BRPI0919447A2 - derivados do ácido 1-amino-2-ciclobutiletilborônico - Google Patents

derivados do ácido 1-amino-2-ciclobutiletilborônico

Info

Publication number: BRPI0919447A2
Authority: BR; Brazil
Prior art keywords: amino; acid derivatives; cyclobutylethylboronic; cyclobutylethylboronic acid; derivatives
Prior art date: 2008-09-29

Application number

BRPI0919447A

Other languages

English (en)

Inventor

Jing Li

Paul E Fleming

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-29

Filing date

2009-09-25

Publication date

2015-12-15

2009-09-25 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2015-12-15 Publication of BRPI0919447A2 publication Critical patent/BRPI0919447A2/pt

2021-03-30 Publication of BRPI0919447B1 publication Critical patent/BRPI0919447B1/pt

2021-05-25 Publication of BRPI0919447B8 publication Critical patent/BRPI0919447B8/pt

Links

BCNMPHGGRXUKHU-UHFFFAOYSA-N (1-amino-2-cyclobutylethyl)boronic acid Chemical class OB(O)C(N)CC1CCC1 BCNMPHGGRXUKHU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Oncology (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Obesity (AREA)
Psychology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)

BRPI0919447A 2008-09-29 2009-09-25 compostos derivados de ácido 1-amino-2- ciclobutiletilborônico, composição farmacêutica e uso dos mesmos para tratar câncer BRPI0919447B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US19461408P	2008-09-29	2008-09-29
US61/194,614		2008-09-29
PCT/US2009/005324 WO2010036357A1 (en)	2008-09-29	2009-09-25	Derivatives of 1-amino-2-cyclobutylethylboronic acid

Publications (3)

Publication Number	Publication Date
BRPI0919447A2 true BRPI0919447A2 (pt)	2015-12-15
BRPI0919447B1 BRPI0919447B1 (pt)	2021-03-30
BRPI0919447B8 BRPI0919447B8 (pt)	2021-05-25

Family

ID=41426361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0919447A BRPI0919447B8 (pt)	2008-09-29	2009-09-25	compostos derivados de ácido 1-amino-2- ciclobutiletilborônico, composição farmacêutica e uso dos mesmos para tratar câncer

Country Status (25)

Country	Link
US (3)	US8664200B2 (pt)
EP (1)	EP2346882B1 (pt)
JP (3)	JP5736314B2 (pt)
KR (1)	KR101739470B1 (pt)
CN (2)	CN103554143B (pt)
AR (1)	AR075090A1 (pt)
AU (1)	AU2009297113B2 (pt)
BR (1)	BRPI0919447B8 (pt)
CA (1)	CA2739375C (pt)
CL (1)	CL2011000653A1 (pt)
CO (1)	CO6362015A2 (pt)
CR (2)	CR20160475A (pt)
DO (1)	DOP2011000086A (pt)
EA (1)	EA030539B1 (pt)
EC (1)	ECSP11011011A (pt)
IL (1)	IL211983A0 (pt)
MA (1)	MA32729B1 (pt)
MX (1)	MX2011003317A (pt)
MY (1)	MY166653A (pt)
NZ (2)	NZ606001A (pt)
SG (1)	SG194388A1 (pt)
TW (2)	TW201024313A (pt)
UA (1)	UA105503C2 (pt)
WO (1)	WO2010036357A1 (pt)
ZA (1)	ZA201203615B (pt)

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2009
- 2009-09-12 AR ARP090103760A patent/AR075090A1/es not_active Application Discontinuation
- 2009-09-25 CR CR20160475A patent/CR20160475A/es unknown
- 2009-09-25 CN CN201310475757.1A patent/CN103554143B/zh active Active
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Also Published As

Publication number	Publication date
WO2010036357A1 (en)	2010-04-01
MY166653A (en)	2018-07-18
CR20160475A (es)	2016-12-19
MA32729B1 (fr)	2011-10-02
CA2739375C (en)	2019-03-12
US9771381B2 (en)	2017-09-26
CA2739375A1 (en)	2010-04-01
JP5736314B2 (ja)	2015-06-17
BRPI0919447B1 (pt)	2021-03-30
US8664200B2 (en)	2014-03-04
IL211983A0 (en)	2011-06-30
AU2009297113A1 (en)	2010-04-01
CL2011000653A1 (es)	2011-09-30
AU2009297113B2 (en)	2016-11-10
US20170349611A1 (en)	2017-12-07
US20100081633A1 (en)	2010-04-01
US10035811B2 (en)	2018-07-31
KR101739470B1 (ko)	2017-05-24
ECSP11011011A (es)	2011-07-29
TW201024313A (en)	2010-07-01
UA105503C2 (uk)	2014-05-26
CO6362015A2 (es)	2012-01-20
MX2011003317A (es)	2011-04-26
SG194388A1 (en)	2013-11-29
AR075090A1 (es)	2011-03-09
CR20110216A (es)	2011-07-14
TWI598352B (zh)	2017-09-11
EA201170508A1 (ru)	2011-10-31
CN103554143B (zh)	2018-02-23
DOP2011000086A (es)	2011-04-15
TW201641504A (zh)	2016-12-01
CN102203103A (zh)	2011-09-28
ZA201203615B (en)	2015-03-25
US20140194387A1 (en)	2014-07-10
BRPI0919447B8 (pt)	2021-05-25
NZ606001A (en)	2014-08-29
EA030539B1 (ru)	2018-08-31
JP2015143264A (ja)	2015-08-06
JP2012504122A (ja)	2012-02-16
JP2017025091A (ja)	2017-02-02
EP2346882A1 (en)	2011-07-27
EP2346882B1 (en)	2017-09-20
KR20110082534A (ko)	2011-07-19
CN103554143A (zh)	2014-02-05
NZ592497A (en)	2013-02-22

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2018-04-03	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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2020-01-28	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-02-27	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-11-03	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
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