02 | 先正达参股股份有限公司 | 具有含硫取代基的杀有害生物活性多环衍生物 |
| WO2017087905A1 (en) | 2015-11-20 | 2017-05-26 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| US10738045B2 (en) | 2015-11-23 | 2020-08-11 | Syngenta Participations Ag | Pesticidally active heterocyclic derivatives with sulphur and cyclopropyl containing substituents |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| IL299415B2 (en) | 2016-06-16 | 2025-09-01 | Denali Therapeutics Inc | Pyrimidine-2-ylamino-1H-pyrazoles as LRRK2 inhibitors for use in the treatment of neurodegenerative disorders |
| CN114456164B (zh) | 2016-10-27 | 2024-03-12 | 先正达参股股份有限公司 | 具有硫和羟胺取代基的杀有害生物活性杂环衍生物 |
| WO2018091389A1 (en) | 2016-11-17 | 2018-05-24 | Syngenta Participations Ag | Pesticidally active heterocyclic derivatives with sulphur containing substituents |
| BR112019012127A2 (pt) | 2016-12-15 | 2019-11-05 | Syngenta Participations Ag | derivados heterocíclicos ativos em termos pesticidas com substituintes contendo enxofre |
| EP3562487B1 (en) | 2016-12-29 | 2023-11-29 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| EP3562306B1 (en) * | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| MX2021011775A (es) | 2017-04-26 | 2023-01-10 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| WO2018215304A1 (en) | 2017-05-22 | 2018-11-29 | Syngenta Participations Ag | Tetracyclic pyridazine sulphur containing compounds and their use as pesticides |
| EP4410295A3 (en) | 2017-06-06 | 2024-10-16 | Urovant Sciences GmbH | Use of vibegron to treat overactive bladder |
| US11399542B2 (en) | 2017-07-05 | 2022-08-02 | Syngenta Participations Ag | Pesticidally active heterocyclic derivatives with sulfur containing substituents |
| JP7288900B2 (ja) * | 2018-05-22 | 2023-06-08 | 日本農薬株式会社 | ベンゾイミダゾール化合物又はその塩類及び該化合物を含有する農園芸用殺虫殺ダニ剤並びにその使用方法 |
| AR115495A1 (es) | 2018-06-06 | 2021-01-27 | Syngenta Crop Protection Ag | Derivados heterocíclicos con sustituyentes que contienen azufre activos como plaguicidas |
| MA52954A (fr) | 2018-06-21 | 2021-04-28 | Cellestia Biotech Ag | Procédé pour la fabrication d'aminoéthers de diaryle et sels de chlorhydrate d'aminoéthers de diaryle |
| CN114269383A (zh) | 2019-01-08 | 2022-04-01 | 菲斯生物制药公司 | 金属酶抑制剂化合物 |
| US20220185797A1 (en) * | 2019-03-25 | 2022-06-16 | The Trustees Of Columbia Universityin The City Of New York | Selective foxo inhibitors for treatment of diabetes and other disorders related to impaired pancreatic function |
| WO2020208139A1 (en) * | 2019-04-10 | 2020-10-15 | Cellestia Biotech Ag | Inhibitors of notch signalling pathway and use thereof in treatment of cancers |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| CA3187867A1 (en) | 2020-07-03 | 2022-01-06 | Nihon Nohyaku Co., Ltd. | Anticoccidial agent and method for using the same |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| CN117396467A (zh) * | 2021-06-02 | 2024-01-12 | 日本农药株式会社 | 苯并咪唑化合物或其盐类和包含该化合物的犬心丝虫病防治剂及其使用方法 |
| CA3222199A1 (en) * | 2021-06-02 | 2022-12-08 | Nihon Nohyaku Co., Ltd. | Benzimidazole compound or salt thereof, canine filariasis control agent containing same, and method of use thereof |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| AU2023389404A1 (en) * | 2022-12-08 | 2025-05-22 | Boehringer Ingelheim International Gmbh | Novel substituted pyrazine-carboxamide-imidazopyridine derivatives |
| CN116332855B (zh) * | 2023-04-04 | 2025-08-01 | 苏州美诺医药科技有限公司 | 一种crf1受体拮抗剂的苯并咪唑衍生物中间体的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0113148A (pt) * | 2000-08-08 | 2003-07-08 | Ortho Mcneil Pharm Inc | Composições de 2-piridinamina e métodos relacionados |
| ES2291455T3 (es) * | 2001-03-12 | 2008-03-01 | Avanir Pharmaceuticals | Compuestos de bencimidazol para modular ige e inhibir la proliferacion celular. |
| EP1539749A4 (en) * | 2002-09-13 | 2007-06-13 | Merck & Co Inc | BY CONDENSED HETEROBICYCLOGRUPPEN SUBSTITUTED PHENYL COMPOUNDS AS METOBOTROPE GLUTAMATE-5 MODULATORS |
| JP2007524682A (ja) * | 2004-02-12 | 2007-08-30 | メルク エンド カムパニー インコーポレーテッド | 代謝調節型グルタミン酸受容体−５の調節物質としてのビピリジルアミド |
| US7459457B2 (en) * | 2004-04-13 | 2008-12-02 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
-
2008
- 2008-04-17 AR ARP080101578A patent/AR068072A1/es unknown
- 2008-04-17 JP JP2010503503A patent/JP2010524892A/ja active Pending
- 2008-04-17 WO PCT/EP2008/054682 patent/WO2008128968A1/en not_active Ceased
- 2008-04-17 BR BRPI0810653-3A2A patent/BRPI0810653A2/pt not_active Application Discontinuation
- 2008-04-17 PE PE2008000666A patent/PE20090074A1/es not_active Application Discontinuation
- 2008-04-17 EP EP08736339A patent/EP2146969A1/en not_active Withdrawn
- 2008-04-17 CN CN200880017209A patent/CN101679299A/zh active Pending
- 2008-04-17 AU AU2008240790A patent/AU2008240790A1/en not_active Abandoned
- 2008-04-17 KR KR1020097024024A patent/KR20090130141A/ko not_active Withdrawn
- 2008-04-17 MX MX2009011208A patent/MX2009011208A/es not_active Application Discontinuation
- 2008-04-17 EA EA200901379A patent/EA200901379A1/ru unknown
- 2008-04-17 CA CA002682676A patent/CA2682676A1/en not_active Abandoned
- 2008-04-18 TW TW097114322A patent/TW200904425A/zh unknown
- 2008-04-18 CL CL2008001114A patent/CL2008001114A1/es unknown
- 2008-04-18 US US12/148,557 patent/US20090105266A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20090074A1 (es) | 2009-03-02 |
| KR20090130141A (ko) | 2009-12-17 |
| JP2010524892A (ja) | 2010-07-22 |
| EA200901379A1 (ru) | 2010-04-30 |
| AR068072A1 (es) | 2009-11-04 |
| MX2009011208A (es) | 2009-10-30 |
| EP2146969A1 (en) | 2010-01-27 |
| CL2008001114A1 (es) | 2008-12-19 |
| AU2008240790A1 (en) | 2008-10-30 |
| US20090105266A1 (en) | 2009-04-23 |
| WO2008128968A1 (en) | 2008-10-30 |
| CN101679299A (zh) | 2010-03-24 |
| TW200904425A (en) | 2009-02-01 |
| CA2682676A1 (en) | 2008-10-30 |
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