BRPI0811687A2 - MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO - Google Patents

MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO

Info

Publication number
BRPI0811687A2
BRPI0811687A2 BRPI0811687-3A2A BRPI0811687A BRPI0811687A2 BR PI0811687 A2 BRPI0811687 A2 BR PI0811687A2 BR PI0811687 A BRPI0811687 A BR PI0811687A BR PI0811687 A2 BRPI0811687 A2 BR PI0811687A2
Authority
BR
Brazil
Prior art keywords
cis
attracurium
isometer
cisatracurium
separating
Prior art date
Application number
BRPI0811687-3A2A
Other languages
English (en)
Inventor
Oded Arad
Elena Ostrovsky
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Publication of BRPI0811687A2 publication Critical patent/BRPI0811687A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0811687-3A2A 2007-06-18 2008-03-05 MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO BRPI0811687A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94459707P 2007-06-18 2007-06-18
PCT/IL2008/000290 WO2008155752A1 (en) 2007-06-18 2008-03-05 (1r,1'r)-atracurium salts separation process

Publications (1)

Publication Number Publication Date
BRPI0811687A2 true BRPI0811687A2 (pt) 2015-02-18

Family

ID=39473371

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0811687-3A2A BRPI0811687A2 (pt) 2007-06-18 2008-03-05 MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO

Country Status (6)

Country Link
US (1) US8357805B2 (pt)
EP (1) EP2132181A1 (pt)
AU (1) AU2008264802A1 (pt)
BR (1) BRPI0811687A2 (pt)
CA (1) CA2687157A1 (pt)
WO (1) WO2008155752A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2125742A2 (en) 2007-03-08 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
EP2125743A1 (en) * 2007-03-26 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
CA2685488A1 (en) 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
BRPI0809893A2 (pt) 2007-05-01 2014-09-30 Chemagis Ltd Processo para prepar um sal de (1r-cis) - [(3,4 - dimetoxifenil) metil] - 1, 2,3,4 - tetraidro - 6,7 - dimetoxi - 2 - metil - 2 - carboxietil - isoquinolínio"
AU2008320380A1 (en) 2007-10-29 2009-05-07 Chemagis Ltd. Novel R,R'-atracurium salts
AU2009241211A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
ES2625329T3 (es) 2012-06-29 2017-07-19 Cornell University Agentes bloqueantes neuromusculares asimétricos reversibles de duración ultra-corta, corta o intermedia
CN104557703B (zh) * 2015-01-27 2018-01-16 江苏嘉逸医药有限公司 一种苯磺顺阿曲库铵精制方法
CN112326809A (zh) * 2020-09-24 2021-02-05 南京斯泰尔医药科技有限公司 一种苯磺顺阿曲库铵对映异构体的检测方法
CN112979547B (zh) * 2021-03-15 2022-10-21 江苏诚信药业有限公司 一种苯磺顺阿曲库铵的纯化方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU506657B2 (en) 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
US4491665A (en) 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4701460A (en) 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) 1984-07-18 1984-08-22 Wellcome Found Compounds
BG41897A1 (en) 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
JPS62265266A (ja) 1986-05-13 1987-11-18 Takasago Corp Ｎ−アシル−テトラヒドロイソキノリン類の製造法
US4988815A (en) 1989-10-26 1991-01-29 Riker Laboratories, Inc. 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
GB9015473D0 (en) 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents
US5240939A (en) 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
DE19535762A1 (de) 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US5684154A (en) 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
AP1797A (en) 1997-03-25 2007-11-15 Avera Pharmaceuticals Inc Substituted isoquinolines as ultra short acting neuromuscular blockers.
CN1241576C (zh) 1999-08-13 2006-02-15 阿克佐诺贝尔公司 化学螯合剂用于制备逆转临床使用的神经肌肉传导阻滞剂药物诱发的神经肌肉传导阻滞的药物的用途
EP1346214A2 (en) 2000-12-29 2003-09-24 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
US20060009485A1 (en) 2005-06-23 2006-01-12 Chemagis Ltd Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
CA2635496A1 (en) 2005-11-14 2007-05-24 Peter D. Winch Novel colored solutions of injectable drugs and their pharmaceutically acceptable salts
KR20070080108A (ko) 2006-02-06 2007-08-09 주식회사종근당 질소의 알파 위치에 비대칭탄소가 있는 라세믹 유도체의광학 이성질체 분리 방법
WO2008070121A1 (en) 2006-12-06 2008-06-12 Cornell Research Foundation, Inc. Intermediate duration neuromuscular blocking agents and antagonists thereof
EP2125742A2 (en) 2007-03-08 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
CN100531734C (zh) 2007-03-13 2009-08-26 黄乐群 阿曲库铵冷冻干燥组合物
EP2125743A1 (en) 2007-03-26 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0809893A2 (pt) 2007-05-01 2014-09-30 Chemagis Ltd Processo para prepar um sal de (1r-cis) - [(3,4 - dimetoxifenil) metil] - 1, 2,3,4 - tetraidro - 6,7 - dimetoxi - 2 - metil - 2 - carboxietil - isoquinolínio"
CA2685488A1 (en) 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CN101337936B (zh) 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
CN101337935B (zh) 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CA2692636A1 (en) 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
AU2008320380A1 (en) 2007-10-29 2009-05-07 Chemagis Ltd. Novel R,R'-atracurium salts
ITMI20080319A1 (it) 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
AU2009241211A1 (en) 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
IT1396543B1 (it) 2008-07-16 2012-12-14 Farmabios Spa Processo per la purificazione di bloccanti neuromuscolari
CN101475530A (zh) 2009-01-16 2009-07-08 东英（江苏）药业有限公司 通过制备液相色谱法分离纯化顺苯磺酸阿曲库铵的方法
CN101845017A (zh) 2009-03-24 2010-09-29 天津市炜杰科技有限公司 苯磺酸阿曲库铵类中间体的制备方法
WO2010128519A1 (en) 2009-05-04 2010-11-11 Kumar C Jairaj A method for detecting neuropathy and predicting foot ulcer development in human beings with health conditions like diabetes mellitus
WO2010128518A2 (en) 2009-05-04 2010-11-11 Gland Pharma Limited Novel process for the preparation of cisatracurium besylate

Also Published As

Publication number Publication date
CA2687157A1 (en) 2008-12-24
US8357805B2 (en) 2013-01-22
US20100174082A1 (en) 2010-07-08
EP2132181A1 (en) 2009-12-16
AU2008264802A1 (en) 2008-12-24
WO2008155752A1 (en) 2008-12-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.